Bioactive polyphenols from wine grapes

Bioactive Polyphenols from Wine Grapes

Volumn , Issue , 2013, Pages 1-66

  Stuart, Jeffrey A ^a   Robb, Ellen L ^a  

^a BROCK UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84985978235     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-6968-1     Document Type: Book

References (335)

1. Adrian M, Jeandet P, Breuil AC, Levite D, Debord S, Bessis R (2000a) Assay of resveratrol and derivative stilbenes in wines by direct injection high performance liquid chromatography. Am J Enol Viticult 51:37-41
2. Adrian M, Jeandet P, Douillet-Breuil AC, Tesson L, Bessis R (2000b) Stilbene content of mature Vitis vinifera berries in response to UV-C elicitation. J Agric Food Chem 48:6103-6105
3. Ahuja I, Kissen R, Bones AM (2012) Phytoalexins in defense against pathogens. Trends Plant Sci 17:73-90
4. Bavaresco L, Pezzutto S, Gatti M, Mattivi F (2007) Role of the variety and some environmental factors on grape stilbenes. Vitis 46:57-61
5. Boso S, Alonso-Villaverde V, Martinez M-C, Kassemeyer H-H (2012) Quantifi cation of stilbenes in Vitis genotypes with different levels of resistance to Plasmopara viticola infection. Am J Enol Viticult 63:419-423
6. Boue SM, Cleveland TE, Carter-Wientjes C, Shih BY, Bhatnagar D, McLachlan JM, Burow ME (2009) Phytoalexin-enriched functional foods. J Agric Food Chem 57:2614-2622
7. Boutegrabet L, Fekete A, Hertkorn N, Papastamoulis Y, Waffo-Téguo P, Mérillon JM, Jeandet P, Gougeon RD, Schmitt-Kopplin P (2011) Determination of stilbene derivatives in Burgundy red wines by ultra-high-pressure liquid chromatography. Anal Bioanal Chem 401:1513-1521
8. Chong J, Poutaraud A, Hugueney P (2009) Metabolism and roles of stilbenes in plants. Plant Sci 177:143-155
9. Coutos-Thevenot P, Poinssot B, Bonomelli A, Yean H, Breda C, Buffard D, Esnault R, Hain R, Boulay M (2001) In vitro tolerance to Botrytis cinerea of grapevine 41B rootstock in transgenic plants expressing the stilbene synthase Vst 1 gene under the control of a pathogen-inducible PR10 promoter. J Exp Bot 52:901-910
10. Douillet-Breuil AC, Jeandet P, Adrian M, Bessis R (1999) Changes in the phytoalexin content of various Vits spp. In response to ultraviolet C elicitation. J Agric Food Chem 47:4456-4461
11. Dourtoglou VG, Makris DP, Bois-Dounasand F, Zonas C (1999) Trans-resveratrol concentration in wines produced in Greece. J Food Comps Anal 12:227-233
12. Gaudette NJ, Pickering GJ (2011) Sensory and chemical characteristics of trans-resveratrol fortifi ed wine. Aust J Grape Wine Res 17:249-257
13. Gonzalez Urena A, Orea JM, Montero C, Jimenez JB, Gonzalez JL, Sanchez A, Dorado M (2003) Improving the post-harvest resistance in fruits by external application of trans-resveratrol. J Agric Food Chem 51:82-89
14. Hurst WJ, Glinski JA, Miller KB, Apgar J, Davey MH, Stuart DA (2008) Survey of the transresveratrol and trans-piceid content of cocoa-containing and chocolate products. J Agric Food Chem 56:8374-8378
15. Ingrosso I, Bonsegna S, De Demonico S, Laddomada B, Blando F, Santino A, Giovinazzo G (2011) Over-expression of a grape stilbene synthase gene in tomato induces parthenocarpy and causes abnormal pollen development. Plant Physiol Biochem 49:1092-1099
16. Jeandet P, Douillet-Breuil A-C, Bessis R, Debord S, Sbaghi M, Adrian M (2002) Phytoalexins from the Vitaceae: biosynthesis, phytoalexin gene expression in transgenic plants, antifungal activity, and metabolism. J Agric Food Chem 50:2731-2741
17. Jimenez JB, Orea JM, Urena AG, Escribano P, de la Osa PL, Guadarrama A (2007) Short anoxic treatments to enhance trans-resveratrol content in grapes and wine. Eur Food Res Technol 224:373-378
18. Larronde F, Gaudilliere JP, Krisa S, Decendit A, Deffieux G, Merillon JM (2003) Airborne methyl jasmonate induces stilbene accumulation in leaves and berries of grapevine plants. Am J Enol Viticult 54:63-66
19. Lijavetzky D, Almagro L, Belchi-Navarro S, Martinez-Zapater JM, Bru L, Pedreno MA (2008) Synergistic effect of methyljasmonate and cyclodextrin on stilbene biosynthesis pathway gene expression and resveratrol production in Monastrell grapevine cell cultures. BMC Res Notes 1:132
20. Liu SJ, Hu YL, Wang XL, Zhong J, Lin ZP (2006) High content of resveratrol in lettuce transformed with a stilbene synthase gene of Parthenocissus henryana. Journal of Agricultural and Food Chemistry 54:8082-8085
21. Liu Z, Zhuang C, Sheng S, Shao L, Zhao W, Zhao S (2011) Overexpression of a resveratrol synthase gene (PcRS) from Polygonum cuspidatum in transgenic Arabidopsis causes the accumulation of trans -piceid with antifungal activity. Plant Cell Rep 30:2027-2036
22. Malacarne G, Vrhovsek U, Zulini L, Cestaro A, Stefanini M, Mattivi F, Delledonne M, Velasco R, Moser C (2011) Resistance to Plasmopara viticola in a grapevine segregating population is associated with stilbenoid accumulation and with specifi c host transcriptional responses. BMC Plant Biol 11:114
23. Mark L, Nikfardjam MS, Avar P, Ohmacht R (2005) A validated HPLC method for the analysis of trans -resveratrol and trans -piceid in Hungarian wines. J Chromatogr Sci 43:445-449
24. Moreno-Labanda JF, Mallavia R, Pérez-Fons L, Lizama V, Saura D, Micol V (2004) Determination of piceid and resveratrol in Spanish wines deriving from Monastrell (Vitis vinifera L.) grape variety. J Agric Food Chem 52:5396-5403
25. Montero C, Cristescu SM, Jime'nez JB, Orea JM, teLintel Hekkert S, Harren FJM, Gonza'lez Uren A (2003) Trans-resveratrol and grape disease resistance. A dynamical study by highresolution laser-based techniques. Plant Physiol 131:129-138
26. Naugler C, McCallum JL, Klassen G, Strommer J (2007) Concentrations of trans -resveratrol and related stilbenes in Nova Scotia wines. Am J Enol Vit 58:117-119
27. Pan Q-H, Wang L, Li J-M (2009) Amounts and subcellular localization of stilbene synthase in response of grape berries to UV irradiation. Plant Sci 176:360-366
28. Parage C, Tavares R, Rety S, Baltenweck-Guyot R, Poutaraud A, Renault L, Heintz D, Lugan R, Marais G, Aubourg S, Hugueney P (2012) Structural, functional and evolutionary analysis of the unusually large stilbene synthase gene family in grapevine (Vitis vinifera). Plant Physiol 160(3):1407-1419
29. Rimando AM, Pan Z, Polashock JJ, Dayan FE, Mizuno CS, Snook ME, Liu C-J, Baserson SR (2012) In planta production of the highly potent resveratrol analogue pterostilbene via stilbene synthase and O-methyltransferase co-expression. Plant Biotech J 10:269-283
30. Romero-Pérez AI, Ibern-Gómez M, Lamuela-Raventós RM, de La Torre-Boronat MC (1999) Piceid, the major resveratrol derivative in grape juices. J Agric Food Chem 47:1533-1536
31. Romero-Pérez AI, Lamuela-Raventós RM, Andrés-Lacueva C, de La Torre-Boronat MC (2001) Method for the quantitative extraction of resveratrol and piceid isomers in grape berry skins. Effect of powdery mildew on the stilbene content. J Agric Food Chem 49:210-215
32. Schmidlin L, Poutaraud A, Claudel P, Mestre P, Prado E, Santos-Rosa M, Wiedemann-Merdinoglu S, Karst F, Merdinolglu D, Hugueney P (2008) A stress-inducible resveratrol O-methyltransferase involved in the biosynthesis of pterostilbene in grapevine. Plant Physiol 148:1630-1639
33. Schnee S, Viret O, Gindro K (2008) Role of stilbenes in the resistance of grapevine to powdery mildew. Physiol Mol Plant Pathol 72:128-133
34. Stervbo U, Vang O, Bonnesen C (2007) A review of the content of the putative chemopreventive phytoalexin resveratrol in red wine. Food Chem 101:449-457
35. Thomzik JE, Stenzel K, Stocker R, Schreier PH, Hain R, Stahl DJ (2001) Synthesis of a grapevine phytoalexin in transgenic tomatoes (Lycopersicon Esculentum Mill.) conditions resistance against Phytophthora infestans. Physiol Mol Plant Pathol 51:265-278
36. Vezzulli S, Civardi S, Ferrari F, Bavaresco L (2007) Methyl jasmonate treatment as a trigger of resveratrol synthesis in cultivated grapevine. Am J Enol Viticult 58:530-533
