Optimization of ultrasonic-assisted extraction (UAE) of betulin from white birch bark using response surface methodology

Ultrasonics Sonochemistry

Volumn 16, Issue 5, 2009, Pages 599-604

  Chen, Qi he ^a   Fu, Ming liang ^a   Liu, Jin ^a   Zhang, Hai feng ^a   He, Guo qing ^a   Ruan, Hui ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Betulin; Optimization; Response surface methodology (RSM); Ultrasonic assisted extraction (UAE); White birch bark

Indexed keywords

BIOACTIVITY; OPTIMIZATION; PRODUCTIVITY; SOLVENTS; SURFACE PROPERTIES;

BETULIN; BIOLOGICALLY ACTIVE COMPOUNDS; CENTRAL COMPOSITE DESIGNS; EXTRACTION TEMPERATURES; FRACTIONAL FACTORIAL DESIGNS; RESPONSE SURFACE METHODOLOGY; ULTRASONIC-ASSISTED EXTRACTIONS; WHITE BIRCHES;

EXTRACTION;

BETULIN; SOLVENT; TRITERPENE;

ARTICLE; BARK; BIRCH; CONCENTRATION (PARAMETERS); EXTRACTION; FACTORIAL ANALYSIS; PREDICTIVE VALIDITY; PRIORITY JOURNAL; RESPONSE SURFACE METHOD; TEMPERATURE; ULTRASOUND;

EID: 65049089402     PISSN: 13504177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ultsonch.2008.11.009     Document Type: Article

References (15)

1. Sami A., Taru M.K., Salme K., and Jari Y.-K. Pharmacological properties of the ubiquitous natural product betulin. Eur. J. Pharm. Sci. 29 (2006) 1-13
2. Eckerman C., and Ekman R. Comparison of solvents for extraction and crystallization of betulin from birch bark waste. Paperi ja Puu 67 (1985) 100-106
3. Guidoin M.-F., Yang J., Pichette A., and Roy C. Betulin isolation from birch bark by vacuum and atmospheric sublimation. A thermogravimetric study. Thermochim. Acta 398 (2003) 153-166
4. Cichewicz R.H., and Kouzi S.A. Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection. Med. Res. Rev. 24 (2003) 90-114
5. Baglin I., Poumaroux A., Nour M., Tan K., Mitaine-Offer A.C., Lacaille-Dubois M.A., Chauffert B., and Cave C. New ursolic and betulinic derivatives as potential cytotoxic agents. J. Enzyme Inhib. Med. Chem. 18 (2003) 111-117
6. Eiznhamer D.A., and Xu Z. Betulinic acid: a promising anticancer candidate. IDrugs: Invest. Drugs J. 7 (2004) 359-373
7. Aiken C., and Chen C.H. Betulinic acid derivatives as HIV-1 antivirals. Trends Mol. Med. 11 (2005) 31-36
8. Yogeeswari P., and Sriram D. Betulinic acid and its derivatives: a review on their biological properties. Curr. Med. Chem. 12 (2005) 657-666
9. Pollard D.J., and Woodley J.M. Biocatalysis for pharmaceutical intermediates: the future is now. Trends Biotechnol. 25 (2007) 66-73
10. Kim D.S.H.L., Chen Z., Van Tuyen N., Pezzuto J.M., Qiu S., and Lu Z. A concise semi-synthetic approach to betulinic acid from betulin. Synth. Commun. 27 (1997) 1607-1612
11. Knorr D., Ade-Omowaye B.I.O., and Heinz V. Nutritional improvement of plant foods by non-thermal processing. Proc. Nutr. Soc. 61 (2002) 311-318
12. Vinatoru M. An overview of the ultrasonically assisted extraction of bioactive principles from herbs. Ultrason. Sonochem. 8 (2001) 303-313
13. Zhao G.L., Yan W.D., and Cao D. Simultaneous determination of betulin and betulinic acid in white birch bark using RP-HPLC. J. Pharm. Biomed. Anal. 43 (2007) 959-962
14. Chen Q.H., and He G.Q. Optimization of medium composition for the production of elastase by Bacillus sp. EL31410 with response surface methodology. Enzyme Microbiol. Technol. 5 (2002) 667-672
15. Montgomery D.C. Design and Analysis of Experiments. third ed. (1991), Wiley, NY