Delipidating effect of resveratrol metabolites in 3T3-L1 adipocytes

Molecular Nutrition and Food Research

Volumn 56, Issue 10, 2012, Pages 1559-1568

  Lasa, Arrate ^a,b   Churruca, Itziar ^a,b   Eseberri, Itziar ^a   Andrés Lacueva, Cristina ^c,d   Portillo, María P ^a,b  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

^d Ministry of Science and Innovation   (Spain)

Author keywords

3T3 L1 maturing pre adipocytes and mature adipocytes; Delipidation; Glucuronide metabolites; Resveratrol; Sulfate metabolites

Indexed keywords

ANTIOBESITY AGENT; FATTY ACID SYNTHASE; GLUCURONIDE; LIPOPROTEIN LIPASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RESVERATROL; RESVERATROL 4' O GLUCURONIDE; RESVERATROL-4'-O-GLUCURONIDE; STILBENE DERIVATIVE; TRIACYLGLYCEROL;

ADIPOCYTE; ANIMAL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; REAL TIME POLYMERASE CHAIN REACTION;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; ANTI-OBESITY AGENTS; CELL DIFFERENTIATION; FATTY ACID SYNTHETASE COMPLEX; GENE EXPRESSION REGULATION; GLUCURONIDES; LIPOPROTEIN LIPASE; MICE; PPAR GAMMA; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; STILBENES; TRIGLYCERIDES;

EID: 84867063845     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201100772     Document Type: Article

References (46)

