Resveratrol, MAP kinases and neuronal cells: Might wine be a neuroprotectant?

Drugs under Experimental and Clinical Research

Volumn 25, Issue 2-3, 1999, Pages 99-103

  Tredici, G ^a   Miloso, M ^a   Nicolini, G ^a   Galbiati, S ^a   Cavaletti, G ^a   Bertelli, Alberto ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b Institute of Human Anatomy   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; NEUROPROTECTIVE AGENT; RESVERATROL;

CONFERENCE PAPER; ENZYME PHOSPHORYLATION; LEARNING; MEMORY; NERVE CELL CULTURE; NEUROBLASTOMA CELL; NEUROPROTECTION; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; WINE;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; ETHANOL; HUMANS; LEARNING; MEMORY; NEUROBLASTOMA; NEURONS; OXIDATIVE STRESS; PHOSPHORYLATION; RATS; STILBENES;

EID: 0033036499     PISSN: 03786501     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (21)

1. Tredici G., Minazzi M. Alcoholic neuropathy. An electronmicroscopic study. J. Neurol. Sci., 25, 333, 1975.
2. Renaud S., De Longeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet, 339, 1523, 1992.
3. Kopp P. Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the "French paradox"? Eur. J. Endocr., 138, 619, 1998.
4. Bertelli A.A.E. Modulatory effect of resveratrol, a natural phytoalexin, on endothelial adhesion molecules and intracellular signal transduction. Pharm. Biol., 36, 1, 1998.
5. Jang M., Cai L., Udeani G.O., et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science, 275, 218, 1997.
6. Subbaramaiah K., Chung W.J., Michaluart P., et al. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J. Biol. Chem., 273, 21875, 1998.
7. Gehm B.D., McAndrews J.M., Chien, P-Y., Jameson, J.L. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc. Natl. Acad. Sci. USA, 941, 4138, 1997
8. Sun A.Y., Chen Y.M., James-Kracke M., Wixom P., Cheng Y. Ethanol-induced cell death peroxidation in PC12 cells Neurochem. Res., 22, 1187, 1997.
9. Chanvitayapongs S., Draczynska-Lusiak B., Sun, A.Y. Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells. NeuroReport, 8, 1499, 1997.
10. Draczynska-Lusiak B., Chen Y.M., Sun, A.Y. Oxidized lipoproteins activate NF-κB binding activity and apoptosis in PC12 cells. NeuroReport, 9, 527, 1998.
11. Ciccarone V., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A. Phenotypic diversification in human neuroblastoma cells: Expression of distinct neural crest lineage. Cancer Res., 49, 219, 1989.
12. Kim B., Leventhal P.S., Saltiel A.R., Feldman E.L. Insulin-like growth factor-l-mediated neurite outgrowth in vitro requires mitogen-activated protein kinase activation. J. Biol. Chem., 272, 21268, 1997.
13. Nicolini G., Miloso M., Zoia C., Di Silvestro A., Cavaletti G., Tredici G. Retinoic acid differentiated SH-SY5Y human neuroblastoma cells: An in vitro model to assess drug neurotoxicity. Anticancer Res., 18, 2477, 1998.
14. Lewis T.S., Shapiro P.S., Ahn N.G. Signal transduction through MAP kinase cascades. Advan. Cancer Res., 74, 49, 1998.
15. Atkins C.M., Selcher J.C., Petraitis J.J., Trzaskos J.M., Sweatt J.D. The MAPK cascade is required for mammalian associative learning. Nature Neurosci., 1, 602, 1998.
16. Kornhauser J.M., Greenberg M.E. A kinase to remember: Dual roles for MAP kinase in long-term memory. Neuron, 18, 839, 1997.
17. Miloso M., Mazzotti M., Vass W.C., Beguinot L. SHC and GRB-2 are constitutively activated by an epidermal growth factor receptor with a point mutation in the transmembrane domain. J. Biol. Chem., 270, 19557, 1995.
18. Bertelli A.A.E., Giovannini L., Stradi R., Urien S., Tillement J.-P., Bertelli A. Kinetics of trans-and cis-resveratrol (3, 4, 5-trihydroxystilbene) after red wine oral administration in rats. Int. J .Clin. Pharm. Res., 16, 77, 1996.
19. Orgogozo J.-M., Dartigues J.-F., Lafont S., et al. Wine consumption and dementia in the elderly: A prospective community study in the Bordeaux area. Rev. Neurol., 153, 185, 1997.
20. Lemeshow S., Letenneur L., Dartigues J.-F., Lafont S., Orgogozo J.-M., Commenges D. Illustration of analysis taking into account complex survey considerations: The association between wine consumption and dementia in the PAQUID study. Am. J. Epidemiol., 148, 298, 1998.
21. Marx J. Searching for drugs that combat Alzheimer's. Science, 273, 50, 1996.