Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 44, 2007, Pages 17323-17328

  Nahoum, Virginie ^a,b   Pérez, Efrén ^c   Germain, Pierre ^c   Rodríguez Barrios, Fátima ^c   Manzo, Fabio ^d,e   Kammerer, Sabrina ^d,f   Lemaire, Geraldine ^d   Hirsch, Oliver ^d   Royer, Catherine A ^a,b   Gronemeyer, Hinrich ^d   De Lera, Angel R ^c   Bourguet, William ^a,b  

^a INSERM   (France)

^b CENTRE DE BIOCHIMIE STRUCTURALE   (France)

^c UNIVERSITY OF VIGO   (Spain)

^d INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^e SECOND UNIVERSITY OF NAPLES   (Italy)

^f ETH ZURICH   (Switzerland)

Author keywords

Agonist; Antagonist; Crystal structure; Ligand design; Nuclear receptor

Indexed keywords

CELL NUCLEUS RECEPTOR; RETINOID X RECEPTOR; RETINOID X RECEPTOR ALPHA; RETINOID X RECEPTOR BETA; RETINOID X RECEPTOR GAMMA;

ANISOTROPY; ARTICLE; CONTROLLED STUDY; CRYSTALLOGRAPHY; CYTOLOGY; FLUORESCENCE; HUMAN; HUMAN CELL; LIGAND BINDING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE;

ANIMALS; CELL LINE; CELL PROLIFERATION; COUMARIC ACIDS; LIGANDS; MICE; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RETINOID X RECEPTORS; TETRAHYDRONAPHTHALENES;

EID: 36849024302     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0705356104     Document Type: Article

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