-
1
-
-
84922381210
-
Heart disease and stroke statistics-2015 update: A report from the American Heart Association
-
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
-
Mozaffarian D, Benjamin EJ, Go AS, et al; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2015 update: A report from the American Heart Association. Circulation. 2015;131:e29-322. doi: 10. 1161/ CIR. 0000000000000152.
-
(2015)
Circulation.
, vol.131
, pp. e29-322
-
-
Mozaffarian, D.1
Benjamin, E.J.2
Go, A.S.3
-
2
-
-
38949104188
-
The coming acceleration of global population ageing
-
Lutz W, Sanderson W, Scherbov S. The coming acceleration of global population ageing. Nature. 2008;451:716-719. doi: 10. 1038/nature06516.
-
(2008)
Nature.
, vol.451
, pp. 716-719
-
-
Lutz, W.1
Sanderson, W.2
Scherbov, S.3
-
3
-
-
0142150152
-
"Successful aging": Effect of subclinical cardiovascular disease
-
Newman AB, Arnold AM, Naydeck BL, Fried LP, Burke GL, Enright P, Gottdiener J, Hirsch C, O'Leary D, Tracy R; Cardiovascular Health Study Research Group. "Successful aging": effect of subclinical cardiovascular disease. Arch Intern Med. 2003;163:2315-2322. doi: 10. 1001/ archinte. 163. 19. 2315.
-
(2003)
Arch Intern Med.
, vol.163
, pp. 2315-2322
-
-
Newman, A.B.1
Arnold, A.M.2
Naydeck, B.L.3
Fried, L.P.4
Burke, G.L.5
Enright, P.6
Gottdiener, J.7
Hirsch, C.8
O'Leary, D.9
Tracy, R.10
-
4
-
-
60449094498
-
Heart disease and stroke statistics-2009 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
-
Lloyd-Jones D, Adams R, Carnethon M, et al; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2009 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009;119:e21-181. doi: 10. 1161/CIRCULATIONAHA. 108. 191261.
-
(2009)
Circulation.
, vol.119
, pp. e21-181
-
-
Lloyd-Jones, D.1
Adams, R.2
Carnethon, M.3
-
5
-
-
78649357985
-
Protein quality control in the cytosol and the endoplasmic reticulum: Brothers in arms
-
Buchberger A, Bukau B, Sommer T. Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms. Mol Cell. 2010;40:238-252. doi: 10. 1016/j. molcel. 2010. 10. 001.
-
(2010)
Mol Cell.
, vol.40
, pp. 238-252
-
-
Buchberger, A.1
Bukau, B.2
Sommer, T.3
-
6
-
-
84896351253
-
Hexosamine pathway metabolites enhance protein quality control and prolong life
-
Denzel MS, Storm NJ, Gutschmidt A, Baddi R, Hinze Y, Jarosch E, Sommer T, Hoppe T, Antebi A. Hexosamine pathway metabolites enhance protein quality control and prolong life. Cell. 2014;156:1167-1178. doi: 10. 1016/j. cell. 2014. 01. 061.
-
(2014)
Cell.
, vol.156
, pp. 1167-1178
-
-
Denzel, M.S.1
Storm, N.J.2
Gutschmidt, A.3
Baddi, R.4
Hinze, Y.5
Jarosch, E.6
Sommer, T.7
Hoppe, T.8
Antebi, A.9
-
7
-
-
34547941973
-
The common biology of cancer and ageing
-
Finkel T, Serrano M, Blasco MA. The common biology of cancer and ageing. Nature. 2007;448:767-774. doi: 10. 1038/nature05985.
-
(2007)
Nature.
, vol.448
, pp. 767-774
-
-
Finkel, T.1
Serrano, M.2
Blasco, M.A.3
-
8
-
-
0015319592
-
The biologic clock: The mitochondria?
-
Harman D. The biologic clock: The mitochondria? J Am Geriatr Soc. 1972;20:145-147.
-
(1972)
J Am Geriatr Soc.
, vol.20
, pp. 145-147
-
-
Harman, D.1
-
9
-
-
0023222894
-
Age-dependent changes in rat brain mitochondria of synaptic and non-synaptic origins
-
Harmon HJ, Nank S, Floyd RA. Age-dependent changes in rat brain mitochondria of synaptic and non-synaptic origins. Mech Ageing Dev. 1987;38:167-177.
-
(1987)
Mech Ageing Dev.
, vol.38
, pp. 167-177
-
-
Harmon, H.J.1
Nank, S.2
Floyd, R.A.3
-
10
-
-
0034626735
-
Oxidants, oxidative stress and the biology of ageing
-
Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000;408:239-247. doi: 10. 1038/35041687.
-
(2000)
Nature.
, vol.408
, pp. 239-247
-
-
Finkel, T.1
Holbrook, N.J.2
-
11
-
-
84859896427
-
Contribution of impaired mitochondrial autophagy to cardiac aging: Mechanisms and therapeutic opportunities
-
Dutta D, Calvani R, Bernabei R, Leeuwenburgh C, Marzetti E. Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities. Circ Res. 2012;110:1125-1138. doi: 10. 1161/ CIRCRESAHA. 111. 246108.
-
(2012)
Circ Res.
, vol.110
, pp. 1125-1138
-
-
Dutta, D.1
Calvani, R.2
Bernabei, R.3
Leeuwenburgh, C.4
Marzetti, E.5
-
12
-
-
43049163718
-
Free radicals and senescence
-
Lu T, Finkel T. Free radicals and senescence. Exp Cell Res. 2008;314:1918-1922. doi: 10. 1016/j. yexcr. 2008. 01. 011.
-
(2008)
Exp Cell Res.
, vol.314
, pp. 1918-1922
-
-
Lu, T.1
Finkel, T.2
-
13
-
-
64249107059
-
Evidence for cardiomyocyte renewal in humans
-
Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, Barnabé-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S, Frisén J. Evidence for cardiomyocyte renewal in humans. Science. 2009;324:98-102. doi: 10. 1126/science. 1164680.
-
(2009)
Science.
, vol.324
, pp. 98-102
-
-
Bergmann, O.1
Bhardwaj, R.D.2
Bernard, S.3
Zdunek, S.4
Barnabé-Heider, F.5
Walsh, S.6
Zupicich, J.7
Alkass, K.8
Buchholz, B.A.9
Druid, H.10
Jovinge, S.11
Frisén, J.12
-
14
-
-
45549108538
-
Protein quality control and degradation in cardiomyocytes
-
Wang X, Su H, Ranek MJ. Protein quality control and degradation in cardiomyocytes. J Mol Cell Cardiol. 2008;45:11-27. doi: 10. 1016/j. yjmcc. 2008. 03. 025.
-
(2008)
J Mol Cell Cardiol.
, vol.45
, pp. 11-27
-
-
Wang, X.1
Su, H.2
Ranek, M.J.3
-
15
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008;132:27-42. doi: 10. 1016/j. cell. 2007. 12. 018.
-
(2008)
Cell.
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
16
-
-
80052303130
-
Autophagy and aging
-
Rubinsztein DC, Mariño G, Kroemer G. Autophagy and aging. Cell. 2011;146:682-695. doi: 10. 1016/j. cell. 2011. 07. 030.
-
(2011)
Cell.
, vol.146
, pp. 682-695
-
-
Rubinsztein, D.C.1
Mariño, G.2
Kroemer, G.3
-
17
-
-
79952319773
-
Mitochondria removal by autophagy
-
Wang K, Klionsky DJ. Mitochondria removal by autophagy. Autophagy. 2011;7:297-300.
-
(2011)
Autophagy.
, vol.7
, pp. 297-300
-
-
Wang, K.1
Klionsky, D.J.2
-
18
-
-
84866312155
-
Pharmacological modulation of autophagy during cardiac stress
-
Sciarretta S, Zhai P, Volpe M, Sadoshima J. Pharmacological modulation of autophagy during cardiac stress. J Cardiovasc Pharmacol. 2012;60:235-241. doi: 10. 1097/FJC. 0b013e3182575f61.
-
(2012)
J Cardiovasc Pharmacol.
, vol.60
, pp. 235-241
-
-
Sciarretta, S.1
Zhai, P.2
Volpe, M.3
Sadoshima, J.4
-
19
-
-
84865544952
-
Mitochondrial fission, fusion, and stress
-
Youle RJ, van der Bliek AM. Mitochondrial fission, fusion, and stress. Science. 2012;337:1062-1065. doi: 10. 1126/science. 1219855.
-
(2012)
Science.
, vol.337
, pp. 1062-1065
-
-
Youle, R.J.1
Van Der Bliek, A.M.2
-
20
-
-
77955351652
-
New insights into the role of mitochondria in aging: Mitochondrial dynamics and more
-
Seo AY, Joseph AM, Dutta D, Hwang JC, Aris JP, Leeuwenburgh C. New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci. 2010;123:2533-2542. doi: 10. 1242/jcs. 070490.
-
(2010)
J Cell Sci.
, vol.123
, pp. 2533-2542
-
-
Seo, A.Y.1
Joseph, A.M.2
Dutta, D.3
Hwang, J.C.4
Aris, J.P.5
Leeuwenburgh, C.6
-
22
-
-
2342466207
-
Myocardial aging and senescence: Where have the stem cells gone?
-
Sussman MA, Anversa P. Myocardial aging and senescence: where have the stem cells gone? Annu Rev Physiol. 2004;66:29-48. doi: 10. 1146/annurev. physiol. 66. 032102. 140723.
-
(2004)
Annu Rev Physiol.
, vol.66
, pp. 29-48
-
-
Sussman, M.A.1
Anversa, P.2
-
23
-
-
0037469206
-
Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises: Part III: Cellular and molecular clues to heart and arterial aging
-
Lakatta EG. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part III: cellular and molecular clues to heart and arterial aging. Circulation. 2003;107:490-497.
-
(2003)
Circulation.
, vol.107
, pp. 490-497
-
-
Lakatta, E.G.1
-
24
-
-
0037422592
-
Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises: Part I: Aging arteries: A "set up" for vascular disease
-
Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: Aging arteries: A "set up" for vascular disease. Circulation. 2003;107:139-146.
-
(2003)
Circulation.
, vol.107
, pp. 139-146
-
-
Lakatta, E.G.1
Levy, D.2
-
25
-
-
0037458070
-
Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises: Part II: The aging heart in health: Links to heart disease
-
Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: The aging heart in health: links to heart disease. Circulation. 2003;107:346-354.
-
(2003)
Circulation.
, vol.107
, pp. 346-354
-
-
Lakatta, E.G.1
Levy, D.2
-
26
-
-
0008235624
-
Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats
-
Kajstura J, Cheng W, Sarangarajan R, Li P, Li B, Nitahara JA, Chapnick S, Reiss K, Olivetti G, Anversa P. Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats. Am J Physiol. 1996;271:H1215-H1228.
-
(1996)
Am J Physiol.
, vol.271
, pp. H1215-H1228
-
-
Kajstura, J.1
Cheng, W.2
Sarangarajan, R.3
Li, P.4
Li, B.5
Nitahara, J.A.6
Chapnick, S.7
Reiss, K.8
Olivetti, G.9
Anversa, P.10
-
27
-
-
0028801292
-
Molecular and cellular biology of the senescent hypertrophied and failing heart
-
Swynghedauw B, Besse S, Assayag P, Carré F, Chevalier B, Charlemagne D, Delcayre C, Hardouin S, Heymes C, Moalic JM. Molecular and cellular biology of the senescent hypertrophied and failing heart. Am J Cardiol. 1995;76:2D-7D.
-
(1995)
Am J Cardiol.
, vol.76
, pp. 2D-7D
-
-
Swynghedauw, B.1
Besse, S.2
Assayag, P.3
Carré, F.4
Chevalier, B.5
Charlemagne, D.6
Delcayre, C.7
Hardouin, S.8
Heymes, C.9
Moalic, J.M.10
-
28
-
-
0028271093
-
Myocyte nuclear and possible cellular hyperplasia contribute to ventricular remodeling in the hypertrophic senescent heart in humans
-
Olivetti G, Melissari M, Balbi T, Quaini F, Sonnenblick EH, Anversa P. Myocyte nuclear and possible cellular hyperplasia contribute to ventricular remodeling in the hypertrophic senescent heart in humans. J Am Coll Cardiol. 1994;24:140-149.
-
(1994)
J Am Coll Cardiol.
