Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy

Circulation Research

Volumn 112, Issue 4, 2013, Pages 651-663

  Matsushima, Shouji ^a   Kuroda, Junya ^a   Ago, Tetsuro ^a   Zhai, Peiyong ^a   Park, Ji Yeon ^a   Xie, Lai Hua ^a   Tian, Bin ^a   Sadoshima, Junichi ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

free radicals; hypertrophy; oxidative stress; reactive oxygen species; remodeling

Indexed keywords

CYSTEINE; HISTONE DEACETYLASE 4; OXYGEN RADICAL; PHENYLEPHRINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4;

ANIMAL CELL; AORTA CONSTRICTION; AORTA PRESSURE; ARTICLE; CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CELL SIZE; CONTROLLED STUDY; ENZYME METABOLISM; GENE SILENCING; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; UPREGULATION; WILD TYPE;

ANIMALS; AORTIC VALVE STENOSIS; CARDIOMEGALY; CELL NUCLEUS; CELL SIZE; CYSTEINE; ENZYME ACTIVATION; ENZYME INDUCTION; HISTONE DEACETYLASES; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MYOCYTES, CARDIAC; NADPH OXIDASE; NUCLEAR ENVELOPE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHENYLEPHRINE; PROTEIN TRANSPORT; RATS; REACTIVE OXYGEN SPECIES; RECOMBINANT FUSION PROTEINS;

EID: 84874242635     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.279760     Document Type: Article

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