-
1
-
-
0032525981
-
β-Cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes
-
Ahlgren U., Jonsson J., Jonsson L., Simu K., Edlund H. β-Cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes. Genes Dev. 1998, 12:1763-1768.
-
(1998)
Genes Dev.
, vol.12
, pp. 1763-1768
-
-
Ahlgren, U.1
Jonsson, J.2
Jonsson, L.3
Simu, K.4
Edlund, H.5
-
2
-
-
0030098799
-
Glucagon-like peptide-1(7-36) amide increases cyclic AMP accumulation in normal islets
-
Ahren B. Glucagon-like peptide-1(7-36) amide increases cyclic AMP accumulation in normal islets. Pancreas 1996, 12:211-213.
-
(1996)
Pancreas
, vol.12
, pp. 211-213
-
-
Ahren, B.1
-
3
-
-
0036690930
-
Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes
-
Amemiya-Kudo M., Shimano H., Hasty A.H., Yahagi N., Yoshikawa T., Matsuzaka T., Okazaki H., Tamura Y., Iizuka Y., Ohashi K., Osuga J., Harada K., Gotoda T., Sato R., Kimura S., Ishibashi S., Yamada N. Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes. J. Lipid Res. 2002, 43:1220-1235.
-
(2002)
J. Lipid Res.
, vol.43
, pp. 1220-1235
-
-
Amemiya-Kudo, M.1
Shimano, H.2
Hasty, A.H.3
Yahagi, N.4
Yoshikawa, T.5
Matsuzaka, T.6
Okazaki, H.7
Tamura, Y.8
Iizuka, Y.9
Ohashi, K.10
Osuga, J.11
Harada, K.12
Gotoda, T.13
Sato, R.14
Kimura, S.15
Ishibashi, S.16
Yamada, N.17
-
4
-
-
0030941803
-
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
-
Brown M.S., Goldstein J.L. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997, 89:331-340.
-
(1997)
Cell
, vol.89
, pp. 331-340
-
-
Brown, M.S.1
Goldstein, J.L.2
-
5
-
-
2942568445
-
Glucagon-like peptide-1 prevents beta cell glucolipotoxicity
-
Buteau J., El-Assaad W., Rhodes C.J., Rosenberg L., Joly E., Prentki M. Glucagon-like peptide-1 prevents beta cell glucolipotoxicity. Diabetologia 2004, 47:806-815.
-
(2004)
Diabetologia
, vol.47
, pp. 806-815
-
-
Buteau, J.1
El-Assaad, W.2
Rhodes, C.J.3
Rosenberg, L.4
Joly, E.5
Prentki, M.6
-
6
-
-
0032768616
-
Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells
-
Buteau J., Roduit R., Susini S., Prentki M. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells. Diabetologia 1999, 42:856-864.
-
(1999)
Diabetologia
, vol.42
, pp. 856-864
-
-
Buteau, J.1
Roduit, R.2
Susini, S.3
Prentki, M.4
-
7
-
-
0037219411
-
β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
-
Butler A.E., Janson J., Bonner-Weir S., Ritzel R., Rizza R.A., Butler P.C. β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 2003, 52:102-110.
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
8
-
-
0035430782
-
Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation
-
Cnop M., Hannaert J.C., Hoorsens A., Eizirik D.L., Pipeleers D.G. Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes 2001, 50:1771-1777.
-
(2001)
Diabetes
, vol.50
, pp. 1771-1777
-
-
Cnop, M.1
Hannaert, J.C.2
Hoorsens, A.3
Eizirik, D.L.4
Pipeleers, D.G.5
-
9
-
-
1642546212
-
Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribomucleoside (AICAR)
-
Diraison F., Parton L., Ferre P., Foufelle F., Briscoe C.P., Leclerc I., Rutter G.A. Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribomucleoside (AICAR). Biochem. J. 2004, 378:769-778.
-
(2004)
Biochem. J.
, vol.378
, pp. 769-778
-
-
Diraison, F.1
Parton, L.2
Ferre, P.3
Foufelle, F.4
Briscoe, C.P.5
Leclerc, I.6
Rutter, G.A.7
-
10
-
-
33847617011
-
Mechanisms of action of glucagon-like peptide 1 in the pancreas
-
Doyle M.E., Egan J.M. Mechanisms of action of glucagon-like peptide 1 in the pancreas. Pharmacol. Ther. 2007, 113:546-593.
