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Volumn 54, Issue 6, 2008, Pages 654-660

Isolation of ursolic acid from apple peels and its specific efficacy as a potent antitumor agent

Author keywords

Apple peels; Cancer; Serum free mouse embryo (SFME); Tumorigenic cells; Ursolic acid

Indexed keywords

AMINOGUANIDINE; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR; URSOLIC ACID;

EID: 57349126352     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.54.654     Document Type: Article
Times cited : (68)

References (42)
  • 2
    • 0343458043 scopus 로고    scopus 로고
    • Antioxidant activity of fresh apples
    • Eberhardt, M. V., Lee, C. Y. and Liu, R. H. (2000) Antioxidant activity of fresh apples. Nature, 405, 903-904.
    • (2000) Nature , vol.405 , pp. 903-904
    • Eberhardt, M.V.1    Lee, C.Y.2    Liu, R.H.3
  • 5
    • 34250659001 scopus 로고    scopus 로고
    • Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple's anticancer activity
    • He, X. and Liu, R. H. (2007) Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple's anticancer activity. J. Agric. Food Chem., 55, 4366-4370.
    • (2007) J. Agric. Food Chem , vol.55 , pp. 4366-4370
    • He, X.1    Liu, R.H.2
  • 6
    • 0037471604 scopus 로고    scopus 로고
    • Antioxidant activity of apple peels
    • Wolfe, K., Wu, X. Z. and Liu, R. H. (2003) Antioxidant activity of apple peels. J. Agric. Food Chem., 51, 609-614.
    • (2003) J. Agric. Food Chem , vol.51 , pp. 609-614
    • Wolfe, K.1    Wu, X.Z.2    Liu, R.H.3
  • 7
    • 0344951109 scopus 로고    scopus 로고
    • Apple peels as a value-added food ingredient
    • Wolfe, K. and Liu, R. H. (2003) Apple peels as a value-added food ingredient. J. Agric. Food Chem., 51, 1676-1683.
    • (2003) J. Agric. Food Chem , vol.51 , pp. 1676-1683
    • Wolfe, K.1    Liu, R.H.2
  • 8
    • 17144439794 scopus 로고    scopus 로고
    • Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages
    • Suh, N., Honda, T., Finlay, H. J., Barchowsky, A., Williams, C., Benoit, N. E., Xie, Q., Nathan, C., Gribble, G. W. and Sporn, M. B. (1998) Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages. Cancer Res., 58, 717-723.
    • (1998) Cancer Res , vol.58 , pp. 717-723
    • Suh, N.1    Honda, T.2    Finlay, H.J.3    Barchowsky, A.4    Williams, C.5    Benoit, N.E.6    Xie, Q.7    Nathan, C.8    Gribble, G.W.9    Sporn, M.B.10
  • 9
    • 0022576865 scopus 로고
    • Search for possible antitumor promoters by inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation; Ursolic acid and oleanolic acid from an anti-inflammatory Chinese medicinal plant, Glechoma hederaceae L
    • Ohigashi, H., Takamura, H., Koshimizu, K., Tokuda, H. and Ito, Y. (1986) Search for possible antitumor promoters by inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation; Ursolic acid and oleanolic acid from an anti-inflammatory Chinese medicinal plant, Glechoma hederaceae L. Cancer Lett., 30, 143-151.
    • (1986) Cancer Lett , vol.30 , pp. 143-151
    • Ohigashi, H.1    Takamura, H.2    Koshimizu, K.3    Tokuda, H.4    Ito, Y.5
  • 10
    • 0023032498 scopus 로고
    • Inhibitory effects of ursolic and oleanolic ancid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
    • Tokuda, H., Ohigashi, H., Koshimizu, K. and Ito, Y. (1986) Inhibitory effects of ursolic and oleanolic ancid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cancer Lett., 33, 279-285.
    • (1986) Cancer Lett , vol.33 , pp. 279-285
    • Tokuda, H.1    Ohigashi, H.2    Koshimizu, K.3    Ito, Y.4
  • 12
    • 0028133481 scopus 로고
    • Ursolic acid inhibits aflatoxin B1-induced mutagenicity in a Salmonella assay system
    • Young, H. S., Chung, H. Y., Lee, C. K., Park, K. Y., Yokozawa, T. and Oura, H. (1994) Ursolic acid inhibits aflatoxin B1-induced mutagenicity in a Salmonella assay system. Biol. Pharm. Bull., 17, 990-992.
    • (1994) Biol. Pharm. Bull , vol.17 , pp. 990-992
