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Volumn 96, Issue 2, 2012, Pages 119-130

Neuroprotection and estrogen receptors

Author keywords

Cerebral ischemia; Estradiol; Estrogen receptor alpha; Estrogen receptor beta; Estrogens; Neuroprotection; Nonfeminizing estrogens; Spinal cord injury; Stroke; Traumatic brain injury

Indexed keywords

5ALPHA ANDROSTAN 3 ONE; AMYLOID BETA PROTEIN; ANDROGEN RECEPTOR; ANDROSTANOLONE; AROMATASE; CATENIN; CONJUGATED ESTROGEN; CONJUGATED ESTROGEN PLUS MEDROXYPROGESTERONE ACETATE; ESTRADIOL; ESTROGEN; ESTROGEN BINDING PROTEIN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; G PROTEIN COUPLED RECEPTOR 30; GENISTEIN; INITIATION FACTOR 4E BINDING PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN BCL 2; PROTEIN KINASE B; TESTOSTERONE;

EID: 84866533340     PISSN: 00283835     EISSN: 14230194     Source Type: Journal    
DOI: 10.1159/000338409     Document Type: Review
Times cited : (86)

References (164)
  • 2
    • 77956178214 scopus 로고    scopus 로고
    • Menopause and Mitochondria: Windows into Estrogen Effects on Alzheimer's Disease Risk and Therapy
    • Henderson VW, Brinton RD: Menopause and mitochondria: windows into estrogen effects on Alzheimer's disease risk and therapy. Prog Brain Res 2010; 182:77-96.
    • (2010) Prog Brain Res , vol.182 , pp. 77-96
    • Henderson, V.W.1    Brinton, R.D.2
  • 3
    • 67349125852 scopus 로고    scopus 로고
    • Neuro-protective actions of sex steroids in Parkinson's disease
    • Bourque M, Dluzen DE, Di Paolo T: Neuro-protective actions of sex steroids in Parkinson's disease. Front Neuroendocrinol 2009; 30:142-157.
    • (2009) Front Neuroendocrinol , vol.30 , pp. 142-157
    • Bourque, M.1    Dluzen, D.E.2    Di Paolo, T.3
  • 4
    • 63649135792 scopus 로고    scopus 로고
    • Estradiol rescues neurons from global ischemia-induced cell death: Multiple cellular pathways of neuroprotection
    • Lebesgue D, Chevaleyre V, Zukin RS, Etgen AM: Estradiol rescues neurons from global ischemia-induced cell death: multiple cellular pathways of neuroprotection. Steroids 2009; 74:555-561.
    • (2009) Steroids , vol.74 , pp. 555-561
    • Lebesgue, D.1    Chevaleyre, V.2    Zukin, R.S.3    Etgen, A.M.4
  • 6
    • 34247150317 scopus 로고    scopus 로고
    • Neurotrophic and neu-roprotective actions of estrogen: Basic mechanisms and clinical implications
    • Brann DW, Dhandapani K, Wakade C, Ma-hesh VB, Khan MM: Neurotrophic and neu-roprotective actions of estrogen: basic mechanisms and clinical implications. Steroids 2007; 72:381-405.
    • (2007) Steroids , vol.72 , pp. 381-405
    • Brann, D.W.1    Dhandapani, K.2    Wakade, C.3    Ma-Hesh, V.B.4    Khan, M.M.5
  • 7
    • 17844399257 scopus 로고    scopus 로고
    • Interdependence of oestrogen and insulin-like growth factor-I in the brain: Potential for analysing neuroprotective mechanisms
    • Mendez P, Azcoitia I, Garcia-Segura LM: Interdependence of oestrogen and insulin-like growth factor-I in the brain: potential for analysing neuroprotective mechanisms. J En-docrinol 2005; 185:11-17.
    • (2005) J En-docrinol , vol.185 , pp. 11-17
    • Mendez, P.1    Azcoitia, I.2    Garcia-Segura, L.M.3
  • 8
    • 33744988733 scopus 로고    scopus 로고
    • Novel mechanisms for estrogen-induced neuroprotection
    • Singh M, Dykens JA, Simpkins JW: Novel mechanisms for estrogen-induced neuroprotection. Exp Biol Med 2006; 231:514-521.
    • (2006) Exp Biol Med , vol.231 , pp. 514-521
    • Singh, M.1    Dykens, J.A.2    Simpkins, J.W.3
  • 9
    • 84866563308 scopus 로고    scopus 로고
    • Estrogen Receptors and the Regulation of Neural Stress Responses
    • Handa RJ, Mani SK, Uht RM: Estrogen receptors and the regulation of neural stress responses. Neuroendocrinology 2012;96:111-118.
    • (2012) Neuroendocrinology , vol.96 , pp. 111-118
    • Handa, R.J.1    Mani, S.K.2    Uht, R.M.3
  • 12
    • 33845590845 scopus 로고    scopus 로고
    • Role of astro-cytes in estrogen-mediated neuroprotection
    • Dhandapani KM, Brann DW: Role of astro-cytes in estrogen-mediated neuroprotection. Exp Gerontol 2007; 42:70-75.
    • (2007) Exp Gerontol , vol.42 , pp. 70-75
    • Dhandapani, K.M.1    Brann, D.W.2
  • 13
    • 0032052288 scopus 로고    scopus 로고
    • Steroid hormone receptors and steroid action in rat glial cells of the central and peripheral nervous system
    • Jung-Testas I, Baulieu EE: Steroid hormone receptors and steroid action in rat glial cells of the central and peripheral nervous system. J Steroid Biochem Mol Biol 1998; 65:243-251.
    • (1998) J Steroid Biochem Mol Biol , vol.65 , pp. 243-251
    • Jung-Testas, I.1    Baulieu, E.E.2
  • 14
    • 33644515318 scopus 로고    scopus 로고
    • Estradiol modulation of astrocytic form and function: Implications for hormonal control of synaptic communication
    • Mong JA, Blutstein T: Estradiol modulation of astrocytic form and function: implications for hormonal control of synaptic communication. Neuroscience 2006; 138:967-975.
    • (2006) Neuroscience , vol.138 , pp. 967-975
    • Mong, J.A.1    Blutstein, T.2
  • 16
    • 0027968210 scopus 로고
    • Estradiol treatment increases viability of glioma and neuroblas-toma cells in vitro
    • Bishop J, Simpkins JW: Estradiol treatment increases viability of glioma and neuroblas-toma cells in vitro. Mol Cell Neurosci 1994; 5:303-308.
    • (1994) Mol Cell Neurosci , vol.5 , pp. 303-308
    • Bishop, J.1    Simpkins, J.W.2
  • 17
    • 0034237128 scopus 로고    scopus 로고
    • Neuroprotective effects of estrogens: Potential mechanisms of action
    • Green PS, Simpkins JW: Neuroprotective effects of estrogens: potential mechanisms of action. Int J Dev Neurosci 2000; 18:347-358.
    • (2000) Int J Dev Neurosci , vol.18 , pp. 347-358
    • Green, P.S.1    Simpkins, J.W.2
  • 19
    • 0031552508 scopus 로고    scopus 로고
    • 17beta-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors
    • Weaver CE Jr, Park-Chung M, Gibbs TT, Farb DH: 17beta-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors. Brain Res 1997; 761:338-341.
    • (1997) Brain Res , vol.761 , pp. 338-341
    • Weaver, Jr.C.E.1    Park-Chung, M.2    Gibbs, T.T.3    Farb, D.H.4
  • 20
    • 0342803689 scopus 로고    scopus 로고
    • Estrogen-induced activation of the mitogen-activated protein ki-nase cascade in the cerebral cortex of estrogen receptor-alpha knock-out mice
    • Singh M, Setalo G Jr, Guan X, Frail DE, Toran-Allerand CD: Estrogen-induced activation of the mitogen-activated protein ki-nase cascade in the cerebral cortex of estrogen receptor-alpha knock-out mice. J Neuro-sci 2000; 20:1694-1700.
    • (2000) J Neuro-sci , vol.20 , pp. 1694-1700
    • Singh, M.1    Setalo, Jr.G.2    Guan, X.3    Frail, D.E.4    Toran-Allerand, C.D.5
  • 25
    • 0033967462 scopus 로고    scopus 로고
    • Ovari-ectomy exacerbates and estrogen replacement attenuates photothrombotic focal isch-emic brain injury in rats
    • Fukuda K, Yao H, Ibayashi S, Nakahara T, Uchimura H, Fujishima M, Hall ED: Ovari-ectomy exacerbates and estrogen replacement attenuates photothrombotic focal isch-emic brain injury in rats. Stroke 2000; 31:155-160.
