Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells

Life Sciences

Volumn 75, Issue 19, 2004, Pages 2303-2316

  Hsu, Ya Ling ^a   Kuo, Po Lin ^b   Lin, Chun Ching ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

Author keywords

Apoptosis; Cell cycle; Fas APO 1, FasL; p53; Ursolic acid

Indexed keywords

CYCLIN D1; CYCLIN D2; CYCLIN E; DNA FRAGMENT; FAS ANTIGEN; FAS LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P21; PROTEIN P53; URSOLIC ACID;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MOLECULAR BIOLOGY; PROTEIN EXPRESSION; UPREGULATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE, TUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FAS LIGAND PROTEIN; HUMANS; LUNG NEOPLASMS; MEMBRANE GLYCOPROTEINS; NF-KAPPA B; SIGNAL TRANSDUCTION; TRITERPENES;

EID: 4444356923     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2004.04.027     Document Type: Article

References (45)

1. R. Agarwal Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents Biochemical pharmacology 60 2000 1051 1059
2. D. Andersson, J.J. Liu, A. Nilsson, and R.D. Duan Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase Anticancer research 23 2003 3317 3322
3. B. Antonsson, and J.C. Martinou The Bcl-2 protein family Experimental cell research 256 2000 50 57
4. J.H. Baek, Y.S. Lee, C.M. Kang, J.A. Kim, K.S. Kwon, H.C. Son, and K.W. Kim Intracellular Ca2+ release mediates ursolic acid-induced apoptosis in human leukemic HL-60 cells International journal of cancer 73 1997 725 728
5. M.R. Bennett Mechanisms of p53-induced apoptosis Biochemical pharmacology 58 1999 1089 1095
6. F. Castaneda, and R.K. Kinne Apoptosis induced in HepG2 cells by short exposure to millimolar concentrations of ethanol involves the Fas-receptor pathway Journal of cancer research and clinical oncology 127 2001 418 424
7. H.J. Cha, S.K. Bae, H.Y. Lee, O.H. Lee, H. Sato, M. Seiki, B.C. Park, and K.W. Kim Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells Cancer research 56 1996 2281 2284
8. H.J. Cha, M.T. Park, H.Y. Chung, N.D. Kim, H. Sato, M. Seiki, and K.W. Kim Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells Oncogene 16 1998 771 778
9. Y.H. Choi, J.H. Baek, M.A. Yoo, H.Y. Chung, N.D. Kim, and K.W. Kim Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human prostate epithelial cells International journal of oncology 17 2000 565 571
10. V. Dixit, and T.W. Mak NF-kappaB signaling. Many roads lead to madrid Cell 111 2002 615 619
11. L.A. Donehower, M. Harvey, B.L. Slagle, M.J. McArthur, C.A. Montgomery Jr., and J.S. Butel Bradley A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours Nature 356 1992 215 221
12. D. Es-Saady, A. Simon, C. Jayat-Vignoles, A.J. Chulia, and C. Delage MCF-7 cell cycle arrested at G1 through ursolic acid, and increased reduction of tetrazolium salts Anticancer research 16 1996 481 486
13. D. Es-Saady, A. Simon, M. Ollier, J.C. Maurizis, A.J. Chulia, and C. Delage Inhibitory effect of ursolic acid on B16 proliferation through cell cycle arrest Cancer letters 106 1996 193 197
14. C. Ferlini, G. Raspaglio, S. Mozzetti, M. Distefano, F. Filippetti, E. Martinelli, G. Ferrandina, D. Gallo, F.O. Ranelletti, and G. Scambia Bcl-2 down-regulation is a novel mechanism of paclitaxel resistance Molecular pharmacology 64 2003 51 58
15. P.O. Harmand, R. Duval, B. Liagre, C. Jayat-Vignoles, J.L. Beneytout, C. Delage, and A. Simon Ursolic acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells International journal of oncology 23 2003 105 112
16. I. Herr, and K.M. Debatin Cellular stress response and apoptosis in cancer therapy Blood 98 2001 2603 2614
17. M.T. Huang, C.T. Ho, Z.Y. Wang, T. Ferraro, Y.R. Lou, K. Stauber, W. Ma, C. Georgiadis, J.D. Laskin, and A.H. Conney Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid Cancer research 54 1994 701 708
18. F.H. Igney, and P.H. Krammer Death and anti-death: tumour resistance to apoptosis. Nature reviews Cancer 2 2002 277 288
19. M. Karin, Y. Cao, F.R. Greten, and Z.W. Li NF-kappaB in cancer: from innocent bystander to major culprit. Nature reviews Cancer 2 2002 301 310
20. N. Kayagaki, A. Kawasaki, T. Ebata, H. Ohmoto, S. Ikeda, S. Inoue, K. Yoshino, K. Okumura, and H. Yagita Metalloproteinase-mediated release of human Fas ligand The Journal of experimental medicine 182 1995 1777 1783