    • Young, H.S.1    Chung, H.Y.2    Lee, C.K.3    Park, K.Y.4    Yokozawa, T.5    Oura, H.6
  • 13
    • 0029567968 scopus 로고
    • Pharmacology of oleanolic acid and ursolic acid
    • Liu, J. (1995) Pharmacology of oleanolic acid and ursolic acid. J. Ethnopharmacol., 49, 57-68.
    • (1995) J. Ethnopharmacol , vol.49 , pp. 57-68
    • Liu, J.1
  • 15
    • 0023732557 scopus 로고
    • Inhibition of the tumor-promoting action of 12-O-tetradecanoylphorbol-13-acetate by some oleanane-type triterpenoid compounds
    • Nishino, H., Nishino, A., Takayasu, J., Hasegawa, T., Iwashima, A., Hirabayashi, K., Iwata, S. and Shibata, S. (1988) Inhibition of the tumor-promoting action of 12-O-tetradecanoylphorbol-13-acetate by some oleanane-type triterpenoid compounds. Cancer Res., 48, 5210-5215.
    • (1988) Cancer Res , vol.48 , pp. 5210-5215
    • Nishino, H.1    Nishino, A.2    Takayasu, J.3    Hasegawa, T.4    Iwashima, A.5    Hirabayashi, K.6    Iwata, S.7    Shibata, S.8
  • 16
    • 0026559650 scopus 로고
    • Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL60 leukemic cells
    • Najid, A., Simon, A., Cook, J., Chable-Rabinovitch, H., Delage, C., Chulia, A. J. and Rigaud, M. (1992) Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL60 leukemic cells. FEBS Lett., 299, 213-217.
    • (1992) FEBS Lett , vol.299 , pp. 213-217
    • Najid, A.1    Simon, A.2    Cook, J.3    Chable-Rabinovitch, H.4    Delage, C.5    Chulia, A.J.6    Rigaud, M.7
  • 17
    • 0343581270 scopus 로고    scopus 로고
    • Effect of selected triterpenoids on chronic dermal inflammation
    • Manez, S., Recio, M. C., Giner, R. M. and Rios, J. L. (1997) Effect of selected triterpenoids on chronic dermal inflammation. Eur. J. Pharmacol., 334, 103-105.
    • (1997) Eur. J. Pharmacol , vol.334 , pp. 103-105
    • Manez, S.1    Recio, M.C.2    Giner, R.M.3    Rios, J.L.4
  • 19
    • 0033673402 scopus 로고    scopus 로고
    • Ursolic acid triggers calcium-dependent apoptosis in human Daudi cells
    • Lauthier, F., Taillet, L., Trouillas, P., Delage, C. and Simon, A. (2000) Ursolic acid triggers calcium-dependent apoptosis in human Daudi cells. Anticancer Drugs, 11, 737-745.
    • (2000) Anticancer Drugs , vol.11 , pp. 737-745
    • Lauthier, F.1    Taillet, L.2    Trouillas, P.3    Delage, C.4    Simon, A.5
  • 20
    • 0028066930 scopus 로고
    • Induction of differentiation in the cultured F9 teratocarcinoma stem cells by triterpene acids
    • Lee, H. Y., Chung, H. Y., Kim, K. H., Lee, J. J. and Kim, K. W. (1994) Induction of differentiation in the cultured F9 teratocarcinoma stem cells by triterpene acids. J. Cancer Res. Clin. Oncol., 120, 513-518.
    • (1994) J. Cancer Res. Clin. Oncol , vol.120 , pp. 513-518
    • Lee, H.Y.1    Chung, H.Y.2    Kim, K.H.3    Lee, J.J.4    Kim, K.W.5
  • 22
    • 0030002548 scopus 로고    scopus 로고
    • Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells
    • Cha, H. J., Bae, S. K., Lee, H. Y., Lee, O. H., Sato, H., Seiki, M., Park, B. C. and Kim, K. W. (1996) Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells. Cancer Res., 56, 2281-2284.
    • (1996) Cancer Res , vol.56 , pp. 2281-2284
    • Cha, H.J.1    Bae, S.K.2    Lee, H.Y.3    Lee, O.H.4    Sato, H.5    Seiki, M.6    Park, B.C.7    Kim, K.W.8
  • 23
    • 0023213621 scopus 로고
    • Extended culture of mouse embryo cells without senescence: Inhibition by serum
    • Loo, D. T., Fuquay, J. I., Rawson, C. L. and Barnes, D. W. (1987) Extended culture of mouse embryo cells without senescence: inhibition by serum. Science, 236, 200-202.
    • (1987) Science , vol.236 , pp. 200-202
    • Loo, D.T.1    Fuquay, J.I.2    Rawson, C.L.3    Barnes, D.W.4
  • 24
    • 0024383517 scopus 로고
    • Serum-free mouse embryo (SFME) cells: Growth responses in vitro
    • Loo, D., Rawson, C., Helmrich, A. and Barnes, D. (1989) Serum-free mouse embryo (SFME) cells: growth responses in vitro. J. Cell. Physiol., 139, 484-491.
