Intestinal absorption and first-pass metabolism of polyphenol compounds in rat and their transport dynamics in caco-2 cells

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Teng, Zenghui ^a   Yuan, Chengjun ^b   Zhang, Feng ^a   Huan, Menglei ^a   Cao, Weidong ^c   Li, Kangchu ^a   Yang, Jingyue ^c   Cao, Dayong ^c   Zhou, Siyuan ^a   Mei, Qibing ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b XI'AN JIAOTONG UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APIGENIN; BETA GLUCURONIDASE; CHRYSOPHANIC ACID; DRUG METABOLIZING ENZYME; EMODIN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 2; POLYPHENOL; RESVERATROL; SODIUM GLUCOSE COTRANSPORTER 1; SULFATASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELL STRAIN CACO 2; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG TRANSPORT; FIRST PASS EFFECT; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; INTESTINE EPITHELIUM CELL; INTESTINE PERFUSION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; ANIMAL; CELL MEMBRANE PERMEABILITY; CHEMISTRY; HUMAN; METABOLISM; ORAL DRUG ADMINISTRATION; SMALL INTESTINE; SPRAGUE DAWLEY RAT; TIME; TRANSPORT AT THE CELLULAR LEVEL;

RATTUS;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; HUMANS; INTESTINAL ABSORPTION; INTESTINE, SMALL; MALE; POLYPHENOLS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 84855828232     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029647     Document Type: Article

References (24)

1. DuPont MS, Bennett RN, Mellon FA, Williamson G, (2002) Polyphenols from Alcoholic Apple Cider Are Absorbed, Metabolized and Excreted by Humans. J Nutr 132: 172-175.
2. Manach C, Williamson G, Morand C, Scalbert A, Remesy C, (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clinical Nutrition 81: 230S-242S.
3. Corder R, Mullen W, Khan NQ, Marks SC, Wood EG, et al. (2006) Oenology: red wine procyanidins and vascular health. Nature 444: 566.
4. Fresco P, Borges F, Diniz C, Marques MP, (2006) New insights on the anticancer properties of dietary polyphenols. Med Res Rev 26: 747-766.
5. Vingtdeux V, Giliberto L, Zhao H, Chandakkar P, Wu Q, et al. (2010) AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem 285: 9100-9113.
6. Kroon PA, Clifford MN, Crozier A, Day AJ, Donovan JL, et al. (2004) How should we assess the effects of exposure to dietary polyphenols in vitro? Am J Clin Nutr 80: 15-21.
7. Prasain JK, Barnes S, (2007) Metabolism and bioavailability of flavonoids in chemoprevention: current analytical strategies and future prospectus. Mol Pharm 4: 846-864.
8. Liu Y, Hu M, (2002) Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model. Drug Metab Dispos 30: 370-377.
9. Nabokina SM, Kashyap ML, Said HM, (2005) Mechanism and regulation of human intestinal niacin uptake. Am J Physiol Cell Physiol 289: C97-103.
10. Teng ZH, Zhou SY, Yang RT, Liu XY, Liu RW, et al. (2007a) Quantitation assay for absorption and first-pass metabolism of emodin in isolated rat small intestine using liquid chromatography-tandem mass spectrometry. Biol Pharm Bull 30: 1628-1633.
11. Teng ZH, Zhou SY, Ran YH, Liu XY, Yang RT, et al. (2007b) Cellular absorption of anthraquinones emodin and chrysophanol in human intestinal Caco-2 cells. Biosci Biotechnol Agrochem 71: 1636-1643.
12. Link A, Balaguer F, Goel A, (2010) Cancer chemoprevention by dietary polyphenols: promising role for epigenetics. Biochem Pharmacol 80: 1771-1792.
13. Silberberg M, Morand C, Mathevon T, Besson C, Manach C, et al. (2006) The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites. Eur J Nutr 45: 88-96.
14. Johnston K, Sharp P, Clifford M, Morgan L, (2005) Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells. FEBS Lett 579: 1653-1657.
15. Cai K, Hagerman AE, Minto RE, Bennick A, (2006) Decreased polyphenol transport across cultured intestinal cells by a salivary proline-rich protein. Biochem Pharmacol 71: 1570-1580.
16. Andlauer W, Kolb J, Stehle P, Fürst P, (2000) Absorption and metabolism of genistein in isolated rat small intestine. J Nutr 130: 843-846.
17. Higaki K, Sone M, Ogawara K, Kimura T, (2004) Regulation of drug absorption from small intestine by enteric nervous system I: a poorly absorbable drug via passive diffusion. Drug Metab Pharmacokin 19: 198-205.
18. Yi W, Akoh CC, Fischer J, Krewer G, (2006) Absorption of anthocyanins from blueberry extracts by caco-2 human intestinal cell monolayers. J Agric Food Chem 54: 5651-5658.
19. Cermak R, Landgraf S, Wolffram S, (2004) Quercetin glucosides inhibit glucose uptake into brush-border-membrane vesicles of porcine jejunum. Br J Nutr 91: 849-855.
20. Chen ZS, Kawabe T, Ono M, Aoki S, Sumizawa T, et al. (1999) Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. Mol Pharmacol 56: 1219-1228.
21. Maier-Salamon A, Hagenauer B, Wirth M, Gabor F, Szekeres T, et al. (2006) Increased transport of resveratrol across monolayers of the human intestinal Caco-2 cells is mediated by inhibition and saturation of metabolites. Pharm Res 23: 2107-2115.
22. Moon YJ, Morris ME, (2007) Pharmacokinetics and bioavailability of the bioflavonoid biochanin A: effects of quercetin and EGCG on biochanin A disposition in rats. Mol Pharm 4: 865-872.
23. Bielawski J, Szulc ZM, Hannun YA, Bielawska A, (2006) Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods 39: 82-91.
24. Ma Y, Li P, Chen D, Fang T, Li H, et al. (2006) LC/MS/MS quantitation assay for pharmacokinetics of naringenin and double peaks phenomenon in rats plasma. Int J Pharm 307: 292-299.