AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction

Aging Cell

Volumn 9, Issue 4, 2010, Pages 592-606

  Turdi, Subat ^a   Fan, Xiujuan ^a   Li, Ji ^a   Zhao, Junxing ^b   Huff, Anna F ^a   Du, Min ^b   Ren, Jun ^a  

^a Department of Medicine   (United States)

^b UNIVERSITY OF WYOMING   (United States)

Author keywords

AMP activated protein kinase; Cardiomyocytes; Contractile function; Morphology; Myocardial

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2A; UNCLASSIFIED DRUG; GLUCOSE TRANSPORTER 4; HEAT SHOCK PROTEIN 90; ISOENZYME; PPARGC1A PROTEIN, MOUSE; SLC2A4 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL STRUCTURE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; GENE OVEREXPRESSION; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE HYPERTROPHY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MYOCARDIAL DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; CALCIUM SIGNALING; CELL MEMBRANE; DRUG EFFECT; ELECTROCARDIOGRAPHY; ENZYMOLOGY; HEART CONTRACTION; HEART MUSCLE; INTRACELLULAR SPACE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; ULTRASTRUCTURE;

AGING; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CALCIUM SIGNALING; CELL MEMBRANE; ELECTROCARDIOGRAPHY; GLUCOSE TRANSPORTER TYPE 4; HSP90 HEAT-SHOCK PROTEINS; INTRACELLULAR SPACE; ISOENZYMES; MEMBRANE POTENTIAL, MITOCHONDRIAL; METFORMIN; MICE; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; TRANS-ACTIVATORS;

EID: 78049438321     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2010.00586.x     Document Type: Article

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