    • (1989) J. Cell. Physiol , vol.139 , pp. 484-491
    • Loo, D.1    Rawson, C.2    Helmrich, A.3    Barnes, D.4
  • 25
    • 0025189806 scopus 로고
    • Death of serum-free mouse embryo cells caused by epidermal growth factor deprivation is prevented by cycloheximide, 12-O-tetradecanoylphorbol-13-acetate, or vanadate
    • Rawson, C., Cosola-Smith, C. and Barnes, D. (1990) Death of serum-free mouse embryo cells caused by epidermal growth factor deprivation is prevented by cycloheximide, 12-O-tetradecanoylphorbol-13-acetate, or vanadate. Exp. Cell Res., 186, 177-181.
    • (1990) Exp. Cell Res , vol.186 , pp. 177-181
    • Rawson, C.1    Cosola-Smith, C.2    Barnes, D.3
  • 26
    • 0026065935 scopus 로고
    • Oncogene transformation frequency of nonsenescent SFME cells is increased by c-myc
    • Rawson, C., Shirahata, S., Collodi, P., Natsuno, T. and Barnes, D. (1991) Oncogene transformation frequency of nonsenescent SFME cells is increased by c-myc. Oncogene, 6, 487-489.
    • (1991) Oncogene , vol.6 , pp. 487-489
    • Rawson, C.1    Shirahata, S.2    Collodi, P.3    Natsuno, T.4    Barnes, D.5
  • 28
    • 0018310017 scopus 로고
    • Media and growth requirements
    • Ham, R. G. and McKeehan, W. L. (1979) Media and growth requirements. Methods Enzymol., 58, 44-93.
    • (1979) Methods Enzymol , vol.58 , pp. 44-93
    • Ham, R.G.1    McKeehan, W.L.2
  • 29
    • 0018627952 scopus 로고
    • The use of hormone-supplemented serum-free media in primary cultures
    • Mather, J. P. and Sato, G. H. (1979) The use of hormone-supplemented serum-free media in primary cultures. Exp. Cell Res., 124, 215-221.
    • (1979) Exp. Cell Res , vol.124 , pp. 215-221
    • Mather, J.P.1    Sato, G.H.2
  • 30
    • 0023158779 scopus 로고
    • Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of radiosensitivity
    • Carmichael, J., DeGraff, W. G., Gazdar, A. F., Minna, J. D. and Mitchell, J. B. (1987) Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of radiosensitivity. Cancer Res., 47, 943-946.
    • (1987) Cancer Res , vol.47 , pp. 943-946
    • Carmichael, J.1    DeGraff, W.G.2    Gazdar, A.F.3    Minna, J.D.4    Mitchell, J.B.5
  • 31
    • 0029824946 scopus 로고    scopus 로고
    • Triple helix-forming oligodeoxyribonucleotides targeted to the human tumor necrosis factor (TNF) gene inhibit TNF production and block the TNF-dependent growth of human glioblastoma tumor cells
    • Aggarwal, B. B., Schwarz, L., Hogan, M. E. and Rando, R. F. (1996) Triple helix-forming oligodeoxyribonucleotides targeted to the human tumor necrosis factor (TNF) gene inhibit TNF production and block the TNF-dependent growth of human glioblastoma tumor cells. Cancer Res., 56, 5156-5164.
    • (1996) Cancer Res , vol.56 , pp. 5156-5164
    • Aggarwal, B.B.1    Schwarz, L.2    Hogan, M.E.3    Rando, R.F.4
  • 32
    • 0032577708 scopus 로고    scopus 로고
    • Constitutive activation of NF-κB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates
    • Giri, D. K. and Aggarwal, B. B. (1998) Constitutive activation of NF-κB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates. J. Biol. Chem., 273, 14008-14014.
    • (1998) J. Biol. Chem , vol.273 , pp. 14008-14014
    • Giri, D.K.1    Aggarwal, B.B.2
  • 33
    • 0035824789 scopus 로고    scopus 로고
    • Ursolic acid enhances nitric oxide and tumor necrosis factor-alpha production via nuclear factor-kappaB activation in the resting macrophages
    • You, H. J., Choi, C. Y., Kim, J. Y., Park, S. J., Hahm, K. S. and Jeong, H. G. (2001) Ursolic acid enhances nitric oxide and tumor necrosis factor-alpha production via nuclear factor-kappaB activation in the resting macrophages. FEBS Lett., 509, 156-160.
    • (2001) FEBS Lett , vol.509 , pp. 156-160
    • You, H.J.1    Choi, C.Y.2    Kim, J.Y.3    Park, S.J.4    Hahm, K.S.5    Jeong, H.G.6
  • 34
    • 0026528681 scopus 로고
    • Effector molecules from antitumor macrophages induced with OK-432 and cyclophosphamide