    • (2000) Stroke , vol.31 , pp. 155-160
    • Fukuda, K.1    Yao, H.2    Ibayashi, S.3    Nakahara, T.4    Uchimura, H.5    Fujishima, M.6    Hall, E.D.7
  • 26
    • 0035906427 scopus 로고    scopus 로고
    • 17beta-Estradiol Reduces Cortical Lesion Size in the Glutamate Excito-toxicity Model by Enhancing Extracellular Lactate: A New Neuroprotective Pathway
    • Mendelowitsch A, Ritz MF, Ros J, Langemann H, Gratzl O: 17beta-Estradiol reduces cortical lesion size in the glutamate excito-toxicity model by enhancing extracellular lactate: a new neuroprotective pathway. Brain Res 200; 1901:230-236.
    • (2000) Brain Res , vol.1901 , pp. 230-236
    • Mendelowitsch, A.1    Ritz, M.F.2    Ros, J.3    Langemann, H.4    Gratzl, O.5
  • 27
    • 0035002097 scopus 로고    scopus 로고
    • 17 beta-Estradiol pro-tects neurons from ischemic damage and attenuates accumulation of extracellular excitatory amino acids
    • Chen J, Xu W, Jiang H: 17 beta-Estradiol pro-tects neurons from ischemic damage and attenuates accumulation of extracellular excitatory amino acids. Anesth Analg 2001; 92:1520-1523.
    • (2001) Anesth Analg , vol.92 , pp. 1520-1523
    • Chen, J.1    Xu, W.2    Jiang, H.3
  • 28
    • 0033497678 scopus 로고    scopus 로고
    • Neuroprotection by estrogens in a mouse model of focal cerebral ischemia and in cultured neurons: Evidence for a receptor-independent antioxidative mechanism
    • Culmsee C, Vedder H, Ravati A, Junker V, Otto D, Ahlemeyer B, Krieg JC, Krieglstein J: Neuroprotection by estrogens in a mouse model of focal cerebral ischemia and in cultured neurons: evidence for a receptor-independent antioxidative mechanism. J Cereb Blood Flow Metab 1999; 19:1263-1269.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 1263-1269
    • Culmsee, C.1    Vedder, H.2    Ravati, A.3    Junker, V.4    Otto, D.5    Ahlemeyer, B.6    Krieg, J.C.7    Krieglstein, J.8
  • 29
    • 0035663680 scopus 로고    scopus 로고
    • Estradiol is a protective factor in the adult and aging brain: Understanding of mechanisms derived from in vivo and in vitro studies
    • Wise PM, Dubal DB, Wilson ME, Rau SW, Böttner M, Rosewell KL: Estradiol is a protective factor in the adult and aging brain: understanding of mechanisms derived from in vivo and in vitro studies. Brain Res Brain Res Rev 37: 2001;313-319.
    • (2001) Brain Res Brain Res Rev , vol.37 , pp. 313-319
    • Wise, P.M.1    Dubal, D.B.2    Wilson, M.E.3    Rau, S.W.4    Böttner, M.5    Rosewell, K.L.6
  • 30
    • 77952626873 scopus 로고    scopus 로고
    • The neurotoxic effects of estrogens on ischemic stroke in older female rats is associated with age-dependent loss of insulin-like growth factor-1
    • Selvamani A, Sohrabji F: The neurotoxic effects of estrogens on ischemic stroke in older female rats is associated with age-dependent loss of insulin-like growth factor-1. J Neuro-sci 2010; 30:6852-6861.
    • (2010) J Neuro-sci , vol.30 , pp. 6852-6861
    • Selvamani, A.1    Sohrabji, F.2
  • 31
    • 84859491886 scopus 로고    scopus 로고
    • Age-related severity of focal ischemia in female rats is associated with impaired astrocyte function
    • Lewis DK, Thomas KT, Selvamani A, Sohrabji F: Age-related severity of focal ischemia in female rats is associated with impaired astrocyte function. Neurobiol Aging 2012; 33:1123.e1-16.
    • (2012) Neurobiol Aging , vol.33
    • Lewis, D.K.1    Thomas, K.T.2    Selvamani, A.3    Sohrabji, F.4
  • 32
    • 0033755647 scopus 로고    scopus 로고
    • Estrogen decreases infarct size after temporary focal ischemia in a genetic model of type 1 diabetes mellitus
    • Toung TK, Hurn PD, Traystman RJ, Sieber FE: Estrogen decreases infarct size after temporary focal ischemia in a genetic model of type 1 diabetes mellitus. Stroke 2000; 31:2701-2706.
    • (2000) Stroke , vol.31 , pp. 2701-2706
    • Toung, T.K.1    Hurn, P.D.2    Traystman, R.J.3    Sieber, F.E.4
  • 33
    • 0033956280 scopus 로고    scopus 로고
    • Estrogen status affects sensitivity to focal cerebral ischemia in stroke-prone spontaneously hypertensive rats
    • Carswell H V, Dominiczak AF, Macrae IM: Estrogen status affects sensitivity to focal cerebral ischemia in stroke-prone spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 278: 2000;H290-H294.
    • (2000) Am J Physiol Heart Circ Physiol , vol.278
    • Carswell, H.V.1    Dominiczak, A.F.2    MacRae, I.M.3
  • 35
    • 0032527057 scopus 로고    scopus 로고
    • Testosterone increases and es-tradiol decreases middle cerebral artery occlusion lesion size in male rats
    • Hawk T, Zhang YQ, Rajakumar G, Day AL, Simpkins JW: Testosterone increases and es-tradiol decreases middle cerebral artery occlusion lesion size in male rats. Brain Res 1998; 796:296-298.
    • (1998) Brain Res , vol.796 , pp. 296-298
    • Hawk, T.1    Zhang, Y.Q.2    Rajakumar, G.3    Day, A.L.4    Simpkins, J.W.5
  • 36
    • 0031904678 scopus 로고    scopus 로고
    • Estrogen-mediated neuroprotection after experimental stroke in male rats
    • Toung TJ, Traystman RJ, Hurn PD: Estrogen-mediated neuroprotection after experimental stroke in male rats. Stroke 1998; 29:1666-1670.
    • (1998) Stroke , vol.29 , pp. 1666-1670
    • Toung, T.J.1    Traystman, R.J.2    Hurn, P.D.3
  • 37
    • 0034745252 scopus 로고    scopus 로고
    • Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke
    • McCullough LD, Alkayed NJ, Traystman RJ, Williams MJ, Hurn PD: Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke. Stroke 32: 2001; 796-802.
    • (2001) Stroke , vol.32 , pp. 796-802
    • McCullough, L.D.1    Alkayed, N.J.2    Traystman, R.J.3    Williams, M.J.4    Hurn, P.D.5
  • 38
    • 0034018107 scopus 로고    scopus 로고
    • Estra-diol exerts neuroprotective effects when administered after ischemic insult
    • Yang SH, Shi J, Day AL, Simpkins JW: Estra-diol exerts neuroprotective effects when administered after ischemic insult. Stroke 31: 2000; 745-749.
    • (2000) Stroke , vol.31 , pp. 745-749
    • Yang, S.H.1    Shi, J.2    Day, A.L.3    Simpkins, J.W.4
  • 39
    • 1342309220 scopus 로고    scopus 로고
    • The use of estrogens and related compounds in the treatment of damage from cerebral ischemia
    • Yang SH, Liu R, Wu SS, Simpkins JW: The use of estrogens and related compounds in the treatment of damage from cerebral ischemia. Ann NY Acad Sci 1007: 2003;101-107.
    • (2003) Ann NY Acad Sci , vol.1007 , pp. 101-107
    • Yang, S.H.1    Liu, R.2    Wu, S.S.3    Simpkins, J.W.4
  • 40
    • 33947186953 scopus 로고    scopus 로고
    • Dose dependence and therapeutic window for the neuroprotective effects of 17be-ta-estradiol when administered after cerebral ischemia
    • Liu R, Wang X, Liu Q, Yang SH, Simpkins JW: Dose dependence and therapeutic window for the neuroprotective effects of 17be-ta-estradiol when administered after cerebral ischemia. Neurosci Lett 2007; 415:237-241.
