Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice

British Journal of Cancer

Volumn 90, Issue 8, 2004, Pages 1672-1678

  Sawada, N ^a,b   Kataoka, K ^b   Kondo, K ^a   Arimochi, H ^b   Fujino, H ^a   Takahashi, Y ^a   Miyoshi, T ^a   Kuwahara, T ^b   Monden, Y ^a   Ohnishi, Y ^b  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Betulinic acid; Cell cycle arrest; G1 phase; Synergistic antitumour effect; Vincristine

Indexed keywords

BETULIC ACID; TRITERPENE DERIVATIVE; VINCRISTINE; ANTINEOPLASTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; TRITERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CELL CYCLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENTIATION; FEMALE; LUNG METASTASIS; LUNG NODULE; MELANOMA CELL; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECT; LUNG TUMOR; MELANOMA; METASTASIS; PATHOLOGY; SKIN TUMOR;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL CYCLE; FEMALE; LUNG NEOPLASMS; MELANOMA; MICE; MICE, INBRED C57BL; SKIN NEOPLASMS; TRITERPENES; TUMOR CELLS, CULTURED; VINCRISTINE;

EID: 2442531882     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601746     Document Type: Article

References (35)

1. Aller P, Rius C, Mata F, Zorilla A, Cabanas C, Bellon T, Barnabeu C (1992) Camptothecin induces differentiation and stimulates the expression of differentiation-related genes in U-937 promonocytic leukemia cells. Cancer Res 52: 1245-1251
2. Bajetta E, Vecchio MD, Marty CB, Vitali M, Buzzoni R, Rixe O, Nova P, Aglione S, Taillibert S, Khayat D (2002) Metastatic melanoma: chemotherapy. Semin Oncol 29: 427-445
3. Berenbaum MC (1981) Criteria for analyzing interactions between biologically active agents. Adv Cancer Res 35: 269-336
4. Bhuyan BK, Groppi VE (1989) Cell cycle specific inhibitors. Pharmacol Ther 42: 307-348
5. Chan DC, Earle KA, Zhao TLM, Helfrich B, Zeng C, Baron A, Whitehead CM, Piazza G, Pamukcu R, Thompson WJ, Alila H, Nelson P, Bunn Jr PA (2002) Exisulind in combination with docetaxel inhibits growth and metastasis of human lung cancer and prolongs survival in athymic nude rats with orthotopic lung tumors. Clin Cancer Res 8: 904-912
6. Christensen JG, LeBlanc GA (1996) Reversal of multidrug resistance in vivo by dietary administration of the phytochemical indole-3-carbinor. Cancer Res 56: 574-581
7. Darzynkiewicz Z (1986) Cell growth and division cycle. In Cell Cycle Effects of Drugs, Dethlefsen L (ed) pp. 1-43. New York: Pergamon Press
8. Darzynkiewicz Z (1995) Apoptosis in antitumor strategies: modulation of cell cycle or differentiation. J Cell Biochem 58: 151-159
9. Feleszko W, Mlynarczuk I, Olszewska D, Jalili A, Stoklosa T, Lasek W, Hoser G, Korczak-Kowalska G, Jakobisiak M (2002) Lovastatin potentiates antitumor activity of doxorubicin in murine melanoma via an apoptosis-dependent mechanism. Int J Cancer 100: 111-118
10. Fidler J, Kripke L (1977) Metastasis results from preexisting variant cells within a malignant tumor. Science 197: 893-895
11. Fulda S, Friesen C, Los M, Scaffidi C, Mier W, Benedict M, Nuòez G, Krammer PH, Peter ME, Debatin KM (1997) Betulinic acid triggers CD95(apo-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer Res 57: 4956-4964
12. Fulda S, Scaffidi C, Susin SA, Krammer PH, Kroemer G, Peter ME, Debatin KM (1998) Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid. J Biol Chem 273: 33942-33948
13. Gohen G.M, Sun X, Snowden RT, Dinsdale D, Skilleter DN (1992) Key morphological features of apoptosis may occur in the absence of internucleosomal fragmentation. Biochem J 286: 331-334
14. Gude RP, Menon LG, Rao SG (2001) Effect of caffeine, a xanthine derivative, in the inhibition of experimental lung metastasis induced by B16F10 melanoma cells. J Exp Clin Cancer Res 20: 287-292