, vol.24
, pp. 140-149
-
-
Olivetti, G.1
Melissari, M.2
Balbi, T.3
Quaini, F.4
Sonnenblick, E.H.5
Anversa, P.6
-
29
-
-
33745026738
-
Autophagy and aging: The importance of maintaining "clean" cells
-
Cuervo AM, Bergamini E, Brunk UT, Dröge W, Ffrench M, Terman A. Autophagy and aging: The importance of maintaining "clean" cells. Autophagy. 2005;1:131-140.
-
(2005)
Autophagy.
, vol.1
, pp. 131-140
-
-
Cuervo, A.M.1
Bergamini, E.2
Brunk, U.T.3
Dröge, W.4
Ffrench, M.5
Terman, A.6
-
30
-
-
84900969225
-
Ink4a/Arf expression is a biomarker of aging
-
Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, Sharpless NE. Ink4a/Arf expression is a biomarker of aging. J Clin Invest. 2004;114:1299-1307. doi: 10. 1172/JCI22475.
-
(2004)
J Clin Invest.
, vol.114
, pp. 1299-1307
-
-
Krishnamurthy, J.1
Torrice, C.2
Ramsey, M.R.3
Kovalev, G.I.4
Al-Regaiey, K.5
Su, L.6
Sharpless, N.E.7
-
31
-
-
84889466595
-
P16 and ARF: Activation of teenage proteins in old age
-
Satyanarayana A, Rudolph KL. p16 and ARF: Activation of teenage proteins in old age. J Clin Invest. 2004;114:1237-1240. doi: 10. 1172/JCI23437.
-
(2004)
J Clin Invest.
, vol.114
, pp. 1237-1240
-
-
Satyanarayana, A.1
Rudolph, K.L.2
-
32
-
-
0033903443
-
Telomere shortening is an in vivo marker of myocyte replication and aging
-
Kajstura J, Pertoldi B, Leri A, Beltrami CA, Deptala A, Darzynkiewicz Z, Anversa P. Telomere shortening is an in vivo marker of myocyte replication and aging. Am J Pathol. 2000;156:813-819. doi: 10. 1016/ S0002-9440(10)64949-8.
-
(2000)
Am J Pathol.
, vol.156
, pp. 813-819
-
-
Kajstura, J.1
Pertoldi, B.2
Leri, A.3
Beltrami, C.A.4
Deptala, A.5
Darzynkiewicz, Z.6
Anversa, P.7
-
33
-
-
0026503396
-
Age-related differences in the expression of protooncogene and contractile protein genes in response to pressure overload in the rat myocardium
-
Takahashi T, Schunkert H, Isoyama S, Wei JY, Nadal-Ginard B, Grossman W, Izumo S. Age-related differences in the expression of protooncogene and contractile protein genes in response to pressure overload in the rat myocardium. J Clin Invest. 1992;89:939-946. doi: 10. 1172/ JCI115675.
-
(1992)
J Clin Invest.
, vol.89
, pp. 939-946
-
-
Takahashi, T.1
Schunkert, H.2
Isoyama, S.3
Wei, J.Y.4
Nadal-Ginard, B.5
Grossman, W.6
Izumo, S.7
-
34
-
-
0037423671
-
Myocyte death, growth, and regeneration in cardiac hypertrophy and failure
-
Nadal-Ginard B, Kajstura J, Leri A, Anversa P. Myocyte death, growth, and regeneration in cardiac hypertrophy and failure. Circ Res. 2003;92:139-150.
-
(2003)
Circ Res.
, vol.92
, pp. 139-150
-
-
Nadal-Ginard, B.1
Kajstura, J.2
Leri, A.3
Anversa, P.4
-
36
-
-
0025096179
-
Severe myocardial dysfunction induced by ventricular remodeling in aging rat hearts
-
Capasso JM, Palackal T, Olivetti G, Anversa P. Severe myocardial dysfunction induced by ventricular remodeling in aging rat hearts. Am J Physiol. 1990;259:H1086-H1096.
-
(1990)
Am J Physiol.
, vol.259
, pp. H1086-H1096
-
-
Capasso, J.M.1
Palackal, T.2
Olivetti, G.3
Anversa, P.4
-
37
-
-
0033774930
-
Tolerance to ischemia and hypoxia is reduced in aged human myocardium
-
Mariani J, Ou R, Bailey M, Rowland M, Nagley P, Rosenfeldt F, Pepe S. Tolerance to ischemia and hypoxia is reduced in aged human myocardium. J Thorac Cardiovasc Surg. 2000;120:660-667. doi: 10. 1067/ mtc. 2000. 106528.
-
(2000)
J Thorac Cardiovasc Surg.
, vol.120
, pp. 660-667
-
-
Mariani, J.1
Ou, R.2
Bailey, M.3
Rowland, M.4
Nagley, P.5
Rosenfeldt, F.6
Pepe, S.7
-
38
-
-
3242710362
-
Impairment of the transcriptional responses to oxidative stress in the heart of aged C57BL/6 mice
-
Edwards MG, Sarkar D, Klopp R, Morrow JD, Weindruch R, Prolla TA. Impairment of the transcriptional responses to oxidative stress in the heart of aged C57BL/6 mice. Ann N Y Acad Sci. 2004;1019:85-95. doi: 10. 1196/annals. 1297. 017.
-
(2004)
Ann N y Acad Sci.
, vol.1019
, pp. 85-95
-
-
Edwards, M.G.1
Sarkar, D.2
Klopp, R.3
Morrow, J.D.4
Weindruch, R.5
Prolla, T.A.6
-
39
-
-
84989870709
-
Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: Implications for age-related macular degeneration
-
Zhang J, Bai Y, Huang L, Qi Y, Zhang Q, Li S, Wu Y, Li X. Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degeneration. Cell Death Dis. 2015;6:e1972. doi: 10. 1038/cddis. 2015. 330.
-
(2015)
Cell Death Dis.
, vol.6
, pp. e1972
-
-
Zhang, J.1
Bai, Y.2
Huang, L.3
Qi, Y.4
Zhang, Q.5
Li, S.6
Wu, Y.7
Li, X.8
-
41
-
-
19544375583
-
Ticking fast or ticking slow, through Shc must you go?
-
Martin FM, Friedman JS. Ticking fast or ticking slow, through Shc must you go? Sci Aging Knowledge Environ. 2004;2004:pe32. doi: 10. 1126/ sageke. 2004. 32. pe32.
-
(2004)
Sci Aging Knowledge Environ.
, vol.2004
, pp. pe32
-
-
Martin, F.M.1
Friedman, J.S.2
-
42
-
-
0036007110
-
Model organisms as a guide to mammalian aging
-
Tissenbaum HA, Guarente L. Model organisms as a guide to mammalian aging. Dev Cell. 2002;2:9-19.
-
(2002)
Dev Cell.
, vol.2
, pp. 9-19
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
44
-
-
84907381203
-
Premature cardiac senescence in DahlS. Z-Lepr(fa)/Lepr(fa) rats as a new animal model of metabolic syndrome
-
Takahashi K, Takatsu M, Hattori T, Murase T, Ohura S, Takeshita Y, Watanabe S, Murohara T, Nagata K. Premature cardiac senescence in DahlS. Z-Lepr(fa)/Lepr(fa) rats as a new animal model of metabolic syndrome. Nagoya J Med Sci. 2014;76:35-49.
-
(2014)
Nagoya J Med Sci.
, vol.76
, pp. 35-49
-
-
Takahashi, K.1
Takatsu, M.2
Hattori, T.3
Murase, T.4
Ohura, S.5
Takeshita, Y.6
Watanabe, S.7
Murohara, T.8
Nagata, K.9
-
45
-
-
84875368182
-
Hypertension accelerates the 'normal' aging process with a premature increase in left atrial volume
-
Boyd AC, Eshoo S, Richards DA, Thomas L. Hypertension accelerates the 'normal' aging process with a premature increase in left atrial volume. J Am Soc Hypertens. 2013;7:149-156. doi: 10. 1016/j. jash. 2012. 12. 008.
-
(2013)
J Am Soc Hypertens.
, vol.7
, pp. 149-156
-
-
Boyd, A.C.1
Eshoo, S.2
Richards, D.A.3
Thomas, L.4
-
46
-
-
84859884412
-
Mitochondria and cardiovascular aging
-
Dai DF, Rabinovitch PS, Ungvari Z. Mitochondria and cardiovascular aging. Circ Res. 2012;110:1109-1124. doi: 10. 1161/CIRCRESAHA. 111. 246140.
-
(2012)
Circ Res.
, vol.110
, pp. 1109-1124
-
-
Dai, D.F.1
Rabinovitch, P.S.2
Ungvari, Z.3
-
47
-
-
33747261456
-
Mitochondrial DNA deletions and the aging heart
-
Mohamed SA, Hanke T, Erasmi AW, Bechtel MJ, Scharfschwerdt M, Meissner C, Sievers HH, Gosslau A. Mitochondrial DNA deletions and the aging heart. Exp Gerontol. 2006;41:508-517. doi: 10. 1016/j. exger. 2006. 03. 014.
-
(2006)
Exp Gerontol.
, vol.41
, pp. 508-517
-
-
Mohamed, S.A.1
Hanke, T.2
Erasmi, A.W.3
Bechtel, M.J.4
Scharfschwerdt, M.5
Meissner, C.6
Sievers, H.H.7
Gosslau, A.8
-
48
-
-
67549136242
-
Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect
-
Veatch JR, McMurray MA, Nelson ZW, Gottschling DE. Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell. 2009;137:1247-1258. doi: 10. 1016/j. cell. 2009. 04. 014.
-
(2009)
Cell.
, vol.137
, pp. 1247-1258
-
-
Veatch, J.R.1
McMurray, M.A.2
Nelson, Z.W.3
Gottschling, D.E.4
-
49
-
-
84858376953
-
Mitochondria: In sickness and in health
-
Nunnari J, Suomalainen A. Mitochondria: in sickness and in health. Cell. 2012;148:1145-1159. doi: 10. 1016/j. cell. 2012. 02. 035.
-
(2012)
Cell.
, vol.148
, pp. 1145-1159
-
-
Nunnari, J.1
Suomalainen, A.2
-
50
-
-
33745274726
-
Mitochondria: Dynamic organelles in disease, aging, and development
-
Chan DC. Mitochondria: dynamic organelles in disease, aging, and development. Cell. 2006;125:1241-1252. doi: 10. 1016/j. cell. 2006. 06. 010.
-
(2006)
Cell.
, vol.125
, pp. 1241-1252
-
-
Chan, D.C.1
-
51
-
-
21144434217
-
Extension of murine life span by overexpression of catalase targeted to mitochondria
-
Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges W, Wolf N, Van Remmen H, Wallace DC, Rabinovitch PS. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 2005;308:1909-1911. doi: 10. 1126/science. 1106653.
-
(2005)
Science.
, vol.308
, pp. 1909-1911
-
-
Schriner, S.E.1
Linford, N.J.2
Martin, G.M.3
Treuting, P.4
Ogburn, C.E.5
Emond, M.6
Coskun, P.E.7
Ladiges, W.8
Wolf, N.9
Van Remmen, H.10
Wallace, D.C.11
Rabinovitch, P.S.12
-
52
-
-
69949091182
-
Is the oxidative stress theory of aging dead?
-
Pérez VI, Bokov A, Van Remmen H, Mele J, Ran Q, Ikeno Y, Richardson A. Is the oxidative stress theory of aging dead? Biochim Biophys Acta. 2009;1790:1005-1014. doi: 10. 1016/j. bbagen. 2009. 06. 003.
-
(2009)
Biochim Biophys Acta.
, vol.1790
, pp. 1005-1014
-
-
Pérez, V.I.1
Bokov, A.2
Van Remmen, H.3
Mele, J.4
Ran, Q.5
Ikeno, Y.6
Richardson, A.7
-
53
-
-
77951281040
-
Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes
-
Ago T, Kuroda J, Pain J, Fu C, Li H, Sadoshima J. Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circ Res. 2010;106:1253-1264. doi: 10. 1161/ CIRCRESAHA. 109. 213116.
-
(2010)
Circ Res.
, vol.106
, pp. 1253-1264
-
-
Ago, T.1
Kuroda, J.2
Pain, J.3
Fu, C.4
Li, H.5
Sadoshima, J.6
-
54
-
-
84874242635
-
Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy
-
Matsushima S, Kuroda J, Ago T, Zhai P, Park JY, Xie LH, Tian B, Sadoshima J. Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy. Circ Res. 2013;112:651-663. doi: 10. 1161/CIRCRESAHA. 112. 279760.
-
(2013)
Circ Res.
