Model organisms as a guide to mammalian aging

Developmental Cell

Volumn 2, Issue 1, 2002, Pages 9-19

  Tissenbaum, Heidi A ^a,b   Guarente, Leonard ^b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

AGING; ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CAENORHABDITIS ELEGANS; CALORIC RESTRICTION; CONTROLLED STUDY; EXPERIMENTAL MODEL; GENE CONTROL; GENE MUTATION; GENETIC ANALYSIS; GENETIC CONSERVATION; LIFESPAN; MAMMAL; NEMATODE; NONHUMAN; NUTRIENT AVAILABILITY; OXIDATIVE STRESS; PHYSIOLOGY; REGULATORY MECHANISM; REVIEW; RODENT; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; YEAST;

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; MAMMALIA; NEMATODA; RODENTIA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

AGING; ANIMALS; CAENORHABDITIS ELEGANS; MAMMALS; MODELS, ANIMAL; SACCHAROMYCES CEREVISIAE;

EID: 0036007110     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(01)00098-3     Document Type: Review

References (104)

1. Neurosecretory control of aging in Caenorhabditis elegans
2. The role of Pl 3-kinase in insulin action
3. 2+ -activated exocytosis
4. daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans
5. Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span
6. Regulation of lifespan by sensory perception in Caenorhabditis elegans
7. Genes that prolong life: Relationships of growth hormone and growth to aging and life span
8. Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans
9. Protein Kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
10. Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4
11. Insulin-like signaling, metabolism, stress resistance and aging in Caenorhabditis elegans
12. Dwarf mice and the ageing process
13. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
14. Transcription-dependent and -independent control of neuronal survival by the P13K-Akt signaling pathway
15. Phosphoinositide 3-kinase signaling pathways
16. The dauer larva, a post-embryonic developmental variant of the nematode Caenorhabditis elegans
17. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
18. Extension of lifespan by loss of CHICO, a Drosophila insulin receptor substrate protein
19. A Heady message for lifespan regulation
20. The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans
21. Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1
22. Regulation of longevity and stress resistance by Sch9 in yeast
23. CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans
24. Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans
25. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
26. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces harmaphrodite fertility
27. Longevity in Caenorhabditis elegans reduced by mating but not gamete production
28. Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans
29. A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span
30. The copper/zinc superoxide dismutase gene of Caenorhabditis elegans
31. The manganese superoxide dismutase gene of Caenorhabditis elegans
32. Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene
33. A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA
34. Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription
35. Cloning and developmental regulation of a novel member of the insulin-like family in Caenorhabditis elegans
36. The aging process
37. Why only time will tell
38. The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
39. Alterations of life span in the nematode Caenorhabditis elegans under monoxenic culture conditions
40. Signals from the reproductive system regulate the lifespan of C. elegans
41. Cloning, expression, and characterization of two manganese superoxide dismutases from Caenorhabditis elegans
42. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
43. A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes
44. Yeast Clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis
45. A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants
46. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
47. Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans
48. A C. elegans mutant that lives twice as long as wild type
49. The insulin receptor and its cellular targets
50. The daf-2 insulin receptor family member regulates longevity and diapause in Caenorhabditis elegans
51. Aging in the nematode Caenorhabditis elegans: Major biological and environmental factors influencing life span
52. A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results
53. Nonaging developmental variant of C. elegans
54. Direct control of the forkhead transcription factor AFX by protein kinase B
55. Determination of life-span in Caenorhabditis elegans by four clock genes
56. The genetics of calorie restriciton in Caenorhabditis elegans
57. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
58. Aging and resistance to oxidative stress in Caenorhabditis elegans
59. Genes that regulate both development and longevity in Caenorhabditis elegans
60. Ubiquinone is necessary for mouse embryonic development but is not essential for mitochondrial respiration
61. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
62. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
63. Requirement of NAD and SIR2 for life span extension by calorie restriction in Saccharomyces cerevisiae
64. Thermotolerance of a long-lived mutant of Caenorhabditis elegans
65. Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress
66. Superoxide dismutase activity is essential for stationary phase survival in Sacchaomyces cerevisiae
67. Mitochondrial superoxide decreases yeast survival in stationary phase
68. Negative control of p53 by Sir2alpha promotes cell survival under stress
69. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
70. Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation
71. The COQ7 gene encodes a protein in Saccharomyces cerevisiae necessary for ubiquinone biosynthesis
72. Caloric restriction and aging: An update
73. Extension of Life-span with superoxide dismutase/catalase mimetics
74. The p66shc adaptor protein controls oxidative stress response and life span in mammals
75. The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway
76. Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans
77. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
78. Life span of individual yeast cells
79. Calendar life span versus budding life span of Saccharomyces cerevisiae
80. A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans
81. The OLD-1 positive regulator of longevity and stress resistance in under DAF-16 regulation in Caenorhabditis elegans
82. Functional properties of the unc-64 gene encoding a Caenorhabditis elegans syntaxin
83. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
84. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway
85. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 P13 kinase to the DAF-16 transcription factor
86. A PDK1 homolog is necessary and sufficient to tranduce AGE-1 P13 kinase signals that regulate diapause in Caenorhabditis elegans
87. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family
88. Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans
89. Genetic and environmental regulation of dauer larva development
90. Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae
91. Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN
92. The Caenorhabditis elegans unc-64 locus encodes a syntaxin that interacts genetically with synaptobrevin
93. A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans
94. Extrachromosomal rDNA circles - A cause of aging in yeast
95. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the sir2 protein family
96. Oxidative stress, caloric restriction, and aging
97. Negative regulation of the forkhead transcription factor FKHR by Akt
98. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
99. A cytosolic catalase is needed to extend adult life-span in C. elegans daf-C and clk-1 mutants
100. An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans
101. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
102. hSIR2(SIRT1) Functions as an NAD-dependent p53 deacetylase
103. Regulation of C. elegans life-span by insulinlike signaling in the nervous system
104. Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioural timing