37. Wang W, Tang K, Yang HR, Wen PF, Zhang P, Wang HL, Huang WD (2010) Distribution of resveratrol and stilbene synthase in young grape plants (Vitis vinifera L. cv. Cabernet Sauvignon) and the effect of UV-C on its accumulation. Plant Physiol Biochem 48:142-152
38. Xu Y, Xu TF, Zhao XC, Zou Y, Li ZQ, Xiang J, Li FJ, Wang YJ (2012) Co-expression of VpROMT gene from Chinese wild Vitis pseudoreticulata with VpSTS in tobacco plants and its effects on the accumulation of pterostilbene. Protoplasma 249:819-833
39. Zamboni A, Gatto P, Cestaro A, Pilati S, Viola R, Mattivi F, Moser C, Velasco R (2009) Grapevine cell early activation of specifi c responses to DIMEB, a resveratrol elicitor. BMC Genomics 10:363
40. Zhu YJ, Agbayani R, Jackson MC, Tang CS, Moore PH (2004) Expression of the grapevine stilbene synthase gene VST1 in papaya provides increased resistance against diseases caused by Phytophthora palmivora. Planta 220:241-250
41. Abraham J, Johnson RW (2009) Consuming a diet supplemented with resveratrol reduced infection-related neuroinfl ammation and defi cits in working memory in aged mice. Rejuvenation Res 12:445-453
42. Agrawal M, Kumar V, Kashyap MP, Khanna VK (2011) Ischemic insult induced apoptosis changes in PC12 cells: protection by trans resveratrol. Eur J Pharmacol 666:5-11
43. Baarine M, Thandapilly S, Louis X, Mazue F, Yu L, Delmas D, Netticadan T, Lizard G, Latruffe N (2011) Pro-apoptotic versus anti-apoptotic properties of dietary resveratrol on tumoral and normal cardiac cells. Genes Nutr 6:161-169
44. Bass TM, Weinkove D, Houthoofd K, Gems D, Partridge L (2007) Effects of resveratrol on lifespan in Drosopholia melanogaster and Caenorhabditis elegans. Mech Ageing Dev 128:546-552
45. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444:337-342
46. Bhatt JK, Thomas S, Nanjan MJ (2012) Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutr Res 32:537-541
47. Bi XL, Yang JY, Dong YX, Wang JM, Cui YH, Ikeshima T, Zhao YQ, Wu CF (2005) Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia. Int Immunopharmacol 5:185-193
48. Billard C, Izard JC, Roman V, Kern C, Mathiot C, Mentz F, Kolb JP (2002) Comparative antiproliferative and apoptotic effects of resveratrol, epsilon-viniferin and vine-shots derived polyphenols (vineatrols) on chronic B lymphocytic leukemia cells and normal human lymphocytes. Leuk Lymphoma 43:1991-2002
49. Bishayee S, Dhir N (2009) Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis. Chem Biol Interact 179:131-144
50. Blanchet J, Longpré F, Bureau G, Morissette M, Dipaolo T, Bronchi G, Martinoli MG (2008) Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice. Prog Neuropsychopharmacol Biol Psychiatry 32:1243-1250
51. Brizuela L, Dayon A, Doumerc N, Ader I, Golzio M, Izard J, Hara Y, Malavaud B, Cuvillier O (2010) The sphingosine kinase-1 survival pathway is a molecular target for the tumorsuppressive tea and wine polyphenols in prostate cancer. FASEB J 24(10):3882-3894
52. Can G, Cakir Z, Kartal M, Gunduz U, Baran Y (2012) Apoptotic effects of resveratrol, a grape polyphenol, on imatinib-sensitive and resistant K562 chronic myeloid leukemia cells. Anticancer Res 32:2673-2678
53. Castillo-Pichardo L, Dharmawardhane S (2012) Grape polyphenols inhibit akt/mammalian target of rapamycin signaling and potentiate the effects of gefi tinib in breast cancer. Nutr Cancer 64:1058-1069
54. Castillo-Pichardo L, Martínez-Montemayor M, Martínez J, Wall K, Cubano L, Dharmawardhane S (2009) Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenols. Clin Exp Metastasis 26:505-516
55. Chang J, Rimando A, Pallas M, Camins A, Porquet D, Reeves J, Shukitt-Hale B, Smith MA, Joseph JA, Casadesus G (2012) Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease. Neurobiol Aging 33:2062-2071
56. Cheng Y, Zhang HT, Sun L, Guo S, Ouyang S, Zhang Y, Xu J (2006) Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury. Brain Res 1110:193-200
57. Colin D, Lancon A, Delmas D, Lizard G, Abrossinow J, Kahn E, Jannin B, Latruffe N (2008) Antiproliferative activities of resveratrol and related compounds in human hepatocyte derived HepG2 cells are associated with biochemical cell disturbance revealed by fl uorescence analyses. Biochimie 90:1674-1684
58. Cruz MN, Luksha L, Logman H, Poston L, Agewall S, Kublickiene K (2006) Acute responses to phytoestrogens in small arteries from men with coronary heart disease. Am J Physiol Heart Circ Physiol 290:H1969-H1975
59. Cui J, Sun R, Yu Y, Gou S, Zhao G, Wang C (2010) Antiproliferative effect of resveratrol in pancreatic cancer cells. Phytother Res 24:1637-1644
60. Dal-Pan A, Blanc S, Aujard F (2010) Resveratrol suppresses body mass gain in a seasonal nonhuman primate model of obesity. BMC Physiol 10:11
61. Dal-Pan A, Pifferi F, Marchal J, Picq JL, Aujard F, RESTRIKAL Consortium (2011a) Cognitive performances are selectively enhanced during chronic caloric restriction or resveratrolsupplementation in a primate. PLoS One 6:e16581
62. Dal-Pan A, Terrien J, Pifferi F, Botalla R, Hardy I, Marchal J, Zahariev A, Chery I, Zizzari P, Perret M, Picq JL, Epelbaum J, Blanc S, Aujard F (2011b) Caloric restriction or resveratrol supple-mentation and ageing in a non-human primate: fi rst-year outcome of the RESTRIKAL study in Microcebus murinus. Age 33:15-31
63. Dasgupta B, Milbrandt J (2007) Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci USA 104:7217-7222
64. Della-Morte D, Dave KR, DeFazio RA, Bao YC, Raval AP, Perez-Pinzon MA (2009) Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway. Neuroscience 159:993-1002
65. Fonseca-Kelly Z, Nassrallah M, Uribe J, Khan RS, Dine K, Dutt M, Shindler KS (2012) Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis. Front Neurol 3:84
66. Frampton G, Lazcano E, Li H, Mohamad A, DeMorrow S (2010) Resveratrol enhances the sensitivity of cholangiocarcinoma to chemotherapeutic agents. Lab Invest 90:1325-1338
67. Fu J, Jin J, Cichewicz RH, Hageman SA, Ellis TK, Xiang L, Peng Q, Jiang M, Arbez N, Hotaling K, Ross CA, Duan W (2012) Trans-(-)-e-viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in model of huntington disease. J Biol Chem 287:24460-24472
68. Gagliano N, Moscheni C, Torri C, Magnani I, Bertelli AA, Gioia M (2005) Effect of resveratrol on matrix metalloproteinase-2 (MMP-2) and secreted protein acidic and rich in cysteine (SPARC) on human cultured glioblastoma cells. Biomed Pharmacother 59:359-364
69. Gakh A, Anisimova N, Kiselevsky M, Sadovnikov S, Stankov I, Yudin M, Rufanov K, Krasavin M, Sosnov A (2010) Dihydro-resveratrol-a potent dietary polyphenol. Bioorg Med Chem Lett 20:6149-6151
70. Ganapathy S, Chen Q, Singh K, Shankar S, Sriivastava R (2010) Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor. PLoS One 5(12):e15627
71. Gao Z, Xu M, Barnett T, Xu W (2011) Resveratrol induces cellular senescence with attenuated mono-ubiquitination of histone H2B in glioma cells. Biochem Biophys Res Commun 407:271-276
72. Gatouillat G, Balasse E, Joseph-Pietras D, Morjani H, Madoulet C (2010) Resveratrol induces cellcycle disruption and apoptosis in chemoresistant B16 melanoma. J Cell Biochem 110:893-902
73. Genade T, Lang DM (2013) Resveratrol extends lifespan and preserves glia but not neurons of the Nothobranchius guentheri optic tectum. Exp Gerontol 48(2):202-212
74. George J, Singh M, Srivastava A, Bhui K, Roy P, Chaturvedi P, Shukla Y (2011) Resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated MAPKs and p53. PLoS One 6:e23395
75. Greer EL, Brunet A (2009) Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell 8:113-127
76. Gruber J, Tang SY, Halliwell B (2007) Evidence for a trade-off between survival and fi tness caused by resveratrol treatment of Caenorhabditis elegans. Ann N Y Acad Sci 1100:530-542
77. Hakimuddin F, Tiwari K, Paliyath G, Mechling K (2008) Grape and wine polyphenols downregulate the expression of signal transduction genes and inhibit the growth of estrogen receptornegative MDA-MB231 tumors in nu/nu mouse xenografts. Nutr Res 28:702-713
