Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

Autophagy

Volumn 4, Issue 2, 2008, Pages 176-184

  Simonsen, Anne ^a,b   Cumming, Robert C ^a,c   Brech, Andreas ^a,b   Isakson, Pauline ^a,b   Schubert, David R ^a   Finley, Kim D ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Aging; Atg8a; Drosophila; Insoluble ubiquitinated proteins; Macroautophagy; Oxidative stress; Protein aggregates; Quantitative RT PCR

Indexed keywords

OXIDIZING AGENT; REACTIVE OXYGEN METABOLITE;

AGING; ARTICLE; ATG8A GENE; AUTOPHAGY; CELL DAMAGE; CONTROLLED STUDY; DROSOPHILA; GENE; GENE EXPRESSION; GENE MUTATION; LIFESPAN; LONGEVITY; NERVE DEGENERATION; NERVOUS SYSTEM; NONHUMAN; OXIDATIVE STRESS; PROTEIN AGGREGATION; UBIQUITINATION;

MUS;

EID: 38949099761     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.5269     Document Type: Article

References (35)

1. Reggiori F, Klionsky DJ. Autophagosomes: Biogenesis from scratch? Curr Opin Cell Biol 2005; 17:415-22.
2. Klionsky DJ, Cregg JM, Dunn Jr WA, Emr SD, Sakai Y, Sandoval IV, Sibirny A, Subramani S, Thumm M, Veenhuis M, Ohsumi Y. A unified nomenclature for yeast autophagy-related genes. Dev Cell 2003; 5:539-45.
3. Cuervo AM, Bergamini E, Brunk UT, Droge W, Ffrench M, Terman A. Autophagy and aging: The importance of maintaining "clean" cells. Autophagy 2005; 1:131-40.
4. Huang J, Klionsky DJ. Autophagy and human disease. Cell Cycle (Georgetown, Tex) 2007; 6:1837-49.
5. Levine B. Cell biology: Autophagy and cancer. Nature 2007; 446:745-7.
6. Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, Mizushima N. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006; 441:885-9.
7. Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, Tanaka K. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006; 441:880-4.
8. Donati A. The involvement of macroautophagy in aging and anti-aging interventions. Mol Aspects Med 2006; 27:455-70.
9. Hwangbo DS, Gershman B, Tu MP, Palmer M, Tatar M. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 2004; 429:562-6.
10. Finley KD, Edeen PT, Cumming RC, Mardahl-Dumesnil MD, Taylor BJ, Rodriguez MH, Hwang CE, Benedetti M, McKeown M. Blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration. J Neurosci 2003; 23:1254-64.
11. Tatar M, Khazaeli AA, Curtsinger JW. Chaperoning extended life. Nature 1997; 390:30.
12. Whitworth AJ, Theodore DA, Greene JC, Benes H, Wes PD, Pallanck LJ. Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. Proc Natl Acad Sci USA 2005; 102:8024-9.
13. Rorth P. A modular misexpression screen in Drosophila detecting tissue-specific phenotypes. Proc Natl Acad Sci USA 1996; 93:12418-22.
14. Simonsen A, Cumming RC, Lindmo K, Galaviz V, Cheng S, Rusten TE, Finley KD. Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles. Genetics 2007; 176:1283-97.
15. Bustin SA. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol 2000; 25:169-93.
16. Bjorkoy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 2005; 171:603-14.
17. Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurtig HI, Ischiropoulos H, Trojanowski JQ, Lee VM. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science 2000; 290:985-9.
18. Yorimitsu T, Klionsky DJ. Autophagy: Molecular machinery for self-eating. Cell Death and Differentiation 2005; 12:1542-52.
19. Girardor F, Lasbleiz C, Monnier V, Tricoire H. Specific age-related signatures in Drosophila body parts transcriptome. BMC Genomics 2006; 7:69.
20. Sou YS, Tanida I, Komatsu M, Ueno T, Kominami E. Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. J Biol Chem 2006; 281:3017-24.
21. Tanida I, Komatsu M, Ueno T, Kominami E. GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3. Biochem Biophys Res Commun 2003; 300:637-44.
22. Johnston JA, Ward CL, Kopito RR. Aggresomes: A cellular response to misfolded proteins. J Cell Biol 1998; 143:1883-98.
23. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 2000; 408:239-47.
24. Brunk UT, Terman A. The mitochondrial-lysosomal axis theory of aging: Accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur J Biochem 2002; 269:1996-2002.
25. Parkes TL, Elia AJ, Dickinson D, Hilliker AJ, Phillips JP, Boulianne GL. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nat Genet 1998; 19:171-4.
26. Das N, Levine RL, Orr WC, Sohal RS. Selectivity of protein oxidative damage during aging in Drosophila melanogaster. Biochem J 2001; 360:209-16.
27. Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C, Cataldo A, Cuervo AM. Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study. J Neuropathol Exp Neurol 2005; 64:113-22.
28. Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A. Opposing activities protect against age-onset proteotoxicity. Science 2006; 313:1604-10.
29. Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 2004; 14:885-90.
30. Hekimi S, Guarente L. Genetics and the specificity of the aging process. Science 2003; 299:1351-4.
31. Melendez A, Talloczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 2003; 301:1387-91.
32. Scott BA, Avidan MS, Crowder CM. Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2. Science 2002; 296:2388-91.
33. Scott RC, Schuldiner O, Neufeld TP. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell 2004; 7:167-78.
34. Tanida I, Sou YS, Ezaki J, Minematsu-Ikeguchi N, Ueno T, Kominami E. HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. J Biol Chem 2004; 279:36268-76.
35. Kumanomidou T, Mizushima T, Komatsu M, Suzuki A, Tanida I, Sou YS, Ueno T, Kominami E, Tanaka K, Yamane T. The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers. J Mol Biol 2006; 355:612-8.