A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients

Food Chemistry

Volumn 136, Issue 2, 2013, Pages 735-741

  Caligiani, Augusta ^a   Malavasi, Giulia ^a   Palla, Gerardo ^a   Marseglia, Angela ^a   Tognolini, Massimiliano ^a   Bruni, Renato ^a  

^a UNIVERSITY OF PARMA   (Italy)

Author keywords

Food supplements; Mass spectrometry; Nutraceuticals; Plant bioactives; Triterpenoids

Indexed keywords

AERIAL PARTS; BETULINIC ACID; BIOACTIVES; CHEMICAL AND PHYSICAL CHARACTERISTICS; COMMERCIAL EXTRACTS; DIETARY SUPPLEMENTS; DRIED EXTRACT; FOOD SUPPLEMENTS; NUTRACEUTICALS; OLEANOLIC ACIDS; SIMULTANEOUS DETERMINATIONS; TRITERPENES; TRITERPENOIDS; URSOLIC ACID; VACCINIUM MYRTILLUS; VITIS VINIFERA;

PLANT EXTRACTS;

BETULIC ACID; COROSOLIC ACID; MASLINIC ACID; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG; URSOLIC ACID;

ARCTOSTAPHYLOS UVA-URSI; ARTICLE; CRATAEGUS; CRATAEGUS MONOGYNA; DIET SUPPLEMENTATION; FRUIT; GRAPE; HARPAGOPHYTON PROCUMBENS; LAGERSTROEMIA; LAGERSTROEMIA SPECIOSA; MASS FRAGMENTOGRAPHY; NONHUMAN; ORTOSIPHON STAMINEUS; PLANT; PLANT LEAF; PLANT ROOT; PLANT SEED; POMEGRANATE; STYRACACEAE; STYRAX BENZOIN; VACCINIUM MYRTILLUS;

DIETARY SUPPLEMENTS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; OLEANOLIC ACID; PLANT EXTRACTS; PLANTS; TRITERPENES;

ARCTOSTAPHYLOS UVA-URSI; CRATAEGUS MONOGYNA; HARPAGOPHYTUM; LAGERSTROEMIA SPECIOSA; PUNICA GRANATUM; STYRAX BENZOIN; VACCINIUM MYRTILLUS; VITIS VINIFERA;

EID: 84866879892     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2012.08.011     Document Type: Article

References (35)

