Lipotoxicity in the pancreatic beta cell: Not just survival and function, but proliferation as well?

Current Diabetes Reports

Volumn 14, Issue 6, 2014, Pages

  Sharma, Rohit B ^a   Alonso, Laura C ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Autophagy; Cell cycle; Endoplasmic reticulumstress; Fatty acid receptor; FFAR1; Free fatty acid; Glucolipotoxicity; gpr40; Growth factors; Inflammation; Insulin secretion; Islet; Lipid; Lipotoxicity; Metabolism; Nonesterified fatty acid; Oxidative stress; Pancreatic beta cell; PPAR; Proliferation; Triglyceride

Indexed keywords

GROWTH FACTOR; HORMONE DERIVATIVE; MEMBRANE RECEPTOR; FATTY ACID; LIPID;

AUTOPHAGY; CELL CYCLE REGULATION; CELL FUNCTION; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; ENDOPLASMIC RETICULUM STRESS; HUMAN; INTRACELLULAR SIGNALING; LIPOTOXICITY; METABOLISM; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; REVIEW; APOPTOSIS; BLOOD; DISEASE COURSE; FEMALE; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; LIPID PEROXIDATION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL PROLIFERATION; CELL SURVIVAL; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DISEASE PROGRESSION; ENDOPLASMIC RETICULUM STRESS; FATTY ACIDS, NONESTERIFIED; FEMALE; HUMANS; INFLAMMATION; INSULIN-SECRETING CELLS; LIPID PEROXIDATION; LIPIDS; MALE; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EID: 84901582555     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-014-0492-2     Document Type: Review

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