Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress

Circulation Research

Volumn 116, Issue 2, 2015, Pages 264-278

  Ikeda, Yoshiyuki ^a   Shirakabe, Akihiro ^a   Maejima, Yasuhiro ^a   Zhai, Peiyong ^a   Sciarretta, Sebastiano ^a,b   Toli, Jessica ^a   Nomura, Masatoshi ^c   Mihara, Katsuyoshi ^c   Egashira, Kensuke ^c   Ohishi, Mitsuru ^d   Abdellatif, Maha ^a   Sadoshima, Junichi ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b IRCCS NEUROMED   (Italy)

^c KYUSHU UNIVERSITY HOSPITAL   (Japan)

^d KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

autophagy; Drp1 protein, mouse; heart; ischemia reperfusion injury; mitochondria

Indexed keywords

DYNAMIN RELATED PROTEIN 1; MDIVI 1; PROTEIN; PROTEIN INHIBITOR; TAMOXIFEN; UNCLASSIFIED DRUG; DNM1L PROTEIN, MOUSE; DYNAMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CONTROLLED STUDY; DIET RESTRICTION; GLUCOSE METABOLISM; HEART INFARCTION SIZE; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART PROTECTION; HEART STRESS; KNOCKOUT MOUSE; LYSOSOME; MITOCHONDRIAL TARGETING SIGNAL; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPERFUSION INJURY; ANIMAL; ENERGY METABOLISM; HEART MITOCHONDRION; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGY; RAT; TRANSGENIC MOUSE; WISTAR RAT;

ANIMALS; AUTOPHAGY; DYNAMINS; ENERGY METABOLISM; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; OXIDATIVE STRESS; RATS; RATS, WISTAR;

EID: 84921985434     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.303356     Document Type: Article

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