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Volumn 120, Issue 4, 2010, Pages 1084-1096

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CELL PROTEIN AUTOPHAGY RELATED 5; PROTEASOME; UBIQUITIN; UNCLASSIFIED DRUG;

EID: 77951169411     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI39492     Document Type: Article
Times cited : (614)

References (61)
  • 1
    • 18844411833 scopus 로고    scopus 로고
    • The slit diaphragm: A signaling platform to regulate podocyte function
    • Huber TB, Benzing T. The slit diaphragm: a signaling platform to regulate podocyte function. Curr Opin Nephrol Hypertens. 2005;14(3):211-216.
    • (2005) Curr Opin Nephrol Hypertens , vol.14 , Issue.3 , pp. 211-216
    • Huber, T.B.1    Benzing, T.2
  • 2
    • 0037207471 scopus 로고    scopus 로고
    • Cell biology of the glomerular podocyte
    • Pavenstadt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev. 2003; 83(1):253-307.
    • (2003) Physiol Rev. , vol.83 , Issue.1 , pp. 253-307
    • Pavenstadt, H.1    Kriz, W.2    Kretzler, M.3
  • 3
    • 0036789206 scopus 로고    scopus 로고
    • Podocyte number in normotensive type 1 diabetic patients with albuminuria
    • White KE, et al. Podocyte number in normotensive type 1 diabetic patients with albuminuria. Diabetes. 2002;51(10):3083-3089.
    • (2002) Diabetes , vol.51 , Issue.10 , pp. 3083-3089
    • White, K.E.1
  • 4
    • 0036223537 scopus 로고    scopus 로고
    • Podocytopenia and disease severity in IgA nephropathy
    • Lemley KV, et al. Podocytopenia and disease severity in IgA nephropathy. Kidney Int. 2002;61(4):1475-1485.
    • (2002) Kidney Int. , vol.61 , Issue.4 , pp. 1475-1485
    • Lemley, K.V.1
  • 5
    • 34250006557 scopus 로고    scopus 로고
    • The spectrum of podocytopathies: A unifying view of glomerular diseases
    • Wiggins RC. The spectrum of podocytopathies: a unifying view of glomerular diseases. Kidney Int. 2007;71(12):1205-1214.
    • (2007) Kidney Int. , vol.71 , Issue.12 , pp. 1205-1214
    • Wiggins, R.C.1
  • 7
    • 60549093216 scopus 로고    scopus 로고
    • Glomerular epithelial cells in the urine: What has to be done to make them worthwhile?
    • Skoberne A, Konieczny A, Schiffer M. Glomerular epithelial cells in the urine: what has to be done to make them worthwhile? Am J Physiol Renal Physiol. 2009;296(2):F230-F241.
    • (2009) Am J Physiol Renal Physiol. , vol.296 , Issue.2
    • Skoberne, A.1    Konieczny, A.2    Schiffer, M.3
  • 8
    • 0031058834 scopus 로고    scopus 로고
    • Age-related glomerulosclerosis and interstitial fibrosis in Milan normotensive rats: A podocyte disease
    • Floege J, et al. Age-related glomerulosclerosis and interstitial fibrosis in Milan normotensive rats: a podocyte disease. Kidney Int. 1997;51(1):230-243.
    • (1997) Kidney Int. , vol.51 , Issue.1 , pp. 230-243
    • Floege, J.1
  • 9
    • 0022512744 scopus 로고
    • Age-dependent glomerulosclerosis and proteinuria occurring in rats of the Milan normotensive strain and not in rats of the Milan hypertensive strain
    • Brandis A, Bianchi G, Reale E, Helmchen U, Kuhn K. Age-dependent glomerulosclerosis and proteinuria occurring in rats of the Milan normotensive strain and not in rats of the Milan hypertensive strain. Lab Invest. 1986;55(2):234-243.
    • (1986) Lab Invest. , vol.55 , Issue.2 , pp. 234-243
    • Brandis, A.1    Bianchi, G.2    Reale, E.3    Helmchen, U.4    Kuhn, K.5
  • 11
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature. 2008;451(7182):1069-1075.
    • (2008) Nature , vol.451 , Issue.7182 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 12
    • 56449083411 scopus 로고    scopus 로고
    • Autophagy in neurodegeneration and development
    • Winslow AR, Rubinsztein DC. Autophagy in neurodegeneration and development. Biochim Biophys Acta. 2008;1782(12):723-729.
