The controversial links among calorie restriction, SIRT1, and resveratrol

Free Radical Biology and Medicine

Volumn 51, Issue 2, 2011, Pages 250-256

  Hu, Yi ^a   Liu, Jing ^b,c   Wang, Junfeng ^b   Liu, Qingsong ^b,d,e  

^a Brigham and Women's Hospital Center for Neurologic Diseases   (United States)

^b Academy of Science   (China)

^c HARVARD MEDICAL SCHOOL   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e Department of Biological Chemistry and Molecular Pharmacology ^*  (United States)

Author keywords

Calorie restriction; Deacetylase; Life span; Resveratrol; SIRT1

Indexed keywords

6 CHLORO 2,3,4,9 TETRAHYDRO 1 H CARBAZOLE 1 CARBOXAMIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EX 527; HISTONE DEACETYLASE; HYDROLASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; PROPYLTHIOURACIL; RESVERATROL; SIRTUIN 1; SIRTUIN 2; SMALL INTERFERING RNA; SOMATOMEDIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; CALORIC RESTRICTION; CELL FUNCTION; COLITIS; DEACETYLATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIFESPAN; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CALORIC RESTRICTION; GENE KNOCKDOWN TECHNIQUES; HUMANS; SIRTUIN 1; STILBENES;

EID: 79959343572     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.04.034     Document Type: Review

References (107)