78. Harper C, Cook L, Patel B, Wang J, Altoum I, Arabshahi A, Shiral T, Lamartiniere C (2009) Genistein and resveratrol, alone and in combination, suppress prostate cancer in SV-40 tag rats. Prostate 69:1668-1682
79. Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425(6954):191-196
80. Hsieh T (2009) Antiproliferative effects of resveratrol and the mediating role of resveratrol targeting protein NQO2 in androgen receptor-positive, hormone-non-responsive CWR22Rv1 cells. Anticancer Res 29:3011-3017
81. Hu L, Cao D, Li Y, He Y, Guo K (2012) Resveratrol sensitized leukemia stem cell-like KG-1a cells to cytokine-induced killer cells-mediated cytolysis through NKG2D ligands and TRAIL receptors. Cancer Biol Ther 13:516-526
82. Huang SS, Tsai MC, Chih CL, Hung LM, Tsai SK (2001) Resveratrol reduction of infarct size in Long-Evans rats subjected to focal cerebral ischemia. Life Sci 69:1057-1065
83. Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275:218-220
84. Jefferson WN, Padilla-Banks E, Newbold RR (2007) Disruption of the developing female reproductive system by phytoestrogens: genistein as an example. Mol Nutr Food Res 51:832-844
85. Jefferson WN, Patisaul HB, Williams CJ (2012) Reproductive consequences of developmental phytoestrogen exposure. Reproduction 143:247-260
86. Jeon BT, Jeong EA, Shin HJ, Lee Y, Lee DH, Kim HJ, Kang SS, Cho GJ, Choi WS, Roh GS (2012) Resveratrol attenuates obesity-associated peripheral and central infl ammation and improves memory defi cit in mice fed a high-fat diet. Diabetes 61:1444-1454
87. Jeong JK, Moon MH, Bae BC, Lee YJ, Seol JW, Kang HS, Kim JS, Kang SJ, Park SY (2012) Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity. Neurosci Res 73:99-105
88. Ji H, Zhang X, Du Y, Liu H, Li S, Li L (2012) Polydatin modulates infl ammation by decreasing NF-βB activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood-brain barrier permeability for its neuroprotective effect in pMCAO rat brain. Brain Res Bull 87:50-59
89. Jin F, Wu Q, Lu YF, Gong QH, Sh JS (2008) Neuroprotective effect of resveratrol on 6-OHDAinduced Parkinson's disease in rats. Eur J Pharmacol 600:7882
90. Joseph JA, Fisher DR, Cheng V, Rimando AM, Shukitt-Hale B (2008) Cellular and behavioural effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging. J Agric Food Chem 56:10544-10561
91. Kaeberlein M, Burtner CR, Kennedy BK (2007) Recent developments in yeast aging. PLoS Genet 3(5):e84
92. Karuppagounder SS, Pinto JT, Xu H, Beal MF, Gibson GE (2009) Dietary supplementation with resveratrol reduced plaque pathology in a transgenic model Alzheimer's disease. Neurochem Int 54:111-118
93. Kim S, Jin Y, Choi Y, Park T (2011) Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and infl ammatory processes in mice. Biochem Pharmacol 81:1343-1351
94. Kim JY, Jeong HY, Lee HK, Kim S, Hwang BY, Bae K, Seong YH (2012) Neuroprotection of the leaf and stem of Vitis amurensis and their active compounds against ischemic brain damage in rats and excitotoxicity in cultured neurons. Phytomedicine 19:150-159
95. Kimura Y, Okuda H (2000) Effects of naturally occurring stilbene glucosides from medicinal plants and wine, on tumour growth and lung metastasis in Lewis lung carcinoma-bearing mice. J Pharm Pharmacol 52:1287-1295
96. Kramer M, Wesierska-Gadek J (2009) Monitoring of long-term effects of resveratrol on cell cycle progression of human HeLa cells after administration of a single dose. Ann N Y Acad Sci 1171:257-263
97. Kukui M, Choi HJ, Zhu BT (2010) Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death. Free Radic Biol Med 49:800-813
98. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127:1109-1122
99. Lea M, Ibeh C, Han L, Desbordes C (2010) Inhibition of growth and induction of differentiation markers by polyphenolic molecules and histone deacetylase inhibitors in colon cancer cells. Anticancer Res 30:311-318
100. Leifert W, Abeywardena M (2008) Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity. Nutr Res 28:842-850
101. Lekakis J, Rallidis LS, Andreadou I, Vamvakou G, Kazantzoglou G, Magiatis P, Skaltsounis AL, Kremastinos DT (2005) Polyphenolic compounds from red grapes acutely improve endothe-lial function in patients with coronary heart disease. Eur J Cardiovasc Prev Rehabil 12: 596-600
102. Lin VC, Tsai YC, Lin JN, Fan LL, Pan MH, Ho CT, Wu JY, Way TD (2012) Activation of AMPK by pterostilbene suppresses lipogenesis and cell-cycle progression in p53 positive and negative human prostate cancer cells. J Agric Food Chem 60:6399-6407
103. Long-tao L, Gang G, Min W, Zhang W (2012) The progress of the research on cardiovascular effects and acting mechanism of polydatin. Chin J Integr Med 18:714-719
104. Lu K, Chen Y, Tsia P, Tsia M, Lee Y, Chiang C, Kao C, Chiou S, Ku H, Lin C, Chen Y (2009) Evaluation of radiotherapy effect in resveratrol-treated medulloblastoma cancer stem-like cells. Childs Nerv Syst 25:543-550
105. Marel AK, Lizard G, Izard JC, Latruffe N, Delmas D (2008) Inhibitory effects of trans-resveratrol analogs molecules on the proliferation and the cell cycle progression of human colon tumoral cells. Mol Nutr Food Res 52:538-548
106. McCormack D, McFadden D (2012) Pterostilbene and cancer: current review. J Surg Res 173:e53-e61
107. Mena S, Rodriguez M, Ponsoda X, Estrela J, Jäättela M, Ortega A (2012) Pterostilbene-induced tumor cytotoxicity: a lysosomal membrane permeabilization-dependent mechanism. PLoS One 7:e44524
108. Miki H, Uehara N, Kimura A, Sasaki T, Yuri T, Yoshizawa K, Tsubura A (2012) Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells. Int J Oncol 40:1020-1028
109. Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R (2011) Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 66:191-201
110. Oi N, Jeong C, Nadas J, Cho Y, Pugliese A, Bode A, Dong Z (2010) Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A 4 hydrolase. Cancer Res 70:9755-9764
111. Palsamy P, Subramanian S (2008) Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats. Biomed Pharmacother 62:598-605
112. Palsamy P, Subramanian S (2010) Ameliorative potential of resveratrol on proinfl ammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic beta-cell dysfunction in streptozotocin-nicotinamide-induced diabetic rats. J Cell Physiol 224:423-432
113. Park ES, Lim Y, Hong JT, Yoo HS, Lee CK, Pyo MY, Yun YP (2010) Pterostilbene, a natural dimethylated analog of resveratrol, inhibits rat aortic vascular smooth muscle cell proliferation by blocking Akt-dependent pathway. Vascul Pharmacol 53:61-67
114. Park HR, Kong KH, Yu BP, Mattson MP, Lee J (2012) Resveratrol inhibits the proliferation of neural progenitor cells and hippocampal neurogenesis. J Biol Chem 287:42588-42600
115. Patel KR, Brown VA, Jones DJ, Britton RG, Hemingway D, Miller AS, West KP, Booth TD, Perloff M, Crowell JA, Brenner DE, Steward WP, Gescher AJ, Brown K (2010) Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Cancer Res 70(19): 7392-7399
116. Penumathsa SV, Thirunavukkarasu M, Zhan L, Maulik G, Menon VP, Bagchi D, Maulik N (2008) Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/ Akt/eNOS signalling pathway in diabetic myocardium. J Cell Mol Med 12:2350-2361
117. Priego S, Feddi F, Ferrer P, Mena S, Beniloch M, Ortega A, Carretero J, Obrador E, Asensi M, Astrela J (2008) Natural polyphenols facilitate elimination of HT-29 colorectal cancer xenografts by chemoradiotherapy: a Bcl-2-and superoxide dismutase 2-dependent mechanism. Mol Cancer Ther 7:3330-3342
118. Ramprasath VR, Jones PJ (2010) Anti-atherogenic effects of resveratrol. Eur J Clin Nutr 64: 660-668
119. Rascón B, Hubbard BP, Sinclair DA, Amdam GV (2012) The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction. Aging 4:499-508
120. Raval AP, Dave KR, Pérez-Pinzón MA (2006) Resveratrol mimics ischemic preconditioning in the brain. J Cereb Blood Flow Metab 26:1141-1147
121. Renaud S, de Lorgeril M (1992) Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339:1523-1526