    • (2007) Neurosci Lett , vol.415 , pp. 237-241
    • Liu, R.1    Wang, X.2    Liu, Q.3    Yang, S.H.4    Simpkins, J.W.5
  • 41
    • 0033485704 scopus 로고    scopus 로고
    • Cli nical trials with neuroprotective drugs in acute isch-aemic stroke: Are we doing the right thing?
    • De Keyser J, Sulter G, Lu iten PG: Cli nical trials with neuroprotective drugs in acute isch-aemic stroke: are we doing the right thing? Trends Neurosci 1999; 22:535-540.
    • (1999) Trends Neurosci , vol.22 , pp. 535-540
    • De Keyser, J.1    Sulter, G.2    Lu Iten, P.G.3
  • 42
    • 0030714666 scopus 로고    scopus 로고
    • Clinical manifestations and predictors of survival in older women infected with HIV
    • Clark RA, Bessinger R: Clinical manifestations and predictors of survival in older women infected with HIV. J Acquir Immune Def ic Sy ndr Hum Retrov irol 1997; 15:341-345.
    • (1997) J Acquir Immune Def Ic Sy Ndr Hum Retrov Irol , vol.15 , pp. 341-345
    • Clark, R.A.1    Bessinger, R.2
  • 43
    • 0028086440 scopus 로고
    • Estrogen replacement therapy in older women. Comparisons between Alzheimer's disease cases and nondemented control subjects
    • Henderson VW, Paganini-Hill A, Emanuel CK, Dunn ME, Buckwalter JG: Estrogen replacement therapy in older women. Comparisons between Alzheimer's disease cases and nondemented control subjects. Arch Neurol 1994; 51:896-900.
    • (1994) Arch Neurol , vol.51 , pp. 896-900
    • Henderson, V.W.1    Paganini-Hill, A.2    Emanuel, C.K.3    Dunn, M.E.4    Buckwalter, J.G.5
  • 44
    • 0028085516 scopus 로고
    • Estrogen deficiency and risk of Alzheimer's disease in women
    • Paganini-Hill A, Henderson VW: Estrogen deficiency and risk of Alzheimer's disease in women. Am J Epidemiol 1994; 140:256-261.
    • (1994) Am J Epidemiol , vol.140 , pp. 256-261
    • Paganini-Hill, A.1    Henderson, V.W.2
  • 45
    • 0027102043 scopus 로고
    • Effects of estrogen on memory function in surgically meno-pausal women
    • Phillips SM, Sherwin BB: Effects of estrogen on memory function in surgically meno-pausal women. Psychoneuroendocrinology 1992; 17:485-495.
    • (1992) Psychoneuroendocrinology , vol.17 , pp. 485-495
    • Phillips, S.M.1    Sherwin, B.B.2
  • 46
    • 0031983510 scopus 로고    scopus 로고
    • Estrogen and cognitive functioning in women
    • Sherwin BB: Estrogen and cognitive functioning in women. Proc Soc Exp Biol Med 1998; 217:17-22.
    • (1998) Proc Soc Exp Biol Med , vol.217 , pp. 17-22
    • Sherwin, B.B.1
  • 47
    • 0030980827 scopus 로고    scopus 로고
    • Estrogen effects on cognition in menopausal women
    • Sherwin BB: Estrogen effects on cognition in menopausal women. Neurology 1997; 48:S21-S26.
    • (1997) Neurology , vol.48
    • Sherwin, B.B.1
  • 48
    • 0035143966 scopus 로고    scopus 로고
    • Enhanced verbal memory in nondemented elderly women receiving hormone-replacement therapy
    • Maki PM, Zonderman AB, Resnick SM: Enhanced verbal memory in nondemented elderly women receiving hormone-replacement therapy. Am J Psychiatry 2001; 158:227-233.
    • (2001) Am J Psychiatry , vol.158 , pp. 227-233
    • Maki, P.M.1    Zonderman, A.B.2    Resnick, S.M.3
  • 49
    • 0035683871 scopus 로고    scopus 로고
    • Effects of hormone replacement therapy on cognitive and brain aging
    • Resnick SM, Maki PM: Effects of hormone replacement therapy on cognitive and brain aging. Ann NY Acad Sci 2001; 949:203-214.
    • (2001) Ann NY Acad Sci , vol.949 , pp. 203-214
    • Resnick, S.M.1    Maki, P.M.2
  • 50
    • 0032191219 scopus 로고    scopus 로고
    • Effects of estrogen replacement therapy on PET cerebral blood flow and neuropsychological performance
    • Resnick SM, Maki PM, Golski S, Kraut MA, Zonderman AB: Effects of estrogen replacement therapy on PET cerebral blood flow and neuropsychological performance. Horm Behav 1998; 34:171-182.
    • (1998) Horm Behav , vol.34 , pp. 171-182
    • Resnick, S.M.1    Maki, P.M.2    Golski, S.3    Kraut, M.A.4    Zonderman, A.B.5
  • 58
    • 0028895128 scopus 로고
    • Estrogen replacement therapy and stroke
    • Paganini-Hill A: Estrogen replacement therapy and stroke. Prog Cardiovasc Dis 1995; 38:223-242.
    • (1995) Prog Cardiovasc Dis , vol.38 , pp. 223-242
    • Paganini-Hill, A.1
  • 60
    • 0027463811 scopus 로고
    • Decreased risk of stroke among postmenopausal hormone users. Results from a national cohort
    • Finucane FF, Madans JH, Bush TL, Wolf PH, Kleinman JC: Decreased risk of stroke among postmenopausal hormone users. Results from a national cohort. Arch Intern Med 1993; 153:73-79.
    • (1993) Arch Intern Med , vol.153 , pp. 73-79
    • Finucane, F.F.1    Madans, J.H.2    Bush, T.L.3    Wolf, P.H.4    Kleinman, J.C.5
  • 61
    • 0026016029 scopus 로고
    • Decreased mortality in users of estrogen replacement therapy
    • Henderson BE, Paganini-Hill A, Ross RK: Decreased mortality in users of estrogen replacement therapy. Arch Intern Med 1991; 151:75-78.
    • (1991) Arch Intern Med , vol.151 , pp. 75-78
    • Henderson, B.E.1    Paganini-Hill, A.2    Ross, R.K.3
  • 62
    • 0027207254 scopus 로고
    • Hormone replacement therapy and the risk of stroke. Follow-up of a population-based cohort in Sweden
    • Falkeborn M, Persson I, Terent A, Adami HO, Lithell H, Bergstrom R: Hormone replacement therapy and the risk of stroke. Follow-up of a population-based cohort in Sweden. Arch Intern Med 1993; 153:1201-1209.
    • (1993) Arch Intern Med , vol.153 , pp. 1201-1209
    • Falkeborn, M.1    Persson, I.2    Terent, A.3    Adami, H.O.4    Lithell, H.5    Bergstrom, R.6
  • 63
    • 0031720131 scopus 로고    scopus 로고
    • Female TBI patients recover better than males
    • Groswasser Z, Cohen M, Keren O: Female TBI patients recover better than males. Brain Inj 1998; 12:805-808.
    • (1998) Brain Inj , vol.12 , pp. 805-808
    • Groswasser, Z.1    Cohen, M.2    Keren, O.3
  • 68
    • 33746191796 scopus 로고    scopus 로고
    • Neuroprotection by ovarian hormones in animal models of neurological disease
    • Hoffman GE, Merchenthaler I, Zup SL: Neuroprotection by ovarian hormones in animal models of neurological disease. Endocrine 2006; 29:217-231.
    • (2006) Endocrine , vol.29 , pp. 217-231
    • Hoffman, G.E.1    Merchenthaler, I.2    Zup, S.L.3
  • 69
    • 1342330571 scopus 로고    scopus 로고
    • Neuroprotection by estrogen in animal models of global and focal ischemia
    • Merchenthaler I, Dellovade TL, Shughrue PJ: Neuroprotection by estrogen in animal models of global and focal ischemia. Ann NY Acad Sci 2003; 1007:89-100.
