Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

Nature

Volumn 419, Issue 6904, 2002, Pages 316-321

  Kops, Geert J P L ^a,e   Dansen, Tobias B ^b   Polderman, Paulien E ^a   Saarloos, Ingrid ^a   Wirtz, Karel W A ^b   Coffer, Paul J ^a   Huang, Ting T ^c   Bos, Johannes L ^a   Medema, René H ^d   Burgering, Boudewijn M T ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NETHERLANDS CANCER INSTITUTE   (Netherlands)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENETIC ENGINEERING; GLUCOSE; OXYGEN; REDUCTION; RNA;

APOPTOSIS; FORKHEAD TRANSCRIPTION FACTOR;

ENZYMES;

GLUCOSE; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; PROTEIN KINASE B; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

BIOCHEMISTRY; OXYGEN;

APOPTOSIS; ARTICLE; CAENORHABDITIS ELEGANS; CHROMATIN; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; IMMUNOPRECIPITATION; MITOCHONDRIAL MEMBRANE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL SURVIVAL; CHROMATIN; CULTURE MEDIA, SERUM-FREE; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ENZYME INDUCTION; FORKHEAD TRANSCRIPTION FACTORS; GLUCOSE; HUMANS; INSULIN; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LONGEVITY; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MUTATION; OXIDATIVE STRESS; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 0037136563     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01036     Document Type: Article

References (27)

1. Beckman, K. B. & Ames, B. N. The free radical theory of aging matures. Physiol. Rev. 78, 547-581 (1998).
2. Gottlob, K. et al. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev. 15, 1406-1418 (2001).
3. Ogg, S. et al. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. Elegans. Nature 389, 994-999 (1997).
4. Paradis, S. & Ruvkun, G. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the to the DAF-16 transcription factor. Genes Dev. 12, 2488-2498 (1998).
5. Honda, Y. & Honda, S. The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J. 13, 1385-1393 (1999).
6. Taub, J. et al. A cytosolic catalase is needed to extend adult lifespan in C. Elegans daf-C and clk-1 mutants. Nature 399, 162-166 (1999).
7. Brunet, A. et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868 (1999).
8. Kops, G. J. et al. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398, 630-634 (1999).
9. Rena, G., Guo, S., Cichy, S. C., Unterman, T. G. & Cohen, P. Phosphorylation of the transcription factor Forkhead family member FKHR by protein kinase B. J. Biol. Chem. 274, 17179-17183 (1999).
10. Medema, R. H., Kops, G. J., Bos, J. L. & Burgering, B. M. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404, 782-787 (2000).
11. Kops, G. J. et al. Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol. Cell. Biol. 22, 2025-2036 (2002).
12. Littlewood, T. D., Hancock, D. C., Danielian, P. S., Parker, M. G. & Evan, G. I. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res. 23, 1686-1690 (1995).
13. 581/591. FEBS Left. 453, 278-282 (1999).
14. shc-dependent signaling pathway. Science 295, 2450-2452 (2002).
15. Dijkers, P. F. etal. FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J. Cell Biol. 156, 531-542 (2002).
16. Kim, H. P., Roe, J. H., Chock, P. B. & Yim, M. B. Transcriptional activation of the human manganese superoxide dismutase gene mediated by tetradecanoylphorbol acetate. J. Biol. Chem. 274, 37455-37460 (1999).
17. Furuyama, T., Nakazawa, T., Nakano, I. & Mori, N. Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem. J. 349, 629-634 (2000).
18. Scaduto, R. C. Jr. & Grotyohann, L. W. Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives. Biophys. J. 76, 469-477 (1999).
19. Aulwurm, U. R. & Brand, K. A. Increased formation of reactive oxygen species due to glucose depletion in primary cultures of rat thymocytes inhibits proliferation. Eur. J. Biochem. 267, 5693-5698 (2000).
20. Lee, Y. J. et al. Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells. J. Biol. Chem. 273, 5294-5299 (1998).
21. Blackburn, R. V. et al. Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumour cells. Free. Radic. Biol. Med. 26, 419-430 (1999).
22. Huang, T. T. et al. Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch. Biochem. Biophys. 344, 424-432 (1997).
23. Nakamura, N. et al. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol. Cell. Biol. 20, 8969-8982 (2000).
24. Tran, H. et al. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296, 530-534 (2002).
25. Kenyon, C. A conserved regulatory system for aging. Cell 105, 165-168 (2001).
26. Guareute, L. & Kenyon, C. Genetic pathways that regulate ageing in model organisms. Nature 408, 255-262 (2000).
27. Boyd, K. E., Wells, J., Gutman, J., Bartley, S. M. & Farnham, P. J. c-Myc target gene specificity is determined by a post-DNA binding mechanism. Proc. Natl Acad. Sci. USA 95, 13887-13892 (1998).