-
(2007)
Pharmacol. Ther.
, vol.113
, pp. 546-593
-
-
Doyle, M.E.1
Egan, J.M.2
-
11
-
-
33846006173
-
The incretin system: glucagonlike peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
-
Drucker D.J., Nauck M.A. The incretin system: glucagonlike peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006, 368:1696-1705.
-
(2006)
Lancet
, vol.368
, pp. 1696-1705
-
-
Drucker, D.J.1
Nauck, M.A.2
-
12
-
-
0037357951
-
GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells
-
Egan J.M., Bulotta A., Hui H., Perfetti R. GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells. Diabetes Metab. Res. Rev. 2003, 19:115-123.
-
(2003)
Diabetes Metab. Res. Rev.
, vol.19
, pp. 115-123
-
-
Egan, J.M.1
Bulotta, A.2
Hui, H.3
Perfetti, R.4
-
13
-
-
48449104756
-
Exendin-4 protects {beta}-cells from interleukin 1{beta}-induced apoptosis by interfering with the c-Jun N-terminal kinases pathway
-
Ferdaoussi M., Abdelli S., Yang J.Y., Cornu M., Niederhauser G., Favre D., Widmann C., Reqazzi R., Thorens B., Waeber G., Abderrahamani A. Exendin-4 protects {beta}-cells from interleukin 1{beta}-induced apoptosis by interfering with the c-Jun N-terminal kinases pathway. Diabetes 2008, 57:1205-1215.
-
(2008)
Diabetes
, vol.57
, pp. 1205-1215
-
-
Ferdaoussi, M.1
Abdelli, S.2
Yang, J.Y.3
Cornu, M.4
Niederhauser, G.5
Favre, D.6
Widmann, C.7
Reqazzi, R.8
Thorens, B.9
Waeber, G.10
Abderrahamani, A.11
-
14
-
-
0036711553
-
New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c
-
Foufelle F., Ferre P. New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem. J. 2002, 366:377-391.
-
(2002)
Biochem. J.
, vol.366
, pp. 377-391
-
-
Foufelle, F.1
Ferre, P.2
-
15
-
-
0033607176
-
Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
-
Foretz M., Guichard C., Ferre P., Foufelle F. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc. Natl. Acad. Sci. USA 1999, 96:12737-12742.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 12737-12742
-
-
Foretz, M.1
Guichard, C.2
Ferre, P.3
Foufelle, F.4
-
16
-
-
77951436599
-
Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
-
Gupta N.A., Mells J., Dunham R.M., Grakoui A., Handy J., Saxena N.K., Anania F.A. Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. Hepatology 2010, 51:1584-1592.
-
(2010)
Hepatology
, vol.51
, pp. 1584-1592
-
-
Gupta, N.A.1
Mells, J.2
Dunham, R.M.3
Grakoui, A.4
Handy, J.5
Saxena, N.K.6
Anania, F.A.7
-
17
-
-
0036251153
-
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
-
Horton J.D., Goldstein J.L., Brown M.S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 2002, 109:1125-1131.
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1125-1131
-
-
Horton, J.D.1
Goldstein, J.L.2
Brown, M.S.3
-
18
-
-
0242584873
-
Increased islet apoptosis in Pdx1 +/- mice
-
Johnson J.D., Ahmed N.T., Luciani D.S., Han Z., Tran H., Fujita J., Misler S., Edlund H., Polonsky K.S. Increased islet apoptosis in Pdx1 +/- mice. J. Clin. Invest. 2003, 111:1147-1160.
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 1147-1160
-
-
Johnson, J.D.1
Ahmed, N.T.2
Luciani, D.S.3
Han, Z.4
Tran, H.5
Fujita, J.6
Misler, S.7
Edlund, H.8
Polonsky, K.S.9
-
19
-
-
0034682474
-
Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets
-
Kakuma T., Lee Y., Higa M., Wang Z., Pan W., Shimomura I., Unger R.H. Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets. Proc. Natl. Acad. Sci. USA 2000, 97:8536-8541.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 8536-8541
-
-
Kakuma, T.1
Lee, Y.2
Higa, M.3
Wang, Z.4
Pan, W.5
Shimomura, I.6
Unger, R.H.7
-
20
-
-
33745116619
-
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis
-
Karaskov E., Scott C., Zhang L., Teodoro T., Ravazzola M., Volchuk A. Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology 2006, 147:3398-3407.
