Activation of NADPH oxidase 4 in the endoplasmic reticulum promotes cardiomyocyte autophagy and survival during energy stress through the protein kinase RNA-activated-like endoplasmic reticulum kinase/eukaryotic initiation factor 2α/activating transcription factor 4 pathway

Circulation Research

Volumn 113, Issue 11, 2013, Pages 1253-1264

  Sciarretta, Sebastiano ^a,b   Zhai, Peiyong ^a   Shao, Dan ^a   Zablocki, Daniela ^a   Nagarajan, Narayani ^a   Terada, Lance S ^c   Volpe, Massimo ^b,d   Sadoshima, Junichi ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b IRCCS NEUROMED   (Italy)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

autophagy; endoplasmic reticulum; fasting; myocardial ischemia; NOX4 protein; reactive oxygen species

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ATG7 PROTEIN; CATALASE; CELL PROTEIN; CHLOROQUINE; GLUCOSE; INITIATION FACTOR 2ALPHA; PEROXIREDOXIN 3; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE 4; PROTEIN KINASE R; PROTEIN KINASE RNA ACTIVATED LIKE ENDOPLASMIC RETICULUM KINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOPHAGY; CELL SURVIVAL; CONTROLLED STUDY; DIET RESTRICTION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENERGY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REACTIVATION; GENE OVEREXPRESSION; GLUCOSE DEPRIVATION; GLUCOSE INTAKE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SYNTHESIS; PROTEIN TARGETING; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

EID: 84888136345     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.113.301787     Document Type: Article

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