1. B.B. Aggarwal, A.B. Kunnumakkara, K.B. Harikumar, S.T. Tharakan, B. Sung, and P. Anand Potential of spice-derived phytochemicals for cancer prevention Planta Medica 74 2008 1560 1569
2. Y. Allouche, G. Beltrán, J.J. Gaforio, M. Uceda, and M.D. Mesa Antioxidant and antiatherogenic activities of pentacyclic triterpenic diols and acids Food and Chemical Toxicology 48 2010 2885 2890
3. I. Apostol, K.J. Miller, J. Ratto, and D.N. Kelner Comparison of different approaches for evaluation of the detection and quantitation limits of a purity method: a case study using a capillary isoelectrofocusing method for a monoclonal antibody Analytical Biochemistry 385 2009 101 106
4. I. Baglin, A.C. Mitaine-Offer, M. Nour, K. Tan, C. Cave, and M.A. Lacaille-Dubois A review of natural and modified betulinic, ursolic and echinocystic acid derivatives as potential antitumor and anti-HIV agents Mini Reviews in Medicinal Chemistry 3 2003 525 539
5. A.R. Bilia, M.C. Bergonzi, F. Morgenni, G. Mazzi, and F.F. Vincieri Evaluation of chemical stability of St. John's wort commercial extract and some preparations International Journal of Pharmaceutics 213 2001 199 208
6. J.H. Cardellina Challenges and opportunities confronting the botanical dietary supplement industry Journal of Natural Products 65 2002 1073 1084
7. R.H. Cichewicz, and S.A. Kouzi Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV Infection Medicinal Research Reviews 24 2003 90 114
8. J.D. Connolly, and R.A. Hill Triterpenoids Natural Product Reports 17 2000 463 482
9. Y.M. Fai, and C.A. Tao Review of presence of oleanolic acid in natural products Natura Proda Medica 2 2009 77 290
10. V. Goulas, and G. Manganaris Towards an efficient protocol for the determination of triterpenic acids in olive fruit: a comparative study of drying and extraction methods Phytochemical Analysis 23 2012 444 449
11. S. Jäger, H. Trojan, T. Kopp, M.N. Laszczyk, and A. Scheffler Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts Molecules 14 2009 2016 2031
12. S. Jäger, K. Winkler, U. Pfüller, and A. Scheffler Solubility studies of oleanolic acid and betulinic acid in aqueous solutions and plant extracts of Viscum album L. Planta medica 73 2 2007 157 162
13. G. Janicsak, K. Veres, A. Zoltankakasy, and I. Mathe Study of the oleanolic and ursolic acid contents of some species of the Lamiaceae Biochemical Systematics and Ecology 34 2006 392 396
14. M.E. Juan, J.M. Planas, V. Ruiz-Gutierrez, H. Daniel, and U. Wenzel Antiproliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells British Journal of Nutrition 100 2008 36 43
15. E. Kim, A. Sy-Cordero, T.N. Graf, S.J. Brantley, M.F. Paine, and N.H. Oberlies Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes Planta Medica 77 2011 265 270
16. R. Kowalski Studies of selected plant raw materials as alternative sources of triterpenes of oleanolic and ursolic acid types Journal of Agricultural and Food Chemistry 55 2007 656 662
17. E.N. Li, J.G. Luo, and L.Y. Kong Qualitative and quantitative determination of seven triterpene acids in Eriobotrya japonica Lindl. By high-performance liquid chromatography with photodiode array detection and mass spectrometry Phytochemical Analysis 20 2009 338 343
18. C.-C. Lin, C.-Y. Huang, M.-C. Mong, C.-Y. Chan, and M.-C. Yin Antiangiogenic potential of three triterpenic acids in human liver cancer cells Journal of Agricultural and Food Chemistry 59 2011 755 762
19. J. Liu Pharmacology of oleanolic acid and ursolic acid Journal of Ethnopharmacology 49 1995 57 68
20. J. Liu Oleanolic acid and ursolic acid: research perspectives Journal of Ethnopharmacology 100 2005 92 94
21. J.N. Losso Targeting excessive angiogenesis with functional foods and nutraceuticals Trends in Food Science & Technology 14 2003 455 468
22. M.K. Lee, Y.M. Ahn, K.R. Lee, J.H. Jung, O.S. Jung, and J. Hong Development of a validated liquid chromatographic method for the quality control of Prunellae Spica: determination of triterpenic acids Analytica Chimica Acta 633 2009 271 277
23. M.P. Montilla, A. Agil, M.C. Navarro, M.I. Jiménez, A. García-Granados, and A. Parra Antioxidant activity of maslinic acid, a triterpene derivative obtained from Olea europaea Planta Medica 69 2003 472 474
24. A. Najid, A. Simon, J. Cook, H. Chable-Rabinovitch, C. Delage, and A. Chulia Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, pltelets and differentiated HL60 leukemic cells FEBS 299 1992 213 217
25. M. Olszewska Optimization and validation of an HPLC-UV method for analysis of corosolic, oleanolic, and ursolic acids in plant material: Application to Prunus serotina Ehrh Acta Chromatographica 20 2008 643 659
26. J. Patocka Biologically active pentacyclic triterpenes and their current medicine signification Journal of Applied Biomechanics 1 2003 7 12
27. M.C. Pérez-Camino, and A. Cert Quantitative determination of hydroxy pentacyclic triterpene acids in vegetable oils Journal of Agricultural and Food Chemistry 47 1999 1558 1562
28. B. Rhourri-Frih, P. Chaimbault, B. Claude, C. Lamy, P. André, and M. Lafosse Analysis of pentacyclic triterpenes by LC-MS. A comparative study between APCI and APPI Journal of Mass Spectrometry 44 2009 71 80
29. J.L. Rios Effects of triterpenes on the immune system Journal of Ethnopharmacology 128 2010 1 14
30. W.M. Setzer, and N.C. Setzer Plant-derived triterpenoids as potential antineoplastic agents Mini Reviews in Medicinal Chemistry 3 2003 540 556
31. G. Sivakumar, D.R. Vail, V. Nair, F. Medina-Bolivar, and J.O. Lay Plant-based corosolic acid: Future anti-diabetic drug? Biotechnology Journal 4 2009 1704 1711
32. S.J. Stohs, H. Miller, and G.R. Kaats A review of the efficacy and safety of Banaba (Lagerstroemia speciosa L.) and corosolic acid Phytotherapy Research 26 2011 317 324
33. K. Vijaykumar, P.B. Murthy, S. Kannababu, and B. Syamasundar Quantitative determination of corosolic acid in Lagerstroemia speciosa leaves, extracts and dosage forms International Journal of Applied Science and Engineering 4 2006 103 114
34. J.-L. Wolfender HPLC in natural product analysis: The detection issue Planta Medica 75 2009 719 734
35. K. Wolska, A. Grudniak, B. Fiecek, A. Kraczkiewicz-Dowjat, and A. Kurek Antibacterial activity of oleanolic and ursolic acids and their derivatives Central European Journal of Biology 5 2010 543 553