-
(2006)
Endocrinology
, vol.147
, pp. 3398-3407
-
-
Karaskov, E.1
Scott, C.2
Zhang, L.3
Teodoro, T.4
Ravazzola, M.5
Volchuk, A.6
-
21
-
-
20144373742
-
Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation
-
Kasai K., Ohara-Imaizumi M., Takahashi N., Mizutani S., Zhao S., Kikuta T., Kasai H., Nagamatsu S., Gomi H., Izumi T. Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. J. Clin. Invest. 2005, 115:388-396.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 388-396
-
-
Kasai, K.1
Ohara-Imaizumi, M.2
Takahashi, N.3
Mizutani, S.4
Zhao, S.5
Kikuta, T.6
Kasai, H.7
Nagamatsu, S.8
Gomi, H.9
Izumi, T.10
-
22
-
-
52749087214
-
Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets
-
Kato T., Shimano H., Yamamoto T., Ishikawa M., Kumadaki S., Matsuzaka T., Nakagawa Y., Yahagi N., Nakakuki M., Hasty A.H., Takeuchi Y., Kobayashi K., Takahashi A., Yatoh S., Suzuki H., Sone H., Yamada N. Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets. Diabetes 2008, 57:2382-2392.
-
(2008)
Diabetes
, vol.57
, pp. 2382-2392
-
-
Kato, T.1
Shimano, H.2
Yamamoto, T.3
Ishikawa, M.4
Kumadaki, S.5
Matsuzaka, T.6
Nakagawa, Y.7
Yahagi, N.8
Nakakuki, M.9
Hasty, A.H.10
Takeuchi, Y.11
Kobayashi, K.12
Takahashi, A.13
Yatoh, S.14
Suzuki, H.15
Sone, H.16
Yamada, N.17
-
24
-
-
78449285422
-
Stimulation of glucagon like peptide-1 secretion in enteroendocrine L cells
-
Kim B.J. Stimulation of glucagon like peptide-1 secretion in enteroendocrine L cells. Koream Diabetes J. 2009, 33:458-463.
-
(2009)
Koream Diabetes J.
, vol.33
, pp. 458-463
-
-
Kim, B.J.1
-
25
-
-
0028963743
-
Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loophelix domain
-
Kim J.B., Spotts G.D., Halvorsen Y.D., Shin H.M., Ellenberger T., Towle H.C., Spieqelman B.M. Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loophelix domain. Mol. Cell Biol. 1995, 15:2582-2588.
-
(1995)
Mol. Cell Biol.
, vol.15
, pp. 2582-2588
-
-
Kim, J.B.1
Spotts, G.D.2
Halvorsen, Y.D.3
Shin, H.M.4
Ellenberger, T.5
Towle, H.C.6
Spieqelman, B.M.7
-
26
-
-
0033524937
-
Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in Type 2 diabetes
-
Kulkarni R.N., Bruning J.C., Winnay J.N., Postic C., Magnuson M.A., Kahn C.R. Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in Type 2 diabetes. Cell 1999, 96:329-339.
-
(1999)
Cell
, vol.96
, pp. 329-339
-
-
Kulkarni, R.N.1
Bruning, J.C.2
Winnay, J.N.3
Postic, C.4
Magnuson, M.A.5
Kahn, C.R.6
-
27
-
-
0036578921
-
Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass
-
Kulkarni R.N., Holzenberger M., Shih D.Q., Ozcan U., Stoffel M., Magnuson M.A., Kahn C.R. Beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat. Genet. 2002, 31:111-115.
-
(2002)
Nat. Genet.
