Synthesis and evaluation of ursolic acid derivatives as potent cytotoxic agents

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2488-2493

  Bai, Kai Kai ^a   Yu, Zhou ^a   Chen, Fen Ling ^a   Li, Feng ^a   Li, Wei Yun ^a   Guo, Yang Hao ^a,b  

^a FUZHOU UNIVERSITY   (China)

^b Fujian Key Laboratory of Medical Instrumentation and Pharmaceutical Technology   (China)

Author keywords

Antitumor activity; Apoptosis; Electrical property; Synthesis; Ursolic acid derivatives

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CYTOTOXIC AGENT; LIPOCORTIN 5; N (3BETA HYDROXY URS 12 EN 28 OYL) 2 AMINOETHYLAMINE; PACLITAXEL; UNCLASSIFIED DRUG; URSOLIC ACID DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL ASSAY; CELL CYCLE ARREST; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LIPOPHILICITY; STOMACH CARCINOMA;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOTOXINS; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; STATIC ELECTRICITY; STOMACH NEOPLASMS; TRITERPENES;

EID: 84862808482     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.009     Document Type: Article

References (25)

1. J. Liu J. Ethnopharmacol. 100 2005 92
2. C.M. Ma, S.Q. Cai, J.R. Cui, R.Q. Wang, P.F. Tu, H. Masao, and D. Mohsen Eur. J. Med. Chem. 40 2005 582
3. H.Y. Hsu, J.J. Yang, and C.C. Lin Cancer Lett. 111 1997 7
4. Y.Q. Meng, D. Liu, L.L. Cai, H. Chen, H. Cao, and Y.Z. Wang Bioorg. Med. Chem. 17 2009 848
5. J.W. Shao, Y.C. Dai, J.P. Xue, J.C. Wang, F.P. Lin, and Y.H. Guo Eur. J. Med. Chem. 46 2011 2652
6. P. Wang, J. Wang, T.T. Guo, and Y.X. Li Carbohydr. Res. 345 2010 607
7. I.J. Jin, Y. Ko III, Y.M. Kim, and S.K. Han Arch. Pharm. Res. 20 1997 269
8. Bai, K. K., P.R. China. Patent. CN201010115902, 2010.
9. R.F. Burton Camp. Biochem. Physiol. 111A 1995 125
10. K. Ishizuka, N.C. Sahara, M. Murayama, Y. Yoshiike, and A. Takashima Neurobiol. Aging. 25 2004 S149
11. V.J. Stella, and K.W. NtiAddae Adv. Drug. Del. Rev. 59 2007 677
12. K.E. Desino, R. Pignatello, S. Guccione, L. Basile, S. Ansar, M.L. Michaelis, R.R. Ramsay, and L.A. Kenneth Biochem. Pharm. 78 2009 1412
13. C.M. Ma, X.H. Wu, H. Masao, X.J. Wang, and Y. Kano J. Pharm. Pharmaceut. Sci. 12 2009 243
14. A.A. Mar, E.L. Szotek, A. Koohang, W.P. Flavin, D.A. Eiznhamer, M.T. Flavin, and Z.Q. Xu Bioorg. Med. Chem. Lett. 20 2010 5389
15. H.Y. Tu, A.M. Huang, B.L. Wei, K.H. Gan, T.C. Hour, S.C. Yang, Y.S. Pu, and C.N. Lin Bioorg. Med. Chem. 17 2009 7265
16. S. Dadashzadeh, N. Mirahmadi, M.H. Babaei, and A.M. Vali J. Control Release 148 2010 177
17. F.M. Engelmann, S.V.O. Rocha, H.E. Toma, K. Araki, and M.S. Baptista Int. J. Pharm. 329 2007 12
18. J. Tu, H.B. Halsall, C.J. Seliskar, P.A. Limbach, F. Arias, K.R. Wehmeyer, and W.R. Heineman J. Pharm. Biomed. Anal. 38 2005 1
19. E.R. Bennett, Jay Clausen, E. Linkov, and I. Linkov Chemosphere 77 2009 1412
20. T. Cheng, Y. Zhao, X. Li, F. Lin, Y. Xu, X. Zhang, Y. Li, R. Wang, and L. Lai J. Chem. Inf. Model. 47 2007 2140
21. http://www.sioc-ccbg.ac.cn/software/xlogp3/; (2011-2-19).
22. M.A. Bakht, M.S. Yar, S.G. Abdel-Hamid, S.I. Al Qasoumi, and A. Samad Eur. J. Med. Chem. 45 2010 5862
23. http://www.molinspiration.com/cgi-bin/properties; (2011-2-24).
24. Y.Q. Ran, Y. He, G. Yang, L.H. Johnson, and H.Y. Samuel Chemosphere 48 2002 487
25. F.A. Macias, J.C. Galindo, D. Castellano, and R.F. Velasco J. Agric. Food. Chem. 53 2005 3530