Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival

Science Translational Medicine

Volumn 4, Issue 144, 2012, Pages

  Ramos, Fresnida J ^a   Chen, Steven C ^a   Garelick, Michael G ^a   Dai, Dao Fu ^a   Liao, Chen Yu ^b   Schreiber, Katherine H ^b   MacKay, Vivian L ^a   An, Elroy H ^a   Strong, Randy ^c,d,e   Ladiges, Warren C ^a   Rabinovitch, Peter S ^a   Kaeberlein, Matt ^a   Kennedy, Brian K ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d Mays Cancer Center at UT Health San Antonio   (United States)

^e SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DESMIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RAPAMYCIN;

ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BIOACCUMULATION; CELL COUNT; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FEMALE; HEART FUNCTION; HEART MUSCLE CELL; MALE; MOUSE; MUSCLE FUNCTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SURVIVAL RATE; SURVIVAL TIME;

ANIMALS; DESMIN; FEMALE; HEART; LAMIN TYPE A; MALE; MICE; MUSCLE, SKELETAL; MYOCARDIUM; PROTEINS; SIGNAL TRANSDUCTION; SIROLIMUS;

EID: 84864523531     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3003802     Document Type: Article

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