Pharmacological modulation of autophagy during cardiac stress

Journal of Cardiovascular Pharmacology

Volumn 60, Issue 3, 2012, Pages 235-241

  Sciarretta, Sebastiano ^a,b   Zhai, Peiyong ^a   Volpe, Massimo ^b,c   Sadoshima, Junichi ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b IRCCS NEUROMED   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

autophagy; cardiac hypertrophy; heart; ischemia; reperfusion

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; AMIODARONE; CARBAMAZEPINE; CHLOROQUINE PLUS HYDROXYCHLOROQUINE SULFATE PLUS MEPACRINE; CLONIDINE; EVEROLIMUS; FLUSPIRILENE; INOSITOL 1,4,5 TRISPHOSPHATE; LITHIUM; LOPERAMIDE; MAMMALIAN TARGET OF RAPAMYCIN; NICLOSAMIDE; NIGULDIPINE; NIMODIPINE; NITRENDIPINE; PERHEXILINE; PERIFOSINE; PIMOZIDE; RAPAMYCIN; RESVERATROL; RILMENIDINE; TEMSIROLIMUS; TRANSCRIPTION FACTOR FOXO; TREHALOSE; TRICIRIBINE; TRIFLUOPERAZINE; UNINDEXED DRUG; VALPROIC ACID; VERAPAMIL; VIDARABINE;

APOPTOSIS; AUTOPHAGOSOME; AUTOPHAGY; CALCIUM CELL LEVEL; CANCER THERAPY; CARCINOGENESIS; CELL DEATH; CELL EXPANSION; CELL MATURATION; CORONARY ARTERY RECANALIZATION; DEACETYLATION; DISEASE SEVERITY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HEART FAILURE; HEART FUNCTION; HEART MUSCLE CELL; HEART STRESS; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HUMAN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; AUTOPHAGY; CARDIOVASCULAR AGENTS; ENZYME INHIBITORS; HEART DISEASES; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE; STRESS, PHYSIOLOGICAL; TOR SERINE-THREONINE KINASES;

EID: 84866312155     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3182575f61     Document Type: Review

References (41)

1. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008;132:27-42.
2. Ravikumar B, Sarkar S, Davies JE, et al. Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev. 2010;90: 1383-1435.
3. Djavaheri-Mergny M, Maiuri MC, Kroemer G. Cross talk between apoptosis and autophagy by caspase-mediated cleavage of beclin 1. Oncogene. 2010;29:1717-1719.
4. Ullman E, Fan Y, Stawowczyk M, et al. Autophagy promotes necrosis in apoptosis-deficient cells in response to er stress. Cell Death Differ. 2008; 15:422-425.
5. Nishida K, Kyoi S, Yamaguchi O, et al. The role of autophagy in the heart. Cell Death Differ. 2009;16:31-38.
6. Youle RJ, Narendra DP. Mechanisms of mitophagy. Nat Rev Mol Cell Biol. 2011;12:9-14.
7. Fleming A, Noda T, Yoshimori T, et al. Chemical modulators of autophagy as biological probes and potential therapeutics. Nat Chem Biol. 2011; 7:9-17.
8. Mihaylova MM, Shaw RJ. The ampk signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol. 2011;13:1016-1023.
9. Meijer AJ, Codogno P. Amp-activated protein kinase and autophagy. Autophagy. 2007;3:238-240. (Pubitemid 46752685)
10. Mammucari C, Schiaffino S, Sandri M. Downstream of akt: FOXO3 and mtor in the regulation of autophagy in skeletal muscle. Autophagy. 2008; 4:524-526. (Pubitemid 351705153)
11. Zhai P, Sciarretta S, Galeotti J, et al. Differential roles of gsk-3{beta} during myocardial ischemia and ischemia/reperfusion. Circ Res. 2011; 109:502-511.
12. Carew JS, Nawrocki ST, Giles FJ, et al. Targeting autophagy: A novel anticancer strategy with therapeutic implications for imatinib resistance. Biologics. 2008;2:201-204.
13. Hidvegi T, Ewing M, Hale P, et al. An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin z and reduces hepatic fibrosis. Science. 2010;329:229-232.
14. Williams A, Sarkar S, Cuddon P, et al. Novel targets for huntington's disease in an mtor-independent autophagy pathway. Nat Chem Biol. 2008;4:295-305. (Pubitemid 351550888)
15. de Medina P, Silvente-Poirot S, Poirot M. Tamoxifen and aebs ligands induced apoptosis and autophagy in breast cancer cells through the stimulation of sterol accumulation. Autophagy. 2009;5:1066-1067.
16. Sarkar S, Davies JE, Huang Z, et al. Trehalose, a novel mtor-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem. 2007;282:5641-5652. (Pubitemid 47093730)
17. Floto RA, Sarkar S, Perlstein EO, et al. Small molecule enhancers of rapamycin-induced tor inhibition promote autophagy, reduce toxicity in huntington's disease models and enhance killing of mycobacteria by macrophages. Autophagy. 2007;3:620-622. (Pubitemid 350060063)
18. Qu X, Yu J, Bhagat G, et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 2003;112: 1809-1820. (Pubitemid 38063704)
19. Kimmelman AC. The dynamic nature of autophagy in cancer. Genes Dev. 2011;25:1999-2010.
20. Nakai A, Yamaguchi O, Takeda T, et al. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med. 2007;13:619-624. (Pubitemid 46828485)
21. Zhu H, Tannous P, Johnstone JL, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007;117:1782-1793. (Pubitemid 47036312)
22. McMullen JR, Sherwood MC, Tarnavski O, et al. Inhibition of mtor signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. Circulation. 2004;109:3050-3055. (Pubitemid 38808328)
23. Zhang CX, Pan SN, Meng RS, et al. Metformin attenuates ventricular hypertrophy by activating the amp-activated protein kinase-endothelial nitric oxide synthase pathway in rats. Clin Exp Pharmacol Physiol. 2011; 38:55-62.
24. Li HL, Yin R, Chen D, et al. Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overload-induced cardiac hypertrophy. J Cell Biochem. 2007;100:1086-1099. (Pubitemid 46480392)
25. Shibata R, Ouchi N, Ito M, et al. Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med. 2004;10:1384-1389. (Pubitemid 40022722)
26. Valentim L, Laurence KM, Townsend PA, et al. Urocortin inhibits beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury. J Mol Cell Cardiol. 2006;40:846-852. (Pubitemid 43817043)
27. Cao DJ, Wang ZV, Battiprolu PK, et al. Histone deacetylase (hdac) inhibitors attenuate cardiac hypertrophy by suppressing autophagy. Proc Natl Acad Sci U S A. 2011;108:4123-4128.
28. Pattison JS, Osinska H, Robbins J. Atg7 induces basal autophagy and rescues autophagic deficiency in cryabr120g cardiomyocytes. Circ Res. 2011;109:151-160.
29. Tannous P, Zhu H, Johnstone JL, et al. Autophagy is an adaptive response in desmin-related cardiomyopathy. Proc Natl Acad Sci U S A. 2008;105:9745-9750. (Pubitemid 352031371)
30. Yan L, Sadoshima J, Vatner DE, et al. Autophagy in ischemic preconditioning and hibernating myocardium. Autophagy. 2009;5:709-712.
31. Matsui Y, Takagi H, Qu X, et al. Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of amp-activated protein kinase and beclin 1 in mediating autophagy. Circ Res. 2007;100:914-922. (Pubitemid 46555697)
32. Sciarretta S, Zhai P, Shao D, et al. Rheb is a critical regulator of autophagy during myocardial ischemia: Pathophysiological implications in obesity and metabolic syndrome. Circulation. 2012;125:1134-1146.
33. Hariharan N, Zhai P, Sadoshima J. Oxidative stress stimulates autophagic flux during ischemia/reperfusion. Antioxid Redox Signal. 2011;14:2179-2190.
34. Sala-Mercado JA, Wider J, Undyala VV, et al. Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury. Circulation. 2010;122:S179-S184.
35. Huang C, Liu W, Perry CN, et al. Autophagy and protein kinase c are required for cardioprotection by sulfaphenazole. Am J Physiol Heart Circ Physiol. 2010;298:H570-H579.
36. Hsu CP, Hariharan N, Alcendor RR, et al. Nicotinamide phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes. Autophagy. 2009;5:1229-1231.
37. Hariharan N, Maejima Y, Nakae J, et al. Deacetylation of foxo by sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes. Circ Res. 2010;107:1470-1482.
38. Noh HS, Shin IW, Ha JH, et al. Propofol protects the autophagic cell death induced by the ischemia/reperfusion injury in rats. Mol Cells. 2010; 30:455-460.
39. Granville DJ, Tashakkor B, Takeuchi C, et al. Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome p450 inhibitors. Proc Natl Acad Sci U S A. 2004;101:1321-1326. (Pubitemid 38182687)
40. Nishida Y, Arakawa S, Fujitani K, et al. Discovery of atg5/atg7-independent alternative macroautophagy. Nature. 2009;461:654-658.
41. Huang C, Andres AM, Ratliff EP, et al. Preconditioning involves selective mitophagy mediated by parkin and p62/sqstm1. PLoS One. 2011;6: E20975.