    • (2008) Biochim Biophys Acta. , vol.1782 , Issue.12 , pp. 723-729
    • Winslow, A.R.1    Rubinsztein, D.C.2
  • 13
    • 0038718698 scopus 로고    scopus 로고
    • MAP-LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis
    • Asanuma K, et al. MAP-LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis. FASEB J. 2003;17(9):1165-1167.
    • (2003) FASEB J. , vol.17 , Issue.9 , pp. 1165-1167
    • Asanuma, K.1
  • 14
    • 1542283812 scopus 로고    scopus 로고
    • In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
    • Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell. 2004;15(3):1101-1111.
    • (2004) Mol Biol Cell , vol.15 , Issue.3 , pp. 1101-1111
    • Mizushima, N.1    Yamamoto, A.2    Matsui, M.3    Yoshimori, T.4    Ohsumi, Y.5
  • 15
    • 33646113500 scopus 로고    scopus 로고
    • Two types of autophagy in the podocytes in renal biopsy specimens: Ultrastructural study
    • Sato S, Kitamura H, Adachi A, Sasaki Y, Ghazizadeh M. Two types of autophagy in the podocytes in renal biopsy specimens: ultrastructural study. J Submicrosc Cytol Pathol. 2006;38(2-3):167-174.
    • (2006) J Submicrosc Cytol Pathol. , vol.38 , Issue.2-3 , pp. 167-174
    • Sato, S.1    Kitamura, H.2    Adachi, A.3    Sasaki, Y.4    Ghazizadeh, M.5
  • 16
    • 11144245626 scopus 로고    scopus 로고
    • The role of autophagy during the early neonatal starvation period
    • Kuma A, et al. The role of autophagy during the early neonatal starvation period. Nature. 2004; 432(7020):1032-1036.
    • (2004) Nature , vol.432 , Issue.7020 , pp. 1032-1036
    • Kuma, A.1
  • 17
    • 33745192802 scopus 로고    scopus 로고
    • Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    • Hara T, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature. 2006;441(7095):885-889.
    • (2006) Nature , vol.441 , Issue.7095 , pp. 885-889
    • Hara, T.1
  • 18
    • 0037247603 scopus 로고    scopus 로고
    • Podocyte-specific expression of cre recombinase in transgenic mice
    • Moeller MJ, Sanden SK, Soofi A, Wiggins RC, Holzman LB. Podocyte-specific expression of cre recombinase in transgenic mice. Genesis. 2003;35(1):39-42.
    • (2003) Genesis , vol.35 , Issue.1 , pp. 39-42
    • Moeller, M.J.1    Sanden, S.K.2    Soofi, A.3    Wiggins, R.C.4    Holzman, L.B.5
  • 19
    • 70349687405 scopus 로고    scopus 로고
    • Discovery of Atg5/Atg7-independent alternative macroautophagy
    • Nishida Y, et al. Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature. 2009; 461(7264):654-658.
    • (2009) Nature , vol.461 , Issue.7264 , pp. 654-658
    • Nishida, Y.1
  • 20
    • 33745023775 scopus 로고    scopus 로고
    • Chaperonemediated autophagy in aging and disease
    • Massey AC, Zhang C, Cuervo AM. Chaperonemediated autophagy in aging and disease. Curr Top Dev Biol. 2006;73:205-235.
    • (2006) Curr Top Dev Biol. , vol.73 , pp. 205-235
    • Massey, A.C.1    Zhang, C.2    Cuervo, A.M.3
  • 21
    • 34249714158 scopus 로고    scopus 로고
    • The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
    • Nakai A, et al. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med. 2007;13(5):619-624.
    • (2007) Nat Med. , vol.13 , Issue.5 , pp. 619-624
    • Nakai, A.1
  • 22
    • 21044455137 scopus 로고    scopus 로고
    • Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
    • Komatsu M, et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol. 2005;169(3):425-434.
    • (2005) J Cell Biol. , vol.169 , Issue.3 , pp. 425-434
    • Komatsu, M.1
  • 23
    • 33646800306 scopus 로고    scopus 로고
    • Loss of autophagy in the central nervous system causes neurodegeneration in mice
    • Komatsu M, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature. 2006;441(7095):880-884.
    • (2006) Nature , vol.441 , Issue.7095 , pp. 880-884
    • Komatsu, M.1
  • 24
    • 52749094770 scopus 로고    scopus 로고
    • Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia
    • Jung HS, et al. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab. 2008;8(4):318-324.
    • (2008) Cell Metab. , vol.8 , Issue.4 , pp. 318-324
    • Jung, H.S.1
  • 25
    • 52749093177 scopus 로고    scopus 로고
    • Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet
    • Ebato C, et al. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab. 2008; 8(4):325-332.