, vol.112
, pp. 651-663
-
-
Matsushima, S.1
Kuroda, J.2
Ago, T.3
Zhai, P.4
Park, J.Y.5
Xie, L.H.6
Tian, B.7
Sadoshima, J.8
-
55
-
-
77957272433
-
NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart
-
Kuroda J, Ago T, Matsushima S, Zhai P, Schneider MD, Sadoshima J. NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proc Natl Acad Sci U S A. 2010;107:15565-15570. doi: 10. 1073/pnas. 1002178107.
-
(2010)
Proc Natl Acad Sci U S A.
, vol.107
, pp. 15565-15570
-
-
Kuroda, J.1
Ago, T.2
Matsushima, S.3
Zhai, P.4
Schneider, M.D.5
Sadoshima, J.6
-
56
-
-
78149239505
-
NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis
-
Zhang M, Brewer AC, Schröder K, Santos CX, Grieve DJ, Wang M, Anilkumar N, Yu B, Dong X, Walker SJ, Brandes RP, Shah AM. NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proc Natl Acad Sci U S A. 2010;107:18121-18126. doi: 10. 1073/pnas. 1009700107.
-
(2010)
Proc Natl Acad Sci U S A.
, vol.107
, pp. 18121-18126
-
-
Zhang, M.1
Brewer, A.C.2
Schröder, K.3
Santos, C.X.4
Grieve, D.J.5
Wang, M.6
Anilkumar, N.7
Yu, B.8
Dong, X.9
Walker, S.J.10
Brandes, R.P.11
Shah, A.M.12
-
57
-
-
84968810258
-
Activation of Nox4 promotes cardiomyocyte autophagy and survival during nutrient starvation
-
Sciarretta S, Zhai P, Volpe M and Sadoshima J. Activation of Nox4 promotes cardiomyocyte autophagy and survival during nutrient starvation. Circulation 2012;126:A18056.
-
(2012)
Circulation
, vol.126
, pp. A18056
-
-
Sciarretta, S.1
Zhai, P.2
Volpe, M.3
Sadoshima, J.4
-
58
-
-
34249013738
-
Thioredoxin1 as a negative regulator of cardiac hypertrophy
-
Ago T, Sadoshima J. Thioredoxin1 as a negative regulator of cardiac hypertrophy. Antioxid Redox Signal. 2007;9:679-687. doi: 10. 1089/ars. 2007. 1529.
-
(2007)
Antioxid Redox Signal.
, vol.9
, pp. 679-687
-
-
Ago, T.1
Sadoshima, J.2
-
59
-
-
0035896205
-
Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction
-
Ide T, Tsutsui H, Hayashidani S, Kang D, Suematsu N, Nakamura K, Utsumi H, Hamasaki N, Takeshita A. Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction. Circ Res. 2001;88:529-535.
-
(2001)
Circ Res.
, vol.88
, pp. 529-535
-
-
Ide, T.1
Tsutsui, H.2
Hayashidani, S.3
Kang, D.4
Suematsu, N.5
Nakamura, K.6
Utsumi, H.7
Hamasaki, N.8
Takeshita, A.9
-
60
-
-
84930040430
-
New roles for mitochondrial proteases in health, ageing and disease
-
Quirós PM, Langer T, López-Otín C. New roles for mitochondrial proteases in health, ageing and disease. Nat Rev Mol Cell Biol. 2015;16:345-359. doi: 10. 1038/nrm3984.
-
(2015)
Nat Rev Mol Cell Biol.
, vol.16
, pp. 345-359
-
-
Quirós, P.M.1
Langer, T.2
López-Otín, C.3
-
61
-
-
84908085343
-
A new pathway for mitochondrial quality control: Mitochondrial-derived vesicles
-
Sugiura A, McLelland GL, Fon EA, McBride HM. A new pathway for mitochondrial quality control: mitochondrial-derived vesicles. EMBO J. 2014;33:2142-2156. doi: 10. 15252/embj. 201488104.
-
(2014)
EMBO J.
, vol.33
, pp. 2142-2156
-
-
Sugiura, A.1
McLelland, G.L.2
Fon, E.A.3
McBride, H.M.4
-
62
-
-
84893500088
-
GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy
-
Scott I, Webster BR, Chan CK, Okonkwo JU, Han K, Sack MN. GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy. J Biol Chem. 2014;289:2864-2872. doi: 10. 1074/jbc. M113. 521641.
-
(2014)
J Biol Chem.
, vol.289
, pp. 2864-2872
-
-
Scott, I.1
Webster, B.R.2
Chan, C.K.3
Okonkwo, J.U.4
Han, K.5
Sack, M.N.6
-
63
-
-
84905820762
-
Mitochondrial proteostasis in the control of aging and longevity
-
Jensen MB, Jasper H. Mitochondrial proteostasis in the control of aging and longevity. Cell Metab. 2014;20:214-225. doi: 10. 1016/j. cmet. 2014. 05. 006.
-
(2014)
Cell Metab.
, vol.20
, pp. 214-225
-
-
Jensen, M.B.1
Jasper, H.2
-
64
-
-
84892989225
-
SirT3 regulates the mitochondrial unfolded protein response
-
Papa L, Germain D. SirT3 regulates the mitochondrial unfolded protein response. Mol Cell Biol. 2014;34:699-710. doi: 10. 1128/MCB. 01337-13.
-
(2014)
Mol Cell Biol.
, vol.34
, pp. 699-710
-
-
Papa, L.1
Germain, D.2
-
65
-
-
84922946917
-
Protein quality control and metabolism: Bidirectional control in the heart
-
Wang ZV, Hill JA. Protein quality control and metabolism: bidirectional control in the heart. Cell Metab. 2015;21:215-226. doi: 10. 1016/j. cmet. 2015. 01. 016.
-
(2015)
Cell Metab.
, vol.21
, pp. 215-226
-
-
Wang, Z.V.1
Hill, J.A.2
-
66
-
-
84945550655
-
Metabolic and phenotypic differences between mice producing a werner syndrome helicase mutant protein and Wrn null mice
-
Aumailley L, Garand C, Dubois MJ, Johnson FB, Marette A, Lebel M. Metabolic and phenotypic differences between mice producing a werner syndrome helicase mutant protein and Wrn null mice. PLoS One. 2015;10:e0140292. doi: 10. 1371/journal. pone. 0140292.
-
(2015)
PLoS One.
, vol.10
, pp. e0140292
-
-
Aumailley, L.1
Garand, C.2
Dubois, M.J.3
Johnson, F.B.4
Marette, A.5
Lebel, M.6
-
67
-
-
84920624510
-
Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice
-
Li-Harms X, Milasta S, Lynch J, Wright C, Joshi A, Iyengar R, Neale G, Wang X, Wang YD, Prolla TA, Thompson JE, Opferman JT, Green DR, Schuetz J, Kundu M. Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice. Blood. 2015;125:162-174. doi: 10. 1182/blood-2014-07-586396.
-
(2015)
Blood.
, vol.125
, pp. 162-174
-
-
Li-Harms, X.1
Milasta, S.2
Lynch, J.3
Wright, C.4
Joshi, A.5
Iyengar, R.6
Neale, G.7
Wang, X.8
Wang, Y.D.9
Prolla, T.A.10
Thompson, J.E.11
Opferman, J.T.12
Green, D.R.13
Schuetz, J.14
Kundu, M.15
-
68
-
-
84924359164
-
Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence
-
Gonzalez-Valdes I, Hidalgo I, Bujarrabal A, Lara-Pezzi E, Padron-Barthe L, Garcia-Pavia P, Gómez-del Arco P, Gomez P, Redondo JM, Ruiz-Cabello JM, Jimenez-Borreguero LJ, Enriquez JA, de la Pompa JL, Hidalgo A, Gonzalez S. Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence. Nat Commun. 2015;6:6473. doi: 10. 1038/ncomms7473.
-
(2015)
Nat Commun.
, vol.6
, pp. 6473
-
-
Gonzalez-Valdes, I.1
Hidalgo, I.2
Bujarrabal, A.3
Lara-Pezzi, E.4
Padron-Barthe, L.5
Garcia-Pavia, P.6
Gómez-Del Arco, P.7
Gomez, P.8
Redondo, J.M.9
Ruiz-Cabello, J.M.10
Jimenez-Borreguero, L.J.11
Enriquez, J.A.12
De La Pompa, J.L.13
Hidalgo, A.14
Gonzalez, S.15
-
69
-
-
84942456107
-
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
-
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science. 2015;349:aaa5612. doi: 10. 1126/science. Aaa5612.
-
(2015)
Science.
, vol.349
, pp. aaa5612
-
-
Kang, C.1
Xu, Q.2
Martin, T.D.3
Li, M.Z.4
Demaria, M.5
Aron, L.6
Lu, T.7
Yankner, B.A.8
Campisi, J.9
Elledge, S.J.10
-
70
-
-
84860751699
-
Telomeres and mitochondria in the aging heart
-
Moslehi J, DePinho RA, Sahin E. Telomeres and mitochondria in the aging heart. Circ Res. 2012;110:1226-1237. doi: 10. 1161/ CIRCRESAHA. 111. 246868.
-
(2012)
Circ Res.
, vol.110
, pp. 1226-1237
-
-
Moslehi, J.1
DePinho, R.A.2
Sahin, E.3
-
72
-
-
84953872755
-
Autophagy maintains stemness by preventing senescence
-
García-Prat L, Martínez-Vicente M, Perdiguero E, Ortet L, Rodríguez-Ubreva J, Rebollo E, Ruiz-Bonilla V, Gutarra S, Ballestar E, Serrano AL, Sandri M, Muñoz-Cánoves P. Autophagy maintains stemness by preventing senescence. Nature. 2016;529:37-42. doi: 10. 1038/nature16187.
-
(2016)
Nature.
, vol.529
, pp. 37-42
-
-
García-Prat, L.1
Martínez-Vicente, M.2
Perdiguero, E.3
Ortet, L.4
Rodríguez-Ubreva, J.5
Rebollo, E.6
Ruiz-Bonilla, V.7
Gutarra, S.8
Ballestar, E.9
Serrano, A.L.10
Sandri, M.11
Muñoz-Cánoves, P.12
-
73
-
-
70449529855
-
Induction of autophagy by spermidine promotes longevity
-
Eisenberg T, Knauer H, Schauer A, et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol. 2009;11:1305-1314. doi: 10. 1038/ncb1975.
-
(2009)
Nat Cell Biol.
, vol.11
, pp. 1305-1314
-
-
Eisenberg, T.1
Knauer, H.2
Schauer, A.3
-
74
-
-
77949887506
-
Mammalian sirtuins: Biological insights and disease relevance
-
Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol. 2010;5:253-295. doi: 10. 1146/annurev. pathol. 4. 110807. 092250.
-
(2010)
Annu Rev Pathol.
, vol.5
, pp. 253-295
-
-
Haigis, M.C.1
Sinclair, D.A.2
-
75
-
-
34249669270
-
Sirt1 regulates aging and resistance to oxidative stress in the heart
-
Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, Yu X, Tian B, Wagner T, Vatner SF, Sadoshima J. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res. 2007;100:1512-1521. doi: 10. 1161/01. RES. 0000267723. 65696. 4a.
-
(2007)
Circ Res.
, vol.100
, pp. 1512-1521
-
-
Alcendor, R.R.1
Gao, S.2
Zhai, P.3
Zablocki, D.4
Holle, E.5
Yu, X.6
Tian, B.7
Wagner, T.8
Vatner, S.F.9
Sadoshima, J.10
-
76
-
-
8844247034
-
Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes
-
Alcendor RR, Kirshenbaum LA, Imai S, Vatner SF, Sadoshima J. Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Circ Res. 2004;95:971-980. doi: 10. 1161/01. RES. 0000147557. 75257. ff.
-
(2004)
Circ Res.
, vol.95
, pp. 971-980
-
-
Alcendor, R.R.1
Kirshenbaum, L.A.2
Imai, S.3
Vatner, S.F.4
Sadoshima, J.5
-
77
-
-
78650691023
-
Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes
-
Hariharan N, Maejima Y, Nakae J, Paik J, Depinho RA, Sadoshima J. Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes. Circ Res. 2010;107:1470-1482. doi: 10. 1161/CIRCRESAHA. 110. 227371.
-
(2010)
Circ Res.
