Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Yamamoto, Takanobu ^a   Byun, Jaemin ^a   Zhai, Peiyong ^a   Ikeda, Yoshiyuki ^a   Oka, Shinichi ^a   Sadoshima, Junichi ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE NUCLEOTIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; SIRTUIN 1; TRANSCRIPTION FACTOR FKHR; CARDIOTONIC AGENT; SIRT1 PROTEIN, MOUSE;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; DRUG MECHANISM; HEART INJURY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; ISCHEMIC PRECONDITIONING; MALE; MOUSE; NONHUMAN; UPREGULATION; ANIMAL; BIOSYNTHESIS; COMPLICATION; DEFICIENCY; DRUG EFFECTS; HEART; METABOLISM; MYOCARDIAL INFARCTION; PATHOPHYSIOLOGY; REPERFUSION INJURY;

ANIMALS; CALORIC RESTRICTION; CARDIOTONIC AGENTS; HEART; ISCHEMIC PRECONDITIONING; MALE; MICE; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; NAD; NICOTINAMIDE MONONUCLEOTIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; REPERFUSION INJURY; SIRTUIN 1; UP-REGULATION;

EID: 84902579141     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0098972     Document Type: Article

References (29)

1. Yellon DM, Hausenloy DJ (2007) Myocardial reperfusion injury. N Engl J Med 357: 1121-1135.
2. Morrison A, Li J (2011) PPAR-γ and AMPK - advantageous targets for myocardial ischemia/reperfusion therapy. Biochem Pharmacol 82: 195-200.
3. Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, et al. (2007) Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion. Roles of AMP-Activated Protein Kinase and Beclin 1 in Mediating Autophagy. Circ Res 100: 914-922. (Pubitemid 46555697)
4. Majno G, Joris I (1995) Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 146: 3-15.
5. Sanada S, Komuro I, Kitakaze M (2011) Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures. Am J Physiol Heart Circ Physiol 301: H1723-1741.
6. Bolli R (2007) Preconditioning: a paradigm shift in the biology of myocardial ischemia. Am J Physiol Heart Circ Physiol 292: H19-27.
7. Nadtochiy SM, Redman E, Rahman I, Brookes PS (2011) Lysine deacetylation in ischaemic preconditioning: the role of SIRT1. Cardiovasc Res 89: 643-649.
8. Hsu CP, Zhai P, Yamamoto T, Maejima Y, Matsushima S, et al. (2010) Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation 122: 2170-2182.
9. Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, et al. (2007) Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res 100: 1512-1521. (Pubitemid 46834764)
10. Imai S, Armstrong CM, Kaeberlein M, Guarente L (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403: 795-800. (Pubitemid 30111843)
11. Stein LR, Imai S (2012) The dynamic regulation of NAD metabolism in mitochondria. Trends Endocrinol Metab 23: 420-428.
12. Imai S (2011) Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis. FEBS Lett 585: 1657-1662.
13. Hsu CP, Oka S, Shao D, Hariharan N, Sadoshima J (2009) Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes. Circ Res 105: 481-491.
14. Revollo JR, Korner A, Mills KF, Satoh A, Wang T, et al. (2007) Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab 6: 363-375. (Pubitemid 350011996)
15. Hariharan N, Zhai P, Sadoshima J (2010) Oxidative Stress Stimulates Autophagic Flux during Ischemia/Reperfusion. Antioxid Redox Signal 14: 2179-2190.
16. Hariharan N, Maejima Y, Nakae J, Paik J, Depinho RA, et al. (2010) Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circ Res 107: 1470-1482.
17. Shinmura K, Tamaki K, Bolli R (2008) Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1. Am J Physiol Heart Circ Physiol 295: H2348-2355.
18. Shinmura K (2013) Post-translational modification of mitochondrial proteins by caloric restriction: possible involvement in caloric restriction-induced cardioprotection. Trends Cardiovasc Med 23: 18-25.
19. Donmez G, Guarente L (2010) Aging and disease: connections to sirtuins. Aging Cell 9: 285-290.
20. Montecucco F, Bauer I, Braunersreuther V, Bruzzone S, Akhmedov A, et al. (2013) Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction. Antioxid Redox Signal 18: 630-641.
21. Pittelli M, Felici R, Pitozzi V, Giovannelli L, Bigagli E, et al. (2011) Pharmacological effects of exogenous NAD on mitochondrial bioenergetics, DNA repair, and apoptosis. Mol Pharmacol 80: 1136-1146.
22. Pillai VB, Sundaresan NR, Kim G, Samant S, Moreno-Vinasco L, et al. Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling. Am J Physiol Heart Circ Physiol 304: H415-426.
23. Yamamoto T, Sadoshima J (2011) Protection of the heart against ischemia/reperfusion by silent information regulator 1. Trends Cardiovasc Med 21: 27-32.
24. Oka S, Hsu CP, Sadoshima J (2012) Regulation of cell survival and death by pyridine nucleotides. Circ Res 111: 611-627.
25. Koltai E, Szabo Z, Atalay M, Boldogh I, Naito H, et al. (2010) Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats. Mech Ageing Dev 131: 21-28.
26. Tao R, Wei D, Gao H, Liu Y, DePinho RA, et al. (2011) Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene. J Biol Chem 286: 14681-14690.
27. Mayi TH, Rigamonti E, Pattou F, Staels B, Chinetti-Gbaguidi G (2011) Liver X Receptor (LXR) activation negatively regulates visfatin expression in macrophages. Biochem Biophys Res Commun 404: 458-462.
28. Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, et al. (2008) Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell 14: 661-673. (Pubitemid 351622608)
29. Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, et al. (2009) Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 324: 651-654.