    • (2003) Ann NY Acad Sci , vol.1007 , pp. 89-100
    • Merchenthaler, I.1    Dellovade, T.L.2    Shughrue, P.J.3
  • 73
    • 79956365652 scopus 로고    scopus 로고
    • Activation of Estrogen Receptor-alpha and of An-giotensin-converting Enzyme 2 Suppresses Ischemic Brain Damage in Oophorectomized Rats
    • Shimada K, Kitazato KT, Kinouchi T, Yagi K, Tada Y, Satomi J, Kageji T, Nagahiro S: Activation of estrogen receptor-alpha and of an-giotensin-converting enzyme 2 suppresses ischemic brain damage in oophorectomized rats. Hyper tension 2011; 57:1161-1166.
    • (2011) Hyper Tension , vol.57 , pp. 1161-1166
    • Shimada, K.1    Kitazato, K.T.2    Kinouchi, T.3    Yagi, K.4    Tada, Y.5    Satomi, J.6    Kageji, T.7    Nagahiro, S.8
  • 74
    • 79959274465 scopus 로고    scopus 로고
    • Differential neuroprotection of selective estrogen receptor agonists against autonomic dysfunction and ischemic cell death in permanent versus reperfusion injury
    • Connell BJ, Saleh TM: Differential neuroprotection of selective estrogen receptor agonists against autonomic dysfunction and ischemic cell death in permanent versus reperfusion injury. Adv Pharmacol Sci 2011; 2011:976951.
    • (2011) Adv Pharmacol Sci , vol.2011 , pp. 976951
    • Connell, B.J.1    Saleh, T.M.2
  • 76
    • 36448946877 scopus 로고    scopus 로고
    • Estrogen receptor beta agonist diarylpropi-olnitrile (DPN) does not mediate neuroprotection in a rat model of permanent focal ischemia
    • Farr TD, Carswell HV, Gsell W, Macrae IM: Estrogen receptor beta agonist diarylpropi-olnitrile (DPN) does not mediate neuroprotection in a rat model of permanent focal ischemia. Brain Res 2007; 1185:275-282.
    • (2007) Brain Res , vol.1185 , pp. 275-282
    • Farr, T.D.1    Carswell, H.V.2    Gsell, W.3    MacRae, I.M.4
  • 78
    • 0023724443 scopus 로고
    • The four-vessel occlusion rat model: Method for complete occlusion of vertebral arteries and control of col lateral circu lation
    • Pulsinelli WA, Buchan AM: The four-vessel occlusion rat model: method for complete occlusion of vertebral arteries and control of col lateral circu lation. Stroke 1988; 19:913-914.
    • (1988) Stroke , vol.19 , pp. 913-914
    • Pulsinelli, W.A.1    Buchan, A.M.2
  • 79
    • 78951474065 scopus 로고    scopus 로고
    • Estrogen receptor agonists and estrogen attenuate TNF-alpha-induced apoptosis in VSC4.1 motoneurons
    • Das A, Smith JA, Gibson C, Varma AK, Ray SK, Banik NL: Estrogen receptor agonists and estrogen attenuate TNF-alpha-induced apoptosis in VSC4.1 motoneurons. J Endo-crinol 2011; 208:171-182.
    • (2011) J Endo-crinol , vol.208 , pp. 171-182
    • Das, A.1    Smith, J.A.2    Gibson, C.3    Varma, A.K.4    Ray, S.K.5    Banik, N.L.6
  • 80
    • 33847062554 scopus 로고    scopus 로고
    • MAPK signaling is critical to estradiol protection of CA1 neurons in global ischemia
    • Jover-Mengual T, Zukin RS, Etgen AM: MAPK signaling is critical to estradiol protection of CA1 neurons in global ischemia. Endocrinology 2007; 148:1131-1143.
    • (2007) Endocrinology , vol.148 , pp. 1131-1143
    • Jover-Mengual, T.1    Zukin, R.S.2    Etgen, A.M.3
  • 81
    • 22144493001 scopus 로고    scopus 로고
    • Estrogen can act via estrogen receptor alpha and beta to protect hippocam-pal neurons against global ischemia-induced cell death
    • Miller NR, Jover T, Cohen HW, Zukin RS, Etgen AM: Estrogen can act via estrogen receptor alpha and beta to protect hippocam-pal neurons against global ischemia-induced cell death. Endocrinology 2005; 146:3070-3079.
    • (2005) Endocrinology , vol.146 , pp. 3070-3079
    • Miller, N.R.1    Jover, T.2    Cohen, H.W.3    Zukin, R.S.4    Etgen, A.M.5
  • 82
    • 70449397081 scopus 로고    scopus 로고
    • Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation
    • Zhang QG, Raz L, Wang R, Han D, De Sevilla L, Yang F, Vadlamudi RK, Brann DW: Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation. J Neurosci 2009; 29:13823-13836.
    • (2009) J Neurosci , vol.29 , pp. 13823-13836
    • Zhang, Q.G.1    Raz, L.2    Wang, R.3    Han, D.4    De Sevilla, L.5    Yang, F.6    Vadlamudi, R.K.7    Brann, D.W.8
  • 83
    • 0033573273 scopus 로고    scopus 로고
    • Neu-roprotective effects of estradiol in the adult rat hippocampus: Interaction with insulinlike growth factor-I signalling
    • Azcoitia I, Sierra A, Garcia-Segura LM: Neu-roprotective effects of estradiol in the adult rat hippocampus: interaction with insulinlike growth factor-I signalling. J Neurosci Res 1999; 58:815-822.
    • (1999) J Neurosci Res , vol.58 , pp. 815-822
    • Azcoitia, I.1    Sierra, A.2    Garcia-Segura, L.M.3
  • 84
    • 33847246279 scopus 로고    scopus 로고
    • Neurosteroid es-tradiol rescues ischemia-induced deficit in the long-term potentiation of rat hippocam-pal CA1 neurons
    • Dai X, Chen L, Sokabe M: Neurosteroid es-tradiol rescues ischemia-induced deficit in the long-term potentiation of rat hippocam-pal CA1 neurons. Neuropharmacology 2007; 52:1124-1138.
    • (2007) Neuropharmacology , vol.52 , pp. 1124-1138
    • Dai, X.1    Chen, L.2    Sokabe, M.3
  • 85
    • 80052293585 scopus 로고    scopus 로고
    • C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection
    • Zhang QG, Han D, Wang RM, Dong Y, Yang F, Vadlamudi RK, Brann DW: C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Proc Natl Acad Sci USA 2011; 108:E617-E624.
    • (2011) Proc Natl Acad Sci USA , vol.108
    • Zhang, Q.G.1    Han, D.2    Wang, R.M.3    Dong, Y.4    Yang, F.5    Vadlamudi, R.K.6    Brann, D.W.7
  • 86
    • 67649365452 scopus 로고    scopus 로고
    • Neuroprotective effects of R, R-tetrahydrochrysene against glutamate-induced cell death through anti-excitotoxic and antioxidant actions involving estrogen receptor-dependent and-independent pathways
    • Xia Y, Xing JZ, Krukoff TL: Neuroprotective effects of R, R-tetrahydrochrysene against glutamate-induced cell death through anti-excitotoxic and antioxidant actions involving estrogen receptor-dependent and-independent pathways. Neuroscience 2009; 162:292-306.
    • (2009) Neuroscience , vol.162 , pp. 292-306
    • Xia, Y.1    Xing, J.Z.2    Krukoff, T.L.3
  • 87
    • 0036320770 scopus 로고    scopus 로고
    • Estrogen-mediated neuroprotection against beta-amyloid toxicity requires expression of estrogen receptor alpha or beta and activation of the MAPK pathway
    • Fitzpatrick JL, Mize AL, Wade CB, Harris JA, Shapiro RA, Dorsa DM: Estrogen-mediated neuroprotection against beta-amyloid toxicity requires expression of estrogen receptor alpha or beta and activation of the MAPK pathway. J Neurochem 2002; 82:674-682.
    • (2002) J Neurochem , vol.82 , pp. 674-682
    • Fitzpatrick, J.L.1    Mize, A.L.2    Wade, C.B.3    Harris, J.A.4    Shapiro, R.A.5    Dorsa, D.M.6
  • 88
    • 1342288028 scopus 로고    scopus 로고
    • An ICI 182, 780-sensitive, membrane-related estrogen receptor contributes to estrogenic neuroprotective actions against amyloid-beta toxicity
    • Marin R, Guerra B, Morales A, Diaz M, Alonso R: An ICI 182, 780-sensitive, membrane-related estrogen receptor contributes to estrogenic neuroprotective actions against amyloid-beta toxicity. Ann NY Acad Sci 2003; 1007:108-116.