, vol.107
, pp. 1470-1482
-
-
Hariharan, N.1
Maejima, Y.2
Nakae, J.3
Paik, J.4
Depinho, R.A.5
Sadoshima, J.6
-
78
-
-
80052580047
-
Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction
-
Zhou S, Chen HZ, Wan YZ, Zhang QJ, Wei YS, Huang S, Liu JJ, Lu YB, Zhang ZQ, Yang RF, Zhang R, Cai H, Liu DP, Liang CC. Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction. Circ Res. 2011;109:639-648. doi: 10. 1161/CIRCRESAHA. 111. 243592.
-
(2011)
Circ Res.
, vol.109
, pp. 639-648
-
-
Zhou, S.1
Chen, H.Z.2
Wan, Y.Z.3
Zhang, Q.J.4
Wei, Y.S.5
Huang, S.6
Liu, J.J.7
Lu, Y.B.8
Zhang, Z.Q.9
Yang, R.F.10
Zhang, R.11
Cai, H.12
Liu, D.P.13
Liang, C.C.14
-
79
-
-
0033581704
-
The p66shc adaptor protein controls oxidative stress response and life span in mammals
-
Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature. 1999;402:309-313. doi: 10. 1038/46311.
-
(1999)
Nature.
, vol.402
, pp. 309-313
-
-
Migliaccio, E.1
Giorgio, M.2
Mele, S.3
Pelicci, G.4
Reboldi, P.5
Pandolfi, P.P.6
Lanfrancone, L.7
Pelicci, P.G.8
-
80
-
-
0037192473
-
Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
-
Nemoto S, Finkel T. Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science. 2002;295:2450-2452. doi: 10. 1126/science. 1069004.
-
(2002)
Science.
, vol.295
, pp. 2450-2452
-
-
Nemoto, S.1
Finkel, T.2
-
81
-
-
22744447211
-
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis
-
Giorgio M, Migliaccio E, Orsini F, Paolucci D, Moroni M, Contursi C, Pelliccia G, Luzi L, Minucci S, Marcaccio M, Pinton P, Rizzuto R, Bernardi P, Paolucci F, Pelicci PG. Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell. 2005;122:221-233. doi: 10. 1016/j. cell. 2005. 05. 011.
-
(2005)
Cell.
, vol.122
, pp. 221-233
-
-
Giorgio, M.1
Migliaccio, E.2
Orsini, F.3
Paolucci, D.4
Moroni, M.5
Contursi, C.6
Pelliccia, G.7
Luzi, L.8
Minucci, S.9
Marcaccio, M.10
Pinton, P.11
Rizzuto, R.12
Bernardi, P.13
Paolucci, F.14
Pelicci, P.G.15
-
82
-
-
33744519939
-
The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism
-
Nemoto S, Combs CA, French S, Ahn BH, Fergusson MM, Balaban RS, Finkel T. The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism. J Biol Chem. 2006;281:10555-10560. doi: 10. 1074/jbc. M511626200.
-
(2006)
J Biol Chem.
, vol.281
, pp. 10555-10560
-
-
Nemoto, S.1
Combs, C.A.2
French, S.3
Ahn, B.H.4
Fergusson, M.M.5
Balaban, R.S.6
Finkel, T.7
-
83
-
-
55749084738
-
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
-
Ahn BH, Kim HS, Song S, Lee IH, Liu J, Vassilopoulos A, Deng CX, Finkel T. A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A. 2008;105:14447-14452. doi: 10. 1073/pnas. 0803790105.
-
(2008)
Proc Natl Acad Sci U S A.
, vol.105
, pp. 14447-14452
-
-
Ahn, B.H.1
Kim, H.S.2
Song, S.3
Lee, I.H.4
Liu, J.5
Vassilopoulos, A.6
Deng, C.X.7
Finkel, T.8
-
84
-
-
79952266729
-
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy
-
Hafner AV, Dai J, Gomes AP, Xiao CY, Palmeira CM, Rosenzweig A, Sinclair DA. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY). 2010;2:914-923.
-
(2010)
Aging (Albany NY).
, vol.2
, pp. 914-923
-
-
Hafner, A.V.1
Dai, J.2
Gomes, A.P.3
Xiao, C.Y.4
Palmeira, C.M.5
Rosenzweig, A.6
Sinclair, D.A.7
-
85
-
-
84857628087
-
The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging
-
Sack MN. The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging. J Mol Cell Cardiol. 2012;52:520-525. doi: 10. 1016/j. yjmcc. 2011. 11. 004.
-
(2012)
J Mol Cell Cardiol.
, vol.52
, pp. 520-525
-
-
Sack, M.N.1
-
86
-
-
84894109257
-
Mammalian target of rapamycin signaling in cardiac physiology and disease
-
Sciarretta S, Volpe M, Sadoshima J. Mammalian target of rapamycin signaling in cardiac physiology and disease. Circ Res. 2014;114:549-564. doi: 10. 1161/CIRCRESAHA. 114. 302022.
-
(2014)
Circ Res.
, vol.114
, pp. 549-564
-
-
Sciarretta, S.1
Volpe, M.2
Sadoshima, J.3
-
87
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011;13:132-141. doi: 10. 1038/ncb2152.
-
(2011)
Nat Cell Biol.
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
88
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009;460:392-395. doi: 10. 1038/ nature08221.
-
(2009)
Nature.
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
Nadon, N.L.7
Wilkinson, J.E.8
Frenkel, K.9
Carter, C.S.10
Pahor, M.11
Javors, M.A.12
Fernandez, E.13
Miller, R.A.14
-
89
-
-
84955179250
-
Sex-and tissue-specific changes in mTOR signaling with age in C57BL/6J mice
-
Baar EL, Carbajal KA, Ong IM, Lamming DW. Sex-and tissue-specific changes in mTOR signaling with age in C57BL/6J mice. Aging Cell. 2016;15:155-166. doi: 10. 1111/acel. 12425.
-
(2016)
Aging Cell.
, vol.15
, pp. 155-166
-
-
Baar, E.L.1
Carbajal, K.A.2
Ong, I.M.3
Lamming, D.W.4
-
90
-
-
84877687210
-
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy
-
Loffredo FS, Steinhauser ML, Jay SM, et al. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell. 2013;153:828-839. doi: 10. 1016/j. cell. 2013. 04. 015.
-
(2013)
Cell.
, vol.153
, pp. 828-839
-
-
Loffredo, F.S.1
Steinhauser, M.L.2
Jay, S.M.3
-
91
-
-
84946492396
-
GDF11 does not rescue aging-related pathological hypertrophy
-
Smith SC, Zhang X, Zhang X, et al. GDF11 does not rescue aging-related pathological hypertrophy. Circ Res. 2015;117:926-932. doi: 10. 1161/ CIRCRESAHA. 115. 307527.
-
(2015)
Circ Res.
, vol.117
, pp. 926-932
-
-
Smith, S.C.1
Zhang, X.2
Zhang, X.3
-
92
-
-
84900323323
-
Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle
-
Sinha M, Jang YC, Oh J, et al. Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science. 2014;344:649-652. doi: 10. 1126/science. 1251152.
-
(2014)
Science.
, vol.344
, pp. 649-652
-
-
Sinha, M.1
Jang, Y.C.2
Oh, J.3
-
93
-
-
0035039021
-
Protein oxidation in aging and age-related diseases
-
Stadtman ER. Protein oxidation in aging and age-related diseases. Ann N Y Acad Sci. 2001;928:22-38.
-
(2001)
Ann N y Acad Sci.
, vol.928
, pp. 22-38
-
-
Stadtman, E.R.1
-
94
-
-
84927584661
-
Molecular mechanisms of autophagy in the cardiovascular system
-
Gatica D, Chiong M, Lavandero S, Klionsky DJ. Molecular mechanisms of autophagy in the cardiovascular system. Circ Res. 2015;116:456-467. doi: 10. 1161/CIRCRESAHA. 114. 303788.
-
(2015)
Circ Res.
, vol.116
, pp. 456-467
-
-
Gatica, D.1
Chiong, M.2
Lavandero, S.3
Klionsky, D.J.4
-
95
-
-
84942817626
-
Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease
-
Hwang S, Disatnik MH, Mochly-Rosen D. Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease. EMBO Mol Med. 2015;7:1307-1326. doi: 10. 15252/emmm. 201505256.
-
(2015)
EMBO Mol Med.
, vol.7
, pp. 1307-1326
-
-
Hwang, S.1
Disatnik, M.H.2
Mochly-Rosen, D.3
-
96
-
-
77955342581
-
Inhibition of autophagy in the heart induces age-related cardiomyopathy
-
Taneike M, Yamaguchi O, Nakai A, et al. Inhibition of autophagy in the heart induces age-related cardiomyopathy. Autophagy. 2010;6:600-606. doi: 10. 4161/auto. 6. 5. 11947.
-
(2010)
Autophagy.
, vol.6
, pp. 600-606
-
-
Taneike, M.1
Yamaguchi, O.2
Nakai, A.3
-
97
-
-
77953272740
-
Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses
-
Blanchet FP, Moris A, Nikolic DS, Lehmann M, Cardinaud S, Stalder R, Garcia E, Dinkins C, Leuba F, Wu L, Schwartz O, Deretic V, Piguet V. Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses. Immunity. 2010;32:654-669. doi: 10. 1016/j. immuni. 2010. 04. 011.
-
(2010)
Immunity.
, vol.32
, pp. 654-669
-
-
Blanchet, F.P.1
Moris, A.2
Nikolic, D.S.3
Lehmann, M.4
Cardinaud, S.5
Stalder, R.6
Garcia, E.7
Dinkins, C.8
Leuba, F.9
Wu, L.10
Schwartz, O.11
Deretic, V.12
Piguet, V.13
-
98
-
-
77955518491
-
Autophagy induced by ischemic preconditioning is essential for cardioprotection
-
Huang C, Yitzhaki S, Perry CN, Liu W, Giricz Z, Mentzer RM Jr, Gottlieb RA. Autophagy induced by ischemic preconditioning is essential for cardioprotection. J Cardiovasc Transl Res. 2010;3:365-373. doi: 10. 1007/ s12265-010-9189-3.
-
(2010)
J Cardiovasc Transl Res.
, vol.3
, pp. 365-373
-
-
Huang, C.1
Yitzhaki, S.2
Perry, C.N.3
Liu, W.4
Giricz, Z.5
Mentzer, R.M.6
Gottlieb, R.A.7
-
99
-
-
84887495190
-
Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2
-
Maejima Y, Kyoi S, Zhai P, Liu T, Li H, Ivessa A, Sciarretta S, Del Re DP, Zablocki DK, Hsu CP, Lim DS, Isobe M, Sadoshima J. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med. 2013;19:1478-1488. doi: 10. 1038/nm. 3322.
-
(2013)
Nat Med.
, vol.19
, pp. 1478-1488
-
-
Maejima, Y.1
Kyoi, S.2
Zhai, P.3
Liu, T.4
Li, H.5
Ivessa, A.6
Sciarretta, S.7
Del Re, D.P.8
Zablocki, D.K.9
Hsu, C.P.10
Lim, D.S.11
Isobe, M.12
Sadoshima, J.13
-
100
-
-
84857914471
-
Rheb is a critical regulator of autophagy during myocardial ischemia: Pathophysiological implications in obesity and metabolic syndrome
-
Sciarretta S, Zhai P, Shao D, Maejima Y, Robbins J, Volpe M, Condorelli G, Sadoshima J. Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome. Circulation. 2012;125:1134-1146. doi: 10. 1161/ CIRCULATIONAHA. 111. 078212.
-
(2012)
Circulation.
, vol.125
, pp. 1134-1146
-
-
Sciarretta, S.1
Zhai, P.2
Shao, D.3
Maejima, Y.4
Robbins, J.5
Volpe, M.6
Condorelli, G.7
Sadoshima, J.8
-
101
-
-
84941659052
-
Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis
-
Liao X, Zhang R, Lu Y, et al. Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis. J Clin Invest. 2015;125:3461-3476. doi: 10. 1172/JCI79964.
-
(2015)
J Clin Invest.
, vol.125
, pp. 3461-3476
-
-
Liao, X.1
Zhang, R.2
Lu, Y.3
-
102
-
-
84876090708
-
ZKSCAN3 is a master transcriptional repressor of autophagy
-
Chauhan S, Goodwin JG, Chauhan S, Manyam G, Wang J, Kamat AM, Boyd DD. ZKSCAN3 is a master transcriptional repressor of autophagy. Mol Cell. 2013;50:16-28. doi: 10. 1016/j. molcel. 2013. 01. 024.
-
(2013)
Mol Cell.
