메뉴 건너뛰기




Volumn 11, Issue 3, 2014, Pages 382-399

Bioactive triterpenic acids: From agroforestry biomass residues to promising therapeutic tools

Author keywords

Antitumoral activity; Betulinic acid; Biological activity; Birch bark; Eucalyptus; Oleanolic acid; Olive; Triterpenic acids; Ursolic acid

Indexed keywords

CARBOXYLIC ACIDS; CELL DEATH;

EID: 84902483676     PISSN: 1570193X     EISSN: 18756298     Source Type: Journal    
DOI: 10.2174/1570193X113106660001     Document Type: Article
Times cited : (50)

References (249)
  • 1
    • 80055018013 scopus 로고    scopus 로고
    • Natural products and Pharma 2011: Strategic changes spur new opportunities
    • Carter, G.T. Natural products and Pharma 2011: Strategic changes spur new opportunities. Nat. Prod. Rep., 2011, 28(11), 1783-1789.
    • (2011) Nat. Prod. Rep , vol.28 , Issue.11 , pp. 1783-1789
    • Carter, G.T.1
  • 2
    • 84892352172 scopus 로고    scopus 로고
    • Terpenoids As Therapeutic Drugs and Pharmaceutical Agents
    • Zhang, L.; Demain, A.L., Eds.; Humana Press
    • Wang, G.; Tang, W.; Bidigare, R.R. Terpenoids As Therapeutic Drugs and Pharmaceutical Agents. In Natural Products, Zhang, L.; Demain, A.L., Eds.; Humana Press, 2005, pp. 197-227.
    • (2005) Natural Products , pp. 197-227
    • Wang, G.1    Tang, W.2    Bidigare, R.R.3
  • 3
    • 80053203292 scopus 로고    scopus 로고
    • Natural products: An evolving role in future drug discovery
    • Mishra, B.B.; Tiwari, V.K. Natural products: An evolving role in future drug discovery. Eur J. Med. Chem., 2011, 46(10), 4769-4807.
    • (2011) Eur J. Med. Chem , vol.46 , Issue.10 , pp. 4769-4807
    • Mishra, B.B.1    Tiwari, V.K.2
  • 4
    • 79955034094 scopus 로고    scopus 로고
    • Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer
    • Bishayee, A.; Ahmed, S.; Brankov, N.; Perloff, M. Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer. Front. Biosci., 2011, 16(3), 980-996.
    • (2011) Front. Biosci , vol.16 , Issue.3 , pp. 980-996
    • Bishayee, A.1    Ahmed, S.2    Brankov, N.3    Perloff, M.4
  • 5
    • 55149083474 scopus 로고    scopus 로고
    • Ursolic, oleanolic and betulinic acids: Antibacterial spectra and selectivity indexes
    • Fontanay, S.; Grare, M.; Mayer, J.; Finance, C.; Duval, R.E. Ursolic, oleanolic and betulinic acids: Antibacterial spectra and selectivity indexes. J. Ethnopharmacol., 2008, 120(2), 272-276.
    • (2008) J. Ethnopharmacol , vol.120 , Issue.2 , pp. 272-276
    • Fontanay, S.1    Grare, M.2    Mayer, J.3    Finance, C.4    Duval, R.E.5
  • 6
    • 74049157757 scopus 로고    scopus 로고
    • Pentacyclic Triterpenes of the Lupane, Oleanane and Ursane Group as Tools in Cancer Therapy
    • Laszczyk, M.N. Pentacyclic Triterpenes of the Lupane, Oleanane and Ursane Group as Tools in Cancer Therapy. Plant. Med., 2009, 75(15), 1549-1560.
    • (2009) Plant. Med , vol.75 , Issue.15 , pp. 1549-1560
    • Laszczyk, M.N.1
  • 7
    • 84862779635 scopus 로고    scopus 로고
    • Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer
    • Shanmugam, M.K.; Nguyen, A.H.; Kumar, A.P.; Tan, B.K.H.; Sethi, G. Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer. Cancer Lett., 2012, 320(2), 158-170.
    • (2012) Cancer Lett , vol.320 , Issue.2 , pp. 158-170
    • Shanmugam, M.K.1    Nguyen, A.H.2    Kumar, A.P.3    Tan, B.K.H.4    Sethi, G.5
  • 8
    • 80052842450 scopus 로고    scopus 로고
    • Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product
    • Sultana, N. Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product. J. Enzyme Inhib. Med. Chem., 2011, 26(5), 616-642.
    • (2011) J. Enzyme Inhib. Med. Chem , vol.26 , Issue.5 , pp. 616-642
    • Sultana, N.1
  • 9
    • 56449128037 scopus 로고    scopus 로고
    • Oleanolic acid and related derivatives as medicinally important compounds
    • Sultana, N.; Ata, A. Oleanolic acid and related derivatives as medicinally important compounds. J. Enzyme Inhib. Med. Chem., 2008, 23(6), 739-756.
    • (2008) J. Enzyme Inhib. Med. Chem , vol.23 , Issue.6 , pp. 739-756
    • Sultana, N.1    Ata, A.2
  • 10
    • 14744293458 scopus 로고    scopus 로고
    • Betulinic acid and its derivatives: A review on their biological properties
    • Yogeeswari, P.; Sriram, D. Betulinic acid and its derivatives: A review on their biological properties. Curr. Med. Chem., 2005, 12(6), 657-666.
    • (2005) Curr. Med. Chem , vol.12 , Issue.6 , pp. 657-666
    • Yogeeswari, P.1    Sriram, D.2
  • 12
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • Aggarwal, B.B.; Shishodia, S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem. Pharmacol., 2006, 71(10), 1397-1421.
    • (2006) Biochem. Pharmacol , vol.71 , Issue.10 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 13
    • 84855856535 scopus 로고    scopus 로고
    • Triterpenoids for cancer prevention and treatment: Current status and future prospects
    • Patlolla, J.M.R.; Rao, C.V. Triterpenoids for cancer prevention and treatment: Current status and future prospects. Curr. Pharm. Biotechnol., 2012, 13(1), 147-155.
    • (2012) Curr. Pharm. Biotechnol , vol.13 , Issue.1 , pp. 147-155
    • Patlolla, J.M.R.1    Rao, C.V.2
  • 16
    • 0742307297 scopus 로고    scopus 로고
    • On the origins of triterpenoid skeletal diversity
    • Xu, R.; Fazio, G.C.; Matsuda, S.P.T. On the origins of triterpenoid skeletal diversity. Phytochemistry, 2004, 65(3), 261-291.
    • (2004) Phytochemistry , vol.65 , Issue.3 , pp. 261-291
    • Xu, R.1    Fazio, G.C.2    Matsuda, S.P.T.3
  • 17
    • 84872769330 scopus 로고    scopus 로고
    • Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs
    • Salvador, J.A.R.; Moreira, V.M.; Goncalves, B.M.F.; Leal, A.S.; Jing, Y. Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs. Nat. Prod. Rep., 2012, 29(12), 1463-1479.
    • (2012) Nat. Prod. Rep , vol.29 , Issue.12 , pp. 1463-1479
    • Salvador, J.A.R.1    Moreira, V.M.2    Goncalves, B.M.F.3    Leal, A.S.4    Jing, Y.5
  • 19
    • 23044440041 scopus 로고    scopus 로고
    • Oleanolic acid and ursolic acid: Research perspectives
    • Liu, J. Oleanolic acid and ursolic acid: Research perspectives. J. Ethnopharmacol., 2005, 100(1-2), 92-94.
    • (2005) J. Ethnopharmacol , vol.100 , Issue.1-2 , pp. 92-94
    • Liu, J.1
  • 20
    • 76649106073 scopus 로고    scopus 로고
    • Betulinic acid, a natural compound with potent anticancer effects
    • Mullauer, F.B.; Kessler, J.H.; Medema, J.P. Betulinic acid, a natural compound with potent anticancer effects. Anti-Cancer Drug, 2010, 21(3), 215-227.
    • (2010) Anti-Cancer Drug , vol.21 , Issue.3 , pp. 215-227
    • Mullauer, F.B.1    Kessler, J.H.2    Medema, J.P.3
  • 21
    • 33747356679 scopus 로고    scopus 로고
    • Protective effects of ursolic acid and oleanolic acid in leukemic cells
    • Ovesna, Z.; Kozics, K.; Slamenova, D. Protective effects of ursolic acid and oleanolic acid in leukemic cells. Mutat. Res. Fundam. Mol. Mech. Mutag., 2006, 600(1-2), 131-137.
    • (2006) Mutat. Res. Fundam. Mol. Mech. Mutag , vol.600 , Issue.1-2 , pp. 131-137
    • Ovesna, Z.1    Kozics, K.2    Slamenova, D.3
  • 23
    • 0029567968 scopus 로고
    • Pharmacology of oleanolic acid and ursolic acid
    • Liu, J. Pharmacology of oleanolic acid and ursolic acid. J. Ethnopharmacol., 1995, 49(2), 57-68.
    • (1995) J. Ethnopharmacol , vol.49 , Issue.2 , pp. 57-68
    • Liu, J.1
  • 24
    • 33645047440 scopus 로고    scopus 로고
    • Study of the oleanolic and ursolic acid contents of some species of the Lamiaceae
    • Janicsák, G.; Veres, K.; Zoltán Kakasy, A.; Máthé, I. Study of the oleanolic and ursolic acid contents of some species of the Lamiaceae. Biochem. Syst. Ecol., 2006, 34(5), 392-396.
    • (2006) Biochem. Syst. Ecol , vol.34 , Issue.5 , pp. 392-396
    • Janicsák, G.1    Veres, K.2    ZoltáN Kakasy, A.3    Máthé, I.4
  • 25
    • 34247853484 scopus 로고    scopus 로고
    • Studies of Selected Plant Raw Materials as Alternative Sources of Triterpenes of Oleanolic and Ursolic Acid Types
    • Kowalski, R. Studies of Selected Plant Raw Materials as Alternative Sources of Triterpenes of Oleanolic and Ursolic Acid Types. J. Agric. Food Chem., 2007, 55(3), 656-662.
    • (2007) J. Agric. Food Chem , vol.55 , Issue.3 , pp. 656-662
    • Kowalski, R.1
  • 26
    • 84866879892 scopus 로고    scopus 로고
    • A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients
    • Caligiani, A.; Malavasi, G.; Palla, G.; Marseglia, A.; Tognolini, M.; Bruni, R. A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients. Food Chem., 2013, 136(2), 735-741.
    • (2013) Food Chem , vol.136 , Issue.2 , pp. 735-741
    • Caligiani, A.1    Malavasi, G.2    Palla, G.3    Marseglia, A.4    Tognolini, M.5    Bruni, R.6
  • 27
    • 67649836518 scopus 로고    scopus 로고
    • Pentacyclic Triterpene Distribution in Various Plants - Rich Sources for a New Group of Multi-Potent Plant Extracts
    • Jager, S.; Trojan, H.; Kopp, T.; Laszczyk, M.N.; Scheffler, A. Pentacyclic Triterpene Distribution in Various Plants - Rich Sources for a New Group of Multi-Potent Plant Extracts. Molecules, 2009, 14(6), 2016-2031.
    • (2009) Molecules , vol.14 , Issue.6 , pp. 2016-2031
    • Jager, S.1    Trojan, H.2    Kopp, T.3    Laszczyk, M.N.4    Scheffler, A.5
  • 28
    • 0000181440 scopus 로고
    • The isoprene rule and the biogenesis of terpenic compounds
    • Ruzicka, L. The isoprene rule and the biogenesis of terpenic compounds. Experientia, 1953, 9(10), 357-367.
    • (1953) Experientia , vol.9 , Issue.10 , pp. 357-367
    • Ruzicka, L.1
  • 29
    • 0036008773 scopus 로고    scopus 로고
    • The genetics and molecular genetics of terpene and sterol origami
    • Chappell, J. The genetics and molecular genetics of terpene and sterol origami. Curr. Opin. Plant Biol., 2002, 5(2), 151-157.
    • (2002) Curr. Opin. Plant Biol , vol.5 , Issue.2 , pp. 151-157
    • Chappell, J.1
  • 31
    • 78650984754 scopus 로고    scopus 로고
    • Two Oxidosqualene Cyclases Responsible for Biosynthesis of Tomato Fruit Cuticular Triterpenoids
    • Wang, Z.; Guhling, O.; Yao, R.; Li, F.; Yeats, T.H.; Rose, J.K.C.; Jetter, R. Two Oxidosqualene Cyclases Responsible for Biosynthesis of Tomato Fruit Cuticular Triterpenoids. Plant Physiol., 2011, 155(1), 540-552.
    • (2011) Plant Physiol , vol.155 , Issue.1 , pp. 540-552
    • Wang, Z.1    Guhling, O.2    Yao, R.3    Li, F.4    Yeats, T.H.5    Rose, J.K.C.6    Jetter, R.7
  • 32
    • 84868091024 scopus 로고    scopus 로고
    • Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus
    • Huang, L.L.; Li, J.; Ye, H.C.; Li, C.F.; Wang, H.; Liu, B.Y.; Zhang, Y.S. Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus. Planta, 2012, 236(5), 1571-1581.
    • (2012) Planta , vol.236 , Issue.5 , pp. 1571-1581
    • Huang, L.L.1    Li, J.2    Ye, H.C.3    Li, C.F.4    Wang, H.5    Liu, B.Y.6    Zhang, Y.S.7
  • 34
    • 0037290913 scopus 로고    scopus 로고
    • Solvent extraction study of antioxidants from Balm (Melissa officinalis L.) leaves
    • Herodež, Š.S.; Hadolin, M.; Škerget, M.; Knez, Ž. Solvent extraction study of antioxidants from Balm (Melissa officinalis L.) leaves. Food Chem., 2003, 80(2), 275-282.
    • (2003) Food Chem , vol.80 , Issue.2 , pp. 275-282
    • Herodež, Š.S.1    Hadolin, M.2    Škerget, M.3    Knez, Ž.4
  • 36
    • 0036321473 scopus 로고    scopus 로고
    • Lipophilic extractives of the inner and outer barks of Eucalyptus globulus
    • Freire, C.S.R.; Silvestre, A.J.D.; Neto, C.P.; Cavaleiro, J.A.S. Lipophilic extractives of the inner and outer barks of Eucalyptus globulus. Holzforschung, 2002, 56(4), 372-379.
    • (2002) Holzforschung , vol.56 , Issue.4 , pp. 372-379
    • Freire, C.S.R.1    Silvestre, A.J.D.2    Neto, C.P.3    Cavaleiro, J.A.S.4
  • 37
    • 71949105556 scopus 로고    scopus 로고
    • Eucalyptus globulus biomass residues from pulping industry as a source of high value triterpenic compounds
    • Domingues, R.M.A.; Sousa, G.D.A.; Freire, C.S.R.; Silvestre, A.J.D.; Neto, C.P. Eucalyptus globulus biomass residues from pulping industry as a source of high value triterpenic compounds. Ind. Crop. Prod., 2010, 31(1), 65-70.
    • (2010) Ind. Crop. Prod , vol.31 , Issue.1 , pp. 65-70
    • Domingues, R.M.A.1    Sousa, G.D.A.2    Freire, C.S.R.3    Silvestre, A.J.D.4    Neto, C.P.5
  • 38
    • 58549089175 scopus 로고    scopus 로고
    • Fast and selective determination of triterpenic compounds in olive leaves by liquid chromatography-tandem mass spectrometry with multiple reaction monitoring after microwaveassisted extraction
    • Sanchez-Avila, N.; Priego-Capote, F.; Ruiz-Jimenez, J.; Luque de Castro, M.D. Fast and selective determination of triterpenic compounds in olive leaves by liquid chromatography-tandem mass spectrometry with multiple reaction monitoring after microwaveassisted extraction. Talanta, 2009, 78(1), 40-48.