    • (2003) Ann NY Acad Sci , vol.1007 , pp. 108-116
    • Marin, R.1    Guerra, B.2    Morales, A.3    Diaz, M.4    Alonso, R.5
  • 89
    • 19444370832 scopus 로고    scopus 로고
    • Neuroprotective properties of selective estrogen receptor agonists in cultured neurons
    • Cordey M, Pike CJ: Neuroprotective properties of selective estrogen receptor agonists in cultured neurons. Brain Res 2005; 1045:217-223.
    • (2005) Brain Res , vol.1045 , pp. 217-223
    • Cordey, M.1    Pike, C.J.2
  • 90
    • 44649182975 scopus 로고    scopus 로고
    • Modulation of Abeta-induced neurotoxicity by estrogen receptor alpha and other associated proteins in lipid rafts
    • Marin R, Ramírez C, Morales A, González M, Alonso R, Díaz M: Modulation of Abeta-induced neurotoxicity by estrogen receptor alpha and other associated proteins in lipid rafts. Steroids 2008; 73:992-996.
    • (2008) Steroids , vol.73 , pp. 992-996
    • Marin, R.1    Ramírez, C.2    Morales, A.3    González, M.4    Alonso, R.5    Díaz, M.6
  • 93
    • 0037233177 scopus 로고    scopus 로고
    • Estrogen receptor-mediated neuroprotection from oxidative stress requires activation of the mitogen-activated protein kinase pathway
    • Mize AL, Shapiro RA, Dorsa DM: Estrogen receptor-mediated neuroprotection from oxidative stress requires activation of the mitogen-activated protein kinase pathway. Endocrinology 2003; 144:306-312.
    • (2003) Endocrinology , vol.144 , pp. 306-312
    • Mize, A.L.1    Shapiro, R.A.2    Dorsa, D.M.3
  • 94
    • 34548681666 scopus 로고    scopus 로고
    • Estrogen receptor alpha and beta differentially regulate intracellular Ca(2+) dynamics leading to ERK phosphorylation and estrogen neuroprotection in hippocampal neurons
    • Zhao L, Brinton RD: Estrogen receptor alpha and beta differentially regulate intracellular Ca(2+) dynamics leading to ERK phosphorylation and estrogen neuroprotection in hippocampal neurons. Brain Res 2007; 1172:48-59.
    • (2007) Brain Res , vol.1172 , pp. 48-59
    • Zhao, L.1    Brinton, R.D.2
  • 95
    • 2342630011 scopus 로고    scopus 로고
    • Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons
    • Zhao L, Wu TW, Brinton RD: Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons. Brain Res 2004; 1010:22-34.
    • (2004) Brain Res , vol.1010 , pp. 22-34
    • Zhao, L.1    Wu, T.W.2    Brinton, R.D.3
  • 96
    • 29744467003 scopus 로고    scopus 로고
    • Estrogen prevents glutamate-induced apoptosis in C6 glioma cells by a receptor-mediated mechanism
    • Sribnick E A, Ray SK, Banik NL: Estrogen prevents glutamate-induced apoptosis in C6 glioma cells by a receptor-mediated mechanism. Neuroscience 2006; 137:197-209.
    • (2006) Neuroscience , vol.137 , pp. 197-209
    • Sribnick, E.A.1    Ray, S.K.2    Banik, N.L.3
  • 97
    • 77955918599 scopus 로고    scopus 로고
    • Estrogen Receptor Alpha and G-protein Coupled Receptor 30 Mediate the Neuroprotective Effects of 17beta-estradiol in Novel Murine Hippocampal Cell Models
    • Gingerich S, Kim GL, Chalmers JA, Koletar MM, Wang X, Wang Y, Belsham DD: Estrogen receptor alpha and G-protein coupled receptor 30 mediate the neuroprotective effects of 17beta-estradiol in novel murine hippocampal cell models. Neuroscience 2010; 170:54-66.
    • (2010) Neuroscience , vol.170 , pp. 54-66
    • Gingerich, S.1    Kim, G.L.2    Chalmers, J.A.3    Koletar, M.M.4    Wang, X.5    Wang, Y.6    Belsham, D.D.7
  • 98
    • 77957115293 scopus 로고    scopus 로고
    • Roles of Estrogen Receptors Alpha and Beta in Sexually Dimorphic Neuroprotection Against Glutamate Toxicity
    • Bryant DN, Dorsa DM: Roles of estrogen receptors alpha and beta in sexually dimorphic neuroprotection against glutamate toxicity. Neuroscience 2010; 170:1261-1269.
    • (2010) Neuroscience , vol.170 , pp. 1261-1269
    • Bryant, D.N.1    Dorsa, D.M.2
  • 99
    • 33644960746 scopus 로고    scopus 로고
    • Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells-implications for neuroprotection against Ca-mediated excitotoxicity
    • Gamerdinger M, Manthey D, Behl C: Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells-implications for neuroprotection against Ca-mediated excitotoxicity. J Neurochem 2006; 97:57-68.
    • (2006) J Neurochem , vol.97 , pp. 57-68
    • Gamerdinger, M.1    Manthey, D.2    Behl, C.3
  • 100
    • 84055188845 scopus 로고    scopus 로고
    • Oestrogen receptors and signalling pathways: Implications for neuroprotective effects of sex steroids in Parkinson's disease
    • Al Sweidi S, Sánchez MG, Bourque M, Morissette M, Dluzen D, Di Paolo T: Oestrogen receptors and signalling pathways: implications for neuroprotective effects of sex steroids in Parkinson's disease. J Neuro-endocrinol 2011; 24:48-61.
    • (2011) J Neuro-endocrinol , vol.24 , pp. 48-61
    • Al Sweidi, S.1    Sánchez, M.G.2    Bourque, M.3    Morissette, M.4    Dluzen, D.5    Di Paolo, T.6
  • 101
    • 33947692720 scopus 로고    scopus 로고
    • Neuroprotection by estrogen against MPP+-in-duced dopamine neuron death is mediated by ERalpha in primary cultures of mouse mesencephalon
    • Bains M, Cousins JC, Roberts JL: Neuroprotection by estrogen against MPP+-in-duced dopamine neuron death is mediated by ERalpha in primary cultures of mouse mesencephalon. Exp Neurol 2007; 204:767-776.
    • (2007) Exp Neurol , vol.204 , pp. 767-776
    • Bains, M.1    Cousins, J.C.2    Roberts, J.L.3
  • 102
    • 33645102888 scopus 로고    scopus 로고
    • Implication of the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in the neuro-protective effect of estradiol in the striatum of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydro-pyridine mice
    • D'Astous M, Mendez P, Morissette M, Gar-cia-Segura LM, Di Paolo T: Implication of the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in the neuro-protective effect of estradiol in the striatum of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydro-pyridine mice. Mol Pharmacol 2006; 69:1492-1498.
    • (2006) Mol Pharmacol , vol.69 , pp. 1492-1498
    • D'Astous, M.1    Mendez, P.2    Morissette, M.3    Gar-Cia-Segura, L.M.4    Di Paolo, T.5
  • 103
    • 9644269044 scopus 로고    scopus 로고
    • Effect of estrogen receptor agon ists treat ment in MPTP mice: Evidence of neuroprotec-t ion by an ER alpha a gonist
    • D'Astous M, Morissette M, Di Paolo T: Effect of estrogen receptor agon ists treat ment in MPTP mice: evidence of neuroprotec-t ion by an ER alpha a gonist. Neu roph a rma-cology 2004; 47:1180-1188.
    • (2004) Neu Roph A Rma-cology , vol.47 , pp. 1180-1188
    • D'Astous, M.1    Morissette, M.2    Di Paolo, T.3
  • 105
    • 80053383728 scopus 로고    scopus 로고
    • 17Beta-es-tradiol Differentially Protects Cortical Peri-contusional Zone from Programmed Cell Death after Traumatic Cerebral Contusion at Distinct Stages Via Non-genomic and Ge-nomic Pathways
    • Bao YJ, Li LZ, Li XG, Wang YJ: 17Beta-es-tradiol differentially protects cortical peri-contusional zone from programmed cell death after traumatic cerebral contusion at distinct stages via non-genomic and ge-nomic pathways. Mol Cell Neurosci 2011; 48:185-194.
