Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 19, 2012, Pages 5774-5786

  Leal, Ana S ^a,b,c   Wang, Rui ^c   Salvador, Jorge A R ^a,b   Jing, Yongkui ^c  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Antiproliferative; Heterocyclic derivatives; NOXA; p53; Ursolic acid

Indexed keywords

2 HYDROXYMETHYLENE 3 OXOURS 12 EN 28 OIC ACID; 28 (1H IMIDAZOL 1 YL) 3,28 DIOXOURS 12 EN 2 (1H IMIDAZOL 1 YL)METHYLENE; 28 (2' METHYL 1H IMIDAZOL 1 YL) 3,28 DIOXOURS 12 EN 2 (2' METHYL 1H IMIDAZOL 1 YL)METHYLENE; 28 (4H TRIAZOL 4 YL) 3,28 DIOXOURS 12 EN 2 (4H TRIAZOL 4 YL)METHYLENE; 3 OXOURS 12 EN 28 OIC ACID; 3 OXOURS 12 EN 28 YL 1H IMIDAZOLE 1 CARBOXYLATE; 3 OXOURS 12 EN 28 YL 2' METHYL 1H IMIDAZOLE 1 CARBOXYLATE; 3 OXOURS 12 EN 28 YL 4H TRIAZOLE 4 CARBOXYLATE; 3,11 DIOXOURS 12 EN 28 OIC ACID; 3,11 DIOXOURS 12 EN 28 YL 1H IMIDAZOLE 1 CARBOXYLATE; 3,11 DIOXOURS 12 EN 28 YL 2' METHYL 1H IMIDAZOLE 1 CARBOXYLATE; 3,11 DIOXOURS 12 EN 28 YL 4H TRIAZOLE 4 CARBOXYLATE; 3BETA ACETOXY 11 OXOURS 12 EN 28 OIC ACID; 3BETA ACETOXY 11 OXOURS 12 EN 28 YL 1H IMIDAZOLE 1 CARBOXYLATE; 3BETA ACETOXY 11 OXOURS 12 EN 28 YL 2' METHYL 1H IMIDAZOLE 1 CARBOXYLATE; 3BETA ACETOXY 11 OXOURS 12 EN 28 YL 4H TRIAZOLE CARBOXYLATE; 3BETA ACETOXY URS 12 EN 28 OIC ACID; 3BETA ACETOXY URS 12 EN 28 YL 1H IMIDAZOLE 1 CARBOXYLATE; 3BETA ACETOXY URS 12 EN 28 YL 2' METHYL 1H IMIDAZOLE 1 CARBOXYLATE; 3BETA ACETOXY URS 12 EN 28 YL 4H TRIAZOLE 1 CARBOXYLATE; CYCLIN DEPENDENT KINASE INHIBITOR 1; METHYL 2 (1H IMIDAZOL 1 YL)METHYLENE 3,11 DIOXOURS 12 EN 28 OATE; METHYL 2 HYDROXYMETHYLENE 3,11 DIOXOURS 12 EN 28 OATE; METHYL 3 OXOURS 12 EN 28 OATE; METHYL 3BETA HYDROXY URS 12 EN 28 OATE; PROTEIN NOXA; PROTEIN P53; UNCLASSIFIED DRUG; UNINDEXED DRUG; URSOLIC ACID; URSOLIC ACID DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CONJUGATION; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; IC 50; PANCREAS CANCER; STRUCTURE ACTIVITY RELATION; UPREGULATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HUMANS; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; TRITERPENES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84866355871     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.08.010     Document Type: Article

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