    • (2009) Talanta , vol.78 , Issue.1 , pp. 40-48
    • Sanchez-Avila, N.1    Priego-Capote, F.2    Ruiz-Jimenez, J.3    Luque De Castro, M.D.4
  • 39
    • 77949264197 scopus 로고    scopus 로고
    • Triterpene Acids in Plantago major: Identification, Quantification and Comparison of Different Extraction Methods
    • Tarvainen, M.; Suomela, J.P.; Kallio, H.; Yang, B.R. Triterpene Acids in Plantago major: Identification, Quantification and Comparison of Different Extraction Methods. Chromatographia, 2010, 71(3-4), 279-284.
    • (2010) Chromatographia , vol.71 , Issue.3-4 , pp. 279-284
    • Tarvainen, M.1    Suomela, J.P.2    Kallio, H.3    Yang, B.R.4
  • 40
    • 0141650464 scopus 로고    scopus 로고
    • Gas chromatographic method for routine determination of oleanolic and ursolic acids in medicinal plants
    • Janicsak, G.; Veres, K.; Kallai, M.; Mathe, I. Gas chromatographic method for routine determination of oleanolic and ursolic acids in medicinal plants. Chromatographia, 2003, 58(5-6), 295-299.
    • (2003) Chromatographia , vol.58 , Issue.5-6 , pp. 295-299
    • Janicsak, G.1    Veres, K.2    Kallai, M.3    Mathe, I.4
  • 41
    • 40849133967 scopus 로고    scopus 로고
    • Selective solid-phase extraction of a triterpene acid from a plant extract by molecularly imprinted polymer
    • Claude, B.; Morin, P.; Lafosse, M.; Belmont, A.-S.; Haupt, K. Selective solid-phase extraction of a triterpene acid from a plant extract by molecularly imprinted polymer. Talanta, 2008, 75(2), 344-350.
    • (2008) Talanta , vol.75 , Issue.2 , pp. 344-350
    • Claude, B.1    Morin, P.2    Lafosse, M.3    Belmont, A.-S.4    Haupt, K.5
  • 42
    • 78349310736 scopus 로고    scopus 로고
    • Molecularly-imprinted polymers: Useful sorbents for selective extractions
    • Beltran, A.; Borrull, F.; Marcé, R.M.; Cormack, P.A.G. Molecularly-imprinted polymers: useful sorbents for selective extractions. TrAC, Trends Anal. Chem., 2010, 29(11), 1363-1375.
    • (2010) TrAC, Trends Anal. Chem , vol.29 , Issue.11 , pp. 1363-1375
    • Beltran, A.1    Borrull, F.2    Marcé, R.M.3    Cormack, P.A.G.4
  • 43
    • 78149416148 scopus 로고    scopus 로고
    • Molecularly imprinted polymers for the selective extraction of glycyrrhizic acid from liquorice roots
    • Cirillo, G.; Curcio, M.; Parisi, O.I.; Puoci, F.; Iemma, F.; Spizzirri, U.G.; Restuccia, D.; Picci, N. Molecularly imprinted polymers for the selective extraction of glycyrrhizic acid from liquorice roots. Food Chem., 2011, 125(3), 1058-1063.
    • (2011) Food Chem , vol.125 , Issue.3 , pp. 1058-1063
    • Cirillo, G.1    Curcio, M.2    Parisi, O.I.3    Puoci, F.4    Iemma, F.5    Spizzirri, U.G.6    Restuccia, D.7    Picci, N.8
  • 44
    • 78649699932 scopus 로고    scopus 로고
    • High value triterpenic compounds from the outer barks of several Eucalyptus species cultivated in Brazil and in Portugal
    • Domingues, R.M.A.; Sousa, G.D.A.; Silva, C.M.; Freire, C.S.R.; Silvestre, A.J.D.; Neto, C.P. High value triterpenic compounds from the outer barks of several Eucalyptus species cultivated in Brazil and in Portugal. Ind. Crop. Prod., 2011, 33(1), 158-164.
    • (2011) Ind. Crop. Prod , vol.33 , Issue.1 , pp. 158-164
    • Domingues, R.M.A.1    Sousa, G.D.A.2    Silva, C.M.3    Freire, C.S.R.4    Silvestre, A.J.D.5    Neto, C.P.6
  • 45
    • 59649084136 scopus 로고    scopus 로고
    • Rapid and novel discrimination and quantification of oleanolic and ursolic acids in complex plant extracts using two-dimensional nuclear magnetic resonance spectroscopy-Comparison with HPLC methods
    • Kontogianni, V.G.; Exarchou, V.; Troganis, A.; Gerothanassis, I.P. Rapid and novel discrimination and quantification of oleanolic and ursolic acids in complex plant extracts using two-dimensional nuclear magnetic resonance spectroscopy-Comparison with HPLC methods. Anal. Chim. Acta, 2009, 635(2), 188-195.
    • (2009) Anal. Chim. Acta , vol.635 , Issue.2 , pp. 188-195
    • Kontogianni, V.G.1    Exarchou, V.2    Troganis, A.3    Gerothanassis, I.P.4
  • 46
    • 26644452309 scopus 로고    scopus 로고
    • HPLC quantification of two isomeric triterpenic acids isolated from Mitracarpus scaber and antimicrobial activity on Dermatophilus congolensis
    • Gbaguidi, F.; Accrombessi, G.; Moudachirou, M.; Quetin-Leclercq, J. HPLC quantification of two isomeric triterpenic acids isolated from Mitracarpus scaber and antimicrobial activity on Dermatophilus congolensis. J. Pharm. Biomed. Anal., 2005, 39(5), 990-995.
    • (2005) J. Pharm. Biomed. Anal , vol.39 , Issue.5 , pp. 990-995
    • Gbaguidi, F.1    Accrombessi, G.2    Moudachirou, M.3    Quetin-Leclercq, J.4
  • 47
    • 33646251639 scopus 로고    scopus 로고
    • Quantitation of oleanolic acid in Oldenlandia corymbosa L. whole-plant powder by high-performance thin-layer chromatography
    • Banerjee, A.; Sane, R.T.; Mangaonkar, K.; Shailajan, S.; Deshpande, A.; Gundi, G. Quantitation of oleanolic acid in Oldenlandia corymbosa L. whole-plant powder by high-performance thin-layer chromatography. J. Planar. Chromatogr. Mod. TLC, 2006, 19(107), 68-72.
    • (2006) J. Planar. Chromatogr. Mod. TLC , vol.19 , Issue.107 , pp. 68-72
    • Banerjee, A.1    Sane, R.T.2    Mangaonkar, K.3    Shailajan, S.4    Deshpande, A.5    Gundi, G.6
  • 48
    • 0042202033 scopus 로고    scopus 로고
    • High-performance liquid chromatographic analysis of bioactive triterpenes in Perilla frutescens
    • Chen, J.H.; Xia, Z.H.; Tan, R.X. High-performance liquid chromatographic analysis of bioactive triterpenes in Perilla frutescens. J. Pharm. Biomed. Anal., 2003, 32(6), 1175-1179.
    • (2003) J. Pharm. Biomed. Anal , vol.32 , Issue.6 , pp. 1175-1179
    • Chen, J.H.1    Xia, Z.H.2    Tan, R.X.3
  • 49
    • 33846589748 scopus 로고    scopus 로고
    • Simultaneous determination of betulin and betulinic acid in white birch bark using RP-HPLC
    • Zhao, G.; Yan, W.; Cao, D. Simultaneous determination of betulin and betulinic acid in white birch bark using RP-HPLC. J. Pharm. Biomed. Anal., 2007, 43(3), 959-962.
    • (2007) J. Pharm. Biomed. Anal , vol.43 , Issue.3 , pp. 959-962
    • Zhao, G.1    Yan, W.2    Cao, D.3
  • 59
    • 84871462479 scopus 로고    scopus 로고
    • Effect of different extraction techniques on quantification of oleanolic and ursolic acid in Lamii albi flos
    • Wójciak-Kosior, M.; Sowa, I.; Kocjan, R.; Nowak, R. Effect of different extraction techniques on quantification of oleanolic and ursolic acid in Lamii albi flos. Ind. Crop. Prod., 2013, 44(0), 373-377.
    • (2013) Ind. Crop. Prod , vol.44 , Issue.0 , pp. 373-377
    • Wójciak-Kosior, M.1    Sowa, I.2    Kocjan, R.3    Nowak, R.4
  • 60
    • 84867573635 scopus 로고    scopus 로고
    • Optimisation of an Ultrasound-assisted Extraction Followed by RP-HPLC Separation for the Simultaneous Determination of Oleanolic Acid, Ursolic Acid and Oridonin Content in Rabdosia rubescens
    • Yang, Y.C.; Wei, M.C.; Huang, T.C. Optimisation of an Ultrasound-assisted Extraction Followed by RP-HPLC Separation for the Simultaneous Determination of Oleanolic Acid, Ursolic Acid and Oridonin Content in Rabdosia rubescens. Phytochem. Anal., 2012, 23(6), 627-636.
    • (2012) Phytochem. Anal , vol.23 , Issue.6 , pp. 627-636
    • Yang, Y.C.1    Wei, M.C.2    Huang, T.C.3
  • 61
    • 65049089402 scopus 로고    scopus 로고
    • Optimization of ultrasonic-assisted extraction (UAE) of betulin from white birch bark using response surface methodology
    • Chen, Q.-H.; Fu, M.-l.; Liu, J.; Zhang, H.-F.; He, G.-Q.; Ruan, H. Optimization of ultrasonic-assisted extraction (UAE) of betulin from white birch bark using response surface methodology. Ultrason. Sonochem., 2009, 16(5), 599-604.
    • (2009) Ultrason. Sonochem , vol.16 , Issue.5 , pp. 599-604
    • Chen, Q.-H.1    Fu, M.-L.2    Liu, J.3    Zhang, H.-F.4    He, G.-Q.5    Ruan, H.6
  • 62
    • 84865077438 scopus 로고    scopus 로고
    • Towards an Efficient Protocol for the Determination of Triterpenic Acids in Olive Fruit: A Comparative Study of Drying and Extraction Methods
    • Goulas, V.; Manganaris, G.A. Towards an Efficient Protocol for the Determination of Triterpenic Acids in Olive Fruit: A Comparative Study of Drying and Extraction Methods. Phytochem. Anal., 2012, 23(5), 444-449.
    • (2012) Phytochem. Anal , vol.23 , Issue.5 , pp. 444-449
    • Goulas, V.1    Manganaris, G.A.2
  • 63
    • 77957305532 scopus 로고    scopus 로고
    • Variation of Oleanolic and Ursolic Acid in the Flesh of Persimmon Fruit among Different Cultivars
    • Zhou, C.; Sheng, Y.; Zhao, D.; Wang, Z.; Tao, J. Variation of Oleanolic and Ursolic Acid in the Flesh of Persimmon Fruit among Different Cultivars. Molecules, 2010, 15(9), 6580-6587.
    • (2010) Molecules , vol.15 , Issue.9 , pp. 6580-6587
    • Zhou, C.1    Sheng, Y.2    Zhao, D.3    Wang, Z.4    Tao, J.5
  • 64
    • 67651097886 scopus 로고    scopus 로고
    • The effect of extraction process on polyphenol content, triterpene composition and bioactivity of yellow birch (Betula alleghaniensis Britton) extracts
    • Diouf, P.N.; Stevanovic, T.; Boutin, Y. The effect of extraction process on polyphenol content, triterpene composition and bioactivity of yellow birch (Betula alleghaniensis Britton) extracts. Ind. Crop. Prod., 2009, 30(2), 297-303.
    • (2009) Ind. Crop. Prod , vol.30 , Issue.2 , pp. 297-303
    • Diouf, P.N.1    Stevanovic, T.2    Boutin, Y.3
  • 65
    • 80052159837 scopus 로고    scopus 로고
    • Microwave-Assisted Extraction of Oleanolic Acid and Ursolic Acid from Ligustrum lucidum Ait
    • Xia, E.-Q.; Wang, B.-W.; Xu, X.-R.; Zhu, L.; Song, Y.; Li, H.-B. Microwave-Assisted Extraction of Oleanolic Acid and Ursolic Acid from Ligustrum lucidum Ait. Int. J. Mol. Sci., 2011, 12(8), 5319-5329.
    • (2011) Int. J. Mol. Sci , vol.12 , Issue.8 , pp. 5319-5329
    • Xia, E.-Q.1    Wang, B.-W.2    Xu, X.-R.3    Zhu, L.4    Song, Y.5    Li, H.-B.6
  • 66
  • 68
    • 84872144974 scopus 로고    scopus 로고
    • Optimization of the supercritical fluid extraction of triterpenic acids from Eucalyptus globulus bark using experimental design
    • Domingues, R.M.A.; de Melo, M.M.R.; Oliveira, E.L.G.; Neto, C.P.; Silvestre, A.J.D.; Silva, C.M. Optimization of the supercritical fluid extraction of triterpenic acids from Eucalyptus globulus bark using experimental design. J. Supercrit. Fluids, 2013, 74(0), 105-114.
    • (2013) J. Supercrit. Fluids , vol.74 , Issue.0 , pp. 105-114
    • Domingues, R.M.A.1    De Melo, M.M.R.2    Oliveira, E.L.G.3    Neto, C.P.4    Silvestre, A.J.D.5    Silva, C.M.6
  • 69
    • 84859127683 scopus 로고    scopus 로고
    • New aspects for biomass processing with ionic liquids: Towards the isolation of pharmaceutically active betulin
    • Ressmann, A.K.; Strassl, K.; Gaertner, P.; Zhao, B.; Greiner, L.; Bica, K. New aspects for biomass processing with ionic liquids: towards the isolation of pharmaceutically active betulin. Green Chem., 2012, 14(4), 940-944.
    • (2012) Green Chem , vol.14 , Issue.4 , pp. 940-944
    • Ressmann, A.K.1    Strassl, K.2    Gaertner, P.3    Zhao, B.4    Greiner, L.5    Bica, K.6
  • 70
    • 76649144170 scopus 로고    scopus 로고
    • Bioactive Compounds with Added Value Prepared from Terpenes Contained in Solid Wastes from the Olive Oil Industry
    • Parra, A.; Lopez, P.E.; Garcia-Granados, A. Bioactive Compounds with Added Value Prepared from Terpenes Contained in Solid Wastes from the Olive Oil Industry. Chem. Biodivers., 2010, 7(2), 421-439.
    • (2010) Chem. Biodivers , vol.7 , Issue.2 , pp. 421-439
    • Parra, A.1    Lopez, P.E.2    Garcia-Granados, A.3
  • 71
    • 84870927749 scopus 로고    scopus 로고
    • Determination of oleanolic and ursolic acid in Chinese herbs using HPLC and gamma-CD as mobile phase modifier
    • Wang, C.; Liu, H.; Zhang, B.; Guo, H. Determination of oleanolic and ursolic acid in Chinese herbs using HPLC and gamma-CD as mobile phase modifier. J. Sep. Sci., 2011, 34(21), 3023-3028.