, vol.50
, pp. 16-28
-
-
Chauhan, S.1
Goodwin, J.G.2
Chauhan, S.3
Manyam, G.4
Wang, J.5
Kamat, A.M.6
Boyd, D.D.7
-
103
-
-
84903318420
-
MIR-216a: A link between endothelial dysfunction and autophagy
-
Menghini R, Casagrande V, Marino A, Marchetti V, Cardellini M, Stoehr R, Rizza S, Martelli E, Greco S, Mauriello A, Ippoliti A, Martelli F, Lauro R, Federici M. MiR-216a: A link between endothelial dysfunction and autophagy. Cell Death Dis. 2014;5:e1029. doi: 10. 1038/ cddis. 2013. 556.
-
(2014)
Cell Death Dis.
, vol.5
, pp. e1029
-
-
Menghini, R.1
Casagrande, V.2
Marino, A.3
Marchetti, V.4
Cardellini, M.5
Stoehr, R.6
Rizza, S.7
Martelli, E.8
Greco, S.9
Mauriello, A.10
Ippoliti, A.11
Martelli, F.12
Lauro, R.13
Federici, M.14
-
104
-
-
84902208708
-
Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy
-
Zaglia T, Milan G, Ruhs A, Franzoso M, Bertaggia E, Pianca N, Carpi A, Carullo P, Pesce P, Sacerdoti D, Sarais C, Catalucci D, Krüger M, Mongillo M, Sandri M. Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy. J Clin Invest. 2014;124:2410-2424. doi: 10. 1172/JCI66339.
-
(2014)
J Clin Invest.
, vol.124
, pp. 2410-2424
-
-
Zaglia, T.1
Milan, G.2
Ruhs, A.3
Franzoso, M.4
Bertaggia, E.5
Pianca, N.6
Carpi, A.7
Carullo, P.8
Pesce, P.9
Sacerdoti, D.10
Sarais, C.11
Catalucci, D.12
Krüger, M.13
Mongillo, M.14
Sandri, M.15
-
105
-
-
84943766398
-
Metabolomic analyses reveal that antiaging metabolites are depleted by palmitate but increased by oleate in vivo
-
Enot DP, Niso-Santano M, Durand S, Chery A, Pietrocola F, Vacchelli E, Madeo F, Galluzzi L, Kroemer G. Metabolomic analyses reveal that antiaging metabolites are depleted by palmitate but increased by oleate in vivo. Cell Cycle. 2015;14:2399-2407. doi: 10. 1080/15384101. 2015. 1064206.
-
(2015)
Cell Cycle.
, vol.14
, pp. 2399-2407
-
-
Enot, D.P.1
Niso-Santano, M.2
Durand, S.3
Chery, A.4
Pietrocola, F.5
Vacchelli, E.6
Madeo, F.7
Galluzzi, L.8
Kroemer, G.9
-
106
-
-
41449102024
-
Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans
-
Tóth ML, Sigmond T, Borsos E, Barna J, Erdélyi P, Takács-Vellai K, Orosz L, Kovács AL, Csikós G, Sass M, Vellai T. Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans. Autophagy. 2008;4:330-338.
-
(2008)
Autophagy.
, vol.4
, pp. 330-338
-
-
Tóth, M.L.1
Sigmond, T.2
Borsos, E.3
Barna, J.4
Erdélyi, P.5
Takács-Vellai, K.6
Orosz, L.7
Kovács, A.L.8
Csikós, G.9
Sass, M.10
Vellai, T.11
-
107
-
-
77952371152
-
A microarray-based genetic screen for yeast chronological aging factors
-
Matecic M, Smith DL, Pan X, Maqani N, Bekiranov S, Boeke JD, Smith JS. A microarray-based genetic screen for yeast chronological aging factors. PLoS Genet. 2010;6:e1000921. doi: 10. 1371/journal. pgen. 1000921.
-
(2010)
PLoS Genet.
, vol.6
, pp. e1000921
-
-
Matecic, M.1
Smith, D.L.2
Pan, X.3
Maqani, N.4
Bekiranov, S.5
Boeke, J.D.6
Smith, J.S.7
-
108
-
-
77749264562
-
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
-
Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 2010;327:1223-1228. doi: 10. 1126/science. 1182228.
-
(2010)
Science.
, vol.327
, pp. 1223-1228
-
-
Lee, J.H.1
Budanov, A.V.2
Park, E.J.3
Birse, R.4
Kim, T.E.5
Perkins, G.A.6
Ocorr, K.7
Ellisman, M.H.8
Bodmer, R.9
Bier, E.10
Karin, M.11
-
109
-
-
38949099761
-
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
-
Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR, Finley KD. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy. 2008;4:176-184.
-
(2008)
Autophagy.
, vol.4
, pp. 176-184
-
-
Simonsen, A.1
Cumming, R.C.2
Brech, A.3
Isakson, P.4
Schubert, D.R.5
Finley, K.D.6
-
110
-
-
57649234905
-
Autophagy genes and ageing
-
Vellai T. Autophagy genes and ageing. Cell Death Differ. 2009;16:94-102. doi: 10. 1038/cdd. 2008. 126.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 94-102
-
-
Vellai, T.1
-
111
-
-
77951169411
-
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice
-
Hartleben B, Gödel M, Meyer-Schwesinger C, et al. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest. 2010;120:1084-1096. doi: 10. 1172/JCI39492.
-
(2010)
J Clin Invest.
, vol.120
, pp. 1084-1096
-
-
Hartleben, B.1
Gödel, M.2
Meyer-Schwesinger, C.3
-
112
-
-
77649265091
-
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
-
Komatsu M, Kurokawa H, Waguri S, et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol. 2010;12:213-223. doi: 10. 1038/ncb2021.
-
(2010)
Nat Cell Biol.
, vol.12
, pp. 213-223
-
-
Komatsu, M.1
Kurokawa, H.2
Waguri, S.3
-
113
-
-
66449099090
-
Autophagy suppresses tumorigenesis through elimination of p62
-
Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY, Bray K, Reddy A, Bhanot G, Gelinas C, Dipaola RS, Karantza-Wadsworth V, White E. Autophagy suppresses tumorigenesis through elimination of p62. Cell. 2009;137:1062-1075. doi: 10. 1016/j. cell. 2009. 03. 048.
-
(2009)
Cell.
, vol.137
, pp. 1062-1075
-
-
Mathew, R.1
Karp, C.M.2
Beaudoin, B.3
Vuong, N.4
Chen, G.5
Chen, H.Y.6
Bray, K.7
Reddy, A.8
Bhanot, G.9
Gelinas, C.10
Dipaola, R.S.11
Karantza-Wadsworth, V.12
White, E.13
-
114
-
-
77952409809
-
Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy
-
Wu JJ, Quijano C, Chen E, Liu H, Cao L, Fergusson MM, Rovira II, Gutkind S, Daniels MP, Komatsu M, Finkel T. Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy. Aging (Albany NY). 2009;1:425-437.
-
(2009)
Aging (Albany NY).
, vol.1
, pp. 425-437
-
-
Wu, J.J.1
Quijano, C.2
Chen, E.3
Liu, H.4
Cao, L.5
Fergusson, M.M.6
Rovira, I.I.7
Gutkind, S.8
Daniels, M.P.9
Komatsu, M.10
Finkel, T.11
-
115
-
-
77956400005
-
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
-
Yang L, Li P, Fu S, Calay ES, Hotamisligil GS. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 2010;11:467-478. doi: 10. 1016/j. cmet. 2010. 04. 005.
-
(2010)
Cell Metab.
, vol.11
, pp. 467-478
-
-
Yang, L.1
Li, P.2
Fu, S.3
Calay, E.S.4
Hotamisligil, G.S.5
-
116
-
-
84884878909
-
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner
-
Gupta VK, Scheunemann L, Eisenberg T, et al. Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. Nat Neurosci. 2013;16:1453-1460. doi: 10. 1038/nn. 3512.
-
(2013)
Nat Neurosci.
, vol.16
, pp. 1453-1460
-
-
Gupta, V.K.1
Scheunemann, L.2
Eisenberg, T.3
-
117
-
-
79951642032
-
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
-
Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, Englert JA, Rabinovitch M, Cernadas M, Kim HP, Fitzgerald KA, Ryter SW, Choi AM. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol. 2011;12:222-230. doi: 10. 1038/ ni. 1980.
-
(2011)
Nat Immunol.
, vol.12
, pp. 222-230
-
-
Nakahira, K.1
Haspel, J.A.2
Rathinam, V.A.3
Lee, S.J.4
Dolinay, T.5
Lam, H.C.6
Englert, J.A.7
Rabinovitch, M.8
Cernadas, M.9
Kim, H.P.10
Fitzgerald, K.A.11
Ryter, S.W.12
Choi, A.M.13
-
118
-
-
78751672975
-
Autophagy in immunity and inflammation
-
Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature. 2011;469:323-335. doi: 10. 1038/nature09782.
-
(2011)
Nature.
, vol.469
, pp. 323-335
-
-
Levine, B.1
Mizushima, N.2
Virgin, H.W.3
-
119
-
-
65949095803
-
Autophagy regulates lipid metabolism
-
Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, Tanaka K, Cuervo AM, Czaja MJ. Autophagy regulates lipid metabolism. Nature. 2009;458:1131-1135. doi: 10. 1038/nature07976.
-
(2009)
Nature.
, vol.458
, pp. 1131-1135
-
-
Singh, R.1
Kaushik, S.2
Wang, Y.3
Xiang, Y.4
Novak, I.5
Komatsu, M.6
Tanaka, K.7
Cuervo, A.M.8
Czaja, M.J.9
-
120
-
-
84880601247
-
Focusing the spotlight on GSK-3 in aging
-
Zhou J, Force T. Focusing the spotlight on GSK-3 in aging. Aging (Albany NY). 2013;5:388-389.
-
(2013)
Aging (Albany NY).
, vol.5
, pp. 388-389
-
-
Zhou, J.1
Force, T.2
-
121
-
-
0030878260
-
Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo
-
Agah R, Frenkel PA, French BA, Michael LH, Overbeek PA, Schneider MD. Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo. J Clin Invest. 1997;100:169-179. doi: 10. 1172/JCI119509.
-
(1997)
J Clin Invest.
, vol.100
, pp. 169-179
-
-
Agah, R.1
Frenkel, P.A.2
French, B.A.3
Michael, L.H.4
Overbeek, P.A.5
Schneider, M.D.6
-
122
-
-
80052641742
-
A genome-wide association study of aging
-
Walter S, Atzmon G, Demerath EW, et al. A genome-wide association study of aging. Neurobiol Aging. 2011;32:2109. e15-2109. e28. doi: 10. 1016/j. neurobiolaging. 2011. 05. 026.
-
(2011)
Neurobiol Aging.
, vol.32
, pp. 2109e15-2109e28
-
-
Walter, S.1
Atzmon, G.2
Demerath, E.W.3
-
123
-
-
84855830535
-
Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics)
-
Uchiki T, Weikel KA, Jiao W, Shang F, Caceres A, Pawlak D, Handa JT, Brownlee M, Nagaraj R, Taylor A. Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics). Aging Cell. 2012;11:1-13. doi: 10. 1111/j. 1474-9726. 2011. 00752. x.
-
(2012)
Aging Cell.
, vol.11
, pp. 1-13
-
-
Uchiki, T.1
Weikel, K.A.2
Jiao, W.3
Shang, F.4
Caceres, A.5
Pawlak, D.6
Handa, J.T.7
Brownlee, M.8
Nagaraj, R.9
Taylor, A.10
-
124
-
-
79960342396
-
Atg7 induces basal autophagy and rescues autophagic deficiency in CryABR120G cardiomyocytes
-
Pattison JS, Osinska H, Robbins J. Atg7 induces basal autophagy and rescues autophagic deficiency in CryABR120G cardiomyocytes. Circ Res. 2011;109:151-160. doi: 10. 1161/CIRCRESAHA. 110. 237339.
-
(2011)
Circ Res.
, vol.109
, pp. 151-160
-
-
Pattison, J.S.1
Osinska, H.2
Robbins, J.3
-
125
-
-
51349095898
-
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
-
Zhang C, Cuervo AM. Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat Med. 2008;14:959-965. doi: 10. 1038/nm. 1851.
-
(2008)
Nat Med.
, vol.14
, pp. 959-965
-
-
Zhang, C.1
Cuervo, A.M.2
-
126
-
-
84921985434
-
Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress
-
Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, Nomura M, Mihara K, Egashira K, Ohishi M, Abdellatif M, Sadoshima J. Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress. Circ Res. 2015;116:264-278. doi: 10. 1161/ CIRCRESAHA. 116. 303356.