122. Robb EL, Stuart JA (2011) Resveratrol interacts with estrogen receptor-ß to inhibit cell replicative growth and enhance stress resistance by upregulating mitochondrial superoxide dismutase. Free Radic Biol Med 50(7):821-831
123. Shamim U, Hanif S, Albanyan A, Beck F, Bao B, Wang Z, Banerjee S, Sarkar F, Mohammad R, Hadi S, Azmi A (2012) Resveratrol-induced apoptosis is enhanced in low pH environments associated with cancer. J Cell Physiol 227:1493-1500
124. Shin JA, Lee KE, Kim HS, Park EM (2012) Acute resveratrol treatment modulates multiple signaling pathways in the ischemic brain. Neurochem Res 37:2686-2696
125. Silan C (2008) The effects of chronic resveratrol treatment on vascular responsiveness of streptozotocin-induced diabetic rats. Biol Pharm Bull 31:897-902
126. Simão F, Matté A, Pagnussat AS, Netto CA, Salbego CG (2012a) Resveratrol prevents CA1 neurons against ischemic injury by parallel modulation of both GSK-3ß and CREB through PI3-K/ Akt pathways. Eur J Neurosci 36:2899-2905
127. Simão F, Matté A, Pagnussat AS, Netto CA, Salbego CG (2012b) Resveratrol preconditioning modulates infl ammatory response in the rat hippocampus following global cerebral ischemia. Neurochem Int 61:659-665
128. Sinha K, Chaudhary G, Gupta YK (2002) Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats. Life Sci 71:655-665
129. Soleas GJ, Diamandis EP, Goldberg DM (1997) Resveratrol: a molecule whose time has come? And gone? Clin Biochem 30:91-113
130. Srivastava G, Dixit A, Yadav S, Patel DK, Prakash O, Singh MP (2012) Resveratrol potentiates cytochrome P450 2 d22-mediated neuroprotection in maneb-and paraquat-induced parkinsonism in the mouse. Free Radic Biol Med 52:1294-1306
131. Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, Harrison DE (2013) Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci 68(1):6-16
132. Szkudelski T, Szkudelska K (2011) Anti-diabetic effects of resveratrol. Ann N Y Acad Sci 1215:34-39
133. Thirunavukkarasu M, Penumathsa SV, Koneru S, Juhasz B, Zhan L, Otani H, Bagchi D, Das DK, Maulik N (2007) Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of nitric oxide, thioredoxin, and heme oxygenase. Free Radic Biol Med 43:720-729
134. Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, Hoeks J, van der Krieken S, Ryu D, Kersten S, Moonen-Kornips E, Hesselink MK, Kunz I, Schrauwen-Hinderling VB, Blaak EE, Auwerx J, Schrauwen P (2011) Calorie restriction-like effects of days of resveratrol supplementation on energy metabolism and metabolic profi le in obese humans. Cell Metab 14:612-622.
135. Tomé-Carneiro J, Gonzálvez M, Larrosa M, García-Almagro FJ, Avilés-Plaza F, Parra S, Yáñez-Gascón MJ, Ruiz-Ros JA, García-Conesa MT, Tomás-Barberán FA, Espín JC (2012a) Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial. Mol Nutr Food Res 56:810-821
136. Tomé-Carneiro J, Gonzálvez M, Larrosa M, Yáñez-Gascón MJ, García-Almagro FJ, Ruiz-Ros JA, García-Conesa MT, Tomás-Barberán FA, Espín JC (2012b) One-year consumption of a grape nutraceutical containing resveratrol improves the infl ammatory and fi brinolytic status of patients in primary prevention of cardiovascular disease. Am J Cardiol 110:356-363
137. Trapp V, Parmakhtiar B, Papazian V, Willmott L, Fruehauf J (2010) Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanomaendothelial cell co-culture. Angiogenesis 13:305-315
138. Tredici G, Miloso M, Nicolini G, Galbiati S, Cavaletti G, Bertelli A (1999) Resveratrol, map kinases and neuronal cells: might wine be a neuroprotectant? Drugs Exp Clin Res 25:99-103
139. Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A (2006) Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol 16:296-300
140. Villa-Cuestra E, Boylan J, Tatar M, Gruppuso P (2011) Resveratrol inhibits protein translation in hepatic cells. PLoS One 6:e29513
141. Virgili M, Contestabile A (2000) Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats. Neurosci Lett 281:123-126
142. Walter A, Etienne-Selloum N, Brasse D, Khallouf H, Bronner C, Rio M, Beretz A, Schini-Kerth V (2010) Intake of grape-derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosis. FASEB J 24:3360-3369
143. Wang Y, Ding L, Wang X, Zhang J, Han W, Feng L, Sun J, Jin H, Wang XJ (2012a) Pterostilbene simultaneously induces apoptosis, cell cycle arrest and cyto-protective autophagy in breast cancer cells. Am J Transl Res 4:44-51
144. Wang Z, Li W, Meng X, Jia B (2012b) Resveratrol induces gastric cancer cell apoptosis via reactive oxygen species, but independent of sirtuin1. Clin Exp Pharmacol Physiol 39:227-232
145. Wang C, Wheeler CT, Alberico T, Sun X, Seeberger J, Laslo M, Spangler E, Kern B, de Cabo R, Zou S (2013) The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster. Age (Dordr) 35(1):69-81
146. Weng C, Yang Y, Ho C, Yen G (2009) Mechanisms of apoptotic effects induced by resveratrol, dibenzoylmethane, and their analogues on human lung carcinoma cells. J Agric Food Chem 57:5235-5243
147. Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430:686-689
148. Yoshino J, Conte C, Fontana L, Mittendorfer B, Imai S, Schechtman KB, Gu C, Kunz I, Rossi Fanelli F, Patterson BW, Klein S (2012) Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metab 16:658-664
149. Yu X, Li G (2012) Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fi sh Nothobranchius guentheri. Exp Gerontol 47:940-949
150. Yusuf N, Nasti T, Meleth S, Elmets C (2009) Resveratrol enhances cell-mediated immune response to DMBA through TLR4 and prevents DMBA induced cutaneous carcinogenesis. Mol Carcinog 48:713-723
151. Zamora-Ros R, Urpi-Sarda M, Lamuela-Raventós RM, Martínez-González Má, Salas-Salvadó J, Arós F, Fitó M, Lapetra J, Estruch R, Andres-Lacueva C, PREDIMED Study Investigators (2012) High urinary levels of resveratrol metabolites are associated with a reduction in the prevalence of cardiovascular risk factors in high-risk patients. Pharmacol Res 65:615-620
152. Zarse K, Schmeisser S, Birringer M, Falk E, Schmoll D, Ristow M (2010) Differential effects of resveratrol and SRT1720 on lifespan of adult Caenorhabditis elegans. Horm Metab Res 42:837-839
153. Zhao H, Niu Q, Li X, Liu T, Xu Y, Han H, Wang W, Fan N, Tian Q, Zhang H, Wang Z (2012) Long-term resveratrol consumption protects ovariectomized rats chronically treated with D-galactose from developing memory decline without effects on the uterus. Brain Res 1467:67-80
154. Zhuang H, Kim YS, Koehler RC, Doré S (2003) Potential mechanism by which resveratrol, a red wine constituent, protects neurons. Ann N Y Acad Sci 993:276-286
155. Zou S, Carey JR, Liedo P, Ingram DK, Müller HG, Wang JL, Yao F, Yu B, Zhou A (2009) The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fl y. Exp Gerontol 44:472-476
156. Agrawal M, Kumar V, Kashyap MP, Khanna VK, Randhawa GS, Pant AB (2011) Ischemic insult induced apoptotic changes in PC12 cells: protection by trans resveratrol. Eur J Pharmacol 666:5-11
157. Aguirre CC, Baudry M (2009) Progesterone reverses 17ß-estradiol-mediated neuroprotection and BDNF induction in cultured hippocampal slices. Eur J Neurosci 29:447-454
158. Aguirre C, Jayaraman A, Pike C, Baudry M (2010) Progesterone inhibits estrogen-mediated neuroprotection against excitotoxicity by down-regulating estrogen receptor-ß. J Neurochem 115:1277-1287
159. Albani D, Polito L, Batelli S, De Mauro S, Fracasso C, Martelli G, Colombo L, Manzoni C, Salmona M, Caccia S, Negro A, Forloni G (2009) The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide. J Neurochem 2110(5):1445-1456
160. Anter E, Chen K, Shapira OM, Karas RH, Keaney JF Jr (2005) p38 mitogen-activated protein kinase activates eNOS in endothelial cells by an estrogen receptor alpha-dependent pathway in response to black tea polyphenols. Circ Res 96:1072-1078
161. Babiker FA, Lips DJ, Delvaux E, Zandberg P, Janssen BJ, Prinzen F, van Eys G, Grohé C, Doevendans PA (2007) Oestrogen modulates cardiac ischaemic remodelling through oestrogen receptor-specifi c mechanisms. Acta Physiol (Oxf) 189:23-31
162. Barros RP, Gustafsson JÅ (2011) Estrogen receptors and the metabolic network. Cell Metab 14:289-299
163. Bass TM, Weinkove D, Houthoofd K, Gems D, Partridge L (2007) Effects of resveratrol on lifespan in Drosopholia melanogaster and Caenorhabditis elegans. Mech Ageing Dev 128:546-552
164. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444:337-342
165. Beher D, Wu J, Cumine S, Kim KW, Lu SC, Atangan L, Wang M (2009) Resveratrol is not a direct activator of SIRT1 enzyme activity. Chem Biol Drug Des 74:619-624
166. Bhat KP, Pezzuto JM (2001) Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma (Ishikawa) cells. Cancer Res 61:6137-6144
167. Bhat KP, Lantvit D, Christov K, Mehta RG, Moon RC, Pezzuto JM (2001) Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res 61:7456-7463
168. Blanchet J, Longpré F, Bureau G, Morissette M, DiPaolo T, Bronchti G, Martinoli MG (2008) Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice. Prog Neuropsychopharmacol Biol Psychiatry 32:1243-1250
169. Boily G, He XH, Pearce B, Jardine K, McBurney MW (2009) SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol. Oncogene 28:2882-2893
170. Borra MT, Smith BC, Denu JM (2005) Mechanism of human SIRT1 activation by resveratrol. J Biol Chem 280:17187-17195
171. Bourque M, Dluzen DE, Di Paolo T (2009) Neuroprotective actions of sex steroids in Parkinson's disease. Front Neuroendocrinol 30:142-157
172. Bowers JL, Tyulmenkov VV, Jernigan SC, Klinge CM (2000) Resveratrol acts as a mixed agonist/ antagonist for estrogen receptors alpha and beta. Endocrinology 141:3657-3667
173. Brandenberger AW, Tee MK, Lee JY, Chao V, Jaffe RB (1997) Tissue distribution of estrogen receptors alpha (ER-alpha) and beta (ER-beta) mRNA in the midgestational human fetus. J Clin Endocrinol Metab 82(10):3509-3512
174. Brinton RD (2008) Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer's disease. Adv Drug Deliv Rev 60:1504-1511
175. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303:2011-2015
176. Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfi la AM, Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Soti C, Partridge L, Gems D (2011) Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 477:482-485
177. Carswell HV, Macrae IM, Gallagher L, Harrop E, Horsburgh KJ (2004) Neuroprotection by a selective estrogen receptor beta agonist in a mouse model of global ischemia. Am J Physiol Heart Circ Physiol 287:H1501-H1504
178. Castillo-Pichardo L, Dharmawardhane SF (2012) Grape polyphenols inhibit akt/mammalian target of rapamycin signaling and potentiate the effects of gefi tinib in breast cancer. Nutr Cancer 64:1058-1069
179. Chan AY, Dolinsky VW, Soltys CL, Viollet B, Baksh S, Light PE, Dyck JR (2008) Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt. J Biol Chem 283:24194-24201
180. Chen JQ, Cammarata PR, Baines CP, Yager JD (2009) Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications. Biochim Biophys Acta 1793:1540-1570
181. Chen S, Li Z, Li W, Shan Z, Zhu W (2011) Resveratrol inhibits cell differentiation in 3T3-L1 adipocytes via activation of AMPK. Can J Physiol Pharmacol 89:793-799
182. Cheng Y, Zhang HT, Sun L, Guo S, Ouyang S, Zhang Y, Xu J (2006) Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury. Brain Res 1110:193-200
183. Csiszar A, Labinskyy N, Pinto JT, Ballabh P, Zhang H, Losonczy G, Pearson K, de Cabo R, Pacher P, Zhang C, Ungvari Z (2009) Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol 297:H13-H20
184. Danz ED, Skramsted J, Henry N, Bennett JA, Keller RS (2009) Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway. Free Radic Biol Med 46:1589-1597
185. Dasgupta B, Milbrandt J (2007) Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci USA 104:7217-7222
186. Della-Morte D, Dave KR, DeFazio RA, Bao YC, Raval AP, Perez-Pinzon MA (2009) Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway. Neuroscience 159:993-1002
187. D'Eon TM, Souza SC, Aronovitz M, Obin MS, Fried SK, Greenberg AS (2005) Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways. J Biol Chem 280:35983-35991
188. D'Eon TM, Rogers NH, Stancheva ZS, Greenberg AS (2008) Estradiol and the estradiol metabolite, 2-hydroxyestradiol, activate AMP-activated protein kinase in C2C12 myotubes. Obesity (Silver Spring) 16:1284-1288
189. Dell'Agli M, Galli GV, Vrhovsek U, Mattivi F, Bosisio E (2005) In vitro inhibition of human cGMP-specifi c phosphodiesterase-5 by polyphenols from red grapes. J Agric Food Chem 53(6):1960-1965
190. Dernek S, Ikizler M, Erkasap N, Ergun B, Koken T, Yilmaz K, Sevin B, Kaygisiz Z, Kural T (2004) Cardioprotection with resveratrol pretreatment: improved benefi cial effects over standard treatment in rat hearts after global ischemia. Scand Cardiovasc J 38:245-254
191. Di Liberto V, Mäkelä J, Korhonen L, Olivieri M, Tselykh T, Mälkiä A, Do Thi H, Belluardo N, Lindholm D, Mudò G (2012) Involvement of estrogen receptors in the resveratrol-mediated increase in dopamine transporter in human dopaminergic neurons and in striatum of female mice. Neuropharmacology 62:1011-1018
192. Duckles SP, Miller VM (2010) Hormonal modulation of endothelial NO production. Pfl ugers Arch-EurJ Physiol 459:841-851
193. El-Mowafy AM, Alkhalaf M (2003) Resveratrol activates adenylyl-cyclase in human breast cancer cells: a novel, estrogen receptor-independent cytostatic mechanism. Carcinogenesis 24(5): 869-873
194. Elangovan S, Ramachandran S, Venkatesan N, Ananth S, Gnana-Prakasam JP, Martin PM, Browning DD, Schoenlein PV, Prasad PD, Ganapathy V, Thangaraju M (2011) SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor a in breast cancer. Cancer Res 71(21):6654-6664
195. Elbaz A, Rivas D, Duque G (2009) Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice. Biogerontology 10(6):747-755
196. Faulds MH, Zhao C, Dahlman-Wright K, Gustafsson JÅ (2012) The diversity of sex steroid action: regulation of metabolism by estrogen signaling. J Endocrinol 212:3-12
197. Filardo EJ, Quinn JA, Frackelton AR Jr, Bland KI (2002) Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis. Mol Endocrinol 16(1):70-84
198. Fitzpatrick DF, Hirschfield SL, Coffey RG (1993) Effects of red and white wine on endotheliumdependent vasorelaxation of rat aort and human coronary arteries. Am J Physiol 275:H1183-H1190
199. Fukui M, Choi HJ, Zhu BT (2010) Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death. Free Radic Biol Med 49(5):800-813
200. Gabel SA, Walker VR, London RE, Steenbergen C, Korach KS, Murphy E (2005) Estrogen receptor beta mediates gender differences in ischemia/reperfusion injury. J Mol Cell Cardiol 38:289-297
201. Gehm BD, McAndrews JM, Chien PY, Jameson JL (1997) Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Acad Sci USA 94:14138-14143
202. Ghosh HS, McBurney M, Robbins PD (2010) SIRT1 negatively regulates the mammalian target of rapamycin. PLoS One 5(2):e9199
203. Gorres BK, Bomhoff GL, Morris JK, Geiger PC (2011) In vivo stimulation of oestrogen receptor a increases insulin-stimulated skeletal muscle glucose uptake. J Physiol 589:2041-2054
204. Guo J, Krause DN, Horne J, Weiss JH, Li X, Duckles SP (2010) Estrogen-receptor-mediated protection of cerebral endothelial cell viability and mitochondrial function after ischemic insult in vitro. J Cereb Blood Flow Metab 30:545-554
205. Guo J, Duckles SP, Weiss JH, Li X, Krause DN (2012) 17ß-Estradiol prevents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen-glucose deprivation/reperfusion. Free Radic Biol Med 52:2151-2160
206. Han HJ, Lee YH, Park SH (2000) Estradiol-17beta-BSA stimulates Ca(2+) uptake through nongenomic pathways in primary rabbit kidney proximal tubule cells: involvement of cAMP and PKC. J Cell Physiol 183(1):37-44
207. Han S, Choi JR, Soon Shin K, Kang SJ (2012) Resveratrol upregulated heat shock proteins and extended the survival of G93A-SOD1 mice. Brain Res 5(1483):112-117
208. Hardie DG (2011) AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev 25:1895-1908
209. Hirschberg AL (2012) Sex hormones, appetite and eating behaviour in women. Maturitas 71:248-256
210. Hoffmann S, Spitkovsky D, Radicella JP, Epe B, Wiesner RJ (2004) Reactive oxygen species derived from the mitochondrial respiratory chain are not responsible for the basal levels of oxidative base modifi cations observed in nuclear DNA of Mammalian cells. Free Radic Biol Med 36(6):765-773
211. Horsburgh K, Macrae IM, Carswell H (2002) Estrogen is neuroprotective via an apolipoprotein E-dependent mechanism in a mouse model of global ischemia. J Cereb Blood Flow Metab 22:1189-1195
212. Hou X, Xu S, Maitland-Toolan KA, Sato K, Jiang B, Ido Y, Lan F, Walsh K, Wierzbicki M, Verbeuren TJ, Cohen RA, Zang M (2008) SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem 283:20015-20026
213. Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425(6954):191-196
214. Hsieh YC, Choudhry MA, Yu HP, Shimizu T, Yang S, Suzuki T, Chen J, Bland KI, Chaudry IH (2006) Inhibition of cardiac PGC-1alpha expression abolishes ERbeta agonist-mediated cardioprotection following trauma-hemorrhage. FASEB J 20:1109-1117
215. Hu Y, Liu J, Wang J, Liu Q (2011) The controversial links among calorie restriction, SIRT1, and resveratrol. Free Radic Biol Med 2011(51):250-256
216. Hwang JT, Kwon DY, Park OJ, Kim MS (2008) Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells. Genes Nutr 2(4):323-326
217. Ji H, Zhang X, Du Y, Liu H, Li S, Li L (2012) Polydatin modulates infl ammation by decreasing NF-βB activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood-brain barrier permeability for its neuroprotective effect in pMCAO rat brain. Brain Res Bull 87:50-59
218. Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK (2005) Substrate-specifi c activation of sirtuins by resveratrol. J Biol Chem 280:17038-17045
219. Kairisalo M, Bonomo A, Hyrskyluoto A, Mudò G, Belluardo N, Korhonen L, Lindholm D (2011) Resveratrol reduces oxidative stress and cell death and increases mitochondrial antioxidants and XIAP in PC6.3-cells. Neurosci Lett 488(3):263-266
220. Kanda N, Watanabe S (2002) 17beta-estradiol enhances vascular endothelial growth factor production and dihydrotestosterone antagonizes the enhancement via the regulation of adenylate cyclase in differentiated THP-1 cells. J Invest Dermatol 118(3):519-529
221. Khan MM, Ahmad A, Ishrat T, Khan MB, Hoda MN, Khuwaja G, Raza SS, Khan A, Javed H, Vaibhav K, Islam F (2010) Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease. Brain Res 1328:139-151
222. Kim JY, Jo KJ, Kim BJ, Baik HW, Lee SK (2012) 17ß-estradiol induces an interaction between adenosine monophosphate-activated protein kinase and the insulin signaling pathway in 3T3-L1 adipocytes. Int J Mol Med, In Press
223. Klinge CM, Blankenship KA, Risinger KE, Bhatnagar S, Noisin EL, Sumanasekera WK, Zhao L, Brey DM, Keynton RS (2005) Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells. J Biol Chem 280:7460-7468
224. Klinge CM (2008) Estrogenic control of mitochondrial function and biogenesis. J Cell Biochem 105(6):1342-1351
225. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127(6):1109-1122
226. Leitman DC, Paruthiyil S, Vivar OI, Saunier EF, Herber CB, Cohen I, Tagliaferri M, Speed TP (2010) Regulation of specifi c target genes and biological responses by estrogen receptor subtype agonists. Curr Opin Pharmacol 10(6):629-636
227. Li H, Xia N, Förstermann U. (2012) Cardiovascular effects and molecular targets of resveratrol. Nitric Oxide 26:102-110
228. Li Y, Xu W, McBurney MW, Longo VD (2008) SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab 8:38-48
229. Lin JN, Lin VC, Rau KM, Shieh PC, Kuo DH, Shieh JC, Chen WJ, Tsai SC, Way TD (2010) Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation. J Agric Food Chem 58:1584-1592
230. Lin VC, Tsai YC, Lin JN, Fan LL, Pan MH, Ho CT, Wu JY, Way TD (2012) Activation of AMPK by pterostilbene suppresses lipogenesis and cell-cycle progression in p53 positive and negative human prostate cancer cells. J Agric Food Chem 60:6399-6407
231. Magyar K, Halmosi R, Palfi A, Feher G, Czopf L, Fulop A, Battyany I, Sumegi B, Toth K, Szabados E (2012) Cardioprotection by resveratrol: a human clinical trial in patients with stable coronary artery disease. Clin Hemorheol Microcirc 50:179-187
232. Mandusic V, Dimitrijevic B, Nikolic-Vukosavljevic D, Neskovic-Konstantinovic Z, Kanjer K, Hamann U (2012) Different associations of estrogen receptor ß isoforms, ERß1 and ERß2, expression levels with tumor size and survival in early-and late-onset breast cancer. Cancer Lett 321(1):73-79
233. Mattingly KA, Ivanova MM, Riggs KA, Wickramasinghe NS, Barch MJ, Klinge CM (2008) Estradiol stimulates transcription of nuclear respiratory factor-1 and increases mitochondrial biogenesis. Mol Endocrinol 22:609-622
234. Movahed A, Yu L, Thandapilly SJ, Louis XL, Netticadan T (2012) Resveratrol protects adult cardiomyocytes against oxidative stress mediated cell injury. Arch Biochem Biophys 527(2):74-80
235. Mokni M, Limam F, Elkahoui S, Amri M, Aouani E (2007) Strong cardioprotective effect of resveratrol, a red wine polyphenol, on isolated rat hearts after ischemia/reperfusion injury. Arch Biochem Biophys 457:1-6
236. Motylewska E, Stasikowska O, Melen-Mucha G (2009) The inhibitory effect of diarylpropionitrile, a selective agonist of estrogen receptor beta, on the growth of MC38 colon cancer line. Cancer Lett 276(1):68-73
237. Muthusamy S, Andersson S, Kim HJ, Butler R, Waage L, Bergerheim U, Gustafsson JÅ (2011) Estrogen receptor ß and 17ß-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer. Proc Natl Acad Sci USA 108(50):20090-20094
238. Nemoto S, Fergusson MM, Finkel T (2005) SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1(alpha). J Biol Chem 280:16456-16460
239. Nikolic I, Liu D, Bell JA, Collins J, Steenbergen C, Murphy E (2007) Treatment with an estrogen receptor-beta-selective agonist is cardioprotective. J Mol Cell Cardiol 42:769-780
240. Nilsson S, Koehler KF, Gustafsson JÅ (2011) Development of subtype-selective oestrogen receptor-based therapeutics. Nat Rev Drug Discov 10:778-792
241. Ostadal B, Netuka I, Maly J, Besik J, Ostadalova I (2009) Gender differences in cardiac ischemic injury and protection-experimental aspects. Exp Biol Med 234:1011-1019
242. Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, Garofalo RS, Griffith D, Griffor M, Loulakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K (2010) SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem 285(11):8340-8351
243. Park CE, Kim MJ, Lee JH, Min BI, Bae H, Choe W, Kim SS, Ha J (2007) Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase. Exp Mol Med 39:222-229
244. Park HR, Kong KH, Yu BP, Mattson MP, Lee JJ (2012) Resveratrol inhibits the proliferation of neural progenitor cells and hippocampal neurogenesis. Biol Chem 287:42588-42600
245. Pedram A, Razandi M, Wallace DC, Levin ER (2006) Functional estrogen receptors in the mitochondria of breast cancer cells. Mol Biol Cell 17(5):2125-2137
246. Price NL, Gomes AP, Ling AJY, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA (2012) SIRT1 is required for AMPK activation and the benefi cial effects of resveratrol on mitochondrial function. Cell Metab 2012(15):675-690
247. Razmara A, Duckles SP, Krause DN, Procaccio V (2007) Estrogen suppresses brain mitochondrial oxidative stress in female and male rats. Brain Res 1176:71-81
248. Raval AP, Dave KR, Pérez-Pinzón MA (2006) Resveratrol mimics ischemic preconditioning in the brain. J Cereb Blood Flow Metab 26:1141-1147
249. Ren J, Fan C, Chen N, Huang J, Yang Q (2011) Resveratrol pretreatment attenuates cerebral ischemic injury by upregulating expression of transcription factor Nrf2 and HO-1 in rats. Neurochem Res 36:2352-2362
250. Rivera L, Moró R, Zarzuelo A, Galisteo M (2009) Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats. Biochem Pharmacol 77:1053-1063
251. Robb EL, Page MM, Wiens BE, Stuart JA (2008a) Molecular mechanisms of oxidative stress resistance induced by resveratrol: specifi c and progressive induction of MnSOD. Biochem Biophys Res Commun 367:406-412
252. Robb EL, Winkelmolen L, Visanji N, Brotchie J, Stuart JA (2008b) Dietary resveratrol administration increases MnSOD expression and activity in mouse brain. Biochem Biophys Res Commun 372:254-259
253. Robb EL, Stuart JA (2011) Resveratrol interacts with estrogen receptor-ß to inhibit cell replicative growth and enhance stress resistance by upregulating mitochondrial superoxide dismutase. Free Radic Biol Med 50(7):821-831
254. Rogers NH, Witczak CA, Hirshman MF, Goodyear LJ, Greenberg AS (2009) Estradiol stimulates Akt, AMP-activated protein kinase (AMPK) and TBC1D1/4, but not glucose uptake in rat soleus. Biochem Biophys Res Commun 382:646-650
255. Sarsour EH, Kalen AL, Xiao Z, Veenstra TD, Chaudhuri L, Venkataraman S, Reigan P, Buettner GR, Goswami PC (2012) Manganese superoxide dismutase regulates a metabolic switch during the mammalian cell cycle. Cancer Res 72(15):3807-3816
256. Schleipen B, Hertrampf T, Fritzemeier KH, Kluxen FM, Lorenz A, Molzberger A, Velders M, Diel P (2011) ERß-specifi c agonists and genistein inhibit proliferation and induce apoptosis in the large and small intestine. Carcinogenesis 32(11):1675-1683
257. Schini-Kerth VB, Auger C, Etienne-Selloum N, Chataigneau T (2010) Polyphenol-induced endothelium-dependent relaxations role of NO and EDHF. Adv Pharmacol 60:133-175
258. Seifert EL, Caron AZ, Morin K, Coulombe J, He XH, Jardine K, Dewar-Darch D, Boekelheide K, Harper ME, McBurney MW (2012) SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice. FASEB J 26:555-566
259. Sequeira J, Boily G, Bazinet S, Saliba S, He X, Jardine K, Kennedy C, Staines W, Rousseaux C, Mueller R, McBurney MW (2008) Sirt1-null mice develop an autoimmune-like condition. Exp Cell Res 314:3069-3074
260. Shin SM, Cho IJ, Kim SG (2009) Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway. Mol Pharmacol 76:884-895
261. Simão F, Matté A, Matté C, Soares FM, Wyse AT, Netto CA, Salbego CG (2011) Resveratrol prevents oxidative stress and inhibition of Na(+)K(+)-ATPase activity induced by transient global cerebral ischemia in rats. J Nutr Biochem 22(10):921-928
262. Simpkins JW, Yi KD, Yang SH, Dykens JA (2010) Mitochondrial mechanisms of estrogen neuroprotection. Biochim Biophys Acta 1800:1113-1120
263. Simpkins JW, Singh M, Brock C, Etgen AM (2012) Neuroprotection and estrogen receptors. Neuroendocrinology 96:119-130
264. Sivritas D, Becher MU, Ebrahimian T, Arfa O, Rapp S, Bohner A, Mueller CF, Umemura T, Wassmann S, Nickenig G, Wassmann K (2011) Antiproliferative effect of estrogen in vascular smooth muscle cells is mediated by Kruppel-like factor-4 and manganese superoxide dismutase. Basic Res Cardiol 106(4):563-575
265. Stirone C, Duckles SP, Krause DN, Procaccio V (2005) Estrogen increases mitochondrial effi -ciency and reduces oxidative stress in cerebral blood vessels. Mol Pharmacol 68:959-965
266. Strehlow K, Rotter S, Wassmann S, Adam O, Grohé C, Laufs K, Böhm M, Nickenig G (2003) Modulation of antioxidant enzyme expression and function by estrogen. Circ Res 93(2):170-177
267. Sugiyama N, Barros RP, Warner M, Gustafsson JA (2010) ERbeta: recent understanding of estrogen signaling. Trends Endocrinol Metab 21:545-552
268. Al Sweidi S, Sánchez MG, Bourque M, Morissette M, Dluzen D, Di Paolo T (2012) Oestrogen receptors and signalling pathways: implications for neuroprotective effects of sex steroids in Parkinson's disease. J Neuroendocrinol 24:48-61
269. Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, Hoeks J, van der Krieken S, Ryu D, Kersten S, Moonen-Kornips E, Hesselink MK, Kunz I, Schrauwen-Hinderling VB, Blaak EE, Auwerx J, Schrauwen P (2011) Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profi le in obese humans. Cell Metab 14:612-622
270. Tissenbaum HA, Guarente L (2001) Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410:227-230
271. Ungvari Z, Labinskyy N, Mukhopadhyay P, Pinto JT, Bagi Z, Ballabh P, Zhang C, Pacher P, Csiszar A (2009) Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. Am J Physiol Heart Circ Physiol 297(5):H1876-H1881
272. Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A (2006) Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol 16:296-300
273. Vingtdeux V, Giliberto L, Zhao H, Chandakkar P, Wu Q, Simon JE, Janle EM, Lobo J, Ferruzzi MG, Davies P, Marambaud P (2010) AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem 285:9100-9113
274. Wang L, Andersson S, Warner M, Gustafsson JA (2001) Morphological abnormalities in the brains of estrogen receptor beta knockout mice. Proc Natl Acad Sci USA 98:2792-2796
275. Wang M, Crisostomo PR, Markel T, Wang Y, Lillemoe KD, Meldrum DR (2008) Estrogen receptor beta mediates acute myocardial protection following ischemia. Surgery 144: 233-238
276. Wang M, Wang Y, Weil B, Abarbanell A, Herrmann J, Tan J, Kelly M, Meldrum DR (2009) Estrogen receptor beta mediates increased activation of PI3K/Akt signaling and improved myocardial function in female hearts following acute ischemia. Am J Physiol Regul Integr Comp Physiol 296(4):R972-R978
277. Westerheide SD, Anckar J, Stevens SM Jr, Sistonen L, Morimoto RI (2009) Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 323:1063-1106
278. Whyte L, Huang YY, Torres K, Mehta RG (2007) Molecular mechanisms of resveratrol action in lung cancer cells using dual protein and microarray analyses. Cancer Res 67:12007-12017
279. Wilson BJ, Tremblay AM, Deblois G, Sylvain-Drolet G, Giguère V (2010) An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha. Mol Endocrinol 24:1349-1358
280. Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair DA (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430:686-689
281. Yao J, Hamilton RT, Cadenas E, Brinton RD (2010a) Decline in mitochondrial bioenergetics and shift to ketogenic profi le in brain during reproductive senescence. Biochim Biophys Acta 1800:1121-1126
282. Yao J, Chen S, Cadenas E, Brinton RD (2010b) Estrogen protection against mitochondrial toxininduced cell death in hippocampal neurons: antagonism by progesterone. Brain Res 1379:2-10
283. Yao Y, Li H, Gu Y, Davidson NE, Zhou Q (2010c) Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling. Carcinogenesis 31:382-387
284. Yao J, Irwin R, Chen S, Hamilton R, Cadenas E, Brinton RD (2012) Ovarian hormone loss induces bioenergetic defi cits and mitochondrial ß-amyloid. Neurobiol Aging 33(8):1507-1521
285. Yepuru M, Eswaraka J, Kearbey JD, Barrett CM, Raghow S, Veverka KA, Miller DD, Dalton JT, Narayanan R (2010) Estrogen receptor-(beta)-selective ligands alleviate high-fat diet-and ovariectomy-induced obesity in mice. J Biol Chem 285:31292-31303
286. Yoshino J, Conte C, Fontana L, Mittendorfer B, Imai S, Schechtman KB, Gu C, Kunz I, Rossi Fanelli F, Patterson BW, Klein S (2012) Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metab 16:658-664
287. Yuan P, Liang K, Ma B, Zheng N, Nussinov R, Huang J (2011) Multiple-targeting and conformational selection in the estrogen receptor: computation and experiment. Chem Biol Drug Des 78(1):137-149
288. Zang M, Xu S, Maitland-Toolan KA, Zuccollo A, Hou X, Jiang B, Wierzbicki M, Verbeuren TJ, Cohen RA (2006) Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-defi cient mice. Diabetes 55:2180-2191
289. Zheng J, Ramirez VD (1999) Rapid inhibition of rat brain mitochondrial proton F0F1-ATPase activity by estrogens: comparison with Na+, K+-ATPase of porcine cortex. Eur J Pharmacol 368:95-102
290. Zheng J, Ramirez VD (2000) Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicals. Br J Pharmacol 130:1115-1123
291. Almeida L, Vaz-da-Silva M, Falcao A, Soares E, Costa R, Loureiro AI, Fernandes-Lopes C, Rocha JF, Nunes T, Wright L, Soares-da-Silva P (2009) Pharmacokinetic and safety profi le of transresveratrol in a rising multiple-dose study in healthy volunteers. Mol Nutr Food Res 53:S7-S15
292. Amri A, Chaumeil JC, Sfar S, Charrueau C (2012) Administration of resveratrol: what formulation solutions to bioavailability limitations? J Control Release 158:182-193
293. Asensi M, Medina I, Ortega A, Carretero J, Bano MC, Obrador E, Estrela JM (2002) Inhibition of cancer growth by resveratrol is related to its low bioavailability. Free Radic Biol Med 33:387-398
294. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444:337-342
295. Boocock DJ, Faust GE, Patel KR, Schinas AM, Brown VA, Ducharme MP, Booth TD, Crowell JA, Perloff M, Gescher AJ, Steward WP, Brenner DE (2007) Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol Biomarkers Prev 16:1246-1252
296. Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Booth TD, Vasilinin G, Sen A, Schinas AM, Piccirilli G, Brown K, Steward WP, Gescher AJ, Brenner DE (2010) Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res 70:9003-9011
297. Coimbra M, Isacchi B, van Bloois L, Torano JS, Ket A, Wu X, Broere F, Metselaar JM, Rijcken CJ, Storm G, Bilia R, Schiffelers RM (2011) Improving solubility and chemical stability of natural compounds for medicinal use by incorporation into liposomes. Int J Pharm 416:433-442
298. Delmas D, Lin HY (2011) Role of membrane dynamics processes and exogenous molecules in cellular resveratrol uptake: consequences in bioavailability and activities. Mol Nutr Food Res 55:1142-1153
299. Delmas D, Jannin B, Cherkaoui Malki M, Latruffe N (2000) Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines. Oncol Rep 7:847-852
300. Edwards JA, Beck M, Riegger C, Bausch J (2011) Safety of resveratrol with examples for high purity, trans-resveratrol, resVida. Ann NY Acad Sci 1215:131-137
301. Gokce EH, Korkmaz E, Dellera E, Sandri G, Bonferoni MC, Ozer O (2012) Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications. Int J Nanomedicine 7:1841-1850
302. Hoshino J, Park EJ, Kondratyuk TP, Marler L, Pezzuto JM, van Breemen RB, Mo S, Li Y, Cushman M (2010) Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J Med Chem 53:5033-5043
303. Hsu CL, Lin YJ, Ho CT, Yen GC (2012) Inhibitory effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells. Food Funct 3:49-57
304. Jannin B, Menzel M, Berlot JP, Delmas D, Lancon A, Latruffe N (2004) Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake. Biochem Pharmacol 68:1113-1118
305. Juan ME, Maijo M, Planas JM (2010) Quantifi cation of trans-resveratrol and its metabolites in rat plasma and tissues by HPLC. J Pharm Biomed Anal 51:391-398
306. Kuhnle G, Spencer JP, Chowrimootoo G, Schroeter H, Debnam ES, Srai SK, Rice-Evans C, Hahn U (2000) Resveratrol is absorbed in the small intestine as resveratrol glucuronide. Biochem Biophys Res Commun 272:212-217
307. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127:1109-1122
308. Lasa A, Churruca I, Eseberri I, Andres-Lacueva C, Portillo MP (2012) Delipidating effect of resveratrol metabolites in 3T3-L1 adipocytes. Mol Nutr Food Res 56:1559-1568
309. Lau BY, Fajardo VA, McMeekin L, Sacco SM, Ward WE, Roy BD, Peters SJ, Leblanc PJ (2010) Infl uence of high-fat diet from differential dietary sources on bone mineral density, bone strength, and bone fatty acid composition in rats. Appl Physiol Nutr Metab 35:598-606
310. Lee MF, Pan MH, Chiou YS, Cheng AC, Huang H (2011) Resveratrol modulates MED28 (Magicin/EG-1) expression and inhibits epidermal growth factor (EGF)-induced migration in MDA-MB-231 human breast cancer cells. J Agric Food Chem 59:11853-11861
311. Lin HS, Yue BD, Ho PC (2009) Determination of pterostilbene in rat plasma by a simple HPLC-UV method and its application in pre-clinical pharmacokinetic study. Biomed Chromatogr 23:1308-1315
312. Marier JF, Vachon P, Gritsas A, Zhang J, Moreau JP, Ducharme MP (2002) Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model. J Pharmacol Exp Ther 302:369-373
313. McCormack D, Schneider J, McDonald D, McFadden D (2011) The antiproliferative effects of pterostilbene on breast cancer in vitro are via inhibition of constitutive and leptin-induced Janus kinase/signal transducer and activator of transcription activation. Am J Surg 202:541-544
314. McCormack DE, Mannal P, McDonald D, Tighe S, Hanson J, McFadden D (2012) Genomic analysis of pterostilbene predicts its antiproliferative effects against pancreatic cancer in vitro and in vivo. J Gastrointest Surg 16:1136-1143
315. Miksits M, Wlcek K, Svoboda M, Kunert O, Haslinger E, Thalhammer T, Szekeres T, Jager W (2009) Antitumor activity of resveratrol and its sulfated metabolites against human breast cancer cells. Planta Med 75:1227-1230
316. Nutakul W, Sobers HS, Qiu P, Dong P, Decker EA, McClements DJ, Xiao H (2011) Inhibitory effects of resveratrol and pterostilbene on human colon cancer cells: a side-by-side comparison. J Agric Food Chem 59:10964-10970
317. Richard T, Poupard P, Nassra M, Papastamoulis Y, Iglesias ML, Krisa S, Waffo-Teguo P, Merillon JM, Monti JP (2011) Protective effect of e-viniferin on ß-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry. Bioorg Med Chem 19:3152-3155
318. Robb EL, Winkelmolen L, Visanji N, Brotchie J, Stuart JA (2008b) Dietary resveratrol administration increases MnSOD expression and activity in mouse brain. Biochem Biophys Res Commun 372:254-259
319. Santos AC, Veiga F, Ribeiro AJ (2011) New delivery systems to improve the bioavailability of resveratrol. Expert Opin Drug Deliv 8:973-990
320. Teng Z, Yuan C, Zhang F, Huan M, Cao W, Li K, Yang J, Cao D, Zhou S, Mei W (2012) Intestinal absorption and fi rst-pass metabolism of polyphenol compounds in rat and their transport dynamics in Caco-2 cells. PLoS One 7:e29647
321. Teskac K, Kristl J (2010) The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol. Int J Pharm 390:61-69
322. Vitaglione P, Sforza S, Galaverna G, Ghidini C, Caporaso N, Vescovi PP, Fogliano V, Marchelli R (2005) Bioavailability of trans-resveratrol from red wine in humans. Mol Nutr Food Res 49:495-504
323. Vitrac X, Desmouliere A, Brouillaud B, Krisa S, Deffieux G, Barthe N, Rosenbaum J, Merillon JM (2003) Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration. Life Sci 72:2219-2233
324. Walle T, Hsieh F, DeLegge MH, Oatis JE Jr, Walle UK (2004) High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 32:1377-1382
325. Wang X, Song R, Bian HN, Brunk UT, Zhao M, Zhao KS (2012) Polydatin, a natural polyphenol, protects arterial smooth muscle cells against mitochondrial dysfunction and lysosomal destabilization following hemorrhagic shock. Am J Physiol 302:R805-R814
326. Wen X, Walle T (2006) Methylated fl avonoids have greatly improved intestinal absorption and metabolic stability. Drug Metab Dispos 34:1786-1792
327. Wenzel E, Somoza V (2005) Metabolism and bioavailability of trans-resveratrol. Mol Nutr Food Res 49:472-481
328. Wenzel E, Soldo T, Erbersdobler H, Somoza V (2005) Bioactivity and metabolism of transresveratrol orally administered to Wistar rats. Mol Nutr Food Res 49:482-494
329. Zghonda N, Yoshida S, Araki M, Kusunoki M, Mliki A, Ghorbel A, Miyazaki H (2011) Greater effectiveness of e-viniferin in red wine than its monomer resveratrol for inhibiting vascular smooth muscle cell proliferation and migration. Biosci Biotechnol Biochem 75:1259-1267
330. Beher D, Wu J, Cumine S, Kim KW, Lu SC, Atangan L, Wang M (2009) Resveratrol is not a direct activator of SIRT1 enzyme activity. Chem Biol Drug Des 74:619-624
331. Borra MT, Smith BC, Denu JM (2005) Mechanism of human SIRT1 activation by resveratrol. J Biol Chem 280:17187-17195
332. Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK (2005) Substrate-specifi c activation of sirtuins by resveratrol. J Biol Chem 280:17038-17045
333. McCormack D, McFadden D (2012) Pterostilbene and cancer: current review. J Surg Res 173:e53-e61
334. Nilsson S, Koehler KF, Gustafsson JÅ (2011) Development of subtype-selective oestrogen receptor-based therapeutics. Nat Rev Drug Discov 10:778-792
335. Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, Garofalo RS, Griffith D, Griffor M, Loulakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K (2010) SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem 285:8340-8351