    • (2008) Cell Metab. , vol.8 , Issue.4 , pp. 325-332
    • Ebato, C.1
  • 26
    • 27944504351 scopus 로고    scopus 로고
    • Et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • Bjorkoy G, et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol. 2005;171(4):603-614.
    • (2005) J Cell Biol. , vol.171 , Issue.4 , pp. 603-614
    • Bjorkoy, G.1
  • 27
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008;132(1):27-42.
    • (2008) Cell , vol.132 , Issue.1 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 28
    • 0026795635 scopus 로고
    • Protein oxidation and aging
    • Stadtman ER. Protein oxidation and aging. Science. 1992;257(5074):1220- 1224.
    • (1992) Science , vol.257 , Issue.5074 , pp. 1220-1224
    • Stadtman, E.R.1
  • 29
    • 0032190090 scopus 로고    scopus 로고
    • The ubiquitin pathway in Parkinson's disease
    • Leroy E, et al. The ubiquitin pathway in Parkinson's disease. Nature. 1998;395(6701):451-452.
    • (1998) Nature , vol.395 , Issue.6701 , pp. 451-452
    • Leroy, E.1
  • 30
    • 60549084713 scopus 로고    scopus 로고
    • A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCHL1) in podocyte process formation and podocyte injury in human glomerulopathies
    • Meyer-Schwesinger C, et al. A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCHL1) in podocyte process formation and podocyte injury in human glomerulopathies. J Pathol. 2009; 217(3):452-464.
    • (2009) J Pathol. , vol.217 , Issue.3 , pp. 452-464
    • Meyer-Schwesinger, C.1
  • 31
    • 0036147231 scopus 로고    scopus 로고
    • Quantitative gene expression analysis in renal biopsies: A novel protocol for a high-throughput multi-center application
    • Cohen CD, Frach K, Schlondorff D, Kretzler M. Quantitative gene expression analysis in renal biopsies: a novel protocol for a high-throughput multi-center application. Kidney Int. 2002;61(1):133-140.
    • (2002) Kidney Int. , vol.61 , Issue.1 , pp. 133-140
    • Cohen, C.D.1    Frach, K.2    Schlondorff, D.3    Kretzler, M.4
  • 32
    • 8344242220 scopus 로고    scopus 로고
    • Autophagy in health and disease: A double-edged sword
    • Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword. Science. 2004;306(5698):990-995.
    • (2004) Science , vol.306 , Issue.5698 , pp. 990-995
    • Shintani, T.1    Klionsky, D.J.2
  • 33
    • 0021999179 scopus 로고
    • Reduced sialylation of podocalyxin - The major sialoprotein of the rat kidney glomerulus - in aminonucleoside nephrosis
    • Kerjaschki D, Vernillo AT, Farquhar MG. Reduced sialylation of podocalyxin - the major sialoprotein of the rat kidney glomerulus - in aminonucleoside nephrosis. Am J Pathol. 1985;118(3):343-349.
    • (1985) Am J Pathol. , vol.118 , Issue.3 , pp. 343-349
    • Kerjaschki, D.1    Vernillo, A.T.2    Farquhar, M.G.3
  • 34
    • 34548511066 scopus 로고    scopus 로고
    • Mizoribine corrects defective nephrin biogenesis by restoring intracellular energy balance
    • Nakajo A, et al. Mizoribine corrects defective nephrin biogenesis by restoring intracellular energy balance. J Am Soc Nephrol. 2007;18(9):2554-2564.
    • (2007) J Am Soc Nephrol. , vol.18 , Issue.9 , pp. 2554-2564
    • Nakajo, A.1
  • 35
    • 0033802098 scopus 로고    scopus 로고
    • Progressive adriamycin nephropathy in mice: Sequence of histologic and immunohistochemical events
    • Wang Y, Wang YP, Tay YC, Harris DC. Progressive adriamycin nephropathy in mice: sequence of histologic and immunohistochemical events. Kidney Int. 2000;58(4):1797-1804.
    • (2000) Kidney Int. , vol.58 , Issue.4 , pp. 1797-1804
    • Wang, Y.1    Wang, Y.P.2    Tay, Y.C.3    Harris, D.C.4
  • 37
    • 26944476342 scopus 로고    scopus 로고
    • Heparan sulfate of perlecan is involved in glomerular filtration
    • Morita H, et al. Heparan sulfate of perlecan is involved in glomerular filtration. J Am Soc Nephrol. 2005; 16(6):1703-1710.