, vol.31
, pp. 111-115
-
-
Kulkarni, R.N.1
Holzenberger, M.2
Shih, D.Q.3
Ozcan, U.4
Stoffel, M.5
Magnuson, M.A.6
Kahn, C.R.7
-
28
-
-
1542365269
-
CAMP Dosedependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells
-
Kwon G., Pappan K.L., Marshall C.A., Schaffer J.E., McDaniel M.L. CAMP Dosedependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells. J. Biol. Chem. 2004, 279:8938-8945.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 8938-8945
-
-
Kwon, G.1
Pappan, K.L.2
Marshall, C.A.3
Schaffer, J.E.4
McDaniel, M.L.5
-
29
-
-
73349123190
-
Sterol regulatory element-binding protein-1c knockdown protected INS-1E cells from lipotoxicity
-
Li J., Liu X., Ran X., Chen J., Li X., Wu W., Huang H., Huang H., Long Y., Liang J., Cheng J., Tian H. Sterol regulatory element-binding protein-1c knockdown protected INS-1E cells from lipotoxicity. Diabetes Obes. Metab. 2010, 12(1):35-46.
-
(2010)
Diabetes Obes. Metab.
, vol.12
, Issue.1
, pp. 35-46
-
-
Li, J.1
Liu, X.2
Ran, X.3
Chen, J.4
Li, X.5
Wu, W.6
Huang, H.7
Huang, H.8
Long, Y.9
Liang, J.10
Cheng, J.11
Tian, H.12
-
30
-
-
23944479411
-
Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B
-
Li L., El-Kholy W., Rhodes C.J., Brubaker P.L. Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B. Diabetologia 2005, 48:1339-1349.
-
(2005)
Diabetologia
, vol.48
, pp. 1339-1349
-
-
Li, L.1
El-Kholy, W.2
Rhodes, C.J.3
Brubaker, P.L.4
-
31
-
-
0037230114
-
Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the β-cell line Ins-1
-
Maestre I., Jordan J., Calvo S., Reig J.A., Cena V., Soria B., Prentki M., Roche E. Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the β-cell line Ins-1. Endocrinology 2003, 144:335-345.
-
(2003)
Endocrinology
, vol.144
, pp. 335-345
-
-
Maestre, I.1
Jordan, J.2
Calvo, S.3
Reig, J.A.4
Cena, V.5
Soria, B.6
Prentki, M.7
Roche, E.8
-
32
-
-
0034775035
-
Pancreatic duodenal homeobox-1, PDX-1, a major regulator of β-cell identity and function
-
McKinnon C.M., Docherty K. Pancreatic duodenal homeobox-1, PDX-1, a major regulator of β-cell identity and function. Diabetologia 2001, 44:1203-1214.
-
(2001)
Diabetologia
, vol.44
, pp. 1203-1214
-
-
McKinnon, C.M.1
Docherty, K.2
-
33
-
-
70349768346
-
Exendin-4 regulates glucokinase expression by CaMKK/CaMKIV pathway in pancreatic β-cell line
-
Murao K., Li J., Imachi H., Muraoka T., Masugata H., Zhang G.X., Kobayashi R., Ishida T., Tokumitsu H. Exendin-4 regulates glucokinase expression by CaMKK/CaMKIV pathway in pancreatic β-cell line. Diabetes, Obesity and Metabolism 2009, 11:939-946.
-
(2009)
Diabetes, Obesity and Metabolism
, vol.11
, pp. 939-946
-
-
Murao, K.1
Li, J.2
Imachi, H.3
Muraoka, T.4
Masugata, H.5
Zhang, G.X.6
Kobayashi, R.7
Ishida, T.8
Tokumitsu, H.9
-
34
-
-
0027248866
-
Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1(7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
-
Nauck M.A., Kleine N., Orskov C., Holst J.J., Willms B., Creutzfeldt W. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1(7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1993, 36:741-744.
-
(1993)
Diabetologia
, vol.36
, pp. 741-744
-
-
Nauck, M.A.1
Kleine, N.2
Orskov, C.3
Holst, J.J.4
Willms, B.5
Creutzfeldt, W.6
-
35
-
-
0348048485
-
Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice
-
Otani K., Kulkarni R.N., Baldwin A.C., Krutzfeldt J., Ueki K., Stoffel M., Kahn C.R., Polonsky K.S. Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am. J. Physiol. Endocrinol. Metab. 2004, 286:E41-E49.