1. Langcake, P., Pryce, R. J., The production of resveratrol by Vitis vinifera and other members of the Vitaceae as a response to infection or injury. Physiol. Plant. Pathol. 1976, 9, 77-86.
2. Signorelli, P., Ghidoni, R., Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. J. Nutr. Biochem. 2005, 16, 449-466.
3. Frémont, L., Biological effects of resveratrol. Life Sci. 2000, 66, 663-673.
4. Goswami, S., Das, D., Resveratrol and chemoprevention. Cancer Lett. 2009, 284, 1-6.
5. Cucciolla, V., Borriello, A., Oliva, A., Galletti, P. et al., Resveratrol: from basic science to the clinic. Cell Cycle 2007, 6, 2495-2510.
6. Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H. et al., Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT-1 and PGC-1alpha. Cell 2006, 27, 1109-1122.
7. Baur, J., Pearson, K., Price, N., Jamieson, H. et al., Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444, 337-342.
8. Ahn, J., Cho, I., Kim, S., Kwon, D. et al., Dietary resveratrol alters lipid metabolism-related gene expression of mice on an atherogenic diet. J. Hepatol. 2008, 49, 1019-1028.
9. Rivera, L., Morón, R., Zarzuelo, A., Galisteo, M., Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats. Biochem. Pharmacol. 2009, 77, 1053-1063.
10. Shang, J., Chen, L., Xiao, F., Sun, H. et al., Resveratrol improves non-alcoholic fatty liver disease nyactivating AMP-activated protein kinase. Acta. Pharmacol. Sin. 2008, 29, 698-706.
11. Wong, Y. T., Gruber, J., Jenner, A. M., Pei-Ern, Ng. M. et al., Elevation of oxidative-damage biomarkers during aging in F2 hybrid mice: Protection by chronic oral intake of resveratrol. Free Radic. Biol. Med. 2009, 46, 799-809.
12. Dal-Pan, A., Blanc, S., Aujard, F., Resveratrol suppresses body mass gain in a seasonal non-human primate model of obesity. BMC Physiology 2010, 10, 11-20.
13. Baile, C. A., Yang, J. Y., Rayalam, S., Hartzell, D. L. et al., Effect of resveratrol on fat mobilization. Ann. NY Acad. Sci. 2011, 1215, 40-47.
14. Macarulla, M., Alberdi, G., Gómez, S., Tueros, I. et al., Effects of different doses of resveratrol on body fat and serum parameters in rats fed a hypercaloric diet. Physiol. Biochem. 2009, 65, 369-376.
15. Alberdi, G., Rodríguez, V. M., Miranda, J., Macarulla, M. T., et al., Changes in white adipose tissue metabolism induced by resveratrol in rats. Nutr. Metab. 2011, 8, 29-35.
16. Kim, S., Jin, Y., Choi, Y., Park, T., Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice. Biochem. Pharmacol. 2011, 81, 1343-1351.
17. Walle, T., Hsieh, F., DeLegge, M.H., Oatis, J. E. et al., High absorption but very low availability of oral resveratrol in humans. Drug. Metab. Dispos. 2004, 32, 1377-1382.
18. Wenzel, E., Somoza, V., Metabolism and bioavailability of trans-resveratrol. Mol. Nutr. Food Res. 2005, 49, 472-481.
19. Asensi, M., Medina, I., Ortega, A., Carretero, J. et al., Inhibition of cancer growth by resveratrol is related to its low bioavailability. Free Radic. Biol. Med. 2002, 33, 387-398.
20. Andrés-Lacueva, C., Urpí-Sardá, M., Zamora-Ros, R., Lamuela-Raventós, R. M., in: Fraga, C. G., (Ed.), in: Plant Phenolics and Human Health: Biochemistry, Nutrition and Pharmacology; John Wiley & Sons, Hoboken, New Jersey, 2009, pp. 265-299.
21. Corder, R., Crozier, A., Kroon, P. A., Drinking your health? It's too early to say. Nature 2003, 426, 119.
22. Kaldas, M. I., Walle, U. K., Walle, T., Resveratrol transport and metabolism by human intestinal Caco-2 cells. J. Pharm. Pharmacol. 2003, 55, 307-312.
23. Juan, M. E., Maijó, M., Planas, J. M., Quantification of trans-resveratrol and its metabolites in rat plasma and tissues by HPLC. J. Pharm Biomed. Anal. 2010, 51, 391-398.
24. Azorín-Ortuño, M., Yáñez-Gascón, M. J., Vallejo, F., Pallarés, F. J. et al., Metabolites and tissue distribution of resveratrol in the pig. Mol. Nutr. Food Res. 2011, 55, 1154-1168.
25. Walle, T., Bioavailability of resveratrol. Ann. NY Acad. Sci. 2011, 1215, 9-15.
26. Delmas, D., Aires, V., Limagne, E., Dutartre, P. et al., Transport, stability and biological activity of resveratrol. Ann. NY Acad. Sci. 2011, 1215, 48-59.
27. Vang, O., Ahmad, N., Baile, C. A., Baur, J. A. et al., What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. PLoS One 2011, 6, e19881-e19891.
28. Halliwell, B., Dietary polyphenols: good, bad, or indifferent for your health? Cardiovasc. Res. 2007, 73, 341-347.
29. Hoshino, J., Park, E. J., Kondratyuk, T. P., Marler, L. et al., Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J. Med. Chem. 2010, 53, 5033-5043.
30. Calamini, B., Ratia, K., Malkowski, M., Cuendet, M. et al., Pleiotropic mechanisms facilitated by resveratrol and its metabolites. Biochem. J. 2010, 429, 273-282.
31. Livak, K., Schmittgen, T., Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25, 402-408.
32. De Santi, C., Pietrabissa, A., Mosca, F., Spisni, R. et al., Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. Xenobiotica 2000, 30, 857-866.
33. Park, H. J., Yang, J. Y., Ambati, S., Della-Fera, M. A. et al., Combined effects of genistein, quercetin and resveratrol in human and 3T3-L1 adipocytes. J. Med. Food 2008, 11, 773-783.
34. Yang, J. Y., Della-Fera, M. A., Rayalam, S., Ambati, S. et al., Enhanced inibition of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Sci. 2008, 82, 1032-1039.
35. Rayalam, S., Yang, J. Y., Ambati, S., Della-Fera, M. A. et al., Resveratrol inuduces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes. Phytoter. Res. 2008, 22, 1367-1371.
36. Pang, W. J., Sun, S. D., Bai, L., Yang, Y. J. et al., Effects of resveratrol on pig primary preadipocytes proliferation, differentiation and transcription expression of Sirt1 gene. Sheng Wu Gong Cheng Xue Bao 2006, 22, 850-855.
37. Bai, L., Pang, W. J., Yang, Y. J., Yang, G. S., Modulation of Sirt-1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes. Mol. Cell. Biochem. 2008, 307, 129-140.
38. Chen, S., Li, Z., Li, W., Shan, Z. et al., Resveratrol inhibits cell differentiation in 3T3-L1 adipocytes via activation of AMPK. Can. J. Physiol. Pharmacol. 2011, 89, 793-799.
39. Picard, F., Kurtev, M., Chung, N., Topark-Ngarm, A. et al., Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 2004, 429, 771-776.
40. Lasa, A., Schweiger, M., Kotzbeck, P., Churruca, I. et al., Resveratrol regulates lipolysis via adipose triglyceride lipase. J. Nutr. Biochem. 2012, 23, 379-384.
41. Rayalam, S., Della-Fera, M. A., Yang, J. Y., Park, H. J. et al., Resveratrol potentiates genistein's antiadipogenic and proapoptotic effects in 3T3-L1 adipocytes. J. Nutr. 2007, 137, 2668-2673.
42. Fajas, L., Fruchart, J. C., Auwerx, J., Transcriptional control of adipogenesis. Curr. Opinion Lipidol. Cell Biol. 1998, 10, 165-173.
43. Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W. et al., Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003, 425, 191-196.
44. Kaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J. et al., Substrate-specific activation of sirtuins by resveratrol. J. Biol. Chem. 2005, 280, 17038-17045.
45. Milne, J. C., Lambert, P. D., Schenk, S., Carney, D. P. et al., Small molecule activators of SIRT-1 as therapeutics for the treatment of type 2 diabetes. Nature 2007, 450, 712-716.
46. Pacholec, M., Chrunyk, B. A., Cunningham, D., Flynn, D. et al., SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT-1. J. Biol. Chem. 2010, 285, 8340-8351.