Betulinic acid: Isolation from Triphyophyllum peltatum and Ancistrocladus heyneanus, antimalarial activity, and crystal structure of the benzyl ester

Planta Medica

Volumn 63, Issue 3, 1997, Pages 255-257

  Bringmann, Gerhard ^a   Saeb, Wael ^a   Assi, Laurent Aké ^b   François, Guido ^c   Sankara Narayanan, A S ^d   Peters, Karl ^e   Peters, Eva Maria ^e  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITÉ NANGUI ABROGOUA   (Côte d’Ivoire)

^c INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^d Native Medicare Charitable Trust   (India)

^e MAX PLANCK INSTITUT FÜR FESTKÖRPERFORSCHUNG   (Germany)

Author keywords

Ancistrocladaceae; Ancistrocladus heyneanus; Antimalarial activity; Betulinic acid; Crystal structure; Dioncophyllaceae; Plasmodium falciparum; Triphyophyllum peltatum; Triterpenes

Indexed keywords

ANCISTROCLADINE; BETULIC ACID; DIONCOPHYLLINE A; ISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG ISOLATION; DRUG STRUCTURE; MALARIA; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; CRYSTALLOGRAPHY, X-RAY; ERYTHROCYTES; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PLANTS, MEDICINAL; PLASMODIUM FALCIPARUM; TRITERPENES;

ANCISTROCLADACEAE; ANCISTROCLADUS HEYNEANUS; DIONCOPHYLLACEAE; PLASMODIUM FALCIPARUM; TRIPHYOPHYLLUM PELTATUM;

EID: 0030854627     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-957666     Document Type: Article

References (20)

1. Bringmann, G., Götz, R., François, G. (1996) Tetrahedron 52, 13419-13426.
2. Hegnauer, R. (1989) Chemotaxonomy of plants, Vol. 8, p. 388-389, Birkhäuser Verlag, Basel.
3. Hegnauer, R. (1989) Chemotaxonomy of plants, Vol. 8, p. 39-42, Birkhäuser Verlag, Basel.
4. Bringmann, G., Pokorny, F. (1995) in: The Alkaloids, Vol. 46 (Cordell, G., ed.), pp. 127-271, Academic Press, New York.
5. Bringmann, G., Pokorny, F. (1991) Der Palmengarten 55/3, 13-18.
6. Bringmann, G., Schneider, C., Pokorny, F., Lorenz, H., Fleischmann, H., Sankara Narayanan, A. S., Almeida, M. R., Govindachari, T. R., Aké Assi, L (1993) Planta Med. 59(Suppl), 623-624.
7. Simonsen, J. L., Ross, W. C. J. (1957) The Terpenes, Vol. 5, pp. 316-319, Cambridge University Press, Cambridge.
8. Sheth, K., Jolad, S., Wiedhopf, R., Cole, J. R. (1972) J. Pharm. Sci. 61., 1819.
9. Trager, W., Jensen, J. B. (1976) Science 193, 673-675.
10. Desjardins, R. E., Canfield, C. J., Haynes, J. D., Chulay, J. D. (1979) Antimicrob. Agents Chemother. 16, 710-718.
11. François, G., Bringmann, G., Phillipson, J. D., Aké Assi, L., Dochez, C., Rübenacker, M., Schneider, C., Wéry, M., Warhurst, D. C., Kirby, G. C. (1994) Phytochemistry 35, 1461-1464.
12. François, G., Timperman, G., Holenz, J., Aké Assi, L., Geuder, T., Maes, L., Dubois, J., Hanocq, M., Bringmann, G. (1996) Ann. Trop. Med. Parasitol. 90, 115-123.
13. Bejar, E., Amarquaye, A., Che, C. T., Malone, M. H., Fong, H. H. S. (1995) Int. J. Pharmacognosy 33, 25-32.
14. Fujioka, T., Kashiwada, Y., Kilkuskie, R. E., Cosentino, L. M., Ballas, L M., Jiang, J. B. Janzen, W. P., Chen, I. S., Lee, K. H. (1994) J. Nat. Prod. 57, 243-247.
15. Pisha, E., Chai, H., Lee, I.-S., Chagwedera, T. E., Farnsworth, N. R., Cordell, G. A., Beecher, C. W., Fong, H. H., Kinghorn, A. D., Brown, D. M., Wani, M. C., Wall, M. E., Hieken, T. J., Gupta, T. K., Pezzuto, J. M. (1995) Nature Med. 1, 1046-1051.
16. Recio, M. C., Giner, R. M., Manez, S., Gueho, J., Julien, H. R., Hostettmann, K., Rios, J. L. (1995) Planta Med. 61, 9-12.
17. Yasukawa, K., Takido, M., Matsumoto, T., Takeuchi, M., Nakagawa, S. (1991) Oncology 48, 72-76.
18. Sauvain, M., Kunesch, N., Poisson, J., Gantier, J. C., Gayral, P., Dedet, J. P. (1996) Phytother. Res. 10, 1-4.
19. Ruangrungsi, N., Wongpanich, V., Tantivatana, P., Cowe, H. J., Cox, P. J., Funayama, S., Cordell, G. A. (1985) J. Nat. Prod. 48, 529-535.
20. Liu, S., Huang, J. (1984) Jiegou Huaxue (J. Struct. Chem.) 3, 225-230.