    • (2011) Mol Cell Neurosci , vol.48 , pp. 185-194
    • Bao, Y.J.1    Li, L.Z.2    Li, X.G.3    Wang, Y.J.4
  • 107
    • 77649275015 scopus 로고    scopus 로고
    • Estrogen-receptor-mediated protection of cerebral endothelial cell viability and mitochondrial function after ischemic insult in vitro
    • Guo J, Krause DN, Horne J, Weiss JH, Li X, Duckles SP: Estrogen-receptor-mediated protection of cerebral endothelial cell viability and mitochondrial function after ischemic insult in vitro. J Cereb Blood Flow Metab 2010; 30:545-554.
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 545-554
    • Guo, J.1    Krause, D.N.2    Horne, J.3    Weiss, J.H.4    Li, X.5    Duckles, S.P.6
  • 108
    • 27244449812 scopus 로고    scopus 로고
    • Estrogen provides neuroprotection against activated microglia-induced dopa-minergic neuronal injury through both estrogen receptor-alpha and estrogen receptor-beta in microglia
    • Liu X, Fan XL, Zhao Y, Luo GR, Li XP, Li R, Le WD: Estrogen provides neuroprotection against activated microglia-induced dopa-minergic neuronal injury through both estrogen receptor-alpha and estrogen receptor-beta in microglia. J Neurosci Res 2005; 81:653-665.
    • (2005) J Neurosci Res , vol.81 , pp. 653-665
    • Liu, X.1    Fan, X.L.2    Zhao, Y.3    Luo, G.R.4    Li, X.P.5    Li, R.6    Le, W.D.7
  • 112
    • 54949145352 scopus 로고    scopus 로고
    • Estradiol attenuates neuroprotective benefits of isoflurane preconditioning in isch-emic mouse brain
    • Wang L, Kitano H, Hurn PD, Murphy SJ: Estradiol attenuates neuroprotective benefits of isoflurane preconditioning in isch-emic mouse brain. J Cereb Blood Flow Metab 2008; 28:1824-1834.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1824-1834
    • Wang, L.1    Kitano, H.2    Hurn, P.D.3    Murphy, S.J.4
  • 115
    • 78149265595 scopus 로고    scopus 로고
    • Progesterone inhibits estrogen-mediated neuroprotection against excitotoxicity by down-regulating estrogen receptor-beta
    • Aguirre C, Jayaraman A, Pike C, Baudry M: Progesterone inhibits estrogen-mediated neuroprotection against excitotoxicity by down-regulating estrogen receptor-beta. J Neurochem 2010; 115:1277-1287.
    • (2010) J Neurochem , vol.115 , pp. 1277-1287
    • Aguirre, C.1    Jayaraman, A.2    Pike, C.3    Baudry, M.4
  • 118
    • 79960354964 scopus 로고    scopus 로고
    • Neuroprotective Effects of Genistein in VSC4.1 Motoneurons Exposed to Activated Microglial Cytokines
    • McDowell ML, Das A, Smith JA, Varma AK, Ray SK, Banik NL: Neuroprotective effects of genistein in VSC4.1 motoneurons exposed to activated microglial cytokines. Neurochem Int 2011; 59:175-184.
    • (2011) Neurochem Int , vol.59 , pp. 175-184
    • McDowell, M.L.1    Das, A.2    Smith, J.A.3    Varma, A.K.4    Ray, S.K.5    Banik, N.L.6
  • 120
    • 85047675402 scopus 로고    scopus 로고
    • Rapid action of 17beta-es-tradiol on kainate-induced currents in hip-pocampal neurons lacking intracellular estrogen receptors
    • Gu Q, Moss RL: Rapid action of 17beta-es-tradiol on kainate-induced currents in hip-pocampal neurons lacking intracellular estrogen receptors. Endocrinology 1999; 140:660-666.
    • (1999) Endocrinology , vol.140 , pp. 660-666
    • Gu, Q.1    Moss, R.L.2
  • 121
    • 0035979810 scopus 로고    scopus 로고
    • Examination of Estradiol Effects on the Rapid Estradiol Mediated Increase in Hippocampal Synaptic Transmission in Estrogen Receptor Alpha Knockout Mice
    • Fugger HN, Kumar A, Lubahn DB, Korach KS, Foster TC: Examination of estradiol effects on the rapid estradiol mediated increase in hippocampal synaptic transmission in estrogen receptor alpha knockout mice. Neurosci Lett 200; 309:207-209.
    • (2000) Neurosci Lett , vol.309 , pp. 207-209
    • Fugger, H.N.1    Kumar, A.2    Lubahn, D.B.3    Korach, K.S.4    Foster, T.C.5
  • 122
    • 0034724442 scopus 로고    scopus 로고
    • The tyrosine kinase and mito-gen-activated protein kinase pathways mediate multiple effects of estrogen in hippocampus
    • Bi R, Broutman G, Foy MR, Thompson RF, Baudry M: The tyrosine kinase and mito-gen-activated protein kinase pathways mediate multiple effects of estrogen in hippocampus. Proc Natl Acad Sci USA. 2000; 97:3602-3607.
    • (2000) Proc Natl Acad Sci USA. , vol.97 , pp. 3602-3607
    • Bi, R.1    Broutman, G.2    Foy, M.R.3    Thompson, R.F.4    Baudry, M.5
  • 123
    • 77649153329 scopus 로고    scopus 로고
    • Acute administration of non-classical estrogen receptor agonists attenuates ischemia-induced hippocampal neuron loss in middle-aged female rats
    • Lebesgue D, Traub M, De Butte-Smith M, Che C, Zukin RS, Kelly MJ, Etgen AM: Acute administration of non-classical estrogen receptor agonists attenuates ischemia-induced hippocampal neuron loss in middle-aged female rats. PLoS One 2010; 5:e8642.
    • (2010) PLoS One , vol.5
    • Lebesgue, D.1    Traub, M.2    De Butte-Smith, M.3    Che, C.4    Zukin, R.S.5    Kelly, M.J.6    Etgen, A.M.7
  • 125
    • 77955918599 scopus 로고    scopus 로고
    • Estrogen Receptor Alpha and G-protein Coupled Receptor 30 Mediate the Neuroprotective Effects of 17beta-estradiol in Novel Murine Hippocampal Cell Models
    • Gingerich S, Kim GL, Chalmers JA, Koletar MM, Wang X, Wang Y, Belsham DD: Estrogen receptor alpha and G-protein coupled receptor 30 mediate the neuroprotective effects of 17beta-estradiol in novel murine hippocampal cell models. Neuroscience 2010; 170:54-66.
    • (2010) Neuroscience , vol.170 , pp. 54-66
    • Gingerich, S.1    Kim, G.L.2    Chalmers, J.A.3    Koletar, M.M.4    Wang, X.5    Wang, Y.6    Belsham, D.D.7
  • 126
    • 80052083256 scopus 로고    scopus 로고
    • Neuroprotective Effects of Oestrogen Against Oxidative Toxicity Through Activation of G-protein-coupled Receptor 30 Receptor
    • Liu S HJ, Zhang N, Tian Z, Li X, Zhao M: Neuroprotective effects of oestrogen against oxidative toxicity through activation of G-protein-coupled receptor 30 receptor. Clin Exp Pharmacol Physiol 2011; 38:577-585.
    • (2011) Clin Exp Pharmacol Physiol , vol.38 , pp. 577-585
    • Liu, S.H.J.1    Zhang, N.2    Tian, Z.3    Li, X.4    Zhao, M.5
  • 127
    • 79952316974 scopus 로고    scopus 로고
    • GPR30 Is Positioned to Mediate Estrogen Effects on Basal Forebrain Cholinergic Neurons and Cognitive Performance
    • Hammond R GR: GPR30 is positioned to mediate estrogen effects on basal forebrain cholinergic neurons and cognitive performance. Brain Res 2010; 1379:53-60.
    • (2010) Brain Res , vol.1379 , pp. 53-60
    • Hammond, R.G.R.1
  • 128
    • 84866552268 scopus 로고    scopus 로고
    • Membrane Estrogen Receptor Regulation of Hypothalamic Function
    • Micevych PE, Kelly MJ: Membrane estrogen receptor regulation of hypothalamic function. Neuroendocrinology 2012;96:103-110.