    • (2011) J. Sep. Sci , vol.34 , Issue.21 , pp. 3023-3028
    • Wang, C.1    Liu, H.2    Zhang, B.3    Guo, H.4
  • 73
    • 84864925214 scopus 로고    scopus 로고
    • Lipophilic extractives from the bark of Eucalyptus grandis x globulus, a rich source of methyl morolate: Selective extraction with supercritical CO2
    • Patinha, D.J.S.; Domingues, R.M.A.; Villaverde, J.J.; Silva, A.M.S.; Silva, C.M.; Freire, C.S.R.; Neto, C.P.; Silvestre, A.J.D. Lipophilic extractives from the bark of Eucalyptus grandis x globulus, a rich source of methyl morolate: Selective extraction with supercritical CO2. Ind. Crop. Prod., 2013, 43(0), 340-348.
    • (2013) Ind. Crop. Prod , vol.43 , Issue.0 , pp. 340-348
    • Patinha, D.J.S.1    Domingues, R.M.A.2    Villaverde, J.J.3    Silva, A.M.S.4    Silva, C.M.5    Freire, C.S.R.6    Neto, C.P.7    Silvestre, A.J.D.8
  • 74
    • 60149113052 scopus 로고    scopus 로고
    • The integration of green chemistry into future biorefineries
    • Clark, J.H.; Deswarte, F.E.I.; Farmer, T.J. The integration of green chemistry into future biorefineries. Biofuel. Bioprod. Bior., 2009, 3(1), 72-90.
    • (2009) Biofuel. Bioprod. Bior , vol.3 , Issue.1 , pp. 72-90
    • Clark, J.H.1    Deswarte, F.E.I.2    Farmer, T.J.3
  • 75
    • 84900804271 scopus 로고    scopus 로고
    • Extraction and purification of triterpenoids using supercritical fluids: From lab to exploitation
    • de Melo, M.M.R.; Domingues, R.M.A.; Silvestre, A.J.D.; Silva, C.M. Extraction and purification of triterpenoids using supercritical fluids: from lab to exploitation. Mini Rev. Org. Chem., 2013, 11(3), 362-381.
    • (2013) Mini Rev. Org. Chem , vol.11 , Issue.3 , pp. 362-381
    • De Melo, M.M.R.1    Domingues, R.M.A.2    Silvestre, A.J.D.3    Silva, C.M.4
  • 76
    • 28244493634 scopus 로고    scopus 로고
    • Simultaneous determination of seven triterpenoids and triterpenoid saponins in Folium llicis Purpureae by high performance liquid chromatography coupled with evaporative light scattering detection
    • Liao, L.P.; Li, S.L.; Li, P. Simultaneous determination of seven triterpenoids and triterpenoid saponins in Folium llicis Purpureae by high performance liquid chromatography coupled with evaporative light scattering detection. J. Sep. Sci., 2005, 28(16), 2061-2066.
    • (2005) J. Sep. Sci , vol.28 , Issue.16 , pp. 2061-2066
    • Liao, L.P.1    Li, S.L.2    Li, P.3
  • 77
    • 67649797798 scopus 로고    scopus 로고
    • Determination of Oleanolic Acid and Ursolic Acid in Oldenlandia diffusa and Its Substitute Using High Performance Liquid Chromatography
    • Liang, Z.; Jiang, Z.; Fong, D.W.; Zhao, Z. Determination of Oleanolic Acid and Ursolic Acid in Oldenlandia diffusa and Its Substitute Using High Performance Liquid Chromatography. J. Food Drug Anal., 2009, 17(2), 69-77.
    • (2009) J. Food Drug Anal , vol.17 , Issue.2 , pp. 69-77
    • Liang, Z.1    Jiang, Z.2    Fong, D.W.3    Zhao, Z.4
  • 78
    • 24944445852 scopus 로고    scopus 로고
    • Determination of oleanolic acid and ursolic acid in cornel by cyclodextrin-modified micellar electrokinetic chromatography
    • Zhang, G.Q.; Qi, Y.P.; Lou, Z.Y.; Liu, C.H.; Wu, X.F.; Chai, Y.F. Determination of oleanolic acid and ursolic acid in cornel by cyclodextrin-modified micellar electrokinetic chromatography. Biomed. Chromatogr., 2005, 19(7), 529-532.
    • (2005) Biomed. Chromatogr , vol.19 , Issue.7 , pp. 529-532
    • Zhang, G.Q.1    Qi, Y.P.2    Lou, Z.Y.3    Liu, C.H.4    Wu, X.F.5    Chai, Y.F.6
  • 79
    • 79960057037 scopus 로고    scopus 로고
    • Simultaneous qualitative and quantitative analysis of triterpenic acids, saponins and flavonoids in the leaves of two Ziziphus species by HPLC-PDA-MS/ELSD
    • Guo, S.; Duan, J.-A.; Tang, Y.; Qian, Y.; Zhao, J.; Qian, D.; Su, S.; Shang, E. Simultaneous qualitative and quantitative analysis of triterpenic acids, saponins and flavonoids in the leaves of two Ziziphus species by HPLC-PDA-MS/ELSD. J. Pharm. Biomed. Anal., 2011, 56(2), 264-270.
    • (2011) J. Pharm. Biomed. Anal , vol.56 , Issue.2 , pp. 264-270
    • Guo, S.1    Duan, J.-A.2    Tang, Y.3    Qian, Y.4    Zhao, J.5    Qian, D.6    Su, S.7    Shang, E.8
  • 80
    • 79953903917 scopus 로고    scopus 로고
    • Development of a New HPLC Method with Precolumn Fluorescent Derivatization for Rapid, Selective and Sensitive Detection of Triterpenic Acids in Fruits
    • Li, G.-L.; You, J.-M.; Song, C.-H.; Xia, L.; Zheng, J.; Suo, Y.-R. Development of a New HPLC Method with Precolumn Fluorescent Derivatization for Rapid, Selective and Sensitive Detection of Triterpenic Acids in Fruits. J. Agric. Food Chem., 2011, 59(7), 2972-2979.
    • (2011) J. Agric. Food Chem , vol.59 , Issue.7 , pp. 2972-2979
    • Li, G.-L.1    You, J.-M.2    Song, C.-H.3    Xia, L.4    Zheng, J.5    Suo, Y.-R.6
  • 81
    • 79959374876 scopus 로고    scopus 로고
    • Qualitative and Quantitative Analysis of 17 Different Types of Tetra- and Pentacyclic Triterpenic Acids in Boswellia papyrifera by a Semi- Automatic Homomodal 2D HPLC method
    • Paul, M.; Bruening, G.; Weihrather, J.; Jauch, J. Qualitative and Quantitative Analysis of 17 Different Types of Tetra- and Pentacyclic Triterpenic Acids in Boswellia papyrifera by a Semi- Automatic Homomodal 2D HPLC method. Chromatographia, 2011, 74(1-2), 29-40.
    • (2011) Chromatographia , vol.74 , Issue.1-2 , pp. 29-40
    • Paul, M.1    Bruening, G.2    Weihrather, J.3    Jauch, J.4
  • 82
  • 83
    • 79951673700 scopus 로고    scopus 로고
    • Highly sensitive and selective pre-column derivatization highperformance liquid chromatography approach for rapid determination of triterpenes oleanolic and ursolic acids and application to Swertia species: Optimization of triterpenic acids extraction and pre-column derivatization using response surface methodology
    • Li, G.; Zhang, X.; You, J.; Song, C.; Sun, Z.; Xia, L.; Suo, Y. Highly sensitive and selective pre-column derivatization highperformance liquid chromatography approach for rapid determination of triterpenes oleanolic and ursolic acids and application to Swertia species: Optimization of triterpenic acids extraction and pre-column derivatization using response surface methodology. Anal. Chim. Acta, 2011, 688(2), 208-218.
    • (2011) Anal. Chim. Acta , vol.688 , Issue.2 , pp. 208-218
    • Li, G.1    Zhang, X.2    You, J.3    Song, C.4    Sun, Z.5    Xia, L.6    Suo, Y.7
  • 84
    • 58249129812 scopus 로고    scopus 로고
    • Development of a validated liquid chromatographic method for the quality control of Prunellae Spica: Determination of triterpenic acids
    • Lee, M.K.; Ahn, Y.M.; Lee, K.R.; Jung, J.H.; Jung, O.S.; Hong, D. Development of a validated liquid chromatographic method for the quality control of Prunellae Spica: Determination of triterpenic acids. Anal. Chim. Acta, 2009, 633(2), 271-277.
    • (2009) Anal. Chim. Acta , vol.633 , Issue.2 , pp. 271-277
    • Lee, M.K.1    Ahn, Y.M.2    Lee, K.R.3    Jung, J.H.4    Jung, O.S.5    Hong, D.6
  • 85
    • 84860485717 scopus 로고    scopus 로고
    • Investigation of porous graphitic carbon for triterpenoids and natural resinous materials analysis by high performance liquid chromatography hyphenated to mass spectrometry
    • Rhourri-Frih, B.; Chaimbault, P.; Dequeral, D.; André, P.; Lafosse, M. Investigation of porous graphitic carbon for triterpenoids and natural resinous materials analysis by high performance liquid chromatography hyphenated to mass spectrometry. J. Chromatogr., 2012, 1240(0), 140-146.
    • (2012) J. Chromatogr , vol.1240 , Issue.0 , pp. 140-146
    • Rhourri-Frih, B.1    Chaimbault, P.2    Dequeral, D.3    André, P.4    Lafosse, M.5
  • 86
    • 4444353930 scopus 로고    scopus 로고
    • Rapid analysis of triterpenic acids by liquid chromatography using porous graphitic carbon and evaporative light scattering detection
    • Bérangère, C.; Caussarieu, N.; Morin, P.; Morin-Allory, L.; Lafosse, M. Rapid analysis of triterpenic acids by liquid chromatography using porous graphitic carbon and evaporative light scattering detection. J. Sep. Sci., 2004, 27(12), 964-970.
    • (2004) J. Sep. Sci , vol.27 , Issue.12 , pp. 964-970
    • Bérangère, C.1    Caussarieu, N.2    Morin, P.3    Morin-Allory, L.4    Lafosse, M.5
  • 87
    • 26844453333 scopus 로고    scopus 로고
    • GC-MS analysis of penta- and tetra-cyclic triterpenes from resins of Pistacia species. Part II. Pistacia terebinthus var. Chia
    • Assimopoulou, A.N.; Papageorgiou, V.P. GC-MS analysis of penta- and tetra-cyclic triterpenes from resins of Pistacia species. Part II. Pistacia terebinthus var. Chia. Biomed. Chromatogr., 2005, 19(8), 586-605.
    • (2005) Biomed. Chromatogr , vol.19 , Issue.8 , pp. 586-605
    • Assimopoulou, A.N.1    Papageorgiou, V.P.2
  • 88
    • 0010418404 scopus 로고
    • Mass spectrometry in structural and stereochemical problems. 32 pentacyclic triterpenes
    • Budzikiewicz, H.; Wilson, J.M.; Djerassi, C. Mass spectrometry in structural and stereochemical problems. 32 pentacyclic triterpenes. J. Am. Chem. Soc., 1963, 85(22), 3688-3699.
    • (1963) J. Am. Chem. Soc , vol.85 , Issue.22 , pp. 3688-3699
    • Budzikiewicz, H.1    Wilson, J.M.2    Djerassi, C.3
  • 89
    • 0001591499 scopus 로고
    • Gas chromatography-mass spectrometry of oleanane-type and ursanetype triterpenes - Application chenopodium-quinoa triterpenes
    • Burnoufradosevich, M.; Delfel, N.E.; England, R. Gas chromatography-mass spectrometry of oleanane-type and ursanetype triterpenes - Application chenopodium-quinoa triterpenes. Phytochemistry, 1985, 24(9), 2063-2066.
    • (1985) Phytochemistry , vol.24 , Issue.9 , pp. 2063-2066
    • Burnoufradosevich, M.1    Delfel, N.E.2    England, R.3
  • 90
    • 40149086804 scopus 로고    scopus 로고
    • Determination of oleanolic, betulinic and ursolic acid in Lamiaceae and mass spectral fragmentation of their trimethylsilylated derivatives
    • Razborsek, M.I.; Voncina, D.B.; Dolecek, V.; Voncina, E. Determination of oleanolic, betulinic and ursolic acid in Lamiaceae and mass spectral fragmentation of their trimethylsilylated derivatives. Chromatographia, 2008, 67(5-6), 433-440.
    • (2008) Chromatographia , vol.67 , Issue.5-6 , pp. 433-440
    • Razborsek, M.I.1    Voncina, D.B.2    Dolecek, V.3    Voncina, E.4
  • 91
    • 0142217492 scopus 로고    scopus 로고
    • MECC determination of oleanolic acid and ursolic acid isomers in Ligustrum lucidum Ait
    • Liu, H.; Shi, Y.; Wang, D.; Yang, G.; Yu, A.; Zhang, H. MECC determination of oleanolic acid and ursolic acid isomers in Ligustrum lucidum Ait. J. Pharm. Biomed. Anal., 2003, 32(3), 479-485.
    • (2003) J. Pharm. Biomed. Anal , vol.32 , Issue.3 , pp. 479-485
    • Liu, H.1    Shi, Y.2    Wang, D.3    Yang, G.4    Yu, A.5    Zhang, H.6
  • 92
    • 30344440383 scopus 로고    scopus 로고
    • Novel and simple nonaqueous capillary electrophoresis separation and determination bioactive triterpenes in Chinese herbs
    • Qi, S.; Ding, L.; Tian, K.; Chen, X.; Hu, Z. Novel and simple nonaqueous capillary electrophoresis separation and determination bioactive triterpenes in Chinese herbs. J. Pharm. Biomed. Anal., 2006, 40(1), 35-41.
    • (2006) J. Pharm. Biomed. Anal , vol.40 , Issue.1 , pp. 35-41
    • Qi, S.1    Ding, L.2    Tian, K.3    Chen, X.4    Hu, Z.5
  • 93
    • 58249105905 scopus 로고    scopus 로고
    • Analysis of pentacyclic triterpenes by LC-MS. A comparative study between APCI and APPI
    • Rhourri-Frih, B.; Chaimbault, P.; Claude, B.; Lamy, C.; André, P.; Lafosse, M. Analysis of pentacyclic triterpenes by LC-MS. A comparative study between APCI and APPI. J. Mass Spectrom., 2009, 44(1), 71-80.
    • (2009) J. Mass Spectrom , vol.44 , Issue.1 , pp. 71-80
    • Rhourri-Frih, B.1    Chaimbault, P.2    Claude, B.3    Lamy, C.4    André, P.5    Lafosse, M.6
  • 94
    • 68349123796 scopus 로고    scopus 로고
    • HPLC in Natural Product Analysis: The Detection Issue
    • Wolfender, J.-L. HPLC in Natural Product Analysis: The Detection Issue. Plant. Med., 2009, 75(07), 719-734.
    • (2009) Plant. Med , vol.75 , Issue.7 , pp. 719-734
    • Wolfender, J.-L.1
  • 96
    • 0001703937 scopus 로고
    • Pentacyclic triterpenoids and sterols from seven species of mangrove
    • Ghosh, A.; Misra, S.; Dutta, A.K.; Choudhury, A. Pentacyclic triterpenoids and sterols from seven species of mangrove. Phytochemistry, 1985, 24(8), 1725-1727.
    • (1985) Phytochemistry , vol.24 , Issue.8 , pp. 1725-1727
    • Ghosh, A.1    Misra, S.2    Dutta, A.K.3    Choudhury, A.4
  • 97
    • 0001115764 scopus 로고
    • The Suberin Monomers and Triterpenoids from the Outer Bark of Betula-verrucosa Ehrh
    • Ekman, R. The Suberin Monomers and Triterpenoids from the Outer Bark of Betula-verrucosa Ehrh. Holzforschung, 1983, 37(4), 205-211.
