MiR-216a: A link between endothelial dysfunction and autophagy

Cell Death and Disease

Volumn 5, Issue 1, 2014, Pages

  Menghini, R ^a   Casagrande, V ^a   Marino, A ^a   Marchetti, V ^a   Cardellini, M ^a   Stoehr, R ^a   Rizza, S ^a   Martelli, E ^a   Greco, S ^b   Mauriello, A ^a   Ippoliti, A ^a   Martelli, F ^b   Lauro, R ^a   Federici, M ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b IRCCS POLICLINICO SAN DONATO   (Italy)

Author keywords

Atherosclerosis; Autophagy; Endothelial dysfunction; microRNAs

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; MICRORNA; MICRORNA 216A; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; OXIDIZED LOW DENSITY LIPOPROTEIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; ATG5 PROTEIN, HUMAN; BECN1 PROTEIN, HUMAN; LOW DENSITY LIPOPROTEIN; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; MIRN216 MICRORNA, HUMAN;

ADULT; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; AUTOPHAGY; CELL ADHESION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; CYTOFLUOROMETRY; ENDOTHELIAL DYSFUNCTION; FEMALE; HEART FAILURE; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; UMBILICAL VEIN ENDOTHELIAL CELL; CYTOLOGY; GENETICS; METABOLISM; PATHOPHYSIOLOGY;

APOPTOSIS REGULATORY PROTEINS; ATHEROSCLEROSIS; AUTOPHAGY; HEART FAILURE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LIPOPROTEINS, LDL; MEMBRANE PROTEINS; MICRORNAS; MICROTUBULE-ASSOCIATED PROTEINS;

EID: 84903318420     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.556     Document Type: Article

References (38)