15. Jani JP, Specht S, Stemmler N, Blanock K, Singh SV, Gupta V, Katoh A (1993) Metastasis of B16F10 mouse melanoma inhibited by lovastatin, an inhibitor of cholesterol biosynthesis. Invas Metast 13: 314-324
16. Kang IC, Kim DS, Jang Y, Chung KH (2000) Suppressive mechanism of salmosin, a novel disintegrin in B16 melanoma cell metastasis. Biochem Biophys Res Commun 275: 169-173
17. Kivela T, Suciu S, Hansson J, Kruit WH, Vuoristo MS, Kloke O, Gore M, Kemppinen MH, Parvinen LM, Kumpulainen E, Humblet Y, Pyrhonen S (2003) Bleomycin, vincristine, lomustine, and dacarbazine (BOLD) in combination with recombinant interferon alpha-2b for metastatic uveal melanoma. Eur J Cancer 39: 1115-1120
18. Ko HH, Yu SM, Ko FN, Teng CM, Lin CN (1997) Bioactive constituents of Morus australis and Broussonetia papyrifera. J Nat Prod 60: 1008-1011
19. Kwon HJ, Shim JS, Kim JH, Cho HY, Yum YN, Kim SH, Yu J (2002) Betulinic acid inhibits growth factor-induced in vitro angiogenesis via the modulation of mitochondrial function in endothelial cells. Jpn J Cancer Res 93: 417-425
20. Lee Y, Shacter E (1999) Oxidative stress inhibits apoptosis in human lymphoma cells. J Biol Chem 274: 19792-19798
21. Liotta LA (1986) Tumor invasion and metastases - role of the extracellular matrix: Rhoads memorial award lecture. Cancer Res 46: 1-7
22. Malafa MP, Fokum FD, Mowlavi A, Abusief M, King M (2002) Vitamin E Inhibits melanoma growth in mice. Surgery 131: 85-91
23. Miyoshi T, Kondo K, Ishikura H, Kinoshita H, Matsumori Y, Monden Y (2000) SCID mouse lymphogenous metastatic model of human lung cancer constructed using orthotopic inoculation of cancer cells. Anticancer Res 20: 161-163
24. Morrow M, Wait RB, Rosenthal RA, Gamelli RL (1987) Verapamil enhances antitumor activity without increasing myeloid toxicity. Surgery 101: 63-68
25. Nicolson GL (1988) Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites. Cancer Metast Rev 7: 143-188
26. Pisha E, Chai H, Lee IS, Chagwedera TE, Farnsworth NR, Cordell GA, Beecher CWW, Fong HHS, Kinghorn AD, Brown DM, Wani MC, Wall ME, Hieken TJ, Gupta TKD, Pezzuto JM (1995) Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nat Med 1: 1046-1051
27. Singh RP, Dhanalakshmi S, Agarwal R (2002) Phytochemicals as cell cycle modulators. Cell Cycle 1: 156-161
28. Sora MK, Kruszewski AA, Stoklosa T, Czyżyk J, Lasek W, Malejczyk J, Jakóbisiak M (1994) Synergistic anti-proliferative activity of tumor necrosis factor-alpha (TNF-α) and lovastatin. Arch Immunol Ther Exp 42: 269-274
29. Suaeyun R, Kinouchi T, Arimochi H, Vinitketkumnuen U, Ohnishi Y (1997) Inhibitory effects of lemon grass (Cymbopogon citratus Stapf) on formation of azoxymethane-induced DNA adducts and aberrant crypt foci in the rat colon. Carcinogenesis 18: 949-955
30. Wachsberger PR, Burd R, Wahl ML, Leeper DB (2002) Betulinic acid sensitization of low pH adapted human melanoma cells to hyperthermia. Int J Hyperthertmia 18: 153-164
31. Wick W, Grimmel C, Wagenknecht B, Dichgans J, Weller M (1999) Betulinic acid-induced apoptosis in glioma cells: a sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing. J Pharmacol Exp Ther 289: 1306-1312
32. Wöll E, Bedikian A, Legha SS (1999) Uveal melanoma: natural history and treatment options for metastatic disease. Melanoma Res 9: 575-581
33. Workman P, Twentyman P, Balkwill F, Balmain A, Chaplin D, Double J, Embleton J, Newell D, Raymond R, Stables J, Stephens T, Wallace J (1998) United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) guidelines for the welfare of animals in experimental neoplasia (Second Edition). Br J Cancer 77: 1-10
34. Wyllie A (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284: 555-556
35. Zhu M, Phillipson JD, Greengrass PM, Bowery NG (1996) Chemical and biological investigation of the root bark of Clerodendrum mandarinorum. Planta Med 62: 393-396