    • (1983) Holzforschung , vol.37 , Issue.4 , pp. 205-211
    • Ekman, R.1
  • 98
    • 0141699719 scopus 로고    scopus 로고
    • Quantitative Determination of Hydroxy Pentacyclic Triterpene Acids in Vegetable Oils
    • Pérez-Camino, M.C.; Cert, A. Quantitative Determination of Hydroxy Pentacyclic Triterpene Acids in Vegetable Oils. J. Agric. Food Chem., 1999, 47(4), 1558-1562.
    • (1999) J. Agric. Food Chem , vol.47 , Issue.4 , pp. 1558-1562
    • Pérez-Camino, M.C.1    Cert, A.2
  • 99
    • 0344256474 scopus 로고    scopus 로고
    • Characterization of archaeological frankincense by gas chromatography-mass spectrometry
    • Mathe, C.; Culioli, G.; Archier, P.; Vieillescazes, C. Characterization of archaeological frankincense by gas chromatography-mass spectrometry. J. Chromatogr., 2004, 1023(2), 277-285.
    • (2004) J. Chromatogr , vol.1023 , Issue.2 , pp. 277-285
    • Mathe, C.1    Culioli, G.2    Archier, P.3    Vieillescazes, C.4
  • 100
    • 21044436946 scopus 로고    scopus 로고
    • GC-MS analysis of penta- and tetra-cyclic triterpenes from resins of Pistacia species. Part I. Pistacia lentiscus var. Chia
    • Assimopoulou, A.N.; Papageorgiou, V.P. GC-MS analysis of penta- and tetra-cyclic triterpenes from resins of Pistacia species. Part I. Pistacia lentiscus var. Chia. Biomed. Chromatogr., 2005, 19(4), 285-311.
    • (2005) Biomed. Chromatogr , vol.19 , Issue.4 , pp. 285-311
    • Assimopoulou, A.N.1    Papageorgiou, V.P.2
  • 101
    • 0029792255 scopus 로고    scopus 로고
    • Mass Spectrometry of Labelled Triterpenoids: Thermospray and Electron Impact Ionization Analysis
    • Heinzen, H.; de Vries, J.X.; Moyna, P.; Remberg, G.; Martinez, R.; Tietze, L.F. Mass Spectrometry of Labelled Triterpenoids: Thermospray and Electron Impact Ionization Analysis. Phytochem. Anal, 1996, 7(5), 237-244.
    • (1996) Phytochem. Anal , vol.7 , Issue.5 , pp. 237-244
    • Heinzen, H.1    De Vries, J.X.2    Moyna, P.3    Remberg, G.4    Martinez, R.5    Tietze, L.F.6
  • 103
    • 58149343667 scopus 로고    scopus 로고
    • Phytochemicals of Apple Peels: Isolation, Structure Elucidation, and Their Antiproliferative and Antioxidant Activities
    • He, X.; Liu, R.H. Phytochemicals of Apple Peels: Isolation, Structure Elucidation, and Their Antiproliferative and Antioxidant Activities. J. Agric. Food Chem., 2008, 56(21), 9905-9910.
    • (2008) J. Agric. Food Chem , vol.56 , Issue.21 , pp. 9905-9910
    • He, X.1    Liu, R.H.2
  • 104
    • 33751330871 scopus 로고    scopus 로고
    • Birch bark research and development
    • Krasutsky, P.A. Birch bark research and development. Nat. Prod. Rep., 2006, 23(6), 919-942.
    • (2006) Nat. Prod. Rep , vol.23 , Issue.6 , pp. 919-942
    • Krasutsky, P.A.1
  • 105
    • 77953266690 scopus 로고    scopus 로고
    • Review of presence of oleanolic acid in natural products
    • Fai, Y.M.; Tao, C.A. Review of presence of oleanolic acid in natural products. Nat. Prod. Med., 2009, 2, 77-290.
    • (2009) Nat. Prod. Med , vol.2 , pp. 77-290
    • Fai, Y.M.1    Tao, C.A.2
  • 107
    • 34548317131 scopus 로고    scopus 로고
    • Isolation of ursolic acid from apple peels by high speed countercurrent chromatography
    • Frighetto, R.T.S.; Welendorf, R.M.; Nigro, E.N.; Frighetto, N.; Siani, A.C. Isolation of ursolic acid from apple peels by high speed countercurrent chromatography. Food Chem., 2008, 106(2), 767-771.
    • (2008) Food Chem , vol.106 , Issue.2 , pp. 767-771
    • Frighetto, R.T.S.1    Welendorf, R.M.2    Nigro, E.N.3    Frighetto Siani, N.4    A.C.5
  • 108
    • 34250659001 scopus 로고    scopus 로고
    • Triterpenoids Isolated from Apple Peels Have Potent Antiproliferative Activity and May Be Partially Responsible for Apple's Anticancer Activity
    • He, X.; Liu, R.H. Triterpenoids Isolated from Apple Peels Have Potent Antiproliferative Activity and May Be Partially Responsible for Apple's Anticancer Activity. J. Agric. Food Chem., 2007, 55(11), 4366-4370.
    • (2007) J. Agric. Food Chem , vol.55 , Issue.11 , pp. 4366-4370
    • He, X.1    Liu, R.H.2
  • 110
    • 84861149095 scopus 로고    scopus 로고
    • Comparison of the Triterpenoid Content of Berries and Leaves of Lingonberry Vaccinium vitis-idaea from Finland and Poland
    • Szakiel, A.; Paczkowski, C.; Koivuniemi, H.; Huttunen, S. Comparison of the Triterpenoid Content of Berries and Leaves of Lingonberry Vaccinium vitis-idaea from Finland and Poland. J. Agric. Food Chem., 2012, 60(19), 4994-5002.
    • (2012) J. Agric. Food Chem , vol.60 , Issue.19 , pp. 4994-5002
    • Szakiel, A.1    Paczkowski, C.2    Koivuniemi, H.3    Huttunen, S.4
  • 111
    • 84911458045 scopus 로고
    • Solvent Extraction of Wax and Ursolic Acid from Cranberry Skins
    • Arnold, L.K.; Hsia, P.R. Solvent Extraction of Wax and Ursolic Acid from Cranberry Skins. Ind. Eng. Chem., 1957, 49(3), 360-363.
    • (1957) Ind. Eng. Chem , vol.49 , Issue.3 , pp. 360-363
    • Arnold, L.K.1    Hsia, P.R.2
  • 112
    • 53449088089 scopus 로고    scopus 로고
    • Anticancer activities of cranberry phytochemicals: An update
    • Neto, C.C.; Amoroso, J.W.; Liberty, A.M. Anticancer activities of cranberry phytochemicals: An update. Mol. Nutr. Food Res., 2008, 52(S1), S18-S27.
    • (2008) Mol. Nutr. Food Res , vol.52 , Issue.S1 , pp. S18-S27
    • Neto, C.C.1    Amoroso, J.W.2    Liberty, A.M.3
  • 113
    • 0001746201 scopus 로고
    • Surface waxes from olive fruits
    • Bianchi, G.; Murelli, C.; Vlahov, G. Surface waxes from olive fruits. Phytochemistry, 1992, 31(10), 3503-3506.
    • (1992) Phytochemistry , vol.31 , Issue.10 , pp. 3503-3506
    • Bianchi, G.1    Murelli, C.2    Vlahov, G.3
  • 114
    • 84864039495 scopus 로고    scopus 로고
    • Towards comprehensive utilization of winemaking residues: Characterization of grape skins from red grape pomaces of variety Touriga Nacional
    • Mendes, J.A.S.; Prozil, S.O.; Evtuguin, D.V.; Lopes, L.P.C. Towards comprehensive utilization of winemaking residues: Characterization of grape skins from red grape pomaces of variety Touriga Nacional. Ind. Crop. Prod., 2013, 43(0), 25-32.
    • (2013) Ind. Crop. Prod , vol.43 , Issue.0 , pp. 25-32
    • Mendes, J.A.S.1    Prozil, S.O.2    Evtuguin, D.V.3    Lopes, L.P.C.4
  • 115
    • 62449189622 scopus 로고    scopus 로고
    • LC-MS method development to evaluate major triterpenes in skins and cuticular waxes of grape berries
    • Orbán, N.; Kozák, I.O.; Drávucz, M.; Kiss, A. LC-MS method development to evaluate major triterpenes in skins and cuticular waxes of grape berries. Int. J. Food Sci. Tech., 2009, 44(4), 869-873.
    • (2009) Int. J. Food Sci. Tech , vol.44 , Issue.4 , pp. 869-873
    • Orbán, N.1    Kozák, I.O.2    Drávucz, M.3    Kiss, A.4
  • 116
    • 1542350038 scopus 로고    scopus 로고
    • Insulin Secretion and Cyclooxygenase Enzyme Inhibition by Cabernet Sauvignon Grape Skin Compounds
    • Zhang, Y.; Jayaprakasam, B.; Seeram, N.P.; Olson, L.K.; DeWitt, D.; Nair, M.G. Insulin Secretion and Cyclooxygenase Enzyme Inhibition by Cabernet Sauvignon Grape Skin Compounds. J. Agric. Food Chem., 2003, 52(2), 228-233.
    • (2003) J. Agric. Food Chem , vol.52 , Issue.2 , pp. 228-233
    • Zhang, Y.1    Jayaprakasam, B.2    Seeram, N.P.3    Olson, L.K.4    Dewitt, D.5    Nair, M.G.6
  • 117
    • 84876413596 scopus 로고    scopus 로고
    • Fruit cuticular waxes as a source of biologically active triterpenoids
    • Szakiel, A.; Pączkowski, C.; Pensec, F.; Bertsch, C. Fruit cuticular waxes as a source of biologically active triterpenoids. Phytochem. Rev., 2012, 1-22.
    • (2012) Phytochem. Rev , pp. 1-22
    • Szakiel, A.1    Pączkowski, C.2    Pensec, F.3    Bertsch, C.4
  • 118
    • 33646431436 scopus 로고    scopus 로고
    • Simultaneous quantification of three major bioactive triterpene acids in the leaves of Diospyros kaki by highperformance liquid chromatography method
    • Fan, J.-P.; He, C.-H. Simultaneous quantification of three major bioactive triterpene acids in the leaves of Diospyros kaki by highperformance liquid chromatography method. J. Pharm. Biomed. Anal., 2006, 41(3), 950-956.
    • (2006) J. Pharm. Biomed. Anal , vol.41 , Issue.3 , pp. 950-956
    • Fan, J.-P.1    He, C.-H.2
  • 119
    • 0028836953 scopus 로고
    • Investigations on the steroidal antiinflammatory activity of triterpenoids from Diospyros leucomelas
    • Recio, M.D.; Giner, R.M.; Manez, S.; Gueho, J.; Julien, H.R.; Hostettmann, K.; Rios, J.L. Investigations on the steroidal antiinflammatory activity of triterpenoids from Diospyros leucomelas. Plant. Med., 1995, 61(1), 9-12.
    • (1995) Plant. Med , vol.61 , Issue.1 , pp. 9-12
    • Recio, M.D.1    Giner, R.M.2    Manez, S.3    Gueho, J.4    Julien, H.R.5    Hostettmann, K.6    Rios, J.L.7
  • 120
    • 0036205958 scopus 로고    scopus 로고
    • Determination of the triterpenoid, betulinic acid, in Doliocarpus schottianus by HPLC
    • Oliveira, B.H.D.; Santos, C.A.M.; Espíndola, A.P.D.M. Determination of the triterpenoid, betulinic acid, in Doliocarpus schottianus by HPLC. Phytochem. Anal., 2002, 13(2), 95-98.
    • (2002) Phytochem. Anal , vol.13 , Issue.2 , pp. 95-98
    • Oliveira, B.H.D.1    Santos, C.A.M.2    Espíndola, A.P.D.M.3
  • 121
    • 0029152546 scopus 로고
    • Triterpenoids from callus tissue cultures of Paeonia species
    • Ikuta, A.; Kamiya, K.; Satake, T.; Saiki, Y. Triterpenoids from callus tissue cultures of Paeonia species. Phytochemistry, 1995, 38(5), 1203-1207.
    • (1995) Phytochemistry , vol.38 , Issue.5 , pp. 1203-1207
    • Ikuta, A.1    Kamiya, K.2    Satake, T.3    Saiki, Y.4
  • 122
    • 0029998029 scopus 로고    scopus 로고
    • Compounds from Syzygium aromaticum possessing growth inhibitory activity against oral pathogens
    • Cai, L.N.; Wu, C.D. Compounds from Syzygium aromaticum possessing growth inhibitory activity against oral pathogens. J. Nat. Prod., 1996, 59(10), 987-990.
    • (1996) J. Nat. Prod , vol.59 , Issue.10 , pp. 987-990
    • Cai, L.N.1    Wu, C.D.2
  • 124
    • 0028176540 scopus 로고
    • Anti- AIDS agents. 11. Betulinic acid and platonic acid as anti-HIV principles from Syzygium-claviflorum,and the anti-HIV activity of structurally related triterpenoids
    • Fujioka, T.; Kashiwada, Y.; Kilkuskie, R.E.; Cosentino, L.M.; Ballas, L.M.; Jiang, J.B.; Janzen, W.P.; Chen, I.S.; Lee, K.H. Anti- AIDS agents. 11. Betulinic acid and platonic acid as anti-HIV principles from Syzygium-claviflorum,and the anti-HIV activity of structurally related triterpenoids. J. Nat. Prod., 1994, 57(2), 243-247.
    • (1994) J. Nat. Prod , vol.57 , Issue.2 , pp. 243-247
    • Fujioka, T.1    Kashiwada, Y.2    Kilkuskie, R.E.3    Cosentino, L.M.4    Ballas, L.M.5    Jiang, J.B.6    Janzen, W.P.7    Chen, I.S.8    Lee, K.H.9
  • 125
    • 84865848349 scopus 로고    scopus 로고
    • A Novel Triterpene Extract from Mistletoe Induces Rapid Apoptosis in Murine B16.F10 Melanoma Cells
    • Strüh, C.M.; Jäger, S.; Schempp, C.M.; Scheffler, A.; Martin, S.F. A Novel Triterpene Extract from Mistletoe Induces Rapid Apoptosis in Murine B16.F10 Melanoma Cells. Phytother. Res., 2012, 26(10), 1507-1512.
    • (2012) Phytother. Res , vol.26 , Issue.10 , pp. 1507-1512
    • Strüh, C.M.1    Jäger, S.2    Schempp, C.M.3    Scheffler, A.4    Martin, S.F.5
  • 126
    • 34250302748 scopus 로고    scopus 로고
    • Solubility studies of oleanolic acid and betulinic acid in aqueous solutions and plant extracts of Viscum album L
    • Jager, S.; Winkler, K.; Pfuller, U.; Scheffler, A. Solubility studies of oleanolic acid and betulinic acid in aqueous solutions and plant extracts of Viscum album L. Plant. Med., 2007, 73(2), 157-162.
    • (2007) Plant. Med , vol.73 , Issue.2 , pp. 157-162
    • Jager, S.1    Winkler, K.2    Pfuller, U.3    Scheffler, A.4
  • 127
    • 0346059345 scopus 로고    scopus 로고
    • Cytotoxic triterpenoids from the fruits of Zizyphus jujuba
    • Lee, S.M.; Min, B.S.; Lee, C.G.; Kim, K.S.; Kho, Y.H. Cytotoxic triterpenoids from the fruits of Zizyphus jujuba. Plant. Med., 2003, 69(11), 1051-1054.