-
(2015)
Circ Res.
, vol.116
, pp. 264-278
-
-
Ikeda, Y.1
Shirakabe, A.2
Maejima, Y.3
Zhai, P.4
Sciarretta, S.5
Toli, J.6
Nomura, M.7
Mihara, K.8
Egashira, K.9
Ohishi, M.10
Abdellatif, M.11
Sadoshima, J.12
-
127
-
-
84935008216
-
Molecular mechanisms of mitochondrial autophagy/ mitophagy in the heart
-
Saito T, Sadoshima J. Molecular mechanisms of mitochondrial autophagy/ mitophagy in the heart. Circ Res. 2015;116:1477-1490. doi: 10. 1161/ CIRCRESAHA. 116. 303790.
-
(2015)
Circ Res.
, vol.116
, pp. 1477-1490
-
-
Saito, T.1
Sadoshima, J.2
-
128
-
-
84876531457
-
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria
-
Chen Y, Dorn GW II. PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science. 2013;340:471-475. doi: 10. 1126/science. 1231031.
-
(2013)
Science.
, vol.340
, pp. 471-475
-
-
Chen, Y.1
Dorn, I.I.G.W.2
-
129
-
-
84939804206
-
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
-
Lazarou M, Sliter DA, Kane LA, Sarraf SA, Wang C, Burman JL, Sideris DP, Fogel AI, Youle RJ. The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature. 2015;524:309-314. doi: 10. 1038/ nature14893.
-
(2015)
Nature.
, vol.524
, pp. 309-314
-
-
Lazarou, M.1
Sliter, D.A.2
Kane, L.A.3
Sarraf, S.A.4
Wang, C.5
Burman, J.L.6
Sideris, D.P.7
Fogel, A.I.8
Youle, R.J.9
-
130
-
-
84913565821
-
Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain
-
Kageyama Y, Hoshijima M, Seo K, Bedja D, Sysa-Shah P, Andrabi SA, Chen W, Höke A, Dawson VL, Dawson TM, Gabrielson K, Kass DA, Iijima M, Sesaki H. Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain. EMBO J. 2014;33:2798-2813. doi: 10. 15252/embj. 201488658.
-
(2014)
EMBO J.
, vol.33
, pp. 2798-2813
-
-
Kageyama, Y.1
Hoshijima, M.2
Seo, K.3
Bedja, D.4
Sysa-Shah, P.5
Andrabi, S.A.6
Chen, W.7
Höke, A.8
Dawson, V.L.9
Dawson, T.M.10
Gabrielson, K.11
Kass, D.A.12
Iijima, M.13
Sesaki, H.14
-
131
-
-
84940718214
-
Mitophagy is primarily due to alternative autophagy and requires the MAPK1 and MAPK14 signaling pathways
-
Hirota Y, Yamashita S, Kurihara Y, Jin X, Aihara M, Saigusa T, Kang D, Kanki T. Mitophagy is primarily due to alternative autophagy and requires the MAPK1 and MAPK14 signaling pathways. Autophagy. 2015;11:332-343. doi: 10. 1080/15548627. 2015. 1023047.
-
(2015)
Autophagy.
, vol.11
, pp. 332-343
-
-
Hirota, Y.1
Yamashita, S.2
Kurihara, Y.3
Jin, X.4
Aihara, M.5
Saigusa, T.6
Kang, D.7
Kanki, T.8
-
132
-
-
84930632378
-
Coordination of mitophagy and mitochondrial biogenesis during ageing in C
-
Palikaras K, Lionaki E, Tavernarakis N. Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans. Nature. 2015;521:525-528. doi: 10. 1038/nature14300.
-
(2015)
Elegans. Nature.
, vol.521
, pp. 525-528
-
-
Palikaras, K.1
Lionaki, E.2
Tavernarakis, N.3
-
133
-
-
84881329174
-
Parkin deficiency results in accumulation of abnormal mitochondria in aging myocytes
-
Kubli DA, Quinsay MN, Gustafsson AB. Parkin deficiency results in accumulation of abnormal mitochondria in aging myocytes. Commun Integr Biol. 2013;6:e24511. doi: 10. 4161/cib. 24511.
-
(2013)
Commun Integr Biol.
, vol.6
, pp. e24511
-
-
Kubli, D.A.1
Quinsay, M.N.2
Gustafsson, A.B.3
-
134
-
-
80052389174
-
Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells
-
Kim KY, Stevens MV, Akter MH, Rusk SE, Huang RJ, Cohen A, Noguchi A, Springer D, Bocharov AV, Eggerman TL, Suen DF, Youle RJ, Amar M, Remaley AT, Sack MN. Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells. J Clin Invest. 2011;121:3701-3712. doi: 10. 1172/JCI44736.
-
(2011)
J Clin Invest.
, vol.121
, pp. 3701-3712
-
-
Kim, K.Y.1
Stevens, M.V.2
Akter, M.H.3
Rusk, S.E.4
Huang, R.J.5
Cohen, A.6
Noguchi, A.7
Springer, D.8
Bocharov, A.V.9
Eggerman, T.L.10
Suen, D.F.11
Youle, R.J.12
Amar, M.13
Remaley, A.T.14
Sack, M.N.15
-
135
-
-
84887499718
-
MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age
-
Ferree AW, Trudeau K, Zik E, Benador IY, Twig G, Gottlieb RA, Shirihai OS. MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age. Autophagy. 2013;9:1887-1896. doi: 10. 4161/auto. 26503.
-
(2013)
Autophagy.
, vol.9
, pp. 1887-1896
-
-
Ferree, A.W.1
Trudeau, K.2
Zik, E.3
Benador, I.Y.4
Twig, G.5
Gottlieb, R.A.6
Shirihai, O.S.7
-
136
-
-
84949663455
-
?-MHC MitoTimer mouse: In vivo mitochondrial turnover model reveals remarkable mitochondrial heterogeneity in the heart
-
Stotland A, Gottlieb RA. ?-MHC MitoTimer mouse: In vivo mitochondrial turnover model reveals remarkable mitochondrial heterogeneity in the heart. J Mol Cell Cardiol. 2016;90:53-58. doi: 10. 1016/j. yjmcc. 2015. 11. 032.
-
(2016)
J Mol Cell Cardiol.
, vol.90
, pp. 53-58
-
-
Stotland, A.1
Gottlieb, R.A.2
-
137
-
-
0034703217
-
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
-
Lin SJ, Defossez PA, Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science. 2000;289:2126-2128.
-
(2000)
Science.
, vol.289
, pp. 2126-2128
-
-
Lin, S.J.1
Defossez, P.A.2
Guarente, L.3
-
138
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
Rogina B, Helfand SL. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A. 2004;101:15998-16003. doi: 10. 1073/pnas. 0404184101.
-
(2004)
Proc Natl Acad Sci U S A.
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
139
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science. 2004;305:390-392. doi: 10. 1126/science. 1099196.
-
(2004)
Science.
, vol.305
, pp. 390-392
-
-
Cohen, H.Y.1
Miller, C.2
Bitterman, K.J.3
Wall, N.R.4
Hekking, B.5
Kessler, B.6
Howitz, K.T.7
Gorospe, M.8
De Cabo, R.9
Sinclair, D.A.10
-
140
-
-
84946020703
-
The role of sirtuins in cardiac disease
-
Matsushima S, Sadoshima J. The role of sirtuins in cardiac disease. Am J Physiol Heart Circ Physiol. 2015;309:H1375-H1389. doi: 10. 1152/ ajpheart. 00053. 2015.
-
(2015)
Am J Physiol Heart Circ Physiol.
, vol.309
, pp. H1375-H1389
-
-
Matsushima, S.1
Sadoshima, J.2
-
141
-
-
84859499343
-
Protection of the heart against ischemia/ reperfusion by silent information regulator 1
-
Yamamoto T, Sadoshima J. Protection of the heart against ischemia/ reperfusion by silent information regulator 1. Trends Cardiovasc Med. 2011;21:27-32. doi: 10. 1016/j. Tcm. 2012. 01. 005.
-
(2011)
Trends Cardiovasc Med.
, vol.21
, pp. 27-32
-
-
Yamamoto, T.1
Sadoshima, J.2
-
142
-
-
3943071801
-
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
-
Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 2004;430:686-689. doi: 10. 1038/nature02789.
-
(2004)
Nature.
, vol.430
, pp. 686-689
-
-
Wood, J.G.1
Rogina, B.2
Lavu, S.3
Howitz, K.4
Helfand, S.L.5
Tatar, M.6
Sinclair, D.7
-
143
-
-
27744596999
-
Sir2 blocks extreme life-span extension
-
Fabrizio P, Gattazzo C, Battistella L, Wei M, Cheng C, McGrew K, Longo VD. Sir2 blocks extreme life-span extension. Cell. 2005;123:655-667. doi: 10. 1016/j. cell. 2005. 08. 042.
-
(2005)
Cell.
, vol.123
, pp. 655-667
-
-
Fabrizio, P.1
Gattazzo, C.2
Battistella, L.3
Wei, M.4
Cheng, C.5
McGrew, K.6
Longo, V.D.7
-
144
-
-
0035913911
-
Negative control of p53 by Sir2alpha promotes cell survival under stress
-
Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell. 2001;107:137-148.
-
(2001)
Cell.
, vol.107
, pp. 137-148
-
-
Luo, J.1
Nikolaev, A.Y.2
Imai, S.3
Chen, D.4
Su, F.5
Shiloh, A.6
Guarente, L.7
Gu, W.8
-
145
-
-
0035913903
-
HSIR2(SIRT1) functions as an NADdependent p53 deacetylase
-
Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA. hSIR2(SIRT1) functions as an NADdependent p53 deacetylase. Cell. 2001;107:149-159.
-
(2001)
Cell.
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
Dessain, S.K.2
Ng Eaton, E.3
Imai, S.I.4
Frye, R.A.5
Pandita, T.K.6
Guarente, L.7
Weinberg, R.A.8
-
146
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet A, Sweeney LB, Sturgill JF, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science. 2004;303:2011-2015. doi: 10. 1126/science. 1094637.
-
(2004)
Science.
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
Sweeney, L.B.2
Sturgill, J.F.3
-
147
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M, Guarente L. Mammalian SIRT1 represses forkhead transcription factors. Cell. 2004;116:551-563.
-
(2004)
Cell.
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
Divecha, N.2
Lemieux, M.3
Kamel, C.4
Chen, D.5
Gu, W.6
Bultsma, Y.7
McBurney, M.8
Guarente, L.9
-
148
-
-
3042750643
-
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
-
Daitoku H, Hatta M, Matsuzaki H, Aratani S, Ohshima T, Miyagishi M, Nakajima T, Fukamizu A. Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A. 2004;101:10042-10047. doi: 10. 1073/ pnas. 0400593101.
-
(2004)
Proc Natl Acad Sci U S A.
, vol.101
, pp. 10042-10047
-
-
Daitoku, H.1
Hatta, M.2
Matsuzaki, H.3
Aratani, S.4
Ohshima, T.5
Miyagishi, M.6
Nakajima, T.7
Fukamizu, A.8
-
149
-
-
0036709074
-
Human Sir2 and the 'silencing' of p53 activity
-
Smith J. Human Sir2 and the 'silencing' of p53 activity. Trends Cell Biol. 2002;12:404-406.
-
(2002)
Trends Cell Biol.
, vol.12
, pp. 404-406
-
-
Smith, J.1
-
150
-
-
0141814680
-
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
-
Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P, Bronson R, Appella E, Alt FW, Chua KF. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A. 2003;100:10794-10799. doi: 10. 1073/pnas. 1934713100.
-
(2003)
Proc Natl Acad Sci U S A.
, vol.100
, pp. 10794-10799
-
-
Cheng, H.L.1
Mostoslavsky, R.2
Saito, S.3
Manis, J.P.4
Gu, Y.5
Patel, P.6
Bronson, R.7
Appella, E.8
Alt, F.W.9
Chua, K.F.10
-
151
-
-
3042681042
-
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
-
Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De Oliveira R, Leid M, McBurney MW, Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature. 2004;429:771-776. doi: 10. 1038/nature02583.
-
(2004)
Nature.