-
(2004)
Am. J. Physiol. Endocrinol. Metab.
, vol.286
-
-
Otani, K.1
Kulkarni, R.N.2
Baldwin, A.C.3
Krutzfeldt, J.4
Ueki, K.5
Stoffel, M.6
Kahn, C.R.7
Polonsky, K.S.8
-
36
-
-
0032475889
-
Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins
-
Pai J.T., Guryev O., Brown M.S., Goldstein J.L. Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins. J. Biol. Chem. 1998, 273:26138-26148.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 26138-26148
-
-
Pai, J.T.1
Guryev, O.2
Brown, M.S.3
Goldstein, J.L.4
-
37
-
-
78449309706
-
New and emerging drugs in type 2 diabetes
-
Park I.B. New and emerging drugs in type 2 diabetes. Korean J. Med. 2007, 72:446-450.
-
(2007)
Korean J. Med.
, vol.72
, pp. 446-450
-
-
Park, I.B.1
-
38
-
-
0036797785
-
Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress
-
Piro S., Anello M., Di Pietro C., Lizzio M.N., Patane G., Rabuazzo A.M., Viqneri R., Purrello M., Purrello F. Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress. Metabolism 2002, 51:1340-1347.
-
(2002)
Metabolism
, vol.51
, pp. 1340-1347
-
-
Piro, S.1
Anello, M.2
Di Pietro, C.3
Lizzio, M.N.4
Patane, G.5
Rabuazzo, A.M.6
Viqneri, R.7
Purrello, M.8
Purrello, F.9
-
39
-
-
0029909112
-
Normalization of insulin responses to glucose by overnight infusion of glucagon-like peptide 1 (7-36) amide in patients with NIDDM
-
Rachman J., Gribble F.M., Barrow B.A., Levy J.C., Buchanan K.D., Turner R.C. Normalization of insulin responses to glucose by overnight infusion of glucagon-like peptide 1 (7-36) amide in patients with NIDDM. Diabetes 1996, 45:1524-1530.
-
(1996)
Diabetes
, vol.45
, pp. 1524-1530
-
-
Rachman, J.1
Gribble, F.M.2
Barrow, B.A.3
Levy, J.C.4
Buchanan, K.D.5
Turner, R.C.6
-
40
-
-
78651323561
-
SREBP-1c, PDX-1, and GLP-1R involved in palmitate-EPA regulated glucose-stimulated insulin secretion in INS-1 cells
-
Shao S., Liu Z., Yang Y., Zhang M., Yu X. SREBP-1c, PDX-1, and GLP-1R involved in palmitate-EPA regulated glucose-stimulated insulin secretion in INS-1 cells. Endocrinology 2010, 111:634-642.
-
(2010)
Endocrinology
, vol.111
, pp. 634-642
-
-
Shao, S.1
Liu, Z.2
Yang, Y.3
Zhang, M.4
Yu, X.5
-
41
-
-
0032478314
-
Fatty acid-induced beta-cell apoptosis: a link between obesity and diabetes
-
Shimabuko M., Zhou Y.T., Levi M., Unger R.H. Fatty acid-induced beta-cell apoptosis: a link between obesity and diabetes. Proc. Natl. Acad. Sci. 1998, 95:2498-2502.
-
(1998)
Proc. Natl. Acad. Sci.
, vol.95
, pp. 2498-2502
-
-
Shimabuko, M.1
Zhou, Y.T.2
Levi, M.3
Unger, R.H.4
-
42
-
-
12244286088
-
Glucagon-like peptide-1 and islet lipolysis
-
Sorhede Winzell M., Ahren B. Glucagon-like peptide-1 and islet lipolysis. Horm. Metab. Res. 2004, 36:795-803.
-
(2004)
Horm. Metab. Res.
, vol.36
, pp. 795-803
-
-
Sorhede Winzell, M.1
Ahren, B.2
-
43
-
-
0034032317
-
Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
-
Stoffers D.A., Kieffer T.J., Hussain M.A., Drucker D.J., Bonner-Weir S., Habener J.F., Eqan J.M. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 2000, 49:741-748.