    • (2003) Plant. Med , vol.69 , Issue.11 , pp. 1051-1054
    • Lee, S.M.1    Min, B.S.2    Lee, C.G.3    Kim, K.S.4    Kho, Y.H.5
  • 129
    • 0343565453 scopus 로고    scopus 로고
    • New triterpenoids with antibacterial activity from Zizyphus joazeiro
    • Schuhly, W.; Heilmann, J.; Calis, I.; Sticher, O. New triterpenoids with antibacterial activity from Zizyphus joazeiro. Plant. Med., 1999, 65(8), 740-743.
    • (1999) Plant. Med , vol.65 , Issue.8 , pp. 740-743
    • Schuhly, W.1    Heilmann, J.2    Calis, I.3    Sticher, O.4
  • 130
    • 73249141897 scopus 로고    scopus 로고
    • Betulaceae and Platanaceae Plants as Alternative Sources of Selected Lupane-Type Triterpenes. Their Composition Profile and Betulin Content
    • Felfoldi-Gava, A.; Simandi, B.; Plander, S.; Szarka, S.; Szoke, E.; Kery, A. Betulaceae and Platanaceae Plants as Alternative Sources of Selected Lupane-Type Triterpenes. Their Composition Profile and Betulin Content. Acta Chromatogr., 2009, 21(4), 671-681.
    • (2009) Acta Chromatogr , vol.21 , Issue.4 , pp. 671-681
    • Felfoldi-Gava, A.1    Simandi, B.2    Plander, S.3    Szarka, S.4    Szoke, E.5    Kery, A.6
  • 131
    • 0025846466 scopus 로고
    • Triterpenoid Constituents in the Outer Bark of Betula alleghaniensis (Yellow Birch)
    • Cole, B.J.W.; Bentley, M.D.; Hua, Y.; Bu, L. Triterpenoid Constituents in the Outer Bark of Betula alleghaniensis (Yellow Birch). J. Wood Chem. Technol., 1991, 11(2), 209-223.
    • (1991) J. Wood Chem. Technol , vol.11 , Issue.2 , pp. 209-223
    • Cole, B.J.W.1    Bentley, M.D.2    Hua, Y.3    Bu, L.4
  • 133
    • 58149240781 scopus 로고    scopus 로고
    • A Preliminary Pharmacokinetic Study of Betulin, the Main Pentacyclic Triterpene from Extract of Outer Bark of Birch (Betulae alba cortex)
    • Jäger, S.; Laszczyk, M.; Scheffler, A. A Preliminary Pharmacokinetic Study of Betulin, the Main Pentacyclic Triterpene from Extract of Outer Bark of Birch (Betulae alba cortex). Molecules, 2008, 13(12), 3224-3235.
    • (2008) Molecules , vol.13 , Issue.12 , pp. 3224-3235
    • Jäger, S.1    Laszczyk, M.2    Scheffler, A.3
  • 134
    • 45549113481 scopus 로고
    • Betulin and lupeol in bark from four white-barked birches
    • O'Connell, M.M.; Bentley, M.D.; Campbell, C.S.; Cole, B.J.W. Betulin and lupeol in bark from four white-barked birches. Phytochemistry, 1988, 27(7), 2175-2176.
    • (1988) Phytochemistry , vol.27 , Issue.7 , pp. 2175-2176
    • O'connell, M.M.1    Bentley, M.D.2    Campbell, C.S.3    Cole, B.J.W.4
  • 135
    • 33751323754 scopus 로고    scopus 로고
    • Extraction of betulin from bark of Betula platyphylla by supercritical carbon dioxide extraction
    • Zhang, Y.H.; Yu, T.; Wang, Y. Extraction of betulin from bark of Betula platyphylla by supercritical carbon dioxide extraction. J. Forens. Res., 2003, 14, 202-204.
    • (2003) J. Forens. Res , vol.14 , pp. 202-204
    • Zhang, Y.H.1    Yu, T.2    Wang, Y.3
  • 136
    • 0030986769 scopus 로고    scopus 로고
    • A Concise Semi-Synthetic Approach to Betulinic Acid from Betulin
    • Kim, D.S.H.L.; Chen, Z.; Nguyen, V.T.; Pezzuto, J.M.; Qiu, S.; Lu, Z.-Z. A Concise Semi-Synthetic Approach to Betulinic Acid from Betulin. Synth. Commun., 1997, 27(9), 1607-1612.
    • (1997) Synth. Commun , vol.27 , Issue.9 , pp. 1607-1612
    • Kim, D.S.H.L.1    Chen, Z.2    Nguyen, V.T.3    Pezzuto, J.M.4    Qiu, S.5    Lu, Z.-Z.6
  • 137
    • 84982077822 scopus 로고
    • Oxydation des Dihydro-betulins und der Dihydro-betulonsäure mit Salpetersäure
    • Ruzicka, L.; Isler, O. Polyterpene und Polyterpenoide CVI. Oxydation des Dihydro-betulins und der Dihydro-betulonsäure mit Salpetersäure. Helv. Chim. Acta, 1936, 19(1), 506-519.
    • (1936) Helv. Chim. Acta , vol.19 , Issue.1 , pp. 506-519
    • Ruzicka, L.1    Isler, O.2    Polyterpene Und Polyterpenoide, V.I.3
  • 138
    • 56649111319 scopus 로고    scopus 로고
    • Quercus suber and Betula pendula outer barks as renewable sources of oleochemicals: A comparative study
    • Pinto, P.C.R.O.; Sousa, A.F.; Silvestre, A.J.D.; Neto, C.P.; Gandini, A.; Eckerman, C.; Holmbom, B. Quercus suber and Betula pendula outer barks as renewable sources of oleochemicals: A comparative study. Ind. Crop. Prod., 2009, 29(1), 126-132.
    • (2009) Ind. Crop. Prod , vol.29 , Issue.1 , pp. 126-132
    • Pinto, P.C.R.O.1    Sousa, A.F.2    Silvestre, A.J.D.3    Neto, C.P.4    Gandini, A.5    Eckerman, C.6    Holmbom, B.7
  • 139
    • 33748895030 scopus 로고    scopus 로고
    • Triterpenic and Other Lipophilic Components from Industrial Cork Byproducts
    • Sousa, A.F.; Pinto, P.C.R.O.; Silvestre, A.J.D.; Pascoal Neto, C. Triterpenic and Other Lipophilic Components from Industrial Cork Byproducts. J. Agric. Food Chem., 2006, 54(18), 6888-6893.
    • (2006) J. Agric. Food Chem , vol.54 , Issue.18 , pp. 6888-6893
    • Sousa, A.F.1    Pinto, P.C.R.O.2    Silvestre, A.J.D.3    Pascoal Neto, C.4
  • 140
    • 0028816211 scopus 로고
    • Chemical-Composition and Biological-Activity of Leaf Exudates from Some Lamiaceae Plants
    • Sattar, A.A.; Bankova, V.; Kujumgiev, A.; Galabov, A.; Ignatova, A.; Todorova, C.; Popov, S. Chemical-Composition and Biological-Activity of Leaf Exudates from Some Lamiaceae Plants. Pharmazie, 1995, 50(1), 62-65.
    • (1995) Pharmazie , vol.50 , Issue.1 , pp. 62-65
    • Sattar, A.A.1    Bankova, V.2    Kujumgiev, A.3    Galabov, A.4    Ignatova, A.5    Todorova, C.6    Popov, S.7
  • 141
    • 1842869270 scopus 로고    scopus 로고
    • Ursolic acid as a trypanocidal constituent in rosemary. Biol. Pharm
    • Abe, F.; Yamauchi, T.; Nagao, T.; Kinjo, J.; Okabe, H.; Higo, H.; Akahane, H. Ursolic acid as a trypanocidal constituent in rosemary. Biol. Pharm. Bull., 2002, 25(11), 1485-1487.
    • (2002) Bull , vol.25 , Issue.11 , pp. 1485-1487
    • Abe, F.1    Yamauchi, T.2    Nagao, T.3    Kinjo, J.4    Okabe, H.5    Higo, H.6    Akahane, H.7
  • 142
    • 84872786101 scopus 로고    scopus 로고
    • Chemical Constituents and Biological Activities of Plants from the Genus Ligustrum
    • Gao, B.-B.; She, G.-M.; She, D.-M. Chemical Constituents and Biological Activities of Plants from the Genus Ligustrum. Chem. Biodivers., 2013, 10(1), 96-128.
    • (2013) Chem. Biodivers , vol.10 , Issue.1 , pp. 96-128
    • Gao, B.-B.1    She, G.-M.2    She, D.-M.3
  • 145
    • 33749481920 scopus 로고    scopus 로고
    • Olive fruit extracts inhibit proliferation and induce apoptosis in HT-29 human colon cancer cells
    • Emilia Juan, M.; Wenzel, U.; Ruiz-Gutierrez, V.; Daniel, H.; Planas, J.M. Olive fruit extracts inhibit proliferation and induce apoptosis in HT-29 human colon cancer cells. J. Nutr., 2006, 136(10), 2553-2557.
    • (2006) J. Nutr , vol.136 , Issue.10 , pp. 2553-2557
    • Emilia Juan, M.1    Wenzel, U.2    Ruiz-Gutierrez, V.3    Daniel, H.4    Planas, J.M.5
  • 146
    • 79251627422 scopus 로고    scopus 로고
    • Herbaceous Peony (Paeonia lactiflora Pall.) as an Alternative Source of Oleanolic and Ursolic Acids
    • Zhou, C.; Zhang, Y.; Sheng, Y.; Zhao, D.; Lv, S.; Hu, Y.; Tao, J. Herbaceous Peony (Paeonia lactiflora Pall.) as an Alternative Source of Oleanolic and Ursolic Acids. Int. J. Mol. Sci., 2011, 12(1), 655-667.
    • (2011) Int. J. Mol. Sci , vol.12 , Issue.1 , pp. 655-667
    • Zhou, C.1    Zhang, Y.2    Sheng, Y.3    Zhao, D.4    Lv, S.5    Hu, Y.6    Tao, J.7
  • 148
    • 34447537703 scopus 로고    scopus 로고
    • Determination of oleanolic acid, ursolic acid and amygdalin in the flower of Eriobotrya japonica Lindl. by HPLC
    • Zhou, C.; Chen, K.; Sun, C.; Chen, Q.; Zhang, W.; Li, X. Determination of oleanolic acid, ursolic acid and amygdalin in the flower of Eriobotrya japonica Lindl. by HPLC. Biomed. Chromatogr., 2007, 21(7), 755-761.
    • (2007) Biomed. Chromatogr , vol.21 , Issue.7 , pp. 755-761
    • Zhou, C.1    Chen, K.2    Sun, C.3    Chen, Q.4    Zhang, W.5    Li, X.6
  • 149
    • 81755173518 scopus 로고    scopus 로고
    • A weed with multiple utility: Lantana camara
    • Patel, S. A weed with multiple utility: Lantana camara. Rev. Environ. Sci. Biotechnol., 2011, 10(4), 341-351.
    • (2011) Rev. Environ. Sci. Biotechnol , vol.10 , Issue.4 , pp. 341-351
    • Patel, S.1
  • 150
    • 84863052092 scopus 로고    scopus 로고
    • Hepatoprotective Effects of Total Triterpenoids and Total Flavonoids from Vitis vinifera L against Immunological Liver Injury in Mice
    • Liu, T.; Zhao, J.; Ma, L.; Ding, Y.S.; Su, D.Q. Hepatoprotective Effects of Total Triterpenoids and Total Flavonoids from Vitis vinifera L against Immunological Liver Injury in Mice. Evid.-based Complement Altern. Med., 2012, 2012, 969386.
    • (2012) Evid.-based Complement Altern. Med , pp. 969386
    • Liu, T.1    Zhao, J.2    Ma, L.3    Ding, Y.S.4    Su, D.Q.5
  • 151
    • 57749089684 scopus 로고    scopus 로고
    • Enrichment of pomace olive oil in triterpenic acids during storage of “Alpeorujo” olive paste
    • García, A.; Brenes, M.; Dobarganes, M.C.; Romero, C.; Ruiz- Méndez, M.V. Enrichment of pomace olive oil in triterpenic acids during storage of “Alpeorujo” olive paste. Eur. J. Lipid Sci. Technol., 2008, 110(12), 1136-1141.
    • (2008) Eur. J. Lipid Sci. Technol , vol.110 , Issue.12 , pp. 1136-1141
    • García, A.1    Brenes, M.2    Dobarganes, M.C.3    Romero, C.4    Ruiz- MéNdez, M.V.5
  • 152
    • 33845778543 scopus 로고    scopus 로고
    • Use of solid residue from the olive industry
    • Guinda, A. Use of solid residue from the olive industry. Grasas Aceites, 2006, 57(1), 107-115.
    • (2006) Grasas Aceites , vol.57 , Issue.1 , pp. 107-115
    • Guinda, A.1
  • 154
    • 0343179100 scopus 로고
    • Minor components of olive oils. I. Triterpenoid acids in an acetone-extracted orujo oil
    • Vioque, E.; Morris, L.J. Minor components of olive oils. I. Triterpenoid acids in an acetone-extracted orujo oil. J. Am. Oil Chem. Soc., 1961, 38(9), 485-488.
    • (1961) J. Am. Oil Chem. Soc , vol.38 , Issue.9 , pp. 485-488
    • Vioque, E.1    Morris, L.J.2
  • 155
    • 79953242026 scopus 로고    scopus 로고
    • New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress
    • Sporn, M.B.; Liby, K.T.; Yore, M.M.; Fu, L.; Lopchuk, J.M.; Gribble, G.W. New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress. J. Nat. Prod., 2011, 74(3), 537-545.
    • (2011) J. Nat. Prod , vol.74 , Issue.3 , pp. 537-545
    • Sporn, M.B.1    Liby, K.T.2    Yore, M.M.3    Fu, L.4    Lopchuk, J.M.5    Gribble, G.W.6
  • 156
    • 77956710443 scopus 로고    scopus 로고
    • Chapter 1 Introduction
    • Michael, N.Constantinos, P.H., Eds., Elsevier
    • Niaounakis, M.P.; Halvadakis, C. Chapter 1 Introduction. In Waste Management Series, Michael, N.Constantinos, P.H., Eds., Elsevier, 2006, pp. 3-22.
    • (2006) Waste Management Series , pp. 3-22
    • Niaounakis, M.P.1    Halvadakis, C.2
  • 157
    • 75849140537 scopus 로고    scopus 로고
    • Did the NPRA mislead the US Senate on ethanol potential?
    • Bruce, E.D. Did the NPRA mislead the US Senate on ethanol potential? Biofuels, Bioprod. Bioref., 2007, 1(4), 243-244.
    • (2007) Biofuels, Bioprod. Bioref , vol.1 , Issue.4 , pp. 243-244
    • Bruce, E.D.1
  • 158
    • 79952354828 scopus 로고    scopus 로고
    • Ursolic acid and its esters: Occurrence in cranberries and other Vaccinium fruit and effects on matrix metalloproteinase activity in DU145 prostate tumor cells
    • Kondo, M.; MacKinnon, S.L.; Craft, C.C.; Matchett, M.D.; Hurta, R.A.R.; Neto, C.C. Ursolic acid and its esters: occurrence in cranberries and other Vaccinium fruit and effects on matrix metalloproteinase activity in DU145 prostate tumor cells. J. Sci. Food Agric., 2011, 91(5), 789-796.
    • (2011) J. Sci. Food Agric , vol.91 , Issue.5 , pp. 789-796
    • Kondo, M.1    Mackinnon, S.L.2    Craft, C.C.3    Matchett, M.D.4    Hurta, R.A.R.5    Neto, C.C.6
  • 160
    • 25844450837 scopus 로고    scopus 로고
    • Chemical composition of the epicuticular wax from the fruits of Eucalyptus globulus
    • Pereira, S.I.; Freire, C.S.R.; Neto, C.P.; Silvestre, A.J.; Silva, A.M.S. Chemical composition of the epicuticular wax from the fruits of Eucalyptus globulus. Phytochem. Anal., 2005, 16(5), 364-369.
