Anabolic activity of ursolic acid in bone: Stimulating osteoblast differentiation in vitro and inducing new bone formation in vivo

Pharmacological Research

Volumn 58, Issue 5-6, 2008, Pages 290-296

  Lee, Su Ui ^a,b   Park, Sang Joon ^a   Kwak, Han Bok ^c   Oh, Jaemin ^c   Min, Yong Ki ^a   Kim, Seong Hwan ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b Chungnam National University   (South Korea)

^c Wonkwang University   (South Korea)

Author keywords

BMP signaling; MAP kinases; Osteoblast differentiation; Transcription factors; Ursolic acid

Indexed keywords

ALKALINE PHOSPHATASE; ANABOLIC AGENT; BONE MORPHOGENETIC PROTEIN 2; MESSENGER RNA; NOGGIN; PLANT EXTRACT; RECOMBINANT PROTEIN; SMAD PROTEIN; TRANSCRIPTION FACTOR; TRITERPENOID; URSOLIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MASS; CALVARIA; CELL DIFFERENTIATION; CELL VIABILITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HERB; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOPOROSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ALKALINE PHOSPHATASE; ANABOLIC AGENTS; ANIMALS; ANTHRAQUINONES; BLOTTING, WESTERN; BONE DEVELOPMENT; CALCIUM; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; COLORING AGENTS; GENES, REPORTER; IMMUNOHISTOCHEMISTRY; MICE; OSTEOBLASTS; RNA, MESSENGER; SKULL; TRITERPENES;

EID: 56649115867     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2008.08.008     Document Type: Article

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