Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle

Science

Volumn 344, Issue 6184, 2014, Pages 649-652

  Sinha, Manisha ^a,b,c,d   Jang, Young C ^a,b,d   Oh, Juhyun ^a,b,d   Khong, Danika ^a,b,d   Wu, Elizabeth Y ^a,b,d   Manohar, Rohan ^a,b,d   Miller, Christine ^a,b,d   Regalado, Samuel G ^a,e   Loffredo, Francesco S ^a,f   Pancoast, James R ^a,f   Hirshman, Michael F ^b   Lebowitz, Jessica ^a,b,d   Shadrach, Jennifer L ^a,b,c   Cerletti, Massimiliano ^a,b,h   Kim, Mi Jeong ^b   Serwold, Thomas ^b   Goodyear, Laurie J ^b,f   Rosner, Bernard ^g   Lee, Richard T ^a,f   Wagers, Amy J ^a,b,c,d  

^a Harvard University   (United States)

^b JOSLIN DIABETES CENTER   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^h UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH DIFFERENTIATION FACTOR 11; GROWTH FACTOR; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; BONE MORPHOGENETIC PROTEIN; GDF11 PROTEIN, MOUSE; GROWTH DIFFERENTIATION FACTOR;

GENOME; GROWTH RATE; MUSCLE; PROTEIN; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDURANCE TRAINING; FUNCTIONAL DISEASE; GENOMICS; MOUSE; MUSCLE CELL; MUSCLE STRENGTH; MYOPATHY; NONHUMAN; PARABIOSIS; PRIORITY JOURNAL; REJUVENATION; SKELETAL MUSCLE; SKELETAL MUSCLE SATELLITE CELL; SUPPLEMENTATION; AGE; AGING; ANIMAL; BLOOD; C57BL MOUSE; DRUG EFFECTS; MALE; MYOBLAST; PHYSIOLOGY; REGENERATION; VASCULARIZATION;

AGE FACTORS; AGING; ANIMALS; BONE MORPHOGENETIC PROTEINS; GROWTH DIFFERENTIATION FACTORS; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; MYOBLASTS, SKELETAL; PARABIOSIS; REGENERATION; REJUVENATION;

EID: 84900323323     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1251152     Document Type: Article

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