, vol.429
, pp. 771-776
-
-
Picard, F.1
Kurtev, M.2
Chung, N.3
Topark-Ngarm, A.4
Senawong, T.5
Machado De Oliveira, R.6
Leid, M.7
McBurney, M.W.8
Guarente, L.9
-
152
-
-
78650172708
-
Silent information regulator 1 protects the heart from ischemia/reperfusion
-
Hsu CP, Zhai P, Yamamoto T, Maejima Y, Matsushima S, Hariharan N, Shao D, Takagi H, Oka S, Sadoshima J. Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation. 2010;122:2170-2182. doi: 10. 1161/CIRCULATIONAHA. 110. 958033.
-
(2010)
Circulation.
, vol.122
, pp. 2170-2182
-
-
Hsu, C.P.1
Zhai, P.2
Yamamoto, T.3
Maejima, Y.4
Matsushima, S.5
Hariharan, N.6
Shao, D.7
Takagi, H.8
Oka, S.9
Sadoshima, J.10
-
153
-
-
78649521247
-
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
-
Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab. 2010;12:662-667. doi: 10. 1016/j. cmet. 2010. 11. 015.
-
(2010)
Cell Metab.
, vol.12
, pp. 662-667
-
-
Qiu, X.1
Brown, K.2
Hirschey, M.D.3
Verdin, E.4
Chen, D.5
-
154
-
-
78651468722
-
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
-
Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM, Prolla TA. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell. 2010;143:802-812. doi: 10. 1016/j. cell. 2010. 10. 002.
-
(2010)
Cell.
, vol.143
, pp. 802-812
-
-
Someya, S.1
Yu, W.2
Hallows, W.C.3
Xu, J.4
Vann, J.M.5
Leeuwenburgh, C.6
Tanokura, M.7
Denu, J.M.8
Prolla, T.A.9
-
155
-
-
84949036094
-
NAD+ in aging, metabolism, and neurodegeneration
-
Verdin E. NAD+ in aging, metabolism, and neurodegeneration. Science. 2015;350:1208-1213. doi: 10. 1126/science. Aac4854.
-
(2015)
Science.
, vol.350
, pp. 1208-1213
-
-
Verdin, E.1
-
156
-
-
70149095672
-
Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes
-
Hsu CP, Oka S, Shao D, Hariharan N, Sadoshima J. Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes. Circ Res. 2009;105:481-491. doi: 10. 1161/ CIRCRESAHA. 109. 203703.
-
(2009)
Circ Res.
, vol.105
, pp. 481-491
-
-
Hsu, C.P.1
Oka, S.2
Shao, D.3
Hariharan, N.4
Sadoshima, J.5
-
157
-
-
73449133720
-
Nicotinamide phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes
-
Hsu CP, Hariharan N, Alcendor RR, Oka S, Sadoshima J. Nicotinamide phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes. Autophagy. 2009;5:1229-1231.
-
(2009)
Autophagy.
, vol.5
, pp. 1229-1231
-
-
Hsu, C.P.1
Hariharan, N.2
Alcendor, R.R.3
Oka, S.4
Sadoshima, J.5
-
158
-
-
84902579141
-
Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion
-
Yamamoto T, Byun J, Zhai P, Ikeda Y, Oka S, Sadoshima J. Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion. PLoS One. 2014;9:e98972. doi: 10. 1371/ journal. pone. 0098972.
-
(2014)
PLoS One.
, vol.9
, pp. e98972
-
-
Yamamoto, T.1
Byun, J.2
Zhai, P.3
Ikeda, Y.4
Oka, S.5
Sadoshima, J.6
-
159
-
-
0030813398
-
Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
-
Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 1997;277:942-946.
-
(1997)
Science.
, vol.277
, pp. 942-946
-
-
Kimura, K.D.1
Tissenbaum, H.A.2
Liu, Y.3
Ruvkun, G.4
-
160
-
-
0042092531
-
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
-
Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature. 2003;424:277-283. doi: 10. 1038/nature01789.
-
(2003)
Nature.
, vol.424
, pp. 277-283
-
-
Murphy, C.T.1
McCarroll, S.A.2
Bargmann, C.I.3
Fraser, A.4
Kamath, R.S.5
Ahringer, J.6
Li, H.7
Kenyon, C.8
-
161
-
-
0032782364
-
The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
-
Honda Y, Honda S. The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J. 1999;13:1385-1393.
-
(1999)
FASEB J.
, vol.13
, pp. 1385-1393
-
-
Honda, Y.1
Honda, S.2
-
162
-
-
0035853552
-
Regulation of longevity and stress resistance by Sch9 in yeast
-
Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD. Regulation of longevity and stress resistance by Sch9 in yeast. Science. 2001;292:288-290. doi: 10. 1126/science. 1059497.
-
(2001)
Science.
, vol.292
, pp. 288-290
-
-
Fabrizio, P.1
Pozza, F.2
Pletcher, S.D.3
Gendron, C.M.4
Longo, V.D.5
-
163
-
-
0037136563
-
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
-
Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH, Burgering BM. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature. 2002;419:316-321. doi: 10. 1038/nature01036.
-
(2002)
Nature.
, vol.419
, pp. 316-321
-
-
Kops, G.J.1
Dansen, T.B.2
Polderman, P.E.3
Saarloos, I.4
Wirtz, K.W.5
Coffer, P.J.6
Huang, T.T.7
Bos, J.L.8
Medema, R.H.9
Burgering, B.M.10
-
164
-
-
0347664057
-
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
-
Holzenberger M, Dupont J, Ducos B, Leneuve P, Géloën A, Even PC, Cervera P, Le Bouc Y. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. 2003;421:182-187. doi: 10. 1038/ nature01298.
-
(2003)
Nature.
, vol.421
, pp. 182-187
-
-
Holzenberger, M.1
Dupont, J.2
Ducos, B.3
Leneuve, P.4
Géloën, A.5
Even, P.C.6
Cervera, P.7
Le Bouc, Y.8
-
165
-
-
0037470501
-
The endocrine regulation of aging by insulinlike signals
-
Tatar M, Bartke A, Antebi A. The endocrine regulation of aging by insulinlike signals. Science. 2003;299:1346-1351. doi: 10. 1126/science. 1081447.
-
(2003)
Science.
, vol.299
, pp. 1346-1351
-
-
Tatar, M.1
Bartke, A.2
Antebi, A.3
-
166
-
-
24944481544
-
Suppression of aging in mice by the hormone Klotho
-
Kurosu H, Yamamoto M, Clark JD, et al. Suppression of aging in mice by the hormone Klotho. Science. 2005;309:1829-1833. doi: 10. 1126/ science. 1112766.
-
(2005)
Science.
, vol.309
, pp. 1829-1833
-
-
Kurosu, H.1
Yamamoto, M.2
Clark, J.D.3
-
167
-
-
8844270819
-
Sir-viving cardiac stress: Cardioprotection mediated by a longevity gene
-
Crow MT. Sir-viving cardiac stress: cardioprotection mediated by a longevity gene. Circ Res. 2004;95:953-956. doi: 10. 1161/01. RES. 0000148666. 20729. 1c.
-
(2004)
Circ Res.
, vol.95
, pp. 953-956
-
-
Crow, M.T.1
-
168
-
-
24744448458
-
Aging and longevity: The IGF-1 enigma
-
Anversa P. Aging and longevity: The IGF-1 enigma. Circ Res. 2005;97:411-414. doi: 10. 1161/01. RES. 0000182212. 09147. 56.
-
(2005)
Circ Res.
, vol.97
, pp. 411-414
-
-
Anversa, P.1
-
169
-
-
84945962512
-
Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/ mammalian target of rapamycin (mTOR) and impaired cardiac adaptation
-
Cattin ME, Wang J, Weldrick JJ, Roeske CL, Mak E, Thorn SL, DaSilva JN, Wang Y, Lusis AJ, Burgon PG. Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/ mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. J Biol Chem. 2015;290:26699-26714. doi: 10. 1074/jbc. M115. 678433.
-
(2015)
J Biol Chem.
, vol.290
, pp. 26699-26714
-
-
Cattin, M.E.1
Wang, J.2
Weldrick, J.J.3
Roeske, C.L.4
Mak, E.5
Thorn, S.L.6
DaSilva, J.N.7
Wang, Y.8
Lusis, A.J.9
Burgon, P.G.10
-
170
-
-
84856746125
-
Chronic Akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: Role of autophagy
-
Hua Y, Zhang Y, Ceylan-Isik AF, Wold LE, Nunn JM, Ren J. Chronic Akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy. Basic Res Cardiol. 2011;106:1173-1191. doi: 10. 1007/s00395-011-0222-8.
-
(2011)
Basic Res Cardiol.
, vol.106
, pp. 1173-1191
-
-
Hua, Y.1
Zhang, Y.2
Ceylan-Isik, A.F.3
Wold, L.E.4
Nunn, J.M.5
Ren, J.6
-
171
-
-
34147168105
-
Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy
-
Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T, Levine B, Sadoshima J. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res. 2007;100:914-922. doi: 10. 1161/01. RES. 0000261924. 76669. 36.
-
(2007)
Circ Res.
, vol.100
, pp. 914-922
-
-
Matsui, Y.1
Takagi, H.2
Qu, X.3
Abdellatif, M.4
Sakoda, H.5
Asano, T.6
Levine, B.7
Sadoshima, J.8
-
172
-
-
84901431879
-
Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart
-
Dai DF, Karunadharma PP, Chiao YA, Basisty N, Crispin D, Hsieh EJ, Chen T, Gu H, Djukovic D, Raftery D, Beyer RP, MacCoss MJ, Rabinovitch PS. Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart. Aging Cell. 2014;13:529-539. doi: 10. 1111/acel. 12203.
-
(2014)
Aging Cell.
, vol.13
, pp. 529-539
-
-
Dai, D.F.1
Karunadharma, P.P.2
Chiao, Y.A.3
Basisty, N.4
Crispin, D.5
Hsieh, E.J.6
Chen, T.7
Gu, H.8
Djukovic, D.9
Raftery, D.10
Beyer, R.P.11
MacCoss, M.J.12
Rabinovitch, P.S.13
-
173
-
-
80052147341
-
Differential roles of GSK-3? during myocardial ischemia and ischemia/reperfusion
-
Zhai P, Sciarretta S, Galeotti J, Volpe M, Sadoshima J. Differential roles of GSK-3? during myocardial ischemia and ischemia/reperfusion. Circ Res. 2011;109:502-511. doi: 10. 1161/CIRCRESAHA. 111. 249532.
-
(2011)
Circ Res.
, vol.109
, pp. 502-511
-
-
Zhai, P.1
Sciarretta, S.2
Galeotti, J.3
Volpe, M.4
Sadoshima, J.5
-
174
-
-
84875858766
-
GSK-3 Is a central regulator of age-related pathologies in mice
-
Zhou J, Freeman TA, Ahmad F, Shang X, Mangano E, Gao E, Farber J, Wang Y, Ma XL, Woodgett J, Vagnozzi RJ, Lal H, Force T. GSK-3? is a central regulator of age-related pathologies in mice. J Clin Invest. 2013;123:1821-1832. doi: 10. 1172/JCI64398.
-
(2013)
J Clin Invest.
, vol.123
, pp. 1821-1832
-
-
Zhou, J.1
Freeman, T.A.2
Ahmad, F.3
Shang, X.4
Mangano, E.5
Gao, E.6
Farber, J.7
Wang, Y.8
Ma, X.L.9
Woodgett, J.10
Vagnozzi, R.J.11
Lal, H.12
Force, T.13
-
175
-
-
84920815706
-
The GSK-3 family as therapeutic target for myocardial diseases
-
Lal H, Ahmad F, Woodgett J, Force T. The GSK-3 family as therapeutic target for myocardial diseases. Circ Res. 2015;116:138-149. doi: 10. 1161/CIRCRESAHA. 116. 303613.
-
(2015)
Circ Res.
, vol.116
, pp. 138-149
-
-
Lal, H.1
Ahmad, F.2
Woodgett, J.3
Force, T.4
-
176
-
-
79251587803
-
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
-
Egan DF, Shackelford DB, Mihaylova MM, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science. 2011;331:456-461. doi: 10. 1126/science. 1196371.
-
(2011)
Science.
, vol.331
, pp. 456-461
-
-
Egan, D.F.1
Shackelford, D.B.2
Mihaylova, M.M.3
-
177
-
-
84881347302
-
Metformin improves healthspan and lifespan in mice
-
Martin-Montalvo A, Mercken EM, Mitchell SJ, et al. Metformin improves healthspan and lifespan in mice. Nat Commun. 2013;4:2192. doi: 10. 1038/ncomms3192.
-
(2013)
Nat Commun.
