Inhibitory effect of ursolic acid on B16 proliferation through cell cycle arrest

Cancer Letters

Volumn 106, Issue 2, 1996, Pages 193-197

  Es saady, D ^a   Simon, A ^a   Ollier, M ^b   Maurizis, J C ^b   Chulia, A J ^a   Delage, C ^a  

^a UNIVERSITY OF LIMOGES   (France)

^b INSERM   (France)

Author keywords

B16 mouse melanoma cell line; Cell cycle analysis; Cytotoxicity; Ursolic acid

Indexed keywords

ANTINEOPLASTIC AGENT; TRITERPENE; URSOLIC ACID;

ANIMAL; ARTICLE; CELL CULTURE; CELL CYCLE; CELL DIVISION; DRUG EFFECT; EXPERIMENTAL MELANOMA; MOUSE; PATHOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL CYCLE; CELL DIVISION; MELANOMA, EXPERIMENTAL; MICE; TRITERPENES; TUMOR CELLS, CULTURED;

EID: 0030578756     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(96)04312-1     Document Type: Article

References (18)

1. Es-saady, D., Najid, A., Simon, A., Chulia, A.J. and Delage, C. (1994) Biological effects of ursolic acid: view and perspectives. Lyon Pharm., 45, 399-404.
2. Es-saady, D., Najid, A., Simon, A., Denizot, Y., Chulia, A.J. and Delage, C. (1994) Effects of ursolic acid and its analogues on soybean 15-lipoxygenase activity and the proliferation rate of a human gastric tumour cell line. Mediators Inflammation, 3, 181-184.
3. Es-saady, D., Simon, A., Jayat-vignoles, C., Chulia, A.J. and Delage, C. (1996) MCF-7 cell cycle arrested at G1 through ursolic acid, and increased reduction of tetrazolium salts. Anticancer Res., 16, 481-486.
4. Hu, Z.H. (1988) Application of glycyrrhizin as drugs. Acta Pharm. Sin., 23, 553-560.
5. Lee, H.Y., Chung, H.Y., Kim, K.H., Lee, J.J. and Kim, K.W. (1994) Induction of differentiation in the cultured F9 teratocarcinoma stem cells by triterpene acids. J. Cancer Res. Clin. Oncol., 120, 513-518.
6. Mahato, S.B., Sarkar, S.K. and Poddar, G. (1988) Triterpenoid saponins. Phytochemistry, 27, 3037-3067.
7. Miller, A.M., Kobb, S.M. and McTiernan, R. (1990) Regulation of HL-60 differentiation by lipoxygenase pathway metabolites in vitro. Cancer Res., 50, 7257-7260.
8. Najid, A., Simon, A., Delage, C., Chulia, A.J. and Rigaud, M. (1992) Characterization of ursolic as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL-60 leukemic cells. FEBS Lett., 299, 213-217.
9. |9] Nishino, H., Nishino, A., Takayasu, J., Iwashima, A., Hirabayashi, K., Iwata, S. and Shibata, S. (1988) Inhibition of the tumor-promoting action of 12-O-tetradacanoy-phorbol-13-acetate by some oleane-type triterpenoid compounds. Cancer Res., 48, 5210-5215.
10. Ondrey, F., Harris J.E. and Anderson, K.M. (1989) Inhibition of U937 eicosanoid and DNA synthesis by 5,8,11,14-eicosatetraynoic acid, an inhibitor of arachidonic acid metabolism and its partial reversal by leukotriene C4. Cancer Res., 49, 1138-1142.
11. Pagliacci, M.C., Spinozzi, F., Migliorati, G., Fumi, G., Smacchia, M., Grignani, M., Riccardi, C. and Nicoletti, I. (1993) Genistein inhibits tumour cell growth in vitro but enhances mitochondrial reduction of tetrazohum salts: a further pitfall in the use of the MTT assay for evaluating cell growth and survival. Eur. J. Cancer. 294, 1573-1577.
12. Price, K.R., Johnson, I.K. and Fenwick, G.R. (1987) The chemistry and biological significance of saponins in food and feedingstuffs. CRC Crit. Rev. Food Sci. Nutr, 26, 27-135.
13. Simon, A., Delage, C., Saux, M., Chulia, A.J., Najid, A. and Rigaud, M. (1992) Structure of ursolic acid ethanol solvate. Acta Crystallogr., C48, 726-728.
14. Simon, A., Najid, A., Chulia, A.J., Delage, C. and Rigaud, M. (1992) Inhibition of lipoxygenase and human leukemic HL-60 cell proliferation by ursolic acid isolated from heather flowers (Calluna vulgaris). Biochim. Biophys. Acta, 1125, 68-72.
15. Mosman, T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65, 55-63.
16. Snyder, D.S., Castro, R. and Desforges, J.F (1986) Anti-proliferative effects of lipoxygenase inhibitors on malignant human hematopoietic cell lines. Exp. Hematol., 17, 6-9.
17. Umehara, K., Takagi, R., Kuroyanagi, M., Ueno, A., Taki, T. and Chen, Y.J. (1992) Studies on differentiation activities of triterpenes. Chem. Bull., 40, 401-405.
18. Wasternack, C., Atzorn, R., Blume, B. Leopold, J. and Parthier, B. (1994) Ursolic acid inhibits synthesis of jasmonate-induced proteins in barley leaves. Phytochemistry, 35, 49-54