    • (2005) Phytochem. Anal , vol.16 , Issue.5 , pp. 364-369
    • Pereira, S.I.1    Freire, C.S.R.2    Neto, C.P.3    Silvestre, A.J.4    Silva, A.M.S.5
  • 161
    • 0034739199 scopus 로고    scopus 로고
    • Triterpenoidal constituents from Eucalyptus camaldulensis var. obtusa leaves
    • Siddiqui, B.S.; Sultana, I.; Begum, S. Triterpenoidal constituents from Eucalyptus camaldulensis var. obtusa leaves. Phytochemistry, 2000, 54(8), 861-865.
    • (2000) Phytochemistry , vol.54 , Issue.8 , pp. 861-865
    • Siddiqui, B.S.1    Sultana, I.2    Begum, S.3
  • 162
    • 34250007728 scopus 로고    scopus 로고
    • Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRIE)
    • Horiuchi, K.; Shiota, S.; Hatano, T.; Yoshida, T.; Kuroda, T.; Tsuchiya, T. Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRIE). Biol. Pharm. Bull., 2007, 30(6), 1147-1149.
    • (2007) Biol. Pharm. Bull , vol.30 , Issue.6 , pp. 1147-1149
    • Horiuchi, K.1    Shiota, S.2    Hatano, T.3    Yoshida, T.4    Kuroda, T.5    Tsuchiya, T.6
  • 163
    • 34447519197 scopus 로고    scopus 로고
    • Antimicrobial activity of the methanolic extract and of the chemical constituents isolated from Newbouldia laevis
    • Kuete, V.; Eyong, K.O.; Folefoc, G.N.; Beng, V.P.; Hussain, H.; Krohn, K.; Nkengfack, A.E. Antimicrobial activity of the methanolic extract and of the chemical constituents isolated from Newbouldia laevis. Pharmazie, 2007, 62(7), 552-556.
    • (2007) Pharmazie , vol.62 , Issue.7 , pp. 552-556
    • Kuete, V.1    Eyong, K.O.2    Folefoc, G.N.3    Beng, V.P.4    Hussain, H.5    Krohn, K.6    Nkengfack, A.E.7
  • 164
    • 0036280433 scopus 로고    scopus 로고
    • Yang, Q.Y. Effects of ursolic acid and oleanolic acid on human colon carcinoma cell line HCT15. World
    • Li, J.; Guo, W.J.; Yang, Q.Y. Effects of ursolic acid and oleanolic acid on human colon carcinoma cell line HCT15. World J. Gastroenterol., 2002, 8(3), 493-495.
    • (2002) J. Gastroenterol , vol.8 , Issue.3 , pp. 493-495
    • Li, J.1    Guo, W.J.2
  • 165
    • 22444434136 scopus 로고    scopus 로고
    • Momordin Ic and oleanolic acid from Kochiae fructus reduce carbon tetrachloride-induced hepatotoxicity in rats
    • Kim, N.Y.; Lee, M.K.; Park, M.J.; Kim, S.J.; Park, H.J.; Choi, J.W.; Kim, S.H.; Cho, S.Y.; Lee, J.S. Momordin Ic and oleanolic acid from Kochiae fructus reduce carbon tetrachloride-induced hepatotoxicity in rats. J. Med. Food, 2005, 8(2), 177-183.
    • (2005) J. Med. Food , vol.8 , Issue.2 , pp. 177-183
    • Kim, N.Y.1    Lee, M.K.2    Park, M.J.3    Kim, S.J.4    Park, H.J.5    Choi, J.W.6    Kim, S.H.7    Cho, S.Y.8    Lee, J.S.9
  • 169
    • 52949132197 scopus 로고    scopus 로고
    • The anti-arthritic effect of ursolic acid on zymosan-induced acute inflammation-induced chronic arthritis models and adjuvant
    • Kang, S.Y.; Yoon, S.Y.; Roh, D.H.; Jeon, M.J.; Seo, H.S.; Uh, D.K.; Kwon, Y.B.; Kim, H.W.; Han, H.J.; Lee, H.J.; Lee, J.H. The anti-arthritic effect of ursolic acid on zymosan-induced acute inflammation-induced chronic arthritis models and adjuvant. J. Pharm. Pharmacol., 2008, 60(10), 1347-1354.
    • (2008) J. Pharm. Pharmacol , vol.60 , Issue.10 , pp. 1347-1354
    • Kang, S.Y.1    Yoon, S.Y.2    Roh, D.H.3    Jeon, M.J.4    Seo, H.S.5    Uh, D.K.6    Kwon, Y.B.7    Kim, H.W.8    Han, H.J.9    Lee, H.J.10    Lee, J.H.11
  • 170
    • 0030854627 scopus 로고    scopus 로고
    • Betulinic acid: Isolation from Triphyophyllum peltatum and Ancistrocladus heyneanus, antimalarial activity, and crystal structure of the benzyl ester
    • Bringmann, G.; Saeb, W.; Assi, L.A.; Francois, G.; Narayanan, A.S.S.; Peters, K.; Peters, E.M. Betulinic acid: Isolation from Triphyophyllum peltatum and Ancistrocladus heyneanus, antimalarial activity, and crystal structure of the benzyl ester. Plant. Med., 1997, 63(3), 255-257.
    • (1997) Plant. Med , vol.63 , Issue.3 , pp. 255-257
    • Bringmann, G.1    Saeb, W.2    Assi, L.A.3    Francois, G.4    Narayanan, A.S.S.5    Peters, K.6    Peters, E.M.7
  • 171
    • 56649115867 scopus 로고    scopus 로고
    • Anabolic activity of ursolic acid in bone: Stimulating osteoblast differentiation in vitro and inducing new bone formation in vivo
    • Lee, S.U.; Park, S.J.; Kwak, H.B.; Oh, J.; Min, Y.K.; Kim, S.H. Anabolic activity of ursolic acid in bone: Stimulating osteoblast differentiation in vitro and inducing new bone formation in vivo. Pharmacol. Res., 2008, 58(5-6), 290-296.
    • (2008) Pharmacol. Res , vol.58 , Issue.5-6 , pp. 290-296
    • Lee, S.U.1    Park, S.J.2    Kwak, H.B.3    Oh, J.4    Min, Y.K.5    Kim, S.H.6
  • 172
    • 33644769461 scopus 로고    scopus 로고
    • Biological activity and pharmacological prospects of lupane terpenoids: I. Natural lupane derivatives
    • Tolstikova, T.G.; Sorokina, I.V.; Tolstikov, G.A.; Tolstikov, A.G.; Flekhter, O.B. Biological activity and pharmacological prospects of lupane terpenoids: I. Natural lupane derivatives. J. Bioorg. Chem., 2006, 32(1), 37-49.
    • (2006) J. Bioorg. Chem , vol.32 , Issue.1 , pp. 37-49
    • Tolstikova, T.G.1    Sorokina, I.V.2    Tolstikov, G.A.3    Tolstikov, A.G.4    Flekhter, O.B.5
  • 173
    • 0035066838 scopus 로고    scopus 로고
    • Anthelmintic activity of the stem bark extracts of Berlina grandiflora and one of its active principles, betulinic acid
    • Enwerem, N.M.; Okogun, J.I.; Wambebe, C.O.; Okorie, D.A.; Akah, P.A. Anthelmintic activity of the stem bark extracts of Berlina grandiflora and one of its active principles, betulinic acid. Phytomedicine, 2001, 8(2), 112-114.
    • (2001) Phytomedicine , vol.8 , Issue.2 , pp. 112-114
    • Enwerem, N.M.1    Okogun, J.I.2    Wambebe, C.O.3    Okorie, D.A.4    Akah, P.A.5
  • 174
    • 21744445246 scopus 로고    scopus 로고
    • Chemical constituents and antioxidant activity of Mallotus roxburghianus leaves
    • Rana, V.S.; Rawat, M.S.M.; Pant, G.; Nagatsu, A. Chemical constituents and antioxidant activity of Mallotus roxburghianus leaves. Chem. Biodivers., 2005, 2(6), 792-798.
    • (2005) Chem. Biodivers , vol.2 , Issue.6 , pp. 792-798
    • Rana, V.S.1    Rawat, M.S.M.2    Pant, G.3    Nagatsu, A.4
  • 176
    • 34948888180 scopus 로고    scopus 로고
    • Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-O-(3 ',3 '-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection
    • Smith, P.F.; Ogundele, A.; Forrest, A.; Wilton, J.; Salzwedel, K.; Doto, J.; Allaway, G.P.; Martin, D.E. Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-O-(3 ',3 '-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection. Antimicrob. Agents Chemother., 2007, 51(10), 3574-3581.
    • (2007) Antimicrob. Agents Chemother , vol.51 , Issue.10 , pp. 3574-3581
    • Smith, P.F.1    Ogundele, A.2    Forrest, A.3    Wilton, J.4    Salzwedel, K.5    Doto, J.6    Allaway, G.P.7    Martin, D.E.8
  • 179
    • 58149357667 scopus 로고    scopus 로고
    • Betulinic acid: A natural product with anticancer activity
    • Fulda, S. Betulinic acid: A natural product with anticancer activity. Mol. Nutr. Food Res., 2009, 53(1), 140-146.
    • (2009) Mol. Nutr. Food Res , vol.53 , Issue.1 , pp. 140-146
    • Fulda, S.1
  • 180
    • 69749094633 scopus 로고    scopus 로고
    • Targeting mitochondrial apoptosis by betulinic acid in human cancers
    • Fulda, S.; Kroemer, G. Targeting mitochondrial apoptosis by betulinic acid in human cancers. Drug Discov. Today, 2009, 14(17-18), 885-890.
    • (2009) Drug Discov. Today , vol.14 , Issue.17-18 , pp. 885-890
    • Fulda, S.1    Kroemer, G.2
  • 181
    • 79955594006 scopus 로고    scopus 로고
    • Lupane triterpenoids--betulin and betulinic acid derivatives induce apoptosis in tumor cells
    • Kommera, H.; Kaluderovic, G.N.; Kalbitz, J.; Paschke, R. Lupane triterpenoids--betulin and betulinic acid derivatives induce apoptosis in tumor cells. Invest. New Drugs, 2009, 29(2), 266-272.
    • (2009) Invest. New Drugs , vol.29 , Issue.2 , pp. 266-272
    • Kommera, H.1    Kaluderovic, G.N.2    Kalbitz, J.3    Paschke, R.4
  • 182
    • 0030815250 scopus 로고    scopus 로고
    • Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors
    • Fulda, S.; Friesen, C.; Los, M.; Scaffidi, C.; Mier, W.; Benedict, M.; Nunez, G.; Krammer, P.H.; Peter, M.E.; Debatin, K.M. Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer Res., 1997, 57(21), 4956-4964.
    • (1997) Cancer Res , vol.57 , Issue.21 , pp. 4956-4964
    • Fulda, S.1    Friesen, C.2    Los, M.3    Scaffidi, C.4    Mier, W.5    Benedict, M.6    Nunez, G.7    Krammer, P.H.8    Peter, M.E.9    Debatin, K.M.10
  • 183
    • 0032545386 scopus 로고    scopus 로고
    • Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid
    • Fulda, S.; Scaffidi, C.; Susin, S.A.; Krammer, P.H.; Kroemer, G.; Peter, M.E.; Debatin, K.M. Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid. J. Biol. Chem., 1998, 273(51), 33942-33948.
    • (1998) J. Biol. Chem , vol.273 , Issue.51 , pp. 33942-33948
    • Fulda, S.1    Scaffidi, C.2    Susin, S.A.3    Krammer, P.H.4    Kroemer, G.5    Peter, M.E.6    Debatin, K.M.7
  • 184
    • 0033023669 scopus 로고    scopus 로고
    • Betulinic acid-induced apoptosis in glioma cells: A sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing
    • Wick, W.; Grimmel, C.; Wagenknecht, B.; Dichgans, J.; Weller, M. Betulinic acid-induced apoptosis in glioma cells: A sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing. J. Pharmacol. Exp. Ther., 1999, 289(3), 1306-1312.
    • (1999) J. Pharmacol. Exp. Ther , vol.289 , Issue.3 , pp. 1306-1312
    • Wick, W.1    Grimmel, C.2    Wagenknecht, B.3    Dichgans, J.4    Weller, M.5
  • 185
    • 34247120086 scopus 로고    scopus 로고
    • Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types
    • Kessler, J.H.; Mullauer, F.B.; de Roo, G.M.; Medema, J.P. Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types. Cancer Lett., 2007, 251(1), 132-145.
    • (2007) Cancer Lett , vol.251 , Issue.1 , pp. 132-145
    • Kessler, J.H.1    Mullauer, F.B.2    De Roo, G.M.3    Medema, J.P.4
  • 187
    • 33644874389 scopus 로고    scopus 로고
    • Experimental study on MCF-7 cell apoptosis induced by ursolic acid
    • Zhang, W.; Li, Y.; Zhang, G.; Lu, J.; Ou, H. Experimental study on MCF-7 cell apoptosis induced by ursolic acid. Zhong Yao Cai, 2005, 28(4), 297-301.
    • (2005) Zhong Yao Cai , vol.28 , Issue.4 , pp. 297-301
    • Zhang, W.1    Li, Y.2    Zhang, G.3    Lu, J.4    Ou, H.5
  • 188
    • 67349181288 scopus 로고    scopus 로고
    • Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells
    • Xavier, C.P.; Lima, C.F.; Preto, A.; Seruca, R.; Fernandes-Ferreira, M.; Pereira-Wilson, C. Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells. Cancer Lett., 2009, 281(2), 162-170.
    • (2009) Cancer Lett , vol.281 , Issue.2 , pp. 162-170
    • Xavier, C.P.1    Lima, C.F.2    Preto, A.3    Seruca, R.4    Fernandes-Ferreira, M.5    Pereira-Wilson, C.6
  • 189
    • 4444356923 scopus 로고    scopus 로고
    • Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells
    • Hsu, Y.L.; Kuo, P.L.; Lin, C.C. Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells. Life Sci., 2004, 75(19), 2303-2316.
    • (2004) Life Sci , vol.75 , Issue.19 , pp. 2303-2316
    • Hsu, Y.L.1    Kuo, P.L.2    Lin, C.C.3
  • 190
    • 27944489889 scopus 로고    scopus 로고
    • Glycyrrhetinic acid and related compounds induce G1 arrest and apoptosis in human hepatocellular carcinoma HepG2
    • Satomi, Y.; Nishino, H.; Shibata, S. Glycyrrhetinic acid and related compounds induce G1 arrest and apoptosis in human hepatocellular carcinoma HepG2. Anticancer Res., 2005, 25(6B), 4043-4047.
    • (2005) Anticancer Res , vol.25 , Issue.6B , pp. 4043-4047
    • Satomi, Y.1    Nishino, H.2    Shibata, S.3
  • 191
    • 80855124898 scopus 로고    scopus 로고
    • Induction of Apoptotic Cell Death by Ursolic Acid through Mitochondrial Death Pathway and Extrinsic Death Receptor Pathway in MDA-MB-231 Cells
    • Kim, K.H.; Seo, H.S.; Choi, H.S.; Choi, I.; Shin, Y.C.; Ko, S.G. Induction of Apoptotic Cell Death by Ursolic Acid through Mitochondrial Death Pathway and Extrinsic Death Receptor Pathway in MDA-MB-231 Cells. Arch. Pharmacal Res., 2011, 34(8), 1363-1372.