21. G.J. Kelloff, J.A. Crowell, V.E. Steele, R.A. Lubet, W.A. Malone, C.W. Boone, L. Kopelovich, E.T. Hawk, R. Lieberman, J.A. Lawrence, I. Ali, J.L. Viner, and C.C. Sigman Progress in cancer chemoprevention: development of diet-derived chemopreventive agents The Journal of nutrition 130 2000 467S 471S
22. A. Khoshnan, C. Tindell, I. Laux, D. Bae, B. Bennett, and A.E. Nel The NF-kappa B cascade is important in Bcl-xL expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4+ lymphocytes Journal of immunology 165 2000 1743 1754
23. D.K. Kim, J.H. Baek, C.M. Kang, M.A. Yoo, J.W. Sung, H. Chung, N.D. Kim, Y.H. Choi, S.H. Lee, and K.W. Kim Apoptotic activity of ursolic acid may correlate with the inhibition of initiation of DNA replication International journal of cancer 87 2000 629 636
24. P.K. Kim, S.Y. Park, P.P. Koty, Y. Hua, J.D. Luketich, and T.R. Billiar Fas-associating death domain protein overexpression induces apoptosis in lung cancer cells The Journal of thoracic and cardiovascular surgery 125 2003 1336 1342
25. F. Lauthier, L. Taillet, P. Trouillas, C. Delage, and A. Simon Ursolic acid triggers calcium-dependent apoptosis in human Daudi cells Anti-cancer drugs 11 2000 737 745
26. H.Y. Lee, H.Y. Chung, K.H. Kim, J.J. Lee, and K.W. Kim Induction of differentiation in the cultured F9 teratocarcinoma stem cells by triterpene acids Journal of cancer research and clinical oncology 120 1994 513 518
27. K.H. Lee, Y.M. Lin, T.S. Wu, D.C. Zhang, T. Yamagishi, T. Hayashi, I.H. Hall, J.J. Chang, R.Y. Wu, and T.H. Yang The cytotoxic principles of Prunella vulgaris, Psychotria serpens, and Hyptis capitata: ursolic acid and related derivatives Planta medica 54 1988 308 311
28. J. Liu Pharmacology of oleanolic acid and ursolic acid Journal of ethnopharmacology 49 1995 57 68
29. P. May, and E. May Twenty years of p53 research: structural and functional aspects of the p53 protein Oncogene 18 1999 7621 7636
30. M.D. Mediavilla, S. Cos, and E.J. Sanchez-Barcelo Melatonin increases p53 and p21WAF1 expression in MCF-7 human breast cancer cells in vitro Life sciences 65 1999 415 420
31. Y. Mizushina, A. Iida, K. Ohta, F. Sugawara, and K. Sakaguchi Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase The Biochemical journal 350 2000 757 763
32. S. Nagata, and P. Golstein The Fas death factor Science 267 1995 1449 1456
33. L. Novotny, A. Vachalkova, and D. Biggs Ursolic acid: an anti-tumorigenic and chemopreventive activity. Minireview Neoplasma 48 2000 241 246
34. N.W. Roehm, G.H. Rodgers, S.M. Hatfield, and A.L. Glasebrook An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT Journal of immunological methods 142 1991 257 265
35. P. Salgame, A.S. Varadhachary, L.L. Primiano, J.E. Fincke, S. Muller, and M. Monestier An ELISA for detection of apoptosis Nucleic acids research 25 1997 680 681
36. C.J. Sherr, and J.M. Roberts CDK inhibitors: positive and negative regulators of G1-phase progression Genes & development 13 1999 1501 1512
37. H. Shirin, E.M. Sordillo, S.H. Oh, H. Yamamoto, T. Delohery, I.B. Weinstein, and S.F. Moss Helicobacter pylori inhibits the G1 to S transition in AGS gastric epithelial cells Cancer research 59 1999 2277 2281
38. S. Shishodia, S. Majumdar, S. Banerjee, and B.B. Aggarwal Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1 Cancer research 63 2003 4375 4383
39. K.H. Sohn, H.Y. Lee, H.Y. Chung, H.S. Young, S.Y. Yi, and K.W. Kim Anti-angiogenic activity of triterpene acids Cancer letters 94 1995 213 218
40. S. Somasundaram, N.A. Edmund, D.T. Moore, G.W. Small, Y.Y. Shi, and R.Z. Orlowski Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer Cancer research 62 2002 3868 3875
41. T. Suda, T. Takahashi, P. Golstein, and S. Nagata Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family Cell 75 1993 1169 1178
42. E. Tarkowski, L. Rosengren, C. Blomstrand, C. Jensen, S. Ekholm, and A. Tarkowski Intrathecal expression of proteins regulating apoptosis in acute stroke Stroke 30 1999 321 327
43. Y. Tendler, G. Weisinger, R. Coleman, E. Diamond, S. Lischinsky, H. Kerner, V. Rotter, and O. Zinder Tissue-specific p53 expression in the nervous system. Brain research Molecular brain research 72 1999 40 46
44. H. Tokuda, H. Ohigashi, K. Koshimizu, and Y. Ito Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-O-tetradecanoylphorbol- 13-acetate Cancer letters 33 1986 279 285
45. L. Wang, W. Ma, R. Markovich, J.W. Chen, and P.H. Wang Regulation of cardiomyocyte apoptotic signaling by insulin-like growth factor I Circulation research 83 1998 516 522