IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Nature

Volumn 421, Issue 6919, 2003, Pages 182-187

  Holzenberger, Martin ^a   Dupont, Joëlle ^b   Ducos, Bertrand ^a   Leneuve, Patricia ^a   Géloën, Alain ^c   Even, Patrick C ^d   Cervera, Pascale ^a   Le Bouc, Yves ^a  

^a HÔPITAL SAINT ANTOINE   (France)

^b CEMAGREF   (France)

^c INSERM   (France)

^d AGROPARISTECH   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; GENES; INSULIN; METABOLISM;

OXIDATIVE STRESS;

GENETIC ENGINEERING;

BILIRUBIN; CHOLESTEROL; CREATININE; GLUCOSE; LACTIC ACID; RNA; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; TRIACYLGLYCEROL; TYROSINE KINASE RECEPTOR; UREA; URIC ACID;

GENE; LIFE EXPECTANCY; STRESS;

ADOLESCENT; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; DWARFISM; EMBRYO; ENERGY METABOLISM; FEMALE; FERTILITY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; KNOCKOUT MOUSE; LIFESPAN; LONGEVITY; MALE; MAMMAL; MOUSE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REPRODUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGING; ANIMALS; BLOOD GLUCOSE; CELLS, CULTURED; FEMALE; FERTILITY; FIBROBLASTS; GENE DELETION; GLUCOSE TOLERANCE TEST; LIGANDS; LONGEVITY; MALE; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS; PHENOTYPE; RECEPTOR, IGF TYPE 1; SEXUAL MATURATION; SIGNAL TRANSDUCTION;

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; INVERTEBRATA; MAMMALIA; MELANOGASTER;

EID: 0347664057     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01298     Document Type: Article

References (30)

1. Guarente, L. & Kenyon, C. Genetic pathways that regulate ageing in model organisms. Nature 408, 255-262 (2000).
2. Kenyon, C. A conserved regulatory system for aging. Cell 105, 165-168 (2001).
3. Gems, D. & Partridge, L. Insulin/IGF signalling and ageing: seeing the bigger picture. Curr. Opin. Genes. Dev. 11, 287-292 (2001).
4. Kimura, K. D., Tissenbaum, H. A., Liu, Y. & Ruvkun, G. Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277, 942-946 (1997).
5. Tissenbaum, H. A. & Ruvkun, G. An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics 148, 703-717 (1998).
6. Tatar, M. et al. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292, 107-110 (2001).
7. Bartke, A. Mutations prolong life in flies; implications for aging in mammals. Trends Endocrinol. Metab. 12, 233-234 (2001).
8. Clancy, D. J. et al. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104-106 (2001).
9. Kulkarni, R. N. et al. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96, 329-339 (1999).
10. Lupu, L., Terwilliger, J. D., Lee, K., Segre, G. V. & Efstratiadis, A. Roles of growth hormone and insulin-like growth factor I in mouse postnatal growth. Dev. Biol. 229, 141-162 (2001).
11. Flurkey, K., Papaconstantinou, J., Miller, R. A. & Harrison, D. E. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl Acad. Sci. USA 98, 6736-6741 (2001).
12. Brown-Borg, H. M., Borg, K. E., Meliska, C. J. & Bartke, A. Dwarf mice and the ageing process. Nature 384, 33 (1996).
13. Coschigano, K. T., Clemmons, D., Bellushi, L. L. & Kopchick, J. J. Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology 141, 2608-2613 (2000).
14. Holzenberger, M. et al. Experimental IGF-I receptor deficiency generates a sexually dimorphic pattern of organ-specific growth deficits in mice, affecting fat tissue in particular. Endocrinology 142, 4469-4478 (2001).
15. Holzenberger, M. et al. A targeted partial invalidation of the insulin-like growth factor I receptor gene in mice causes a postnatal growth deficit. Endocrinology 141, 2557-2566 (2000).
16. Liu, J. P., Baker, J., Perkins, A. S., Robertson, E. J. & Efstratiadis, A. Mice carrying null mutations of the genes encoding insulin-like growth factor 1 (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75, 59-72 (1993).
17. Storer, J. B. Longevity and gross pathology at death in 22 inbred mouse strains. J. Gerontol. 21, 404-409 (1966).
18. Stevens, L. C. & Little, C. C. Spontaneous testicular teratomas in an inbred strain of mice. Proc. Natl Acad. Sci. USA 40, 1080-1087 (1954).
19. Smith, G. S., Walford, R. L. & Mickey, M. R. Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their F1 hybrids. J. Natl Cancer Inst. 50, 1195-1213 (1973).
20. Whithers, D. J. et al. Irs-2 coordinates IGF-1 receptor-mediated β-cell development and peripheral insulin signalling. Nature Genet. 23, 32-39 (1999).
21. Hunter, W. S., Croson, W. B., Bartke, A., Gentry, M. V. & Meliska, C. J. Low body temperature in long-lived Ames dwarf mice at rest and during stress.-Physiol. Behav. 67, 433-437 (1999).
22. Finkel, T. & Holbrook, N. J. Oxidants, oxidative stress and the biology of ageing. Nature 408, 239-247 (2000).
23. she adaptor protein controls oxidative stress response and life span in mammals. Nature 402, 309-313 (1999).
24. Sun, J. & Tower, J. FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol. Cell Biol. 19, 216-228 (1999).
25. Bartke, A. et al. Extending the lifespan of long-lived mice. Nature 414, 412 (2001).
26. Kulkarni, R. N. et al. β-cell specific deletion of the IGF-1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass. Nature Genet. 31, 111-115 (2002).
27. Clancy, D. J., Gems, D., Hafen, E., Leevers, S. J. & Partridge, L. Dietary restriction in long-lived dwarf flies. Science 296, 319 (2002).
28. Honda, Y. & Honda, S. Oxidative stress and life span determination in the nematode Caenorhabditis elegans. Ann. NY Acad. Sci. 959, 466-474 (2002).
29. Wolkow, C. A., Kimura, K. D., Lee,M. S. & Ruvkun, G. Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science 290, 147-150 (2000).
30. Dupont, J., Karas, M. & LeRoith, D. The potentiation of estrogen on insulin-like growth factor 1 action in MCF-7 human breast cancer cells includes cell cycle components. J. Biol. Chem. 275, 35893-35901 (2000).