    • (2011) Arch. Pharmacal Res , vol.34 , Issue.8 , pp. 1363-1372
    • Kim, K.H.1    Seo, H.S.2    Choi, H.S.3    Choi, I.4    Shin, Y.C.5    Ko, S.G.6
  • 192
    • 80052674065 scopus 로고    scopus 로고
    • Ursolic acid inhibits proliferation and induces apoptosis of cancer cells in vitro and in vivo
    • Wang, X.; Zhang, F.; Yang, L.; Mei, Y.; Long, H.; Zhang, X.; Zhang, J.; Qimuge, S.; Su, X. Ursolic acid inhibits proliferation and induces apoptosis of cancer cells in vitro and in vivo. J. Biomed. Biotechnol., 2011, 2011, 419343.
    • (2011) J. Biomed. Biotechnol , vol.2011 , pp. 419343
    • Wang, X.1    Zhang, F.2    Yang, L.3    Mei, Y.4    Long, H.5    Zhang, X.6    Zhang, J.7    Qimuge, S.8    Su, X.9
  • 193
    • 78649573167 scopus 로고    scopus 로고
    • Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway
    • Yu, Y.X.; Gu, Z.L.; Yin, J.L.; Chou, W.H.; Kwok, C.Y.; Qin, Z.H.; Liang, Z.Q. Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway. Chin. Med. J. (Engl.), 2010, 123(14), 1915-1923.
    • (2010) Chin. Med. J. (Engl.) , vol.123 , Issue.14 , pp. 1915-1923
    • Yu, Y.X.1    Gu, Z.L.2    Yin, J.L.3    Chou, W.H.4    Kwok, C.Y.5    Qin, Z.H.6    Liang, Z.Q.7
  • 194
    • 33746233612 scopus 로고    scopus 로고
    • Effect of ursolic acid on caspase-3 and PARP expression of human MCF-7 cells
    • Zhang, G.P.; Lu, Y.Y.; Lv, J.C.; Ou, H.J. Effect of ursolic acid on caspase-3 and PARP expression of human MCF-7 cells. Zhongguo Zhong Yao Za Zhi, 2006, 31(2), 141-144.
    • (2006) Zhongguo Zhong Yao Za Zhi , vol.31 , Issue.2 , pp. 141-144
    • Zhang, G.P.1    Lu, Y.Y.2    Lv, J.C.3    Ou, H.J.4
  • 195
    • 69949122837 scopus 로고    scopus 로고
    • Ursolic acid inhibits proliferation and induces apoptosis of HT-29 colon cancer cells by inhibiting the EGFR/MAPK pathway
    • Shan, J.Z.; Xuan, Y.Y.; Zheng, S.; Dong, Q.; Zhang, S.Z. Ursolic acid inhibits proliferation and induces apoptosis of HT-29 colon cancer cells by inhibiting the EGFR/MAPK pathway. J. Zhejiang Univ. Sci. B., 2009, 10(9), 668-674.
    • (2009) J. Zhejiang Univ. Sci. B , vol.10 , Issue.9 , pp. 668-674
    • Shan, J.Z.1    Xuan, Y.Y.2    Zheng, S.3    Dong, Q.4    Zhang, S.Z.5
  • 196
    • 77649184736 scopus 로고    scopus 로고
    • Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines
    • Yan, S.L.; Huang, C.Y.; Wu, S.T.; Yin, M.C. Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines. Toxicol. In Vitro, 2010, 24(3), 842-848.
    • (2010) Toxicol. In Vitro , vol.24 , Issue.3 , pp. 842-848
    • Yan, S.L.1    Huang, C.Y.2    Wu, S.T.3    Yin, M.C.4
  • 197
    • 84855172051 scopus 로고    scopus 로고
    • Proliferationinhibiting and apoptosis-inducing effects of ursolic acid and oleanolic acid on multi-drug resistance cancer cells in vitro
    • Shan, J.Z.; Xuan, Y.Y.; Ruan, S.Q.; Sun, M. Proliferationinhibiting and apoptosis-inducing effects of ursolic acid and oleanolic acid on multi-drug resistance cancer cells in vitro. Chin. J. Integr. Med., 2011, 17(8), 607-611.
    • (2011) Chin. J. Integr. Med , vol.17 , Issue.8 , pp. 607-611
    • Shan, J.Z.1    Xuan, Y.Y.2    Ruan, S.Q.3    Sun, M.4
  • 198
    • 77952615172 scopus 로고    scopus 로고
    • Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP
    • Shyu, M.H.; Kao, T.C.; Yen, G.C. Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP. J. Agric. Food Chem., 2010, 58(10), 6110-6118.
    • (2010) J. Agric. Food Chem , vol.58 , Issue.10 , pp. 6110-6118
    • Shyu, M.H.1    Kao, T.C.2    Yen, G.C.3
  • 199
    • 79958816438 scopus 로고    scopus 로고
    • Oleanolic acid from Prunella Vulgaris L. induces SPC-A-1 cell line apoptosis via regulation of Bax, Bad and Bcl-2 expression
    • Feng, L.; Au-Yeung, W.; Xu, Y.H.; Wang, S.S.; Zhu, Q.; Xiang, P. Oleanolic acid from Prunella Vulgaris L. induces SPC-A-1 cell line apoptosis via regulation of Bax, Bad and Bcl-2 expression. Asian Pac. J. Cancer Prev., 2011, 12(2), 403-408.
    • (2011) Asian Pac. J. Cancer Prev , vol.12 , Issue.2 , pp. 403-408
    • Feng, L.1    Au-Yeung, W.2    Xu, Y.H.3    Wang, S.S.4    Zhu, Q.5    Xiang, P.6
  • 200
    • 83055199995 scopus 로고    scopus 로고
    • Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo
    • Lucio, K.A.; Rocha Gda, G.; Moncao-Ribeiro, L.C.; Fernandes, J.; Takiya, C.M.; Gattass, C.R. Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo. PLoS ONE, 2011, 6(12), e28596.
    • (2011) PLoS ONE , vol.6 , Issue.12
    • Lucio, K.A.1    Rocha Gda, G.2    Moncao-Ribeiro, L.C.3    Fernandes, J.4    Takiya, C.M.5    Gattass, C.R.6
  • 201
    • 53049095071 scopus 로고    scopus 로고
    • Antiproliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells
    • Juan, M.E.; Planas, J.M.; Ruiz-Gutierrez, V.; Daniel, H.; Wenzel, U. Antiproliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells. Br. J. Nutr., 2008, 100(1), 36-43.
    • (2008) Br. J. Nutr , vol.100 , Issue.1 , pp. 36-43
    • Juan, M.E.1    Planas, J.M.2    Ruiz-Gutierrez, V.3    Daniel, H.4    Wenzel, U.5
  • 202
    • 78651102365 scopus 로고    scopus 로고
    • Antioxidant, antiproliferative, and pro-apoptotic capacities of pentacyclic triterpenes found in the skin of olives on MCF-7 human breast cancer cells and their effects on DNA damage
    • Allouche, Y.; Warleta, F.; Campos, M.; Sanchez-Quesada, C.; Uceda, M.; Beltran, G.; Gaforio, J.J. Antioxidant, antiproliferative, and pro-apoptotic capacities of pentacyclic triterpenes found in the skin of olives on MCF-7 human breast cancer cells and their effects on DNA damage. J. Agric. Food Chem., 2011, 59(1), 121-130.
    • (2011) J. Agric. Food Chem , vol.59 , Issue.1 , pp. 121-130
    • Allouche, Y.1    Warleta, F.2    Campos, M.3    Sanchez-Quesada, C.4    Uceda, M.5    Beltran, G.6    Gaforio, J.J.7
  • 203
    • 0038052805 scopus 로고    scopus 로고
    • The cell cycle: A review of regulation, deregulation and therapeutic targets in cancer
    • Vermeulen, K.; Van Bockstaele, D.R.; Berneman, Z.N. The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif., 2003, 36(3), 131-149.
    • (2003) Cell Prolif , vol.36 , Issue.3 , pp. 131-149
    • Vermeulen, K.1    Van Bockstaele, D.R.2    Berneman, Z.N.3
  • 204
    • 79952084572 scopus 로고    scopus 로고
    • Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer
    • Yadav, V.R.; Prasad, S.; Sung, B.; Kannappan, R.; Aggarwal, B.B. Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer. Toxins, 2010, 2(10), 2428-2466.
    • (2010) Toxins , vol.2 , Issue.10 , pp. 2428-2466
    • Yadav, V.R.1    Prasad, S.2    Sung, B.3    Kannappan, R.4    Aggarwal, B.B.5
  • 205
    • 0029960889 scopus 로고    scopus 로고
    • MCF-7 cell cycle arrested at G1 through ursolic acid, and increased reduction of tetrazolium salts
    • Es-Saady, D.; Simon, A.; Jayat-Vignoles, C.; Chulia, A.J.; Delage, C. MCF-7 cell cycle arrested at G1 through ursolic acid, and increased reduction of tetrazolium salts. Anticancer Res., 1996, 16(1), 481-486.
    • (1996) Anticancer Res , vol.16 , Issue.1 , pp. 481-486
    • Es-Saady, D.1    Simon, A.2    Jayat-Vignoles, C.3    Chulia, A.J.4    Delage, C.5
  • 206
    • 0030578756 scopus 로고    scopus 로고
    • Inhibitory effect of ursolic acid on B16 proliferation through cell cycle arrest
    • Es-saady, D.; Simon, A.; Ollier, M.; Maurizis, J.C.; Chulia, A.J.; Delage, C. Inhibitory effect of ursolic acid on B16 proliferation through cell cycle arrest. Cancer Lett., 1996, 106(2), 193-197.
    • (1996) Cancer Lett , vol.106 , Issue.2 , pp. 193-197
    • Es-Saady, D.1    Simon, A.2    Ollier, M.3    Maurizis, J.C.4    Chulia, A.J.5    Delage, C.6
  • 207
    • 84880328502 scopus 로고    scopus 로고
    • Safe, S. Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: Role of Sp transcription factors and microRNA-27a:ZBTB10
    • Mertens-Talcott, S.U.; Noratto, G.D.; Li, X.; Angel-Morales, G.; Bertoldi, M.C.; Safe, S. Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: Role of Sp transcription factors and microRNA-27a:ZBTB10. Mol. Carcinog., 2012, 52(8):591-602.
    • (2012) Mol. Carcinog , vol.52 , Issue.8 , pp. 591-602
    • Mertens-Talcott, S.U.1    Noratto, G.D.2    Li, X.3    Angel-Morales, G.4    Bertoldi, M.C.5
  • 208
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • Folkman, J. Angiogenesis: an organizing principle for drug discovery? Nat. Rev. Drug Discov., 2007, 6(4), 273-286.
    • (2007) Nat. Rev. Drug Discov , vol.6 , Issue.4 , pp. 273-286
    • Folkman, J.1
  • 209
    • 0036244345 scopus 로고    scopus 로고
    • Betulinic acid inhibits growth factor-induced in vitro angiogenesis via the modulation of mitochondrial function in endothelial cells
    • Kwon, H.J.; Shim, J.S.; Kim, J.H.; Cho, H.Y.; Yum, Y.N.; Kim, S.H.; Yu, J. Betulinic acid inhibits growth factor-induced in vitro angiogenesis via the modulation of mitochondrial function in endothelial cells. Jpn. J. Cancer Res., 2002, 93(4), 417-425.
    • (2002) Jpn. J. Cancer Res , vol.93 , Issue.4 , pp. 417-425
    • Kwon, H.J.1    Shim, J.S.2    Kim, J.H.3    Cho, H.Y.4    Yum, Y.N.5    Kim, S.H.6    Yu, J.7
  • 210
    • 34047261665 scopus 로고    scopus 로고
    • Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors
    • Chintharlapalli, S.; Papineni, S.; Ramaiah, S.K.; Safe, S. Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Cancer Res., 2007, 67(6), 2816-2823.
    • (2007) Cancer Res , vol.67 , Issue.6 , pp. 2816-2823
    • Chintharlapalli, S.1    Papineni, S.2    Ramaiah, S.K.3    Safe, S.4
  • 212
    • 84873738624 scopus 로고    scopus 로고
    • Betulinic Acid selectively increases protein degradation and enhances prostate cancer-specific apoptosis: Possible role for inhibition of deubiquitinase activity
    • Reiner, T.; Parrondo, R.; de Las Pozas, A.; Palenzuela, D.; Perez- Stable, C. Betulinic Acid selectively increases protein degradation and enhances prostate cancer-specific apoptosis: possible role for inhibition of deubiquitinase activity. PLoS ONE, 2013, 8(2), e56234.
    • (2013) PLoS ONE , vol.8 , Issue.2
    • Reiner, T.1    Parrondo, R.2    De Las Pozas, A.3    Palenzuela, D.4    Perez- Stable, C.5
  • 213
    • 79960957703 scopus 로고    scopus 로고
    • Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis
    • Gao, Y.; Jia, Z.; Kong, X.; Li, Q.; Chang, D.Z.; Wei, D.; Le, X.; Suyun, H.; Huang, S.; Wang, L.; Xie, K. Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis. Cancer Res., 2011, 71(15), 5182-5193.
    • (2011) Cancer Res , vol.71 , Issue.15 , pp. 5182-5193
    • Gao, Y.1    Jia, Z.2    Kong, X.3    Li, Q.4    Chang, D.Z.5    Wei, D.6    Le, X.7    Suyun, H.8    Huang, S.9    Wang, L.10    Xie, K.11
  • 215
    • 2942741025 scopus 로고    scopus 로고
    • Effects of ursolic acid on different steps of the angiogenic process
    • Cardenas, C.; Quesada, A.R.; Medina, M.A. Effects of ursolic acid on different steps of the angiogenic process. Biochem. Biophys. Res. Commun., 2004, 320(2), 402-408.
    • (2004) Biochem. Biophys. Res. Commun , vol.320 , Issue.2 , pp. 402-408
    • Cardenas, C.1    Quesada, A.R.2    Medina, M.A.3
  • 217
    • 33846554357 scopus 로고    scopus 로고
    • Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalis
    • Jedinak, A.; Muckova, M.; Kost'alova, D.; Maliar, T.; Masterova, I. Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalis. Z Naturforsch C, 2006, 61(11-12), 777-782.
    • (2006) Z Naturforsch C , vol.61 , Issue.11-12 , pp. 777-782
    • Jedinak, A.1    Muckova, M.2    Kost'alova, D.3    Maliar, T.4    Masterova, I.5
  • 218
    • 77952625527 scopus 로고    scopus 로고
    • Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling
    • Yeh, C.T.; Wu, C.H.; Yen, G.C. Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling. Mol. Nutr. Food Res., 2010, 54(9), 1285-1295.
    • (2010) Mol. Nutr. Food Res , vol.54 , Issue.9 , pp. 1285-1295
    • Yeh, C.T.1    Wu, C.H.2    Yen, G.C.3
  • 219
    • 78751497839 scopus 로고    scopus 로고
    • Antiangiogenic potential of three triterpenic acids in human liver cancer cells
    • Lin, C.C.; Huang, C.Y.; Mong, M.C.; Chan, C.Y.; Yin, M.C. Antiangiogenic potential of three triterpenic acids in human liver cancer cells. J. Agric. Food Chem., 2011, 59(2), 755-762.