-
(2000)
Diabetes
, vol.49
, pp. 741-748
-
-
Stoffers, D.A.1
Kieffer, T.J.2
Hussain, M.A.3
Drucker, D.J.4
Bonner-Weir, S.5
Habener, J.F.6
Eqan, J.M.7
-
44
-
-
0026775150
-
Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1
-
Thorens B. Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc. Natl. Acad. Sci. USA 1992, 89:8641-8645.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 8641-8645
-
-
Thorens, B.1
-
45
-
-
24344472642
-
Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats
-
Tovar A.R., Torre-Villalvazo I., Ochoa M., Elías A.L., Ortíz V., Aguilar-Salinas C.A., Torres N. Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats. J. Lipid Res. 2005, 46:1823-1832.
-
(2005)
J. Lipid Res.
, vol.46
, pp. 1823-1832
-
-
Tovar, A.R.1
Torre-Villalvazo, I.2
Ochoa, M.3
Elías, A.L.4
Ortíz, V.5
Aguilar-Salinas, C.A.6
Torres, N.7
-
46
-
-
33646351975
-
Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes
-
Ueki K., Okada T., Hu J., Liew C.W., Assmann A., Dahlgren G.M., Peters J.L., Shackman J.G., Zhang M., Artner I., Satin L.S., Stein R., Holzenberger M., Kennedy R.T., Kahn C.R., Kulkarni R.N. Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat. Genet. 2006, 38:583-588.
-
(2006)
Nat. Genet.
, vol.38
, pp. 583-588
-
-
Ueki, K.1
Okada, T.2
Hu, J.3
Liew, C.W.4
Assmann, A.5
Dahlgren, G.M.6
Peters, J.L.7
Shackman, J.G.8
Zhang, M.9
Artner, I.10
Satin, L.S.11
Stein, R.12
Holzenberger, M.13
Kennedy, R.T.14
Kahn, C.R.15
Kulkarni, R.N.16
-
47
-
-
0029151863
-
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
-
Unger R.H. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 1995, 44:863-870.
-
(1995)
Diabetes
, vol.44
, pp. 863-870
-
-
Unger, R.H.1
-
48
-
-
0036182137
-
Lipotoxic diseases
-
Unger R.H. Lipotoxic diseases. Annu. Rev. Med. 2002, 53:319-336.
-
(2002)
Annu. Rev. Med.
, vol.53
, pp. 319-336
-
-
Unger, R.H.1
-
49
-
-
0037203345
-
Lipoapoptosis: its mechanism and its diseases
-
Unger R.H., Orci L. Lipoapoptosis: its mechanism and its diseases. Biochimica Bipphysica Acta 2002, 1585:202-212.
-
(2002)
Biochimica Bipphysica Acta
, vol.1585
, pp. 202-212
-
-
Unger, R.H.1
Orci, L.2
-
50
-
-
0035125917
-
Lipotoxicity of β-cells in obesity and in other causes of fatty acid spillover
-
Unger R.H., Zhou Y.T. Lipotoxicity of β-cells in obesity and in other causes of fatty acid spillover. Diabetes 2001, 50:S118-S121.
-
(2001)
Diabetes
, vol.50
-
-
Unger, R.H.1
Zhou, Y.T.2
-
51
-
-
0033514956
-
Regulation of fatty acid homeostasis in cells: novel role of leptin
-
Unger R.H., Zhou Y.T., Orci L. Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc. Natl. Acad. Sci. USA 1999, 96:2327-2332.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2327-2332
-
-
Unger, R.H.1
Zhou, Y.T.2
Orci, L.3
-
52
-
-
0036381989
-
Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice
-
Wang Q., Brubaker P.L. Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice. Diabetologia 2002, 45:1263-1273.
-
(2002)
Diabetologia
, vol.45
, pp. 1263-1273
-
-
Wang, Q.1
Brubaker, P.L.2
-
53
-
-
1842855402
-
Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells
-
Wang Q., Li L., Xu E., Wong V., Rhodes C., Brubaker P.L. Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells. Diabetologia 2004, 47:478-487.
-
(2004)
Diabetologia
, vol.47
, pp. 478-487
-
-
Wang, Q.1
Li, L.2
Xu, E.3
Wong, V.4
Rhodes, C.5
Brubaker, P.L.6
-
54
-
-
9444242665
-
Five stages of evolving beta-cell dysfunction during progression to diabetes
-
Weir G.C., Bonner-Weir S. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes 2004, 53:S16-S21.