    • Ryoyama, K. (1992) Effector molecules from antitumor macrophages induced with OK-432 and cyclophosphamide. Cancer Immunol. Immunother., 35, 7-13.
    • (1992) Cancer Immunol. Immunother , vol.35 , pp. 7-13
    • Ryoyama, K.1
  • 35
    • 0027958098 scopus 로고
    • Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells
    • Dong, Z., Staroselsky, A. H., Qi, X., Xie, K. and Fidler, I. J. (1994) Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells. Cancer Res., 54, 789-793.
    • (1994) Cancer Res , vol.54 , pp. 789-793
    • Dong, Z.1    Staroselsky, A.H.2    Qi, X.3    Xie, K.4    Fidler, I.J.5
  • 36
    • 0028929559 scopus 로고
    • Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells
    • Xie, K., Huang, S., Dong, Z., Juang, S. H., Gutman, M., Xie, Q. W., Nathan, C. and Fidler, I. J. (1995) Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells. J. Exp. Med., 181, 1333-1343.
    • (1995) J. Exp. Med , vol.181 , pp. 1333-1343
    • Xie, K.1    Huang, S.2    Dong, Z.3    Juang, S.H.4    Gutman, M.5    Xie, Q.W.6    Nathan, C.7    Fidler, I.J.8
  • 37
    • 0032503018 scopus 로고    scopus 로고
    • Suppression of tumorigenicity and metastasis of human renal carcinoma cells by infection with retroviral vectors harboring the murine inducible nitric oxide synthase gene
    • Juang, S. H., Xie, K., Xu, L., Shi, Q., Wang, Y., Yoneda, J. and Fidler, I. J. (1998) Suppression of tumorigenicity and metastasis of human renal carcinoma cells by infection with retroviral vectors harboring the murine inducible nitric oxide synthase gene. Hum. Gene Ther., 9, 845-854.
    • (1998) Hum. Gene Ther , vol.9 , pp. 845-854
    • Juang, S.H.1    Xie, K.2    Xu, L.3    Shi, Q.4    Wang, Y.5    Yoneda, J.6    Fidler, I.J.7
  • 38
    • 0029951079 scopus 로고    scopus 로고
    • Tumor cell nitric oxide inhibits cell growth in vitro, but stimulates tumorigenesis and experimental lung metastasis in vivo
    • Edwards, P., Cendan, J. C., Topping, D. B., Moldawer, L. L., MacKay, S., Copeland, E. M., IIIrd and Lind, D. S. (1996) Tumor cell nitric oxide inhibits cell growth in vitro, but stimulates tumorigenesis and experimental lung metastasis in vivo. J. Surg. Res., 63, 49-52.
    • (1996) J. Surg. Res , vol.63 , pp. 49-52
    • Edwards, P.1    Cendan, J.C.2    Topping, D.B.3    Moldawer, L.L.4    MacKay, S.5    Copeland, E.M.6    IIIrd7    Lind, D.S.8
  • 39
    • 0034657272 scopus 로고    scopus 로고
    • Influence of nitric oxide synthase II gene disruption on tumor growth and metastasis
    • Shi, Q., Xiong, Q., Wang, B., Le, X., Khan, N. A. and Xie, K. (2000) Influence of nitric oxide synthase II gene disruption on tumor growth and metastasis. Cancer Res., 60, 2579-2583.
    • (2000) Cancer Res , vol.60 , pp. 2579-2583
    • Shi, Q.1    Xiong, Q.2    Wang, B.3    Le, X.4    Khan, N.A.5    Xie, K.6
  • 41
    • 0031949941 scopus 로고    scopus 로고
    • Therapy of cancer metastasis by activation of the inducible nitric oxide synthase
    • Xie, K. and Fidler, I. J. (1998) Therapy of cancer metastasis by activation of the inducible nitric oxide synthase. Cancer Metastasis Rev., 17, 55-75.
    • (1998) Cancer Metastasis Rev , vol.17 , pp. 55-75
    • Xie, K.1    Fidler, I.J.2
  • 42
    • 21044435404 scopus 로고    scopus 로고
    • LC-MS detection and pharmacokinetic studies of ursolic acid in rat plasma after administration of the traditional Chinese medicinal preparation Lu-Ying extract
    • Liao, Q., Yang, W., Jia, Y., Chen, X., Gao, Q. and Bi, K. (2005) LC-MS detection and pharmacokinetic studies of ursolic acid in rat plasma after administration of the traditional Chinese medicinal preparation Lu-Ying extract. Yakugaku Zasshi, 125, 509-515.
    • (2005) Yakugaku Zasshi , vol.125 , pp. 509-515
    • Liao, Q.1    Yang, W.2    Jia, Y.3    Chen, X.4    Gao, Q.5    Bi, K.6


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