    • (2011) J. Agric. Food Chem , vol.59 , Issue.2 , pp. 755-762
    • Lin, C.C.1    Huang, C.Y.2    Mong, M.C.3    Chan, C.Y.4    Yin, M.C.5
  • 221
    • 67650097012 scopus 로고    scopus 로고
    • Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cells in vitro and suppress experimental metastasis in vivo
    • Yamai, H.; Sawada, N.; Yoshida, T.; Seike, J.; Takizawa, H.; Kenzaki, K.; Miyoshi, T.; Kondo, K.; Bando, Y.; Ohnishi, Y.; Tangoku, A. Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cells in vitro and suppress experimental metastasis in vivo. Int. J. Cancer, 2009, 125(4), 952-960.
    • (2009) Int. J. Cancer , vol.125 , Issue.4 , pp. 952-960
    • Yamai, H.1    Sawada, N.2    Yoshida, T.3    Seike, J.4    Takizawa, H.5    Kenzaki, K.6    Miyoshi, T.7    Kondo, K.8    Bando, Y.9    Ohnishi, Y.10    Tangoku, A.11
  • 222
    • 36649016713 scopus 로고    scopus 로고
    • Effect of betulinic acid on anticancer drug-resistant colon cancer cells. Basic Clin. Pharmacol
    • Jung, G.R.; Kim, K.J.; Choi, C.H.; Lee, T.B.; Han, S.I.; Han, H.K.; Lim, S.C. Effect of betulinic acid on anticancer drug-resistant colon cancer cells. Basic Clin. Pharmacol. Toxicol., 2007, 101(4), 277-285.
    • (2007) Toxicol , vol.101 , Issue.4 , pp. 277-285
    • Jung, G.R.1    Kim, K.J.2    Choi, C.H.3    Lee, T.B.4    Han, S.I.5    Han, H.K.6    Lim, S.C.7
  • 223
    • 17144439794 scopus 로고    scopus 로고
    • Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages
    • Suh, N.; Honda, T.; Finlay, H.J.; Barchowsky, A.; Williams, C.; Benoit, N.E.; Xie, Q.W.; Nathan, C.; Gribble, G.W.; Sporn, M.B. Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages. Cancer Res., 1998, 58(4), 717-723.
    • (1998) Cancer Res , vol.58 , Issue.4 , pp. 717-723
    • Suh, N.1    Honda, T.2    Finlay, H.J.3    Barchowsky, A.4    Williams, C.5    Benoit, N.E.6    Xie, Q.W.7    Nathan, C.8    Gribble, G.W.9    Sporn, M.B.10
  • 225
    • 0141507973 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor gamma by a novel synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest and apoptosis in breast cancer cells
    • Lapillonne, H.; Konopleva, M.; Tsao, T.; Gold, D.; McQueen, T.; Sutherland, R.L.; Madden, T.; Andreeff, M. Activation of peroxisome proliferator-activated receptor gamma by a novel synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest and apoptosis in breast cancer cells. Cancer Res., 2003, 63(18), 5926-5939.
    • (2003) Cancer Res , vol.63 , Issue.18 , pp. 5926-5939
    • Lapillonne, H.1    Konopleva, M.2    Tsao, T.3    Gold, D.4    McQueen, T.5    Sutherland, R.L.6    Madden, T.7    Andreeff, M.8
  • 226
    • 0942269005 scopus 로고    scopus 로고
    • Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines
    • Chang, C.I.; Kuo, C.C.; Chang, J.Y.; Kuo, Y.H. Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines. J. Nat. Prod., 2004, 67(1), 91-93.
    • (2004) J. Nat. Prod , vol.67 , Issue.1 , pp. 91-93
    • Chang, C.I.1    Kuo, C.C.2    Chang, J.Y.3    Kuo, Y.H.4
  • 227
    • 4544277618 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets
    • Honda, T.; Janosik, T.; Honda, Y.; Han, J.; Liby, K.T.; Williams, C.R.; Couch, R.D.; Anderson, A.C.; Sporn, M.B.; Gribble, G.W. Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets. J. Med. Chem., 2004, 47(20), 4923-4932.
    • (2004) J. Med. Chem , vol.47 , Issue.20 , pp. 4923-4932
    • Honda, T.1    Janosik, T.2    Honda, Y.3    Han, J.4    Liby, K.T.5    Williams, C.R.6    Couch, R.D.7    Anderson, A.C.8    Sporn, M.B.9    Gribble, G.W.10
  • 228
    • 21144438719 scopus 로고    scopus 로고
    • Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells
    • Hyer, M.L.; Croxton, R.; Krajewska, M.; Krajewski, S.; Kress, C.L.; Lu, M.; Suh, N.; Sporn, M.B.; Cryns, V.L.; Zapata, J.M.; Reed, J.C. Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells. Cancer Res., 2005, 65(11), 4799-4808.
    • (2005) Cancer Res , vol.65 , Issue.11 , pp. 4799-4808
    • Hyer, M.L.1    Croxton, R.2    Krajewska, M.3    Krajewski, S.4    Kress, C.L.5    Lu, M.6    Suh, N.7    Sporn, M.B.8    Cryns, V.L.9    Zapata, J.M.10    Reed, J.C.11
  • 229
    • 33645090927 scopus 로고    scopus 로고
    • Anti-hepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decaisneana
    • Tian, Z.; Lin, G.; Zheng, R.X.; Huang, F.; Yang, M.S.; Xiao, P.G. Anti-hepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decaisneana. World J. Gastroenterol, 2006, 12(6), 874-879.
    • (2006) World J. Gastroenterol , vol.12 , Issue.6 , pp. 874-879
    • Tian, Z.1    Lin, G.2    Zheng, R.X.3    Huang, F.4    Yang, M.S.5    Xiao, P.G.6
  • 232
    • 34547621658 scopus 로고    scopus 로고
    • Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling
    • Gao, X.; Deeb, D.; Jiang, H.; Liu, Y.; Dulchavsky, S.A.; Gautam, S.C. Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling. J. Neurooncol., 2007, 84(2), 147-157.
    • (2007) J. Neurooncol , vol.84 , Issue.2 , pp. 147-157
    • Gao, X.1    Deeb, D.2    Jiang, H.3    Liu, Y.4    Dulchavsky, S.A.5    Gautam, S.C.6
  • 233
    • 34249337388 scopus 로고    scopus 로고
    • The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12- dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling
    • Ling, X.; Konopleva, M.; Zeng, Z.; Ruvolo, V.; Stephens, L.C.; Schober, W.; McQueen, T.; Dietrich, M.; Madden, T.L.; Andreeff, M. The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12- dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling. Cancer Res., 2007, 67(9), 4210-4218.
    • (2007) Cancer Res , vol.67 , Issue.9 , pp. 4210-4218
    • Ling, X.1    Konopleva, M.2    Zeng, Z.3    Ruvolo, V.4    Stephens, L.C.5    Schober, W.6    McQueen, T.7    Dietrich, M.8    Madden, T.L.9    Andreeff, M.10
  • 234
    • 41849130295 scopus 로고    scopus 로고
    • Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives
    • Chadalapaka, G.; Jutooru, I.; McAlees, A.; Stefanac, T.; Safe, S. Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives. Bioorg. Med. Chem. Lett., 2008, 18(8), 2633-2639.
    • (2008) Bioorg. Med. Chem. Lett , vol.18 , Issue.8 , pp. 2633-2639
    • Chadalapaka, G.1    Jutooru, I.2    McAlees, A.3    Stefanac, T.4    Safe, S.5
  • 235
    • 42349104546 scopus 로고    scopus 로고
    • Triterpenoid CDDOmethyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3
    • Ahmad, R.; Raina, D.; Meyer, C.; Kufe, D. Triterpenoid CDDOmethyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3. Cancer Res., 2008, 68(8), 2920-2926.
    • (2008) Cancer Res , vol.68 , Issue.8 , pp. 2920-2926
    • Ahmad, R.1    Raina, D.2    Meyer, C.3    Kufe, D.4
  • 236
    • 58549091468 scopus 로고    scopus 로고
    • The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their preliminary mechanism of action. Bioorg. Med
    • Meng, Y.Q.; Liu, D.; Cai, L.L.; Chen, H.; Cao, B.; Wang, Y.Z. The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their preliminary mechanism of action. Bioorg. Med. Chem., 2009, 17(2), 848-854.
    • (2009) Chem , vol.17 , Issue.2 , pp. 848-854
    • Meng, Y.Q.1    Liu, D.2    Cai, L.L.3    Chen, H.4    Cao, B.5    Wang, Y.Z.6
  • 237
    • 73349109760 scopus 로고    scopus 로고
    • Triterpenoids as new promising anticancer drugs
    • Petronelli, A.; Pannitteri, G.; Testa, U. Triterpenoids as new promising anticancer drugs. Anticancer Drugs, 2009, 20(10), 880-892.
    • (2009) Anticancer Drugs , vol.20 , Issue.10 , pp. 880-892
    • Petronelli, A.1    Pannitteri, G.2    Testa, U.3
  • 238
    • 58849152837 scopus 로고    scopus 로고
    • CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells
    • Duan, Z.; Ames, R.Y.; Ryan, M.; Hornicek, F.J.; Mankin, H.; Seiden, M.V. CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells. Cancer Chemother. Pharmacol., 2009, 63(4), 681-689.
    • (2009) Cancer Chemother. Pharmacol , vol.63 , Issue.4 , pp. 681-689
    • Duan, Z.1    Ames, R.Y.2    Ryan, M.3    Hornicek, F.J.4    Mankin, H.5    Seiden, M.V.6
  • 239
    • 77954267414 scopus 로고    scopus 로고
    • Synthesis and in vitro cytotoxicity of novel ursolic acid derivatives
    • Meng, Y.; Song, Y.; Yan, Z.; Xia, Y. Synthesis and in vitro cytotoxicity of novel ursolic acid derivatives. Molecules, 2010, 15(6), 4033-4040.
    • (2010) Molecules , vol.15 , Issue.6 , pp. 4033-4040
    • Meng, Y.1    Song, Y.2    Yan, Z.3    Xia, Y.4
  • 240
    • 79959527087 scopus 로고    scopus 로고
    • Synthesis of [3beta-acetoxy-urs-12-en-28-oyl]-1-monoglyceride and investigation on its anti tumor effects against BGC-823
    • Bai, K.K.; Chen, F.L.; Yu, Z.; Zheng, Y.Q.; Li, Y.N.; Guo, Y.H. Synthesis of [3beta-acetoxy-urs-12-en-28-oyl]-1-monoglyceride and investigation on its anti tumor effects against BGC-823. Bioorg. Med. Chem., 2011, 19(13), 4043-4050.
    • (2011) Bioorg. Med. Chem , vol.19 , Issue.13 , pp. 4043-4050
    • Bai, K.K.1    Chen, F.L.2    Yu, Z.3    Zheng, Y.Q.4    Li, Y.N.5    Guo, Y.H.6
  • 241
    • 79957503743 scopus 로고    scopus 로고
    • In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives
    • Shao, J.W.; Dai, Y.C.; Xue, J.P.; Wang, J.C.; Lin, F.P.; Guo, Y.H. In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives. Eur. J. Med. Chem., 2011, 46(7), 2652-2661.
    • (2011) Eur. J. Med. Chem , vol.46 , Issue.7 , pp. 2652-2661
    • Shao, J.W.1    Dai, Y.C.2    Xue, J.P.3    Wang, J.C.4    Lin, F.P.5    Guo, Y.H.6
  • 242
    • 84862796321 scopus 로고    scopus 로고
    • New ionic derivatives of betulinic acid as highly potent anti-cancer agents
    • Suresh, C.; Zhao, H.; Gumbs, A.; Chetty, C.S.; Bose, H.S. New ionic derivatives of betulinic acid as highly potent anti-cancer agents. Bioorg. Med. Chem. Lett., 2012, 22(4), 1734-1738.
    • (2012) Bioorg. Med. Chem. Lett , vol.22 , Issue.4 , pp. 1734-1738
    • Suresh, C.1    Zhao, H.2    Gumbs, A.3    Chetty, C.S.4    Bose, H.S.5
  • 243
    • 84866355871 scopus 로고    scopus 로고
    • Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells
    • Leal, A.S.; Wang, R.; Salvador, J.A.; Jing, Y. Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells. Bioorg. Med. Chem., 2012, 20(19), 5774-5786.
    • (2012) Bioorg. Med. Chem , vol.20 , Issue.19 , pp. 5774-5786
    • Leal, A.S.1    Wang, R.2    Salvador, J.A.3    Jing, Y.4
  • 244
    • 84868242594 scopus 로고    scopus 로고
    • Synthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety
    • Liu, M.C.; Yang, S.J.; Jin, L.H.; Hu, D.Y.; Xue, W.; Song, B.A.; Yang, S. Synthesis and cytotoxicity of novel ursolic acid derivatives containing an acyl piperazine moiety. Eur. J. Med. Chem., 2012, 58, 128-135.
    • (2012) Eur. J. Med. Chem , vol.58 , pp. 128-135
    • Liu, M.C.1    Yang, S.J.2    Jin, L.H.3    Hu, D.Y.4    Xue, W.5    Song, B.A.6    Yang, S.7
  • 245
    • 84862808482 scopus 로고    scopus 로고
    • Synthesis and evaluation of ursolic acid derivatives as potent cytotoxic agents
    • Bai, K.K.; Yu, Z.; Chen, F.L.; Li, F.; Li, W.Y.; Guo, Y.H. Synthesis and evaluation of ursolic acid derivatives as potent cytotoxic agents. Bioorg. Med. Chem. Lett., 2012, 22(7), 2488-2493.
    • (2012) Bioorg. Med. Chem. Lett , vol.22 , Issue.7 , pp. 2488-2493
    • Bai, K.K.1    Yu, Z.2    Chen, F.L.3    Li, F.4    Li, W.Y.5    Guo, Y.H.6
  • 246
    • 84865591129 scopus 로고    scopus 로고
    • Semisynthetic ursolic acid fluorolactone derivatives inhibit growth with induction of p21(waf1) and induce apoptosis with upregulation of NOXA and downregulation of c-FLIP in cancer cells
    • Leal, A.S.; Wang, R.; Salvador, J.A.; Jing, Y. Semisynthetic ursolic acid fluorolactone derivatives inhibit growth with induction of p21(waf1) and induce apoptosis with upregulation of NOXA and downregulation of c-FLIP in cancer cells. ChemMedChem, 2012, 7(9), 1635-1646.
    • (2012) ChemMedChem , vol.7 , Issue.9 , pp. 1635-1646
    • Leal, A.S.1    Wang, R.2    Salvador, J.A.3    Jing, Y.4
  • 247
    • 77951968251 scopus 로고    scopus 로고
    • Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway
    • Ryu, K.; Susa, M.; Choy, E.; Yang, C.; Hornicek, F.; Mankin, H.; Duan, Z. Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. BMC Cancer, 2010, 10(1), 187.
    • (2010) BMC Cancer , vol.10 , Issue.1 , pp. 187
    • Ryu, K.1    Susa, M.2    Choy, E.3    Yang, C.4    Hornicek, F.5    Mankin, H.6    Duan, Z.7
  • 249
    • 0032491276 scopus 로고    scopus 로고
    • Design and synthesis of 2-cyano-3,12- dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages
    • Honda, T.; Rounds, B.V.; Gribble, G.W.; Suh, N.J.; Wang, Y.P.; Sporn, M.B. Design and synthesis of 2-cyano-3,12- dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages. Bioorg. Med. Chem. Lett., 1998, 8(19), 2711-2714.
    • (1998) Bioorg. Med. Chem. Lett , vol.8 , Issue.19 , pp. 2711-2714
    • Honda, T.1    Rounds, B.V.2    Gribble, G.W.3    Suh, N.J.4    Wang, Y.P.5    Sporn, M.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.