Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 12, 2007, Pages 3491-3496

  Lagu, Bharat ^a   Lebedev, Rimma ^a   Pio, Barbara ^a   Yang, Maria ^a   Pelton, Patricia D ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

ABCA 1; Dyslipidemia; LXR; RXR; Triglycerides

Indexed keywords

ABC TRANSPORTER A1; ANTILIPEMIC AGENT; DIHYDRO (1H) QUINOLIN 2 ONE DERIVATIVE; DRUG VEHICLE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; RETINOID X RECEPTOR; RETINOID X RECEPTOR ALPHA; RETINOID X RECEPTOR STIMULATING AGENT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE MODEL; DRUG DOSE COMPARISON; DRUG SCREENING; DRUG SYNTHESIS; DYSLIPIDEMIA; IN VIVO CULTURE; MALE; NONHUMAN; RACEMIC MIXTURE; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; DYSLIPIDEMIAS; HYPOGLYCEMIC AGENTS; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY; RETINOID X RECEPTORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34249304805     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.01.049     Document Type: Article

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