    • (2005) J Am Soc Nephrol. , vol.16 , Issue.6 , pp. 1703-1710
    • Morita, H.1
  • 38
    • 85047691168 scopus 로고    scopus 로고
    • Induction of B7-1 in podocytes is associated with nephrotic syndrome
    • Reiser J, et al. Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest. 2004; 113(10):1390-1397.
    • (2004) J Clin Invest. , vol.113 , Issue.10 , pp. 1390-1397
    • Reiser, J.1
  • 39
    • 38749153591 scopus 로고    scopus 로고
    • Podocyte injury in focal segmental glomerulosclerosis: Lessons from animal models (a play in five acts)
    • D'Agati VD. Podocyte injury in focal segmental glomerulosclerosis: Lessons from animal models (a play in five acts). Kidney Int. 2008;73(4):399-406.
    • (2008) Kidney Int. , vol.73 , Issue.4 , pp. 399-406
    • D'Agati, V.D.1
  • 40
    • 0028107511 scopus 로고
    • Dysfunctions of cell biological mechanisms of visceral epithelial cell (podocytes) in glomerular diseases
    • Kerjaschki D. Dysfunctions of cell biological mechanisms of visceral epithelial cell (podocytes) in glomerular diseases. Kidney Int. 1994;45(2):300-313.
    • (1994) Kidney Int. , vol.45 , Issue.2 , pp. 300-313
    • Kerjaschki, D.1
  • 41
    • 0023197950 scopus 로고
    • The aging kidney: Structure, function, mechanisms, and therapeutic implications
    • Anderson S, Brenner BM. The aging kidney: structure, function, mechanisms, and therapeutic implications. J Am Geriatr Soc. 1987;35(6):590-593.
    • (1987) J Am Geriatr Soc. , vol.35 , Issue.6 , pp. 590-593
    • Anderson, S.1    Brenner, B.M.2
  • 42
    • 0016791510 scopus 로고
    • Agerelated incidence of sclerotic glomeruli in human kidneys
    • Kaplan C, Pasternack B, Shah H, Gallo G. Agerelated incidence of sclerotic glomeruli in human kidneys. Am J Pathol. 1975;80(2):227-234.
    • (1975) Am J Pathol. , vol.80 , Issue.2 , pp. 227-234
    • Kaplan, C.1    Pasternack, B.2    Shah, H.3    Gallo, G.4
  • 43
    • 37349003177 scopus 로고    scopus 로고
    • The role of autophagy in age-related neurodegeneration
    • McCray BA, Taylor JP. The role of autophagy in age-related neurodegeneration. Neurosignals. 2008; 16(1):75-84.
    • (2008) Neurosignals. , vol.16 , Issue.1 , pp. 75-84
    • McCray, B.A.1    Taylor, J.P.2
  • 44
    • 34250183177 scopus 로고    scopus 로고
    • HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
    • Pandey UB, et al. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature. 2007;447(7146):859-863.
    • (2007) Nature , vol.447 , Issue.7146 , pp. 859-863
    • Pandey, U.B.1
  • 45
    • 77951248828 scopus 로고    scopus 로고
    • Autophagy: Links with the proteasome published online ahead of print December 2
    • doi:10.1016/j.ceb.2009.11.002
    • Lamark T, Johansen T. Autophagy: links with the proteasome [published online ahead of print December 2, 2009]. Curr Opin Cell Biol. doi:10.1016/j.ceb.2009.11.002.
    • (2009) Curr Opin Cell Biol.
    • Lamark, T.1    Johansen, T.2
  • 46
    • 60549093730 scopus 로고    scopus 로고
    • Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates
    • Korolchuk VI, Mansilla A, Menzies FM, Rubinsztein DC. Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol Cell. 2009;33(4):517-527.
    • (2009) Mol Cell , vol.33 , Issue.4 , pp. 517-527
    • Korolchuk, V.I.1    Mansilla, A.2    Menzies, F.M.3    Rubinsztein, D.C.4
  • 48
    • 33644850764 scopus 로고    scopus 로고
    • In mice, proteinuria and renal inflammatory responses to albumin overload are strain-dependent
    • Ishola DA Jr, et al. In mice, proteinuria and renal inflammatory responses to albumin overload are strain-dependent. Nephrol Dial Transplant. 2006; 21(3):591-597.
