Deletion of MLIP (Muscle-enriched A-type Lamin-interacting Protein) leads to cardiac hyperactivation of akt/mammalian target of rapamycin (MTOR) and impaired cardiac adaptation

Journal of Biological Chemistry

Volumn 290, Issue 44, 2015, Pages 26699-26714

  Cattin, Marie Elodie ^a   Wang, Jessica ^b   Weldrick, Jonathan J ^a   Roeske, Cassandra L ^a   Mak, Esther ^a   Thorn, Stephanie L ^a,c   DaSilva, Jean N ^a,d   Wang, Yibin ^b   Lusis, Aldon J ^b   Burgon, Patrick G ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MUSCLE; PHYSIOLOGY; PROTEINS; TISSUE HOMEOSTASIS;

CARDIAC FUNCTIONS; CARDIAC STRESS; DIRECT IMPACT; GENOME-WIDE ASSOCIATION STUDIES; HYPERACTIVATION; OVER-EXPRESSION; SIGNALING PATHWAYS; TARGET OF RAPAMYCIN;

HEART;

BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MUSCLE ENRICHED A TYPE LAMIN INTERACTING PROTEIN; PROTEIN KINASE B; UNCLASSIFIED DRUG; CARRIER PROTEIN; ISOPRENALINE; MLIP PROTEIN, MOUSE; MTOR PROTEIN, MOUSE; NUCLEAR PROTEIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DOWN REGULATION; GENE; GENETIC ASSOCIATION; HEART DISEASE; HEART STRESS; MALE; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MOUSE; MUSCLE ENRICHED A TYPE LAMIN INTERACTING PROTEIN GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ADAPTATION; ANIMAL; C57BL MOUSE; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; CARDIOMEGALY; CHEMICALLY INDUCED; DEFICIENCY; DIAGNOSTIC IMAGING; ECHOGRAPHY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HEART FUNCTION TEST; HEMODYNAMICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGICAL STRESS;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; CARDIOMEGALY; CARRIER PROTEINS; FEMALE; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; HEART FUNCTION TESTS; HEMODYNAMICS; ISOPROTERENOL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIUM; MYOCYTES, CARDIAC; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TOR SERINE-THREONINE KINASES; ULTRASONOGRAPHY;

EID: 84945962512     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.678433     Document Type: Article

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