Diphenylamine-based retinoid antagonists: Regulation of RAR and RXR function depending on the N-substituent

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 8, 2011, Pages 2501-2507

  Ohta, Kiminori ^a   Kawachi, Emiko ^b   Fukasawa, Hiroshi ^c   Shudo, Koichi ^d   Kagechika, Hiroyuki ^b  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c Inst of Medicinal Molecular Design   (Japan)

^d Kawasaki   (Japan)

Author keywords

Antagonist; Diphenylamine; RAR; Retinoid

Indexed keywords

4 [N (4 ETHOXY 2,3,5,6 TETRAFLUORO)BENZYL N (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYLNAPHTHALENE 2 YL)AMINO]BENZOIC ACID; 4 [N (4 METHYLBENZYL) N (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYLNAPHTHALENE 2 YL)AMINO]BENZOIC ACID; 4 [N (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYLNAPHTHALENE 2 YL) N (4 TRIFLUOROMETHYLBENZYL)AMINO]BENZOIC ACID; 4 [N (BIPHEN 2 YLMETHYL) N (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYLNAPHTHALENE 2 YL)AMINO]BENZOIC ACID; 4 [N (NAPHTHALEN 2 YLMETHYL) N (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYLNAPHTHALENE 2 YL)AMINO]BENZOIC ACID; 4 [N BENZYL N (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYLNAPHTHALENE 2 YL)AMINO]BENZOIC ACID; 4 [N N HEPTYL N (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYLNAPHTHALENE 2 YL)AMINO]BENZOIC ACID; 4 [N N OCTYL N (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYLNAPHTHALENE 2 YL)AMINO]BENZOIC ACID; ALKYL GROUP; DIPHENYLAMINE DERIVATIVE; ETHYL 4 [N (4 METHYLBENZYL) N (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYLNAPHTHALENE 2 YL)AMINO]BENZOATE; ETHYL 4 [N (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYLNAPHTHALENE 2 YL) N (4 TRIFLUOROMETHYLBENZYL)AMINO]BENZOATE; ETHYL 4 [N (BIPHEN 2 YLMETHYL) N (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYLNAPHTHALENE 2 YL)AMINO]BENZOATE; ETHYL 4 [N (NAPHTHALENE 2 YLMETHYL) N (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYLNAPHTHALENE 2 YL)AMINO]BENZOATE; ETHYL 4 [N BENZYL N (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYLNAPHTHALENE 2 YL)AMINO]BENZOATE; ETHYL 4 [N N HEPTYL N (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYLNAPHTHALENE 2 YL)AMINO]BENZOATE; ETHYL 4 [N N OCTYL N (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYLNAPHTHALENE 2 YL)AMINO]BENZOATE; ETHYL 4 [N PENTAFLUOROBENZYL N (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYLNAPHTHALENE 2 YL)AMINO]BENZOATE; RECEPTOR BLOCKING AGENT; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROTEIN FUNCTION; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; TRANSACTIVATION;

CELL DIFFERENTIATION; DIPHENYLAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HL-60 CELLS; HUMANS; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; RETINOIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79954419081     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.03.026     Document Type: Article

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