    • (2006) Nephrol Dial Transplant. , vol.21 , Issue.3 , pp. 591-597
    • Ishola Jr., D.A.1
  • 49
    • 40849130173 scopus 로고    scopus 로고
    • VEGF inhibition and renal thrombotic microangiopathy
    • Eremina V, et al. VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med. 2008; 358(11):1129-1136.
    • (2008) N Engl J Med. , vol.358 , Issue.11 , pp. 1129-1136
    • Eremina, V.1
  • 50
    • 46749088320 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis
    • Neubert K, et al. The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nat Med. 2008; 14(7):748-755.
    • (2008) Nat Med. , vol.14 , Issue.7 , pp. 748-755
    • Neubert, K.1
  • 51
    • 0025606873 scopus 로고
    • A practical method to count the number of glomeruli in the kidney as exemplified in various animal species
    • Nyengaard JR, Bendtsen TF. A practical method to count the number of glomeruli in the kidney as exemplified in various animal species. Acta Stereol. 1990; 9(Pt 2):243-258.
    • (1990) Acta Stereol. , vol.9 , Issue.PART 2 , pp. 243-258
    • Nyengaard, J.R.1    Bendtsen, T.F.2
  • 52
    • 0022612268 scopus 로고
    • Endothelial cell membranes contain podocalyxin - The major sialoprotein of visceral glomerular epithelial cells
    • Horvat R, Hovorka A, Dekan G, Poczewski H, Kerjaschki D. Endothelial cell membranes contain podocalyxin - the major sialoprotein of visceral glomerular epithelial cells. J Cell Biol. 1986;102(2):484-491. (Pubitemid 16140809)
    • (1986) Journal of Cell Biology , vol.102 , Issue.2 , pp. 484-491
    • Horvat, R.1    Hovorka, A.2    Dekan, G.3
  • 53
    • 0036733653 scopus 로고    scopus 로고
    • A new method for large scale isolation of kidney glomeruli from mice
    • Takemoto M, et al. A new method for large scale isolation of kidney glomeruli from mice. Am J Pathol. 2002;161(3):799-805.
    • (2002) Am J Pathol. , vol.161 , Issue.3 , pp. 799-805
    • Takemoto, M.1
  • 54
    • 53149104790 scopus 로고    scopus 로고
    • Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity
    • Hartleben B, et al. Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. J Biol Chem. 2008;283(34):23033-23038.
    • (2008) J Biol Chem. , vol.283 , Issue.34 , pp. 23033-23038
    • Hartleben, B.1
  • 55
    • 55749105700 scopus 로고    scopus 로고
    • Proteinuria and hyperglycemia induce endoplasmic reticulum stress
    • Lindenmeyer MT, et al. Proteinuria and hyperglycemia induce endoplasmic reticulum stress. J Am Soc Nephrol. 2008;19(11):2225-2236.
    • (2008) J Am Soc Nephrol. , vol.19 , Issue.11 , pp. 2225-2236
    • Lindenmeyer, M.T.1
  • 56
    • 0036189998 scopus 로고    scopus 로고
    • A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression
    • Saleem MA, et al. A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J Am Soc Nephrol. 2002; 13(3):630-638.
    • (2002) J Am Soc Nephrol. , vol.13 , Issue.3 , pp. 630-638
    • Saleem, M.A.1
  • 57
    • 0031563832 scopus 로고    scopus 로고
    • Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines
    • Mundel P, et al. Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res. 1997;236(1):248-258.
    • (1997) Exp Cell Res. , vol.236 , Issue.1 , pp. 248-258
    • Mundel, P.1
  • 58
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya Y, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000; 19(21):5720-5728.
    • (2000) EMBO J. , vol.19 , Issue.21 , pp. 5720-5728
    • Kabeya, Y.1
  • 59
    • 33751225687 scopus 로고    scopus 로고
    • Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels
    • Huber TB, et al. Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A. 2006;103(46):17079-17086.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.46 , pp. 17079-17086
    • Huber, T.B.1
  • 60
    • 0038788840 scopus 로고    scopus 로고
    • Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling
    • Huber TB, et al. Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling. Mol Cell Biol. 2003;23(14):4917-4928.
    • (2003) Mol Cell Biol. , vol.23 , Issue.14 , pp. 4917-4928
    • Huber, T.B.1
  • 61
    • 0033536599 scopus 로고    scopus 로고
    • Congenital nephrotic syndrome in mice lacking CD2-associated protein
    • Shih NY, et al. Congenital nephrotic syndrome in mice lacking CD2-associated protein. Science. 1999;286(5438):312-315.
    • (1999) Science , vol.286 , Issue.5438 , pp. 312-315
    • Shih, N.Y.1


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