, vol.4
, pp. 2192
-
-
Martin-Montalvo, A.1
Mercken, E.M.2
Mitchell, S.J.3
-
178
-
-
78049438321
-
AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction
-
Turdi S, Fan X, Li J, Zhao J, Huff AF, Du M, Ren J. AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction. Aging Cell. 2010;9:592-606. doi: 10. 1111/j. 1474-9726. 2010. 00586. x.
-
(2010)
Aging Cell.
, vol.9
, pp. 592-606
-
-
Turdi, S.1
Fan, X.2
Li, J.3
Zhao, J.4
Huff, A.F.5
Du, M.6
Ren, J.7
-
179
-
-
84922209831
-
New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart
-
Ikeda Y, Sciarretta S, Nagarajan N, Rubattu S, Volpe M, Frati G, Sadoshima J. New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart. Oxid Med Cell Longev. 2014;2014:210934. doi: 10. 1155/2014/210934.
-
(2014)
Oxid Med Cell Longev.
, vol.2014
, pp. 210934
-
-
Ikeda, Y.1
Sciarretta, S.2
Nagarajan, N.3
Rubattu, S.4
Volpe, M.5
Frati, G.6
Sadoshima, J.7
-
180
-
-
79956126271
-
Oxidative stress stimulates autophagic flux during ischemia/reperfusion
-
Hariharan N, Zhai P, Sadoshima J. Oxidative stress stimulates autophagic flux during ischemia/reperfusion. Antioxid Redox Signal. 2011;14:2179-2190. doi: 10. 1089/ars. 2010. 3488.
-
(2011)
Antioxid Redox Signal.
, vol.14
, pp. 2179-2190
-
-
Hariharan, N.1
Zhai, P.2
Sadoshima, J.3
-
181
-
-
84888136345
-
Activation of NADPH oxidase 4 in the endoplasmic reticulum promotes cardiomyocyte autophagy and survival during energy stress through the protein kinase RNA-activated-like endoplasmic reticulum kinase/ eukaryotic initiation factor 2?/activating transcription factor 4 pathway
-
Sciarretta S, Zhai P, Shao D, Zablocki D, Nagarajan N, Terada LS, Volpe M, Sadoshima J. Activation of NADPH oxidase 4 in the endoplasmic reticulum promotes cardiomyocyte autophagy and survival during energy stress through the protein kinase RNA-activated-like endoplasmic reticulum kinase/ eukaryotic initiation factor 2?/activating transcription factor 4 pathway. Circ Res. 2013;113:1253-1264. doi: 10. 1161/CIRCRESAHA. 113. 301787.
-
(2013)
Circ Res.
, vol.113
, pp. 1253-1264
-
-
Sciarretta, S.1
Zhai, P.2
Shao, D.3
Zablocki, D.4
Nagarajan, N.5
Terada, L.S.6
Volpe, M.7
Sadoshima, J.8
-
182
-
-
0037312020
-
How does calorie restriction work?
-
Koubova J, Guarente L. How does calorie restriction work? Genes Dev. 2003;17:313-321. doi: 10. 1101/gad. 1052903.
-
(2003)
Genes Dev.
, vol.17
, pp. 313-321
-
-
Koubova, J.1
Guarente, L.2
-
183
-
-
0037130175
-
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
-
Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, Fink GR, Guarente L. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature. 2002;418:344-348. doi: 10. 1038/nature00829.
-
(2002)
Nature.
, vol.418
, pp. 344-348
-
-
Lin, S.J.1
Kaeberlein, M.2
Andalis, A.A.3
Sturtz, L.A.4
Defossez, P.A.5
Culotta, V.C.6
Fink, G.R.7
Guarente, L.8
-
184
-
-
24944559665
-
HST2 mediates SIR2-independent lifespan extension by calorie restriction
-
Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, Lin SJ, Sinclair DA. HST2 mediates SIR2-independent lifespan extension by calorie restriction. Science. 2005;309:1861-1864. doi: 10. 1126/science. 1113611.
-
(2005)
Science.
, vol.309
, pp. 1861-1864
-
-
Lamming, D.W.1
Latorre-Esteves, M.2
Medvedik, O.3
Wong, S.N.4
Tsang, F.A.5
Wang, C.6
Lin, S.J.7
Sinclair, D.A.8
-
185
-
-
0030038103
-
Oxidative stress, caloric restriction, and aging
-
Sohal RS, Weindruch R. Oxidative stress, caloric restriction, and aging. Science. 1996;273:59-63.
-
(1996)
Science.
, vol.273
, pp. 59-63
-
-
Sohal, R.S.1
Weindruch, R.2
-
186
-
-
27744511769
-
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
-
Kaeberlein M, Powers RW III, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science. 2005;310:1193-1196. doi: 10. 1126/science. 1115535.
-
(2005)
Science.
, vol.310
, pp. 1193-1196
-
-
Kaeberlein, M.1
Powers, R.W.2
Steffen, K.K.3
Westman, E.A.4
Hu, D.5
Dang, N.6
Kerr, E.O.7
Kirkland, K.T.8
Fields, S.9
Kennedy, B.K.10
-
187
-
-
84864523531
-
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival
-
Ramos FJ, Chen SC, Garelick MG, Dai DF, Liao CY, Schreiber KH, MacKay VL, An EH, Strong R, Ladiges WC, Rabinovitch PS, Kaeberlein M, Kennedy BK. Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Sci Transl Med. 2012;4:144ra103. doi: 10. 1126/ scitranslmed. 3003802.
-
(2012)
Sci Transl Med.
, vol.4
, pp. 144ra103
-
-
Ramos, F.J.1
Chen, S.C.2
Garelick, M.G.3
Dai, D.F.4
Liao, C.Y.5
Schreiber, K.H.6
MacKay, V.L.7
An, E.H.8
Strong, R.9
Ladiges, W.C.10
Rabinovitch, P.S.11
Kaeberlein, M.12
Kennedy, B.K.13
-
188
-
-
0036847345
-
Survival characteristics and age-adjusted disease incidences in C57BL/6 mice fed a commonly used cereal-based diet modulated by dietary restriction
-
Turturro A, Duffy P, Hass B, Kodell R, Hart R. Survival characteristics and age-adjusted disease incidences in C57BL/6 mice fed a commonly used cereal-based diet modulated by dietary restriction. J Gerontol A Biol Sci Med Sci. 2002;57:B379-B389.
-
(2002)
J Gerontol A Biol Sci Med Sci.
, vol.57
, pp. B379-B389
-
-
Turturro, A.1
Duffy, P.2
Hass, B.3
Kodell, R.4
Hart, R.5
-
189
-
-
78650835776
-
Impact of long-term caloric restriction on cardiac senescence: Caloric restriction ameliorates cardiac diastolic dysfunction associated with aging
-
Shinmura K, Tamaki K, Sano M, Murata M, Yamakawa H, Ishida H, Fukuda K. Impact of long-term caloric restriction on cardiac senescence: caloric restriction ameliorates cardiac diastolic dysfunction associated with aging. J Mol Cell Cardiol. 2011;50:117-127. doi: 10. 1016/j. yjmcc. 2010. 10. 018.
-
(2011)
J Mol Cell Cardiol.
, vol.50
, pp. 117-127
-
-
Shinmura, K.1
Tamaki, K.2
Sano, M.3
Murata, M.4
Yamakawa, H.5
Ishida, H.6
Fukuda, K.7
-
190
-
-
84941731395
-
Mitochondrial dysfunction in cardiac aging
-
Tocchi A, Quarles EK, Basisty N, Gitari L, Rabinovitch PS. Mitochondrial dysfunction in cardiac aging. Biochim Biophys Acta. 2015;1847:1424-1433. doi: 10. 1016/j. bbabio. 2015. 07. 009.
-
(2015)
Biochim Biophys Acta.
, vol.1847
, pp. 1424-1433
-
-
Tocchi, A.1
Quarles, E.K.2
Basisty, N.3
Gitari, L.4
Rabinovitch, P.S.5
-
191
-
-
84863393597
-
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
-
He C, Bassik MC, Moresi V, et al. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature. 2012;481:511-515. doi: 10. 1038/nature10758.
-
(2012)
Nature.
, vol.481
, pp. 511-515
-
-
He, C.1
Bassik, M.C.2
Moresi, V.3
-
192
-
-
84890072367
-
Enhanced autophagy ameliorates cardiac proteinopathy
-
Bhuiyan MS, Pattison JS, Osinska H, James J, Gulick J, McLendon PM, Hill JA, Sadoshima J, Robbins J. Enhanced autophagy ameliorates cardiac proteinopathy. J Clin Invest. 2013;123:5284-5297. doi: 10. 1172/ JCI70877.
-
(2013)
J Clin Invest.
, vol.123
, pp. 5284-5297
-
-
Bhuiyan, M.S.1
Pattison, J.S.2
Osinska, H.3
James, J.4
Gulick, J.5
McLendon, P.M.6
Hill, J.A.7
Sadoshima, J.8
Robbins, J.9
-
193
-
-
84905491871
-
Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family
-
Lu K, Psakhye I, Jentsch S. Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family. Cell. 2014;158:549-563. doi: 10. 1016/j. cell. 2014. 05. 048.
-
(2014)
Cell.
, vol.158
, pp. 549-563
-
-
Lu, K.1
Psakhye, I.2
Jentsch, S.3
-
194
-
-
84937425943
-
Toll-interacting protein contributes to mortality following myocardial infarction through promoting inflammation and apoptosis
-
Wan N, Liu X, Zhang XJ, Zhao Y, Hu G, Wan F, Zhang R, Zhu X, Xia H, Li H. Toll-interacting protein contributes to mortality following myocardial infarction through promoting inflammation and apoptosis. Br J Pharmacol. 2015;172:3383-3396. doi: 10. 1111/bph. 13130.
-
(2015)
Br J Pharmacol.
, vol.172
, pp. 3383-3396
-
-
Wan, N.1
Liu, X.2
Zhang, X.J.3
Zhao, Y.4
Hu, G.5
Wan, F.6
Zhang, R.7
Zhu, X.8
Xia, H.9
Li, H.10
-
195
-
-
84953226488
-
Trehalose accumulation triggers autophagy during plant desiccation
-
Williams B, Njaci I, Moghaddam L, Long H, Dickman MB, Zhang X, Mundree S. Trehalose accumulation triggers autophagy during plant desiccation. PLoS Genet. 2015;11:e1005705. doi: 10. 1371/journal. pgen. 1005705.
-
(2015)
PLoS Genet.
, vol.11
, pp. e1005705
-
-
Williams, B.1
Njaci, I.2
Moghaddam, L.3
Long, H.4
Dickman, M.B.5
Zhang, X.6
Mundree, S.7
-
196
-
-
84968786652
-
Trehalose, a natural dissachride, reduces cardiac remodeling after myocardial infarction through autophagy activation
-
Sciarretta S, Zhai P, Volpe M, Sadoshima J. Trehalose, a natural dissachride, reduces cardiac remodeling after myocardial infarction through autophagy activation. Circulation. 2012;126:A18096.
-
(2012)
Circulation.
, vol.126
, pp. A18096
-
-
Sciarretta, S.1
Zhai, P.2
Volpe, M.3
Sadoshima, J.4
-
197
-
-
84874700585
-
MicroRNA-34a regulates cardiac ageing and function
-
Boon RA, Iekushi K, Lechner S, et al. MicroRNA-34a regulates cardiac ageing and function. Nature. 2013;495:107-110. doi: 10. 1038/ nature11919.
-
(2013)
Nature.
, vol.495
, pp. 107-110
-
-
Boon, R.A.1
Iekushi, K.2
Lechner, S.3
-
198
-
-
84908258052
-
Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex
-
Liang N, Zhang C, Dill P, et al. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med. 2014;211:2249-2263. doi: 10. 1084/jem. 20140341.
-
(2014)
J Exp Med.
, vol.211
, pp. 2249-2263
-
-
Liang, N.1
Zhang, C.2
Dill, P.3
-
199
-
-
84937522438
-
NAD(+) Metabolism and the control of energy homeostasis: A balancing act between mitochondria and the nucleus
-
Cantó C, Menzies KJ, Auwerx J. NAD(+) Metabolism and the control of energy homeostasis: A balancing act between mitochondria and the nucleus. Cell Metab. 2015;22:31-53. doi: 10. 1016/j. cmet. 2015. 05. 023.
-
(2015)
Cell Metab.
, vol.22
, pp. 31-53
-
-
Cantó, C.1
Menzies, K.J.2
Auwerx, J.3
|