-
(2004)
Diabetes
, vol.53
-
-
Weir, G.C.1
Bonner-Weir, S.2
-
55
-
-
33750458026
-
Extending beta cell survival by UP Regulating ATF4 translation
-
Wek R.C., Anthony T.G. Extending beta cell survival by UP Regulating ATF4 translation. Cell Metab. 2006, 4:333-334.
-
(2006)
Cell Metab.
, vol.4
, pp. 333-334
-
-
Wek, R.C.1
Anthony, T.G.2
-
56
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
Withers D.J., Gutierrez J.S., Towery H., Burks D.J., Ren J.M., Previs S., Zhang Y., Bernal D., Pons S., Shulman G.I., Bonner-Weir S., White M.F. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 1998, 391:900-904.
-
(1998)
Nature
, vol.391
, pp. 900-904
-
-
Withers, D.J.1
Gutierrez, J.S.2
Towery, H.3
Burks, D.J.4
Ren, J.M.5
Previs, S.6
Zhang, Y.7
Bernal, D.8
Pons, S.9
Shulman, G.I.10
Bonner-Weir, S.11
White, M.F.12
-
57
-
-
0037147215
-
Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1)
-
Wrede C.E., Dickson L.M., Lingohr M.K., Briaud I., Rhodes C.J. Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J. Biol. Chem. 2002, 277:49676-49684.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 49676-49684
-
-
Wrede, C.E.1
Dickson, L.M.2
Lingohr, M.K.3
Briaud, I.4
Rhodes, C.J.5
-
58
-
-
34249724553
-
Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes
-
Xu G., Kaneto H., Laybutt D.R., Duvivier-Kali V.F., Trivedi N., Suzuma K., King G.L., Weir G.C., Bonner-Weir S. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes 2007, 56:1551-1558.
-
(2007)
Diabetes
, vol.56
, pp. 1551-1558
-
-
Xu, G.1
Kaneto, H.2
Laybutt, D.R.3
Duvivier-Kali, V.F.4
Trivedi, N.5
Suzuma, K.6
King, G.L.7
Weir, G.C.8
Bonner-Weir, S.9
-
59
-
-
33646492251
-
GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts
-
Xu G., Kaneto H., Lopez-Avalos M.D., Weir G.C., Bonner-Weir S. GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts. Diabetes Res. Clin. Pract. 2006, 73:107-110.
-
(2006)
Diabetes Res. Clin. Pract.
, vol.73
, pp. 107-110
-
-
Xu, G.1
Kaneto, H.2
Lopez-Avalos, M.D.3
Weir, G.C.4
Bonner-Weir, S.5
-
60
-
-
0033513455
-
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
-
Xu G., Stoffers D.A., Habener J.F., Bonner-Weir S. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 1999, 48:2270-2276.
-
(1999)
Diabetes
, vol.48
, pp. 2270-2276
-
-
Xu, G.1
Stoffers, D.A.2
Habener, J.F.3
Bonner-Weir, S.4
-
61
-
-
0036181537
-
The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules
-
Yi Z., Yokota H., Torii S., Aoki T., Hosaka M., Zhao S., Takata K., Takeuchi T., Izumi T. The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. Mol. Cell Biol. 2002, 22:1858-1867.
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 1858-1867
-
-
Yi, Z.1
Yokota, H.2
Torii, S.3
Aoki, T.4
Hosaka, M.5
Zhao, S.6
Takata, K.7
Takeuchi, T.8
Izumi, T.9
-
62
-
-
33750448469
-
GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress
-
Yusta B., Baggio L.L., Estall J.L., Koehler J.A., Holland D.P., Li H., Pipeleers D., Ling Z., Drucker D.J. GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress. Cell Metab. 2006, 4:391-406.
-
(2006)
Cell Metab.
, vol.4
, pp. 391-406
-
-
Yusta, B.1
Baggio, L.L.2
Estall, J.L.3
Koehler, J.A.4
Holland, D.P.5
Li, H.6
Pipeleers, D.7
Ling, Z.8
Drucker, D.J.9
|