    • (2012) Neuroendocrinology , vol.96 , pp. 103-110
    • Micevych, P.E.1    Kelly, M.J.2
  • 130
    • 14844343093 scopus 로고    scopus 로고
    • A transmembrane intracellu-lar estrogen receptor mediates rapid cell signaling
    • Revankar CM CD, Sklar LA, Arterburn JB, Prossnitz ER: A transmembrane intracellu-lar estrogen receptor mediates rapid cell signaling. Science 2005; 307:1625-1630.
    • (2005) Science , vol.307 , pp. 1625-1630
    • Revankar, C.M.C.D.1    Sklar, L.A.2    Arterburn, J.B.3    Prossnitz, E.R.4
  • 133
    • 14744293013 scopus 로고    scopus 로고
    • Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo
    • Perez E, Liu R, Yang SH, Cai ZY, Covey DF, Simpkins JW: Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo. Brain Res 2005; 1038:216-222.
    • (2005) Brain Res , vol.1038 , pp. 216-222
    • Perez, E.1    Liu, R.2    Yang, S.H.3    Cai, Z.Y.4    Covey, D.F.5    Simpkins, J.W.6
  • 134
    • 33644835248 scopus 로고    scopus 로고
    • Neuroprotective effects of estratriene analogs: Structure-activity relationships and molecular optimization
    • Perez E, Cai ZY, Covey DF, Simpkins JW: Neuroprotective effects of estratriene analogs: structure-activity relationships and molecular optimization. Drug Dev Res 2006; 66:78-92.
    • (2006) Drug Dev Res , vol.66 , pp. 78-92
    • Perez, E.1    Cai, Z.Y.2    Covey, D.F.3    Simpkins, J.W.4
  • 135
    • 0031021372 scopus 로고    scopus 로고
    • 17 alpha-estradiol exerts neuroprotective effects on SK-N-SH cells
    • Green PS, Bishop J, Simpkins JW: 17 alpha-estradiol exerts neuroprotective effects on SK-N-SH cells. J Neurosci 1997; 17:511-515.
    • (1997) J Neurosci , vol.17 , pp. 511-515
    • Green, P.S.1    Bishop, J.2    Simpkins, J.W.3
  • 136
    • 79959404165 scopus 로고    scopus 로고
    • Estrogen Protection in Friedreich's Ataxia Skin Fibroblasts
    • Richardson TE, Yang SH, Wen Y, Simpkins JW: Estrogen protection in Friedreich's ataxia skin fibroblasts. Endocrinology 2011; 152:2742-2749.
    • (2011) Endocrinology , vol.152 , pp. 2742-2749
    • Richardson, T.E.1    Yang, S.H.2    Wen, Y.3    Simpkins, J.W.4
  • 138
    • 0033529941 scopus 로고    scopus 로고
    • The antioxidant neu-roprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties
    • Moosmann B, Behl C: The antioxidant neu-roprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties. Proc Natl Acad Sci USA 1999; 96:8867-8872.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8867-8872
    • Moosmann, B.1    Behl, C.2
  • 139
    • 0346022988 scopus 로고    scopus 로고
    • Subcellular localization of estrogen receptor beta in mouse hippocampus
    • Nishio MY, Watanabe Y: Subcellular localization of estrogen receptor beta in mouse hippocampus. Neurosci Lett 2004; 355:109-112.
    • (2004) Neurosci Lett , vol.355 , pp. 109-112
    • Nishio, M.Y.1    Watanabe, Y.2
  • 140
    • 0035863873 scopus 로고    scopus 로고
    • Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites
    • Milner TA, McEwen BS, Hayashi S, Li CJ, Reagan LP, Alves SE: Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites. J Comp Neurosci 2001; 429:355-371.
    • (2001) J Comp Neurosci , vol.429 , pp. 355-371
    • Milner, T.A.1    McEwen, B.S.2    Hayashi, S.3    Li, C.J.4    Reagan, L.P.5    Alves, S.E.6
  • 141
  • 142
    • 67449123067 scopus 로고    scopus 로고
    • Control of CNS neuronal excitability by estrogens via membrane-initiated signaling
    • Kelly MJ, Rønnekleiv OK: Control of CNS neuronal excitability by estrogens via membrane-initiated signaling. Mol Cell Endo-crinol 2009; 308:17-25.
    • (2009) Mol Cell Endo-crinol , vol.308 , pp. 17-25
    • Kelly, M.J.1    Rønnekleiv, O.K.2
  • 143
    • 45849083496 scopus 로고    scopus 로고
    • Estrogen receptor alpha is expressed on the cell-surface of embryonic hypothalamic neurons
    • Gorosito SV, Lorenzo AG, Cambiasso MJ: Estrogen receptor alpha is expressed on the cell-surface of embryonic hypothalamic neurons. Neuroscience 2008; 154:1173-1177.
    • (2008) Neuroscience , vol.154 , pp. 1173-1177
    • Gorosito, S.V.1    Lorenzo, A.G.2    Cambiasso, M.J.3
  • 144
    • 0033135265 scopus 로고    scopus 로고
    • Localization of estrogen receptor beta-immu-noreactivity in astrocytes of the adult rat brain
    • Azcoitia I, Sierra A, Garcia-Segura LM: Localization of estrogen receptor beta-immu-noreactivity in astrocytes of the adult rat brain. Glia 1999; 26:260-267.
    • (1999) Glia , vol.26 , pp. 260-267
    • Azcoitia, I.1    Sierra, A.2    Garcia-Segura, L.M.3
  • 145
    • 72849152546 scopus 로고    scopus 로고
    • Estradiol-induced estrogen receptor trafficking
    • Bondar G, Kuo J, Hamid N, Micevych P: Estradiol-induced estrogen receptor trafficking. J Neurosci 2009; 29:15323-15330.
    • (2009) J Neurosci , vol.29 , pp. 15323-15330
    • Bondar, G.1    Kuo, J.2    Hamid, N.3    Micevych, P.4
  • 146
    • 77957345404 scopus 로고    scopus 로고
    • Membrane estrogen receptors stimulate intracellular calcium release and progesterone sy nthesis in hy pothalamic as-trocytes
    • Kuo J, Hamid N, Bondar G, Prossnitz ER, Micevych P: Membrane estrogen receptors stimulate intracellular calcium release and progesterone sy nthesis in hy pothalamic as-trocytes. J Neurosci 2010; 30:12950-12957.
    • (2010) J Neurosci , vol.30 , pp. 12950-12957
    • Kuo, J.1    Hamid, N.2    Bondar, G.3    Prossnitz, E.R.4    Micevych, P.5
  • 147
    • 77957200484 scopus 로고    scopus 로고
    • Estradiol rapidly regulates membrane estrogen receptor alpha levels in hypothalamic neurons
    • Dominguez R, Micevych P: Estradiol rapidly regulates membrane estrogen receptor alpha levels in hypothalamic neurons. J Neurosci 2010; 30:12589-12596.
    • (2010) J Neurosci , vol.30 , pp. 12589-12596
    • Dominguez, R.1    Micevych, P.2
  • 148
    • 80053383728 scopus 로고    scopus 로고
    • 17Beta-es-tradiol Differentially Protects Cortical Peri-contusional Zone from Programmed Cell Death after Traumatic Cerebral Contusion at Distinct Stages Via Non-genomic and Ge-nomic Pathways
    • Bao YJ, Li LZ, Li XG, Wang YJ: 17Beta-es-tradiol differentially protects cortical peri-contusional zone from programmed cell death after traumatic cerebral contusion at distinct stages via non-genomic and ge-nomic pathways. Mol Cell Neurosci 2011; 48:185-194.
    • (2011) Mol Cell Neurosci , vol.48 , pp. 185-194
    • Bao, Y.J.1    Li, L.Z.2    Li, X.G.3    Wang, Y.J.4
  • 149
    • 0344097487 scopus 로고    scopus 로고
    • Estrogen-induced activation of mitogen-activated protein ki-nase in cerebral cortical explants: Convergence of estrogen and neurotrophin signaling pathways
    • Singh M, Sétáló G Jr, Guan X, Warren M, Toran-Allerand CD: Estrogen-induced activation of mitogen-activated protein ki-nase in cerebral cortical explants: convergence of estrogen and neurotrophin signaling pathways. J Neurosci 1999; 19:1179-1188.