1. North BJ, Sinclair DA. The intersection between aging and cardiovascular disease. Circ Res 2012; 110: 1097-1108.
2. Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation 2004; 109: III27-III32. (Pubitemid 38786440)
3. Martinet W, De Meyer GR. Autophagy in atherosclerosis: a cell survival and death phenomenon with therapeutic potential. Circ Res 2009; 104: 304-317.
4. Gustafsson ÅB, Gottlieb RA. Autophagy in ischemic heart disease. Circ Res. 2009; 104: 150-158.
5. Cuervo AM. Autophagy and aging: keeping that old broom working. Trends Genet 2008; 24: 604-612.
6. Salminen A, Kaarniranta K. Regulation of the aging process by autophagy. Trends Mol Med 2009; 15: 217-224.
7. Lewis A. Oxidative modification of LDL and atherogenesis. Steinberg D. Circulation 1997; 95: 1062-1071.
8. Zhang YL, Cao YJ, Zhang X, Liu HH, Tong T, Xiao GD et al. The autophagy-lysosome pathway: a novel mechanism involved in the processing of oxidized LDL in human vascular endothelial cells. Biochem Biophys Res Commun 2010; 394: 377-382.
9. Muller C, Salvayre R, Nègre-Salvayre A, Vindis C. HDLs inhibit endoplasmic reticulum stress and autophagic response induced by oxidized LDLs. Cell Death Differ 2011; 18: 817-828.
10. Ding Z, Wang X, Schnackenberg L, Khaidakov M, Liu S, Singla S et al. Regulation of autophagy and apoptosis in response to ox-LDL in vascular smooth muscle cells, and the modulatory effects of the microRNA hsa-let-7g. Int J Cardiol 2013; 168: 1378-1385.
11. Fridman AL, Tainsky MA. Critical pathways in cellular senescence and immortalization revealed by gene expression profiling. Oncogene 2008; 27: 5975-5987.
12. Urbich C, Kuehbacher A, Dimmeler S. Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res 2008; 79: 581-588.
13. Schroen B, Heymans S. Small but smart-microRNAs in the centre of inflammatory processes during cardiovascular diseases, the metabolic syndrome, and ageing. Cardiovasc Res 2012; 93: 605-613.
14. Menghini R, Casagrande V, Cardellini M, Martelli E, Terrinoni A, Amati F et al. MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation 2009; 120: 1524-1532.
15. Vasa-Nicotera M, Chen H, Tucci P, Yang AL, Saintigny G, Menghini R et al. miR-146a is modulated in human endothelial cell with aging. Atherosclerosis 2011; 217: 326-330.
16. Razani B, Feng C, Coleman T, Emanuel R, Wen H, Hwang S et al. Autophagy links inflammasomes to atherosclerotic progression. Cell Metab 2012; 15: 534-544.
17. Greco S, Fasanaro P, Castelvecchio S, D'Alessandra Y, Arcelli D, Di Donato M et al. MicroRNA Dysregulation in Diabetic Ischemic Heart Failure Patients. Diabetes 2012; 61: 1633-1641.
18. Tsutsui T, Tsutamoto T, Wada A, Maeda K, Mabuchi N, Hayashi M et al. Plasma oxidized low-density lipoprotein as a prognostic predictor in patients with chronic congestive heart failure. J Am Coll Cardiol 2002; 39: 957-962. (Pubitemid 34234116)
19. Rubinsztein DC, Mariño G, Kroemer G. Autophagy and aging. Cell 2011; 146: 682-695.
20. Kang HT, Lee KB, Kim SY, Choi HR, Park SC. Autophagy impairment induces premature senescence in primary human fibroblasts. PLoS One 2011; 6: e23367.
21. Korkmaz G, le Sage C, Tekirdag KA, Agami R, Gozuacik D. miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy 2012; 8: 165-176.
22. Zhu H, Wu H, Liu X, Li B, Chen Y, Ren X et al. Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy 2009; 5: 816-823.
23. Pan W, Zhong Y, Cheng C, Liu B, Wang L, Li A et al. MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy. PLoS One 2013; 8: e53950.
24. Brown MS, Goldstein JL. Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu Rev Biochem 1983; 52: 223-261. (Pubitemid 13030685)
25. Liu ML, Ylitalo K, Salonen R, Salonen JT, Taskinen MR. Circulating oxidized low-density lipoprotein and its association with carotid intima-media thickness in asymptomatic members of familial combined hyperlipidemia families. Arterioscler Thromb Vasc Biol 2004; 24: 1492-1497. (Pubitemid 39050446)
26. Wu J, Shi YH, Niu DM, Li HQ, Zhang CN, Wang J. Association among retinol-binding protein 4, small dense LDL cholesterol and oxidized LDL levels in dyslipidemia subjects. J Clin Biochem 2012; 45: 619-622.
27. Boak L, Chin-Dusting JP. Hypercholesterolemia and endothelium dysfunction: role of dietary supplementation as vascular protective agents. Curr Vasc Pharmacol 2004; 2: 45-52. (Pubitemid 38855014)
28. MacCarthy PA, Shah AM. Impaired endothelium-dependent regulation of ventricular relaxation in pressure-overload cardiac hypertrophy. Circulation 2000; 101: 1854-1860. (Pubitemid 30213109)
29. Fraccarollo D, Widder JD, Galuppo P, Thum T, Tsikas D, Hoffmann M et al. Improvementin left ventricular remodeling by the endothelial nitric oxide synthase enhancerAVE9488 after experimental myocardial infarction. Circulation 2008; 118: 818-827.
30. Singal PK, Kapur N, Dhillon KS, Beamish RE, Dhalla NS. Role of free radicals in catecholamine-induced cardiomyopathy. Can J Physiol Pharmacol 1982; 60: 1390-1397. (Pubitemid 13209544)
31. Buss SJ, Muenz S, Riffel JH, Malekar P, Hagenmueller M, Weiss CS et al. Beneficial effects of Mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction. J Am Coll Cardiol 2009; 54: 2435-2446.
32. Menghini R, Casagrande V, Federici M. MicroRNAs in Endothelial Senescence and Atherosclerosis. J Cardiovasc Transl Res 2013; 6: 924-930.
33. Tijsen AJ, Pinto YM, Creemers EE. Non-cardiomyocyte microRNAs in heart failure. Cardiovasc Res 2012; 93: 573-582.
34. Federici M, Pandolfi A, De Filippis EA, Pellegrini G, Menghini R, Lauro D et al. G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells. Circulation 2004; 109: 399-405. (Pubitemid 38133910)
35. Maciag T, Hoover GA, Stemerman MB, Weinstein R. Serial propagation of human endothelial cells in vitro. J Cell Biol 1981; 91: 420-426. (Pubitemid 12215630)
36. Menghini R, Menini S, Amoruso R, Fiorentino L, Casagrande V, Marzano V et al. Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice. Gastroenterology 2009; 136: 663-672.
37. Mauriello A, Sangiorgi GM, Virmani R, Trimarchi S, Holmes DR Jr, Kolodgie FD et al. A pathobiologic link between risk factors profile and morphological markers of carotid instability. Atherosclerosis 2010; 208: 572-580.
38. Castelvecchio S, Menicanti L, Donato MD. Surgical ventricular restoration to reverse left ventricular remodeling. Curr Cardiol Rev 2010; 6: 15-23.