1. C.M. McCay, M.F. Crowell, and L.A. Maynard The effect of retarded growth upon the length of life span and upon the ultimate body size J. Nutr. 10 1935 63 79
2. L. Fontana, L. Partridge, and V.D. Longo Extending healthy life span-from yeast to humans Science 328 2010 321 326
3. L. Bordone, and L. Guarente Calorie restriction, SIRT1 and metabolism: understanding longevity Nat. Rev. Mol. Cell Biol. 6 2005 298 305 (Pubitemid 40516896)
4. J.O. Holloszy, and L. Fontana Caloric restriction in humans Exp. Gerontol. 42 2007 709 712 (Pubitemid 47058857)
5. M. Kaeberlein, M. McVey, and L. Guarente The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms Genes Dev. 13 1999 2570 2580 (Pubitemid 29489648)
6. S.J. Lin, P.A. Defossez, and L. Guarente Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae Science 289 2000 2126 2128
7. H.Y. Cohen, C. Miller, K.J. Bitterman, N.R. Wall, B. Hekking, B. Kessler, K.T. Howitz, M. Gorospe, R. de Cabo, and D.A. Sinclair Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase Science 305 2004 390 392 (Pubitemid 38938153)
8. C.B. Brachmann, J.M. Sherman, S.E. Devine, E.E. Cameron, L. Pillus, and J.D. Boeke The Sir2 gene family, conserved from bacteria to humans, functions in silencing, cell-cycle progression, and chromosome stability Genes Dev. 9 1995 2888 2902
9. S. Imai, C.M. Armstrong, M. Kaeberlein, and L. Guarente Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase Nature 403 2000 795 800 (Pubitemid 30111843)
10. L. Guarente Sirtuins as potential targets for metabolic syndrome Nature 444 2006 868 874 (Pubitemid 46024994)
11. T. Finkel, C.X. Deng, and R. Mostoslavsky Recent progress in the biology and physiology of sirtuins Nature 460 2009 587 591
12. K.T. Howitz, K.J. Bitterman, H.Y. Cohen, D.W. Lamming, S. Lavu, J.G. Wood, R.E. Zipkin, P. Chung, A. Kisielewski, L.L. Zhang, B. Scherer, and D.A. Sinclair Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan Nature 425 2003 191 196 (Pubitemid 37150899)
13. J.G. Wood, B. Rogina, S. Lavu, K. Howitz, S.L. Helfand, M. Tatar, and D. Sinclair Sirtuin activators mimic caloric restriction and delay ageing in metazoans Nature 430 2004 686 689 (Pubitemid 39061685)
14. J.L. Barger, T. Kayo, J.M. Vann, E.B. Arias, J.L. Wang, T.A. Hacker, Y. Wang, D. Raederstorff, J.D. Morrow, C. Leeuwenburgh, D.B. Allison, K.W. Saupe, G.D. Cartee, R. Weindruch, and T.A. Prolla A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice PLoS One 3 2008 e2264
15. K.J. Pearson, J.A. Baur, K.N. Lewis, L. Peshkin, N.L. Price, N. Labinskyy, W.R. Swindell, D. Kamara, R.K. Minor, E. Perez, H.A. Jamieson, Y. Zhang, S.R. Dunn, K. Sharma, N. Pleshko, L.A. Woollett, A. Csiszar, Y. Ikeno, D. Le Couteur, P.J. Elliott, K.G. Becker, P. Navas, D.K. Ingram, N.S. Wolf, Z. Ungvari, D.A. Sinclair, and R. de Cabo Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span Cell Metab. 8 2008 157 168
16. C.J. Kenyon The genetics of ageing Nature 464 2010 504 512
17. G. Donmez, and L. Guarente Aging and disease: connections to sirtuins Aging Cell 9 2010 285 290
18. J.T. Rodgers, C. Lerin, W. Haas, S.P. Gygi, B.M. Spiegelman, and P. Puigserver Nutrient control of glucose homeostasis through a complex of PGC-1 alpha and SIRT1 Nature 434 2005 113 118 (Pubitemid 40349395)
19. A.E. Civitarese, S. Carling, L.K. Heilbronn, M.H. Hulver, B. Ukropcova, W.A. Deutsch, S.R. Smith, and E. Ravussin CALERIE Pennington Team. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans PLoS Med. 4 2007 e76
20. L. Bordone, D. Cohen, A. Robinson, M.C. Motta, E. van Veen, A. Czopik, A.D. Steele, H. Crowe, S. Marmor, J.Y. Luo, W. Gu, and L. Guarente SIRT1 transgenic mice show phenotypes resembling calorie restriction Aging Cell 6 2007 759 767 (Pubitemid 350131044)
21. A.S. Banks, N. Kon, C. Knight, M. Matsumoto, R. Gutierrez-Juarez, L. Rossetti, W. Gu, and D. Accili SirT1 gain of function increases energy efficiency and prevents diabetes in mice Cell Metab. 8 2008 333 341
22. D. Chen, A.D. Steele, S. Lindquist, and L. Guarente Increase in activity during calorie restriction requires Sirt1 Science 310 2005 1641 (Pubitemid 41780779)
23. G. Boily, E.L. Seifert, L. Bevilacqua, X.H. He, G. Sabourin, C. Estey, C. Moffat, S. Crawford, S. Saliba, K. Jardine, J. Xuan, M. Evans, M.E. Harper, and M.W. McBurney SirT1 regulates energy metabolism and response to caloric restriction in mice PLoS One 3 2008 e1759
24. Y. Li, W. Xu, M.W. McBurney, and V.D. Longo SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons Cell Metab. 8 2008 38 48 (Pubitemid 351859225)
25. J.J. Smith, R.D. Kenney, D.J. Gagne, B.P. Frushour, W. Ladd, H.L. Galonek, K. Israelian, J. Song, G. Razvadauskaite, A.V. Lynch, D.P. Carney, R.J. Johnson, S. Lavu, A. Iffland, P.J. Elliott, P.D. Lambert, K.O. Elliston, M.R. Jirousek, J.C. Milne, and O. Boss Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo BMC Syst. Biol. 3 2009 31
26. J.A. Baur, K.J. Pearson, N.L. Price, H.A. Jamieson, C. Lerin, A. Kalra, V.V. Prabhu, J.S. Allard, G. Lopez-Lluch, K. Lewis, P.J. Pistell, S. Poosala, K.G. Becker, O. Boss, D. Gwinn, M.Y. Wang, S. Ramaswamy, K.W. Fishbein, R.G. Spencer, E.G. Lakatta, D. Le Couteur, R.J. Shaw, P. Navas, P. Puigserver, D.K. Ingram, R. de Cabo, and D.A. Sinclair Resveratrol improves health and survival of mice on a high-calorie diet Nature 444 2006 337 342 (Pubitemid 44764104)
27. J.C. Milne, P.D. Lambert, S. Schenk, D.P. Carney, J.J. Smith, D.J. Gagne, L. Jin, O. Boss, R.B. Perni, C.B. Vu, J.E. Bemis, R. Xie, J.S. Disch, P.Y. Ng, J.J. Nunes, A.V. Lynch, H.Y. Yang, H. Galonek, K. Israelian, W. Choy, A. Iffland, S. Lavu, O. Medvedik, D.A. Sinclair, J.M. Olefsky, M.R. Jirousek, P.J. Elliott, and C.H. Westphal Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes Nature 450 2007 712 716 (Pubitemid 350207685)
28. F. Picard, M. Kurtev, N.J. Chung, A. Topark-Ngarm, T. Senawong, R.M. de Oliveira, M. Leid, M.W. McBurney, and L. Guarente Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma Nature 429 2004 771 776 (Pubitemid 38833129)
29. L.A. Wakeling, L.J. Ions, and D. Ford Could Sirt1-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions? Age 31 2009 327 341
30. M.J. Holness, P.W. Caton, and M.C. Sugden Acute and long-term nutrient-led modifications of gene expression: potential role of SIRT1 as a central co-ordinator of short and longer-term programming of tissue function Nutrition 26 2010 491 501
31. P. Fabrizio, C. Gattazzo, L. Battistella, M. Wei, C. Cheng, K. McGrew, and V.D. Longo Sir2 blocks extreme life-span extension Cell 123 2005 655 667 (Pubitemid 41608467)
32. M. Kaeberlein, K.T. Kirkland, S. Fields, and B.K. Kennedy Sir2-independent life span extension by calorie restriction in yeast PLoS Biol. 2 2004 e296
33. M. Kaeberlein, and R.W. Powers Sir2 and calorie restriction in yeast: a skeptical perspective Ageing Res. Rev. 6 2007 128 140 (Pubitemid 47017806)
34. D. Chen, J. Bruno, E. Easlon, S.J. Lin, H.L. Cheng, F.W. Alt, and L. Guarente Tissue-specific regulation of SIRT1 by calorie restriction Genes Dev. 22 2008 1753 1757 (Pubitemid 351915500)
35. D. Chen, A.D. Steele, G. Hutter, J. Bruno, A. Govindarajan, E. Easlon, S.J. Lin, A. Aguzzi, S. Lindquist, and L. Guarente The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration Exp. Gerontol. 43 2008 1086 1093
36. R.R. Alcendor, S.M. Gao, P.Y. Zhai, D. Zablocki, E. Holle, X.Z. Yu, B. Tian, T. Wagner, S.F. Vatner, and J. Sadoshima Sirt1 regulates aging and resistance to oxidative stress in the heart Circ. Res. 100 2007 1512 1521 (Pubitemid 46834764)
37. S. Cadenas, and G. Barja Resveratrol, melatonin, vitamin E, and PBN protect against renal oxidative DNA damage induced by the kidney carcinogen KBrO3 Free Radic. Biol. Med. 26 1999 1531 1537 (Pubitemid 29302287)
38. P.S. Ray, G. Maulik, G.A. Cordis, A.A.E. Bertelli, A. Bertelli, and D.K. Das The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury Free Radic. Biol. Med. 27 1999 160 169 (Pubitemid 29353096)
39. S. Shigematsu, S. Ishida, M. Hara, N. Takahashi, H. Yoshimatsu, T. Sakata, and R.J. Korthuis Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants Free Radic. Biol. Med. 34 2003 810 817 (Pubitemid 36316064)
40. S. Das, N. Khan, S. Mukherjee, D. Bagchi, N. Gurusamy, H. Swartz, and D.K. Das Redox regulation of resveratrol-mediated switching of death signal into survival signal Free Radic. Biol. Med. 44 2008 82 90 (Pubitemid 350138631)
41. S.C. Barber, A. Higginbottom, R.J. Mead, S. Barber, and P.J. Shaw An in vitro screening cascade to identify neuroprotective antioxidants in ALS Free Radic. Biol. Med. 46 2009 1127 1138
42. Y.D.C. Schilder, E.H. Heiss, D. Schachner, J. Ziegler, G. Reznicek, D. Sorescu, and V.M. Dirsch NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cells Free Radic. Biol. Med. 46 2009 1598 1606
43. A. Sobotkova, L. Masova-Chrastinova, J. Suttnar, J. Stikarova, P. Majek, Z. Reicheltova, R. Kotlin, J.W. Weisel, M. Maly, and J.E. Dyr Antioxidants change platelet responses to various stimulating events Free Radic. Biol. Med. 47 2009 1707 1714
44. M. Fukui, H.J. Choi, and B.T. Zhu Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death Free Radic. Biol. Med. 49 2010 800 813
45. M. Kaeberlein, T. McDonagh, B. Heltweg, J. Hixon, E.A. Westman, S.D. Caldwell, A. Napper, R. Curtis, P.S. DiStefano, S. Fields, A. Bedalov, and B.K. Kennedy Substrate-specific activation of sirtuins by resveratrol J. Biol. Chem. 280 2005 17038 17045 (Pubitemid 41389166)
46. T.M. Bass, D. Weinkove, K. Houthoofd, D. Gems, and L. Partridge Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans Mech. Ageing Dev. 128 2007 546 552 (Pubitemid 47498522)
47. J.R. Mayers, B.W. Iliff, and S.J. Swoap Resveratrol treatment in mice does not elicit the bradycardia and hypothermia associated with calorie restriction FASEB J. 23 2009 1032 1040
48. F. Yeung, J.E. Hoberg, C.S. Ramsey, M.D. Keller, D.R. Jones, R.A. Frye, and M.W. Mayo Modulation of NF-kappa B-dependent transcription and cell survival by the SIRT1 deacetylase EMBO J. 23 2004 2369 2380 (Pubitemid 38954844)
49. H.S. Zhang, Y. Zhou, M.R. Wu, H.S. Zhou, and F. Xu Resveratrol inhibited Tat-induced HIV-1 LTR transactivation via NAD(+)-dependent SIRT1 activity Life Sci. 85 2009 484 489
50. Z. Ungvari, N. Labinskyy, P. Mukhopadhyay, J.T. Pinto, Z. Bagi, P. Ballabh, C.H. Zhang, P. Pacher, and A. Csiszar Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells Am. J. Physiol. Heart Circ. Physiol. 297 2009 H1876 H1881
51. J.H. Lee, M.Y. Song, E.K. Song, E.K. Kim, W.S. Moon, M.K. Han, J.W. Park, K.B. Kwon, and B.H. Park Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway Diabetes 58 2009 344 351
52. J.B. Pillai, M. Chen, S.B. Rajamohan, S. Samant, V.B. Pillai, M. Gupta, and M.P. Gupta Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the alpha-myosin heavy chain expression Am. J. Physiol. Heart Circ. Physiol. 294 2008 H1388 H1397
53. C.H. Peng, Y.L. Chang, C.L. Kao, L.M. Tseng, C.C. Wu, Y.C. Chen, C.Y. Tsai, L.C. Woung, J.H. Liu, S.H. Chiou, and S.J. Chen SirT1-a sensor for monitoring self-renewal and aging process in retinal stem cells Sensors 10 2010 6172 6194
54. C.J. Chen, W. Yu, Y.C. Fu, X. Wang, J.L. Li, and W. Wang Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1-FoxO1 pathway Biochem. Biophys. Res. Commun. 378 2009 389 393
55. S. Mukherjee, I. Lekli, N. Gurusamy, A.A.A. Bertelli, and D.K. Das Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol Free Radic. Biol. Med. 46 2009 573 578
56. M. Sulaiman, M.J. Matta, N.R. Sunderesan, M.P. Gupta, M. Periasamy, and M. Gupta Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy Am. J. Physiol. Heart Circ. Physiol. 298 2010 H833 H843
57. A. Csiszar, N. Labinskyy, J.T. Pinto, P. Ballabh, H.R. Zhang, G. Losonczy, K. Pearson, R. de Cabo, P. Pacher, C.H. Zhang, and Z. Ungvari Resveratrol induces mitochondrial biogenesis in endothelial cells Am. J. Physiol. Heart Circ. Physiol. 297 2009 H13 H20
58. 2-induced oxidative stress and senescence via SirT1 activation J. Atheroscler. Thromb. 17 2010 970 979
59. J.W. Hwang, S.W. Chung, I.K. Sundar, H.W. Yao, G. Arunachalam, M.W. McBurney, and I. Rahman Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: Implication in pathogenesis of COPD Arch. Biochem. Biophys. 500 2010 203 209
60. G.L. Wang, Y.C. Fu, W.C. Xu, Y.Q. Feng, S.R. Fang, and X.H. Zhou Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway Biochem. Biophys. Res. Commun. 380 2009 644 649
61. J.N. Lin, V.C.H. Lin, K.M. Rau, P.C. Shieh, D.H. Kuo, J.C. Shieh, W.J. Chen, S.C. Tsai, and T.D. Way Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation J. Agric. Food Chem. 58 2010 1584 1592
62. 2-induced apoptosis and expression of SIRTs in H9c2 cells J. Cell. Biochem. 107 2009 741 747
63. U.P. Singh, N.P. Singh, B. Singh, L.J. Hofseth, R.L. Price, M. Nagarkatti, and P.S. Nagarkatti Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis J. Pharmacol. Exp. Ther. 332 2010 829 839
64. M. Lagouge, C. Argmann, Z. Gerhart-Hines, H. Meziane, C. Lerin, F. Daussin, N. Messadeq, J. Milne, P. Lambert, P. Elliott, B. Geny, M. Laakso, P. Puigserver, and J. Auwerx Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1 alpha Cell 127 2006 1109 1122 (Pubitemid 44894520)
65. J. Gracia-Sancho, G. Villarreal, Y.Z. Zhang, and G. Garcia-Cardena Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype Cardiovasc. Res. 85 2010 514 519
66. S.V. de Kreutzenberg, G. Ceolotto, I. Papparella, A. Bortoluzzi, A. Semplicini, C. Dalla Man, C. Cobelli, G.P. Fadini, and A. Avogaro Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms Diabetes 59 2010 1006 1015
67. M. Tanno, A. Kuno, T. Yano, T. Miura, S. Hisahara, S. Ishikawa, K. Shimamoto, and Y. Horio Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure J. Biol. Chem. 285 2010 8375 8382
68. T. Yoshizaki, S. Schenk, T. Imamura, J.L. Babendure, N. Sonoda, E.J. Bae, D.Y. Oh, M. Lu, J.C. Milne, C. Westphal, G. Bandyopadhyay, and J.M. Olefsky SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity Am. J. Physiol. Endocrinol. Metab. 298 2010 E419 E428
69. J.H. Yang, N. Wang, J.Y. Li, J.J. Zhang, and P. Feng Effects of resveratrol on NO secretion stimulated by insulin and its dependence on SIRT1 in high glucose cultured endothelial cells Endocrine 37 2010 365 372
70. D. Albani, L. Polito, S. Batelli, S. De Mauro, C. Fracasso, G. Martelli, L. Colombo, C. Manzoni, M. Salmona, S. Caccia, A. Negro, and G. Forloni The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide J. Neurochem. 110 2009 1445 1456
71. W.J. He, Y.Y. Wang, M.Z. Zhang, L. You, L.S. Davis, H. Fan, H.C. Yang, A.B. Fogo, R. Zent, R.C. Harris, M.D. Breyer, and C.M. Hao Sirt1 activation protects the mouse renal medulla from oxidative injury J. Clin. Invest. 120 2010 1056 1068
72. P. Fischer-Posovszky, V. Kukulus, D. Tews, T. Unterkircher, K.M. Debatin, S. Fulda, and M. Wabitsch Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner Am. J. Clin. Nutr. 92 2010 5 15
73. I. Mader, M. Wabitsch, K.M. Debatin, P. Fischer-Posovszky, and S. Fulda Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis FASEB J. 24 2010 1997 2009
74. G. Boily, X.H. He, B. Pearce, K. Jardine, and M.W. McBurney SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol Oncogene 28 2009 2882 2893
75. J.D. Zhang Resveratrol inhibits insulin responses in a SirT1-independent pathway Biochem. J. 397 2006 519 527
76. V.C.J. de Boer, M.C. de Goffau, I.C.W. Arts, P.C.H. Hollman, and J. Keijer SIRT1 stimulation by polyphenols is affected by their stability and metabolism Mech. Ageing Dev. 127 2006 618 627 (Pubitemid 43729534)
77. X.Y. Hou, S.Q. Xu, K.A. Maitland-Toolan, K. Sato, B.B. Jiang, Y.S. Ido, F. Lan, K. Walsh, M. Wierzbicki, T.J. Verbeuren, R.A. Cohen, and M.W. Zang SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase J. Biol. Chem. 283 2008 20015 20026
78. D. Della-Morte, K.R. Dave, R.A. Defazio, Y.C. Bao, A.P. Raval, and M.A. Perez-Pinzon Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway Neuroscience 159 2009 993 1002
79. G. Arunachalam, H.W. Yao, I.K. Sundar, S. Caito, and I. Rahman SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: role of resveratrol Biochem. Biophys. Res. Commun. 393 2010 66 72
80. T. Tsukamoto, R. Nakata, E. Tamura, Y. Kosuge, A. Kariya, M. Katsukawa, S. Mishima, T. Ito, M. Iinuma, Y. Akao, Y. Nozawa, Y. Arai, S. Namura, and H. Inoue Vaticanol C, a resveratrol tetramer, activates PPAR alpha and PPAR beta/delta in vitro and in vivo Nutr. Metab. 7 2010 46
81. S. Sharma, C.S. Misra, S. Arumugam, S. Roy, V. Shah, J.A. Davis, R.K. Shirumalla, and A. Ray Antidiabetic activity of resveratrol, a known SIRT1 activator in a genetic model for type-2 diabetes Phytother. Res. 25 2011 67 73
82. M.T. Borra, B.C. Smith, and J.M. Denu Mechanism of human SIRT1 activation by resveratrol J. Biol. Chem. 280 2005 17187 17195 (Pubitemid 41389185)
83. D. Beher, J. Wu, S. Cumine, K.W. Kim, S.C. Lu, L. Atangan, and M. Wang Resveratrol is not a direct activator of SIRT1 enzyme activity Chem. Biol. Drug Des. 74 2009 619 624
84. M. Pacholec, J.E. Bleasdale, B. Chrunyk, D. Cunningham, D. Flynn, R.S. Garofalo, D. Griffith, M. Griffor, P. Loulakis, B. Pabst, X.Y. Qiu, B. Stockman, V. Thanabal, A. Varghese, J. Ward, J. Withka, and K. Ahn SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1 J. Biol. Chem. 285 2010 8340 8351
85. H. Dai, L. Kustigian, D. Carney, A. Case, T. Considine, B.P. Hubbard, R.B. Perni, T.V. Riera, B. Szczepankiewicz, G.P. Vlasuk, and R.L. Stein SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator J. Biol. Chem. 285 2010 32695 32703
86. H. Vaziri, S.K. Dessain, E.N. Eagon, S.I. Imai, R.A. Frye, T.K. Pandita, L. Guarente, and R.A. Weinberg hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase Cell 107 2001 149 159 (Pubitemid 33035942)
87. J.A. Parker, M. Arango, S. Abderrahmane, E. Lambert, C. Tourette, H. Catoire, and C. Neri Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons Nat. Genet. 37 2005 349 350
88. C.M. Backesjo, Y. Li, U. Lindgren, and L.A. Haldosen Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells J. Bone Miner. Res. 21 2006 993 1002 (Pubitemid 43962828)
89. L. Bai, W.J. Pang, Y.J. Yang, and G.S. Yang Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes Mol. Cell. Biochem. 307 2008 129 140 (Pubitemid 350238655)
90. D.M. Breen, T. Sanli, A. Giacca, and E. Tsiani Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK Biochem. Biophys. Res. Commun. 374 2008 117 122
91. E.D.B. Danz, J. Skramsted, N. Henry, J.A. Bennett, and R.S. Keller Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway Free Radic. Biol. Med. 46 2009 1589 1597
92. K.J. Bitterman, R.M. Anderson, H.Y. Cohen, M. Latorre-Esteves, and D.A. Sinclair Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1 J. Biol. Chem. 277 2002 45099 45107 (Pubitemid 36159111)
93. B. Dasgupta, and J. Milbrandt Resveratrol stimulates AMP kinase activity in neurons Proc. Natl Acad. Sci. U. S. A. 104 2007 7217 7222 (Pubitemid 47186035)
94. J.A. Pfister, C. Ma, B.E. Morrison, and S.R. D'Mello Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity PLoS One 3 2008 e4090
95. A.D. Napper, J. Hixon, T. McDonagh, K. Keavey, J.F. Pons, J. Barker, W.T. Yau, P. Amouzegh, A. Flegg, E. Hamelin, R.J. Thomas, M. Kates, S. Jones, M.A. Navia, J. Saunders, P.S. DiStefano, and R. Curtis Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1 J. Med. Chem. 48 2005 8045 8054 (Pubitemid 41798434)
96. L. Pirola, and S. Frojdo Resveratrol: one molecule, many targets IUBMB Life 60 2008 323 332
97. J.A. Baur Biochemical effects of SIRT1 activators Biochim. Biophys. Acta 1804 2010 1626 1634
98. S.A. Hawley, F.A. Ross, C. Chevtzoff, K.A. Green, A. Evans, S. Fogarty, M.C. Towler, L.J. Brown, O.A. Ogunbayo, A.M. Evans, and D.G. Hardie Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation Cell Metab. 11 2010 554 565
99. M.W. Zang, S.Q. Xu, K.A. Maitland-Toolan, A. Zuccollo, X.Y. Hou, B.B. Jiang, M. Wierzbicki, T.J. Verbeuren, and R.A. Cohen Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice Diabetes 55 2006 2180 2191 (Pubitemid 44743614)
100. C.E. Park, M.J. Kim, J.H. Lee, B.I. Min, H. Bae, W. Choe, S.S. Kim, and J. Ha Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase Exp. Mol. Med. 39 2007 222 229 (Pubitemid 46683408)
101. J.T. Hwang, D.Y. Kwon, O.J. Park, and M.S. Kim Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells Genes Nutr. 2 2008 323 326 (Pubitemid 351447706)
102. G. Suchankova, L.E. Nelson, Z. Gerhart-Hines, M. Kelly, M.S. Gauthier, A.K. Saha, Y. Ido, P. Puigserver, and N.B. Ruderman Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells Biochem. Biophys. Res. Commun. 378 2009 836 841
103. J.H. Um, S.J. Park, H. Kang, S.T. Yang, M. Foretz, M.W. McBurney, M.K. Kim, B. Viollet, and J.H. Chung AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol Diabetes 59 2010 554 563
104. C. Canto, Z. Gerhart-Hines, J.N. Feige, M. Lagouge, L. Noriega, J.C. Milne, P.J. Elliott, P. Puigserver, and J. Auwerx AMPK regulates energy expenditure by modulating NAD(+) metabolism and SIRT1 activity Nature 458 2009 1056 1060
105. C. Canto, L.Q. Jiang, A.S. Deshmukh, C. Mataki, A. Coste, M. Lagouge, J.R. Zierath, and J. Auwerx Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle Cell Metab. 11 2010 213 219
106. R.H. Houtkooper, R.W. Williams, and J. Auwerx Metabolic networks of longevity Cell 142 2010 9 14
107. M. Fulco, Y. Cen, P. Zhao, E.P. Hoffman, M.W. McBurney, A.A. Sauve, and V. Sartorelli Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt Dev. Cell 14 2008 661 673 (Pubitemid 351622608)