    • (1999) J Neurosci , vol.19 , pp. 1179-1188
    • Singh, M.1    Sétáló, Jr.G.2    Guan, X.3    Warren, M.4    Toran-Allerand, C.D.5
  • 150
    • 0034969952 scopus 로고    scopus 로고
    • Ovarian hormones elicit phos-phorylation of Akt and extracellular-signal regulated kinase in explants of the cerebral cortex
    • Singh M: Ovarian hormones elicit phos-phorylation of Akt and extracellular-signal regulated kinase in explants of the cerebral cortex. Endocrine 2001; 14:407-415.
    • (2001) Endocrine , vol.14 , pp. 407-415
    • Singh, M.1
  • 151
    • 0033118665 scopus 로고    scopus 로고
    • The mitogen activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons
    • Singer CA, Figueroa-Masot XA, Batchelor RH, Dorsa DM: The mitogen activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons. J Neurosci 1999; 19:2455-2463.
    • (1999) J Neurosci , vol.19 , pp. 2455-2463
    • Singer, C.A.1    Figueroa-Masot, X.A.2    Batchelor, R.H.3    Dorsa, D.M.4
  • 152
    • 33847062554 scopus 로고    scopus 로고
    • MAPK signaling is critical to estradiol protection of CA1 neurons in global ischemia
    • Jover-Mengual T, Zukin RS, Etgen AM: MAPK signaling is critical to estradiol protection of CA1 neurons in global ischemia. Endocrinology 2007; 148:1131-1143.
    • (2007) Endocrinology , vol.148 , pp. 1131-1143
    • Jover-Mengual, T.1    Zukin, R.S.2    Etgen, A.M.3
  • 153
  • 154
    • 77957161470 scopus 로고    scopus 로고
    • Membrane Estrogen Receptors Activate the Metabotropic Glutamate Receptors MGluR5 and MGluR3 to Bidirection-ally Regulate CREB Phosphorylation in Female Rat Striatal Neurons
    • Grove-Strawser D, Boulware MI, Mermel-stein PG: Membrane estrogen receptors activate the metabotropic glutamate receptors mGluR5 and mGluR3 to
    • (2010) Neuroscience , vol.170 , pp. 1045-1055
    • Grove-Strawser, D.1    Boulware, M.I.2    Mermel-Stein, P.G.3
  • 155
    • 7944227783 scopus 로고    scopus 로고
    • 17 Be-ta-estradiol prevents focal cerebral isch-emic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats
    • Choi YC, Lee JH, Hong KW, Lee KS: 17 Be-ta-estradiol prevents focal cerebral isch-emic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats. Fundam Clin Pharmacol 2004; 18:547-557.
    • (2004) Fundam Clin Pharmacol , vol.18 , pp. 547-557
    • Choi, Y.C.1    Lee, J.H.2    Hong, K.W.3    Lee, K.S.4
  • 156
    • 77956285989 scopus 로고    scopus 로고
    • Extra-nuclear estrogen receptors mediate the neuroprotective effects of estrogen in the rat hippocampus
    • Yang LC, Zhang QG, Zhou CF, Yang F, Zhang YD, Wang RM, Brann DW: Extra-nuclear estrogen receptors mediate the neuroprotective effects of estrogen in the rat hippocampus. PLoS One 2010; 5:e9851.
    • (2010) PLoS One , vol.5
    • Yang, L.C.1    Zhang, Q.G.2    Zhou, C.F.3    Yang, F.4    Zhang, Y.D.5    Wang, R.M.6    Brann, D.W.7
  • 157
    • 77549084058 scopus 로고    scopus 로고
    • Acute es-tradiol protects CA1 neurons from ischemia-induced apoptotic cell death via the PI3K/A kt pathway
    • Jover-Mengual T, Miyawaki T, Latuszek A, Alborch E, Zukin RS, Etgen AM: Acute es-tradiol protects CA1 neurons from ischemia-induced apoptotic cell death via the PI3K/A kt pathway. Bra in Res 2010; 1321:1-12.
    • (2010) Bra in Res , vol.1321 , pp. 1-12
    • Jover-Mengual, T.1    Miyawaki, T.2    Latuszek, A.3    Alborch, E.4    Zukin, R.S.5    Etgen, A.M.6
  • 158
    • 0037444460 scopus 로고    scopus 로고
    • Estrogen stimulates postsynaptic density-95 rapid protein synthesis via the Akt/protein kinase B pat hway
    • Akama KT, McEwen BS: Estrogen stimulates postsynaptic density-95 rapid protein synthesis via the Akt/protein kinase B pat hway. J Neurosci 2003; 23:2333-2339.
    • (2003) J Neurosci , vol.23 , pp. 2333-2339
    • Akama, K.T.1    McEwen, B.S.2
  • 159
    • 70350463625 scopus 로고    scopus 로고
    • Cytoskeletal changes underlie estrogen's acute effects on synaptic transmissions and plasticity
    • Kramár EA, Chen LY, Brandon NJ, Rex CS, Liu F, Gall CM, Lynch G: Cytoskeletal changes underlie estrogen's acute effects on synaptic transmissions and plasticity. J Neurosci 2009; 29:12982-12993.
    • (2009) J Neurosci , vol.29 , pp. 12982-12993
    • Kramár, E.A.1    Chen, L.Y.2    Brandon, N.J.3    Rex, C.S.4    Liu, F.5    Gall, C.M.6    Lynch, G.7
  • 160
    • 51649110188 scopus 로고    scopus 로고
    • Role of Dickkopf-1, an antagonist of the Wnt/beta-catenin signaling pathway, in estrogen-induced neuroprotection and attenuation of tau phosphoryla-tion
    • Zhang QG, Wang R, Khan M, Mahesh V, Brann DW: Role of Dickkopf-1, an antagonist of the Wnt/beta-catenin signaling pathway, in estrogen-induced neuroprotection and attenuation of tau phosphoryla-tion. J Neurosci 2008; 28:8430-8441.
    • (2008) J Neurosci , vol.28 , pp. 8430-8441
    • Zhang, Q.G.1    Wang, R.2    Khan, M.3    Mahesh, V.4    Brann, D.W.5
  • 161
    • 80055034825 scopus 로고    scopus 로고
    • Acetylation of the pro-apoptotic factor, p53 in the hippocampus following cerebral ischemia and modulation by estrogen
    • Raz L, Zhang QG, Han D, Dong Y, De Sevilla L, Brann DW: Acetylation of the pro-apoptotic factor, p53 in the hippocampus following cerebral ischemia and modulation by estrogen. PLoS One 2011; 6:e27039.
    • (2011) PLoS One , vol.6
    • Raz, L.1    Zhang, Q.G.2    Han, D.3    Dong, Y.4    De Sevilla, L.5    Brann, D.W.6
  • 162
    • 84866556005 scopus 로고    scopus 로고
    • The role of the estrogen receptor in the protective effects of DHT
    • Program No. 595.14. Washington, Society for Neurosience online
    • Mirshams N, Singh M: The Role of the Estrogen Receptor in the Protective Effects of DHT. Neuroscience Meeting Planner. Program No. 595.14. Washington, Society for Neurosience, 2011, online.
    • (2011) Neuroscience Meeting Planner
    • Mirshams, N.1    Singh, M.2
  • 163
    • 33750414318 scopus 로고    scopus 로고
    • Effects of 3-beta-diol, an and ro-gen metabolite with intrinsic estrogen-like effects, in modulating the aquaporin-9 expression in the rat efferent ductules
    • Picciarel li-Lima P, Oliveira AG, Reis A, Ka-lapothakis E, Mahecha G, Rex A, Hess E, Oliveira C: Effects of 3-beta-diol, an and ro-gen metabolite with intrinsic estrogen-like effects, in modulating the aquaporin-9 expression in the rat efferent ductules. Reprod Biol Endocrinol 2006;4:51-61.
    • (2006) Reprod Biol Endocrinol , vol.4 , pp. 51-61
    • Picciarelli-Lima, P.1    Oliveira, A.G.2    Reis, A.3    Ka-Lapothakis, E.4    Mahecha, G.5    Rex, A.6    Hess, E.7    Oliveira, C.8
  • 164
    • 78650380875 scopus 로고    scopus 로고
    • Rationale for routine and immediate administration of intravenous estrogen for all critically ill and injured patients
    • Wigginton JG, Pepe PE, Idris AH: Rationale for routine and immediate administration of intravenous estrogen for all critically ill and injured patients. Crit Care Med 2010; 38:S620-S629.
    • (2010) Crit Care Med , vol.38
    • Wigginton, J.G.1    Pepe, P.E.2    Idris, A.H.3


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