Estrogen receptor β and 17β-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 50, 2011, Pages 20090-20094

  Muthusamy, Selvaraj ^a   Andersson, Stefan ^a   Kim, Hyun Jin ^a   Butler, Ryan ^a   Waage, Linda ^b   Bergerheim, Ulf ^b   Gustafsson, Jan Åke ^c  

^a University of Houston   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c DANDERYD HOSPITAL   (Sweden)

Author keywords

HSD17B6; Intracrinology; Prereceptor regulation; Short chain dehydrogenase; Steroid metabolism

Indexed keywords

17BETA HYDROXYSTEROID DEHYDROGENASE TYPE 6; ANDROSTANOLONE; ESTROGEN RECEPTOR BETA; HYDROXYSTEROID DEHYDROGENASE; LUCIFERASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CONCENTRATION (PARAMETERS); EPITHELIUM CELL; ESTROGEN RESPONSIVE ELEMENT; GLEASON SCORE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION;

ANDROSTANE-3,17-DIOL; CELL PROLIFERATION; DIHYDROTESTOSTERONE; EPITHELIUM; ESTROGEN RECEPTOR BETA; HEK293 CELLS; HUMANS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; MALE; MODELS, BIOLOGICAL; PROSTATE; PROSTATIC NEOPLASMS; RACEMASES AND EPIMERASES; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION;

EID: 84055187654     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1117772108     Document Type: Article

References (26)

1. Heldring N, et al. (2007) Estrogen receptors: How do they signal and what are their targets. Physiol Rev 87:905-931. (Pubitemid 47084672)
2. Weihua Z, et al. (2001) A role for estrogen receptor β in the regulation of growth of the ventral prostate. Proc Natl Acad Sci USA 98:6330-6335. (Pubitemid 32492315)
3. Matthews J, et al. (2006) Estrogen receptor (ER) β modulates ERalpha-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen-responsive promoters. Mol Endocrinol 20:534-543. (Pubitemid 43292585)
4. Ricke WA, et al. (2008) Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha signaling. FASEB J 22:1512-1520. (Pubitemid 351656791)
5. Bélanger A, Couture J, Caron S, Roy R (1990) Determination of nonconjugated and conjugated steroid levels in plasma and prostate after separation on C-18 columns. Ann N Y Acad Sci 595:251-259. (Pubitemid 20282956)
6. Penning TM, et al. (2000) Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: Functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. Biochem J 351:67-77.
7. Hyndman D, Bauman DR, Heredia VV, Penning TM (2003) The aldo-keto reductase superfamily homepage. Chem Biol Interact 143-144:621-631. (Pubitemid 36246464)
8. Steckelbroeck S, Jin Y, Gopishetty S, Oyesanmi B, Penning TM (2004) Human cytosolic 3α-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3β-hydroxysteroid dehydrogenase activity: Implications for steroid hormone metabolism and action. J Biol Chem 279:10784-10795. (Pubitemid 38379543)
9. Rizner TL, et al. (2003) Human type 3 3α-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells. Endocrinology 144:2922-2932. (Pubitemid 36819895)
10. Bauman DR, Steckelbroeck S, Peehl DM, Penning TM (2006) Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer. Endocrinology 147:5806-5816. (Pubitemid 44833497)
11. Biswas MG, Russell DW (1997) Expression cloning and characterization of oxidative 17β- and 3α-hydroxysteroid dehydrogenases from rat and human prostate. J Biol Chem 272:15959-15966. (Pubitemid 27265577)
12. Huang X-F, Luu-The V (2000) Molecular characterization of a first human 3 (α→β)-hydroxysteroid epimerase. J Biol Chem 275:29452-29457. (Pubitemid 32043820)
13. Chetyrkin SV, Hu J, Gough WH, Dumaual N, Kedishvili NY (2001) Further characterization of human microsomal 3α-hydroxysteroid dehydrogenase. Arch Biochem Biophys 386:1-10. (Pubitemid 32980170)
14. Belyaeva OV, et al. (2007) Role of microsomal retinol/sterol dehydrogenase-like short-chain dehydrogenases/reductases in the oxidation and epimerization of 3α-hydroxysteroids in human tissues. Endocrinology 148:2148-2156. (Pubitemid 46997028)
15. Gleason DF, Mellinger GT (1974) Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J Urol 11:58-64.
16. Lee KL, Peehl DM (2004) Molecular and cellular pathogenesis of benign prostatic hyperplasia. J Urol 172:1784-1791. (Pubitemid 39363056)
17. Leav I, et al. (2001) Comparative studies of the estrogen receptors β and α and the androgen receptor in normal human prostate glands, dysplasia, and in primary and metastatic carcinoma. Am J Pathol 159:79-92. (Pubitemid 33704195)
18. Andersson S, Berman DM, Jenkins EP, Russell DW (1991) Deletion of steroid 5 α-reductase 2 gene in male pseudohermaphroditism. Nature 354:159-161. (Pubitemid 21896802)
19. Russell DW, Wilson JD (1994) Steroid 5 α-reductase: Two genes/two enzymes. Annu Rev Biochem 63:25-61.
20. Bauman DR, Steckelbroeck S, Williams MV, Peehl DM, Penning TM (2006) Identification of the major oxidative 3α-hydroxysteroid dehydrogenase in human prostate that converts 5α-androstane-3α,17β-diol to 5α-dihydrotestosterone: A potential therapeutic target for androgen-dependent disease. Mol Endocrinol 20:444-458. (Pubitemid 43152517)
21. Stiles AR, McDonald JG, Bauman DR, Russell DW (2009) CYP7B1: One cytochrome P450, two human genetic diseases, and multiple physiological functions. J Biol Chem 284:28485-28489.
22. Weihua Z, Lathe R, Warner M, Gustafsson J-Å (2002) An endocrine pathway in the prostate, ERbeta, AR, 5α-androstane-3β,17β-diol, and CYP7B1, regulates prostate growth. Proc Natl Acad Sci USA 99:13589-13594. (Pubitemid 35221316)
23. Huang X-F, Luu-The V (2001) Gene structure, chromosomal localization and analysis of 3-ketosteroid reductase activity of the human 3(α→β) -hydroxysteroid epimerase. Biochim Biophys Acta 1520:124-130. (Pubitemid 32763134)
24. Saijo K, Collier JG, Li AC, Katzenellenbogen JA, Glass CK (2011) An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Cell 145:584-595.
25. Ogawa S, et al. (1998) The complete primary structure of human estrogen receptor β(hER β) and its heterodimerization with ERα in vivo and in vitro. Biochem Biophys Res Commun 243:122-126. (Pubitemid 28414201)
26. Saji S, et al. (2000) Estrogen receptors α and β in the rodent mammary gland. Proc Natl Acad Sci USA 97:337-342. (Pubitemid 30055832)