Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain

EMBO Journal

Volumn 33, Issue 23, 2014, Pages 2798-2813

  Kageyama, Yusuke ^a   Hoshijima, Masahiko ^b   Seo, Kinya ^a   Bedja, Djahida ^a   Sysa Shah, Polina ^a   Andrabi, Shaida A ^a,c   Chen, Weiran ^a   Höke, Ahmet ^a   Dawson, Valina L ^a,c   Dawson, Ted M ^a,c   Gabrielson, Kathleen ^a   Kass, David A ^a   Iijima, Miho ^a   Sesaki, Hiromi ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c ADRIENNE HELIS MALVIN MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

mice; mitochondria; organelle division; respiration

Indexed keywords

DRP1 PROTEIN; DYNAMIN; PARKIN; UBIQUITINATED PROTEIN; UNCLASSIFIED DRUG; DNM1L PROTEIN, MOUSE; MYH6 PROTEIN, MOUSE; MYOSIN HEAVY CHAIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CELL FUNCTION; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; HEART; HEART DISEASE; HEART FUNCTION; HEART MUSCLE CELL; HOMEOSTASIS; MAMMAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MITOPHAGY; MOUSE; NONHUMAN; PROTEIN DEGRADATION; UBIQUITINATION; ANIMAL; ELECTRON TOMOGRAPHY; FLUORESCENCE MICROSCOPY; GENETICS; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY;

MAMMALIA; MUS;

ANIMALS; BRAIN; DYNAMINS; ELECTRON MICROSCOPE TOMOGRAPHY; MICE; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MYOCYTES, CARDIAC; MYOSIN HEAVY CHAINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84913565821     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201488658     Document Type: Article

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