Aberrant activation of Liver X receptors impairs pancreatic beta cell function through Upregulation of sterol regulatory element-binding protein 1c in Mouse islets and rodent cell lines

Diabetologia

Volumn 55, Issue 6, 2012, Pages 1733-1744

  Meng, Z X ^a   Yin, Y ^a   Lv, J H ^a   Sha, M ^a   Lin, Y ^a   Gao, L ^a   Zhu, Y X ^a   Sun, Y J ^a   Han, X ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Beta cell; Dysfunction; Insulin secretion; Liver X receptors; SREBP1c

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; FAS ANTIGEN; FATTY ACID; GLUCOSE; ICOSAPENTAENOIC ACID; INSULIN; LIVER X RECEPTOR; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; OXYGEN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; VOLTAGE GATED CALCIUM CHANNEL; FLUORINATED HYDROCARBON; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; ORPHAN NUCLEAR RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; SULFONAMIDE; TO-901317;

ACACA GENE; ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CELL STIMULATION; CONTROLLED STUDY; CPT1A GENE; DIABETOGENESIS; FAS GENE; FATTY ACID OXIDATION; GENE; GENE EXPRESSION REGULATION; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; LIPID METABOLISM; LIPID STORAGE; LIPOTOXICITY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXYGEN CONSUMPTION; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET DISEASE; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN SYNTHESIS; RECEPTOR UPREGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL LINE; DRUG EFFECT; DRUG POTENTIATION; ELECTROPHYSIOLOGY; GENETICS; HAMSTER; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; METABOLISM; PANCREAS ISLET; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; CRICETINAE; ELECTROPHYSIOLOGY; HYDROCARBONS, FLUORINATED; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; ORPHAN NUCLEAR RECEPTORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; SULFONAMIDES;

EID: 84865429632     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2516-2     Document Type: Article

References (48)

1. Saltiel AR (2001) New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 104:517-529 (Pubitemid 32201947)
2. Del Guerra S, Lupi R, Marselli L et al (2005) Functional and molecular defects of pancreatic islets in human type 2 diabetes. Diabetes 54:727-735 (Pubitemid 40322075)
3. Poitout V, Robertson RP (2008) Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev 29:351-366 (Pubitemid 351679704)
4. Prentki M, Nolan CJ (2006) Islet beta cell failure in type 2 diabetes. J Clin Invest 116:1802-1812 (Pubitemid 44033300)
5. Henquin JC (2000) Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 49:1751-1760
6. Nenquin M, Szollosi A, Aguilar-Bryan L, Bryan J, Henquin JC (2004) Both triggering and amplifying pathways contribute to fuelinduced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic beta-cells. J Biol Chem 279:32316-32324 (Pubitemid 39014683)
7. Bernal-Mizrachi E, Fatrai S, Johnson JD et al (2004) Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells. J Clin Invest 114:928-936 (Pubitemid 39578720)
8. Brunham LR, Kruit JK, Verchere CB, Hayden MR (2008) Cholesterol in islet dysfunction and type 2 diabetes. J Clin Invest 118:403-408 (Pubitemid 351206525)
9. Leahy JL (2005) Pathogenesis of type 2 diabetes mellitus. Arch Med Res 36:197-209 (Pubitemid 40755133)
10. Steffensen KR, Gustafsson JA (2004) Putative metabolic effects of the liver X receptor (LXR). Diabetes 53(Suppl 1):S36-S42 (Pubitemid 38168691)
11. Korach-Andre M, Archer A, Barros RP, Parini P, Gustafsson JA (2011) Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity. Proc Natl Acad Sci USA 108:403-408
12. Gerin I, Dolinsky VW, Shackman JG et al (2005) LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function. J Biol Chem 280:23024-23031 (Pubitemid 40861694)
13. Meng ZX, Nie J, Ling JJ et al (2009) Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest. Diabetologia 52:125-135
14. Choe SS, Choi AH, Lee JW et al (2007) Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells. Diabetes 56:1534-1543 (Pubitemid 46842606)
15. Murakami H, Tamasawa N, Matsui J, Yasujima M, Suda T (2000) Plasma oxysterols and tocopherol in patients with diabetes mellitus and hyperlipidemia. Lipids 35:333-338 (Pubitemid 30198779)
16. Ferderbar S, Pereira EC, Apolinario E et al (2007) Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus. Diabetes Metab Res Rev 23:35-42 (Pubitemid 46152484)
17. Mitro N, Mak PA, Vargas L et al (2007) The nuclear receptor LXR is a glucose sensor. Nature 445:219-223 (Pubitemid 46095727)
18. Lazar MA, Willson TM (2007) Sweet dreams for LXR. Cell Metab 5:159-161 (Pubitemid 46335591)
19. Cao G, Liang Y, Jiang XC, Eacho PI (2004) Liver X receptors as potential therapeutic targets for multiple diseases. Drug News Perspect 17:35-41 (Pubitemid 38419370)
20. Bruemmer D, Law RE (2005) Liver x receptors: potential novel targets in cardiovascular diseases. Curr Drug Targets Cardiovasc Haematol Disord 5:533-540 (Pubitemid 43008526)
21. Kakuma T, Lee Y, Higa M et al (2000) Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets. Proc Natl Acad Sci USA 97:8536-8541 (Pubitemid 30639708)
22. Hansmannel F, Mordier S, Iynedjian PB (2006) Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the roles of sterol-regulatory-element-binding protein-1c and liver X receptor. Biochem J 399:275-283 (Pubitemid 44570290)
23. Talukdar S, Hillgartner FB (2006) The mechanism mediating the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317. J Lipid Res 47:2451-2461 (Pubitemid 44936107)
24. Takahashi A, Motomura K, Kato T et al (2005) Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells. Diabetes 54:492-499
25. Diraison F, Parton L, Ferre P et al (2004) Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucosestimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). Biochem J 378:769-778 (Pubitemid 38406852)
26. Poitout V (2004) Beta-cell lipotoxicity: burning fat into heat? Endocrinology 145:3563-3565 (Pubitemid 39037535)
27. Felder TK, Oberkofler H, Weitgasser R et al (2007) The SREBF-1 locus is associated with type 2 diabetes and plasma adiponectin levels in a middle-aged Austrian population. Int J Obes (Lond) 31:1099-1103 (Pubitemid 46987758)
28. Shimano H, Amemiya-Kudo M, Takahashi A, Kato T, Ishikawa M, Yamada N (2007) Sterol regulatory element-binding protein-1c and pancreatic beta-cell dysfunction. Diabetes Obes Metab 9(Suppl 2):133-139 (Pubitemid 47543135)
29. Faulds MH, Zhao C, Dahlman-Wright K (2010) Molecular biology and functional genomics of liver X receptors (LXR) in relationship to metabolic diseases. Curr Opin Pharmacol 10:692-697
30. Ogihara T, Chuang JC, Vestermark GL et al (2010) Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling. J Biol Chem 285:5392-5404
31. Wente W, Brenner MB, Zitzer H, Gromada J, Efanov AM (2007) Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells. Endocrinology 148:1843-1849 (Pubitemid 46457111)
32. Miyazaki J, Araki K, Yamato E et al (1990) Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127:126-132 (Pubitemid 20228111)
33. Santerre RF, Cook RA, Crisel RM et al (1981) Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells. Proc Natl Acad Sci USA 78:4339-4343 (Pubitemid 11010201)
34. Meng ZX, Sun JX, Ling JJ et al (2006) Prostaglandin E2 regulates Foxo activity via the Akt pathway: implications for pancreatic islet beta cell dysfunction. Diabetologia 49:2959-2968 (Pubitemid 44730299)
35. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B (1998) A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 95:2509-2514 (Pubitemid 28145972)
36. Sakurai K, Cederbaum AI (1998) Oxidative stress and cytotoxicity induced by ferric-nitrilotriacetate in HepG2 cells that express cytochrome P450 2E1. