ERβ-specific agonists and genistein inhibit proliferation and induce apoptosis in the large and small intestine

Carcinogenesis

Volumn 32, Issue 11, 2011, Pages 1675-1683

  Schleipen, B ^a   Hertrampf, T ^a   Fritzemeier, K H ^b   Kluxen, F M ^a   Lorenz, A ^a   Molzberger, A ^a   Velders, M ^a   Diel, P ^a  

^a GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

^b BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG VEHICLE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA SPECIFIC AGONIST; ESTROGEN RECEPTOR BETA; ESTROGEN RECEPTOR BETA SPECIFIC AGONIST; FULVESTRANT; GENISTEIN; HORMONE RECEPTOR AFFECTING AGENT; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; LARGE INTESTINE; NONHUMAN; ONCOGENE; OVARIECTOMY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; SMALL INTESTINE; WISTAR RAT;

ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CELL PROLIFERATION; DRUG SYNERGISM; ESTRADIOL; ESTROGEN ANTAGONISTS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; FEMALE; GENE EXPRESSION PROFILING; GENISTEIN; IMMUNOENZYME TECHNIQUES; INTESTINE, LARGE; INTESTINE, SMALL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 80755169508     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr188     Document Type: Article

References (54)

1. Javid,S.H. et al. (2005) Modulation of tumor formation and intestinal cell migration by estrogens in the Apc(Min/+) mouse model of colorectal cancer. Carcinogenesis, 26, 587-595.
2. Wada-Hiraike,O. et al. (2006) Role of estrogen receptor beta in colonic epithelium. Proc. Natl Acad. Sci. USA, 103, 2959-2964.
3. Chlebowski,R.T. et al. (2004) Estrogen plus progestin and colorectal cancer in postmenopausal women. N. Engl. J. Med., 350, 991-1004.
4. Farquhar,C.M. et al. (2005) Long term hormone therapy for perimenopausal and postmenopausal women. Cochrane Database Syst. Rev., 3, CD004143.
5. Dinger,J.C. et al. (2007) Colon cancer risk and different HRT formulations: a case-control study. BMC Cancer, 7, 76.
6. Korach,K.S. et al. (2003) Update on animal models developed for analyses of estrogen receptor biological activity. J. Steroid Biochem. Mol. Biol., 86, 387-391.
7. Gustafsson,J.A. (2003) What pharmacologists can learn from recent advances in estrogen signalling. Trends Pharmacol. Sci., 24, 479-485.
8. Carpenter,K.D. et al. (2006) Potential biological functions emerging from the different estrogen receptors. Ann. N.Y. Acad. Sci., 1092, 361-373.
9. Koehler,K.F. et al. (2005) Reflections on the discovery and significance of estrogen receptor beta. Endocr. Rev., 26, 465-478.
10. Kuiper,G.G. et al. (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology, 138, 863-870.
11. Weihua,Z. et al. (2001) A role for estrogen receptor beta in the regulation of growth of the ventral prostate. Proc. Natl Acad. Sci. USA, 98, 6330-6335.
12. Campbell-Thompson,M. et al. (2001) Expression of estrogen receptor (ER) subtypes and ERbeta isoforms in colon cancer. Cancer Res., 61, 632-640.
13. Konstantinopoulos,P.A. et al. (2003) Oestrogen receptor beta (ERbeta) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour's dedifferentiation. Eur. J. Cancer, 39, 1251-1258.
14. Harris,H.A. et al. (2003) Evaluation of an estrogen receptor-beta agonist in animal models of human disease. Endocrinology, 144, 4241-4249.
15. Wada-Hiraike,O. et al. (2006) New developments in oestrogen signalling in colonic epithelium. Biochem. Soc. Trans., 34, 1114-1116.
16. Weige,C.C. et al. (2009) Estradiol alters cell growth in nonmalignant colonocytes and reduces the formation of preneoplastic lesions in the colon. Cancer Res., 69, 9118-9124.
17. Martineti,V. et al. (2005) ERbeta is a potent inhibitor of cell proliferation in the HCT8 human colon cancer cell line through regulation of cell cycle components. Endocr. Relat. Cancer, 12, 455-469.
18. Jassam,N. et al. (2005) Loss of expression of oestrogen receptor beta in colon cancer and its association with Dukes' staging. Oncol. Rep., 14, 17-21
19. Lechner,D. et al. (2005) Phytoestrogens and colorectal cancer prevention. Vitam. Horm., 70, 169-198.
20. deVere White,R.W. et al. (2004) Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer. Urology, 63, 259-263.
21. Sarkar,F.H. et al. (2006) The role of genistein and synthetic derivatives of isoflavone in cancer prevention and therapy. Mini Rev. Med. Chem., 6, 401-407.
22. Mak,P. et al. (2010) ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell, 17, 319-332.
23. Hegele-Hartung,C. et al. (2004) Impact of isotype-selective estrogen receptor agonists on ovarian function. Proc. Natl Acad. Sci. USA, 101, 5129-5134.
24. Hillisch,A. et al. (2004) Dissecting physiological roles of estrogen receptor alpha and beta with potent selective ligands from structure-based design. Mol. Endocrinol., 18, 1599-1609.
25. West,N.J. et al. (2009) Apoptosis in the colonic crypt, colorectal adenomata, and manipulation by chemoprevention. Cancer Epidemiol. Biomarkers Prev., 18, 1680-1687.
26. Gavrieli,Y. et al. (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol., 119, 493-501.
27. Hertrampf,T. et al. (2008) Estrogen receptor subtype-specific effects on markers of bone homeostasis. Mol. Cell. Endocrinol., 291, 104-108.
28. Hertrampf,T. et al. (2005) Tissue-specific modulation of cyclooxygenase-2 (Cox-2) expression in the uterus and the v. cava by estrogens and phytoestrogens. Mol. Cell. Endocrinol., 243, 51-57.
29. Kubben,F.J. et al. (1994) Proliferating cell nuclear antigen (PCNA): a new marker to study human colonic cell proliferation. Gut, 35, 530-535.
30. Dvorakova,K. et al. (2005) Apoptosis resistance in Barrett's esophagus: ex vivo bioassay of live stressed tissues. Am. J. Gastroenterol., 100, 424-431.
31. Holubec,H. et al. (2005) Assessment of apoptosis by immunohistochemical markers compared to cellular morphology in ex vivo-stressed colonic mucosa. J. Histochem. Cytochem., 53, 229-235.
32. Koornstra,J.J. et al. (2003) Changes in apoptosis during the development of colorectal cancer: a systematic review of the literature. Crit. Rev. Oncol. Hematol., 45, 37-53.
33. Diebold,J. et al. (1992) Analysis of proliferative activity in colorectal mucosa by immunohistochemical detection of proliferating cell nuclear antigen (PCNA). Methodological aspects and application to routine diagnostic material. Virchows Arch. B Cell Pathol. Incl. Mol. Pathol., 62, 283-289.
34. Leonardos,L. et al. (1999) The activity of caspase-3-like proteases is elevated during the development of colorectal carcinoma. Cancer Lett., 143, 29-35.
35. Barone,M. et al. (2010) Dietary-induced ERbeta upregulation counteracts intestinal neoplasia development in intact male ApcMin/+ mice. Carcinogenesis, 31, 269-274.
36. Suh,K.Y. et al. (2007) p63 in primary cutaneous carcinosarcoma. Am. J. Dermatopathol., 29, 374-377.
37. Flores,E.R. (2007) The roles of p63 in cancer. Cell Cycle, 6, 300-304.
38. Owens,S.R. et al. (2007) Immunohistochemical staining for p63 is useful in the diagnosis of anal squamous cell carcinomas. Am. J. Surg. Pathol., 31, 285-290.
39. Thomas,C.G. et al. (2010) Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G(2)/M checkpoint signaling. Breast Cancer Res. Treat, 127, 417-427.
40. Park,J.H. et al. (2001) Synergistic effects of dexamethasone and genistein on the expression of Cdk inhibitor p21WAF1/CIP1 in human hepatocellular and colorectal carcinoma cells. Int. J. Oncol., 18, 997-1002.
41. Potten,C.S. et al. (1987) A comprehensive model of the crypts of the small intestine of the mouse provides insight into the mechanisms of cell migration and the proliferation hierarchy. J. Theor. Biol., 127, 381-391.
42. Marshman,E. et al. (2002) The intestinal epithelial stem cell. Bioessays, 24, 91-98.
43. Bardin,A. et al. (2004) Loss of ERbeta expression as a common step in estrogen-dependent tumor progression. Endocr. Relat. Cancer, 11, 537-551.
44. Hao,X. et al. (1998) Imbalance between proliferation and apoptosis in the development of colorectal carcinoma. Virchows Arch., 433, 523-527.
45. Carr,N.J. (2000) M30 expression demonstrates apoptotic cells, correlates with in situ end-labeling, and is associated with Ki-67 expression in large intestinal neoplasms. Arch. Pathol. Lab. Med., 124, 1768-1772.
46. Kikuchi,Y. et al. (1997) Proliferation and apoptosis in proliferative lesions of the colon and rectum. Virchows Arch., 431, 111-117.
47. Tanimoto,T. et al. (1998) Growth patterns in various macroscopic types of noninvasive intramucosal colorectal carcinoma with special reference to apoptosis and cell proliferation. Dis. Colon Rectum, 41, 1376-1384.
48. O'Mahony,F. et al. (2009) Novel female sex-dependent actions of oestrogen in the intestine. J. Physiol., 587, 5039-5044.
49. Cleveland,A.G. et al. (2009) Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc(Min/+) mice. Carcinogenesis, 30, 1581-1590.
50. Hope,C. et al. (2008) Low concentrations of resveratrol inhibit Wnt signal throughput in colon-derived cells: implications for colon cancer prevention. Mol. Nutr. Food Res., 52 (suppl. 1), S52-S61.
51. Zhao,C. et al. (2010) Estrogen signaling via estrogen receptor {beta}. J. Biol. Chem., 285, 39575-39579.
52. Chen,A.C. et al. (2005) Genistein inhibits intestinal cell proliferation in piglets. Pediatr. Res., 57, 192-200.
53. Booth,C. et al. (1999) In vivo administration of genistein has no effect on small intestinal epithelial proliferation and apoptosis, but a modest effect on clonogen survival. Cancer Lett., 144, 169-175.
54. Gee,J.M. et al. (2000) Increased induction of aberrant crypt foci by 1,2-dimethylhydrazine in rats fed diets containing purified genistein or genistein-rich soya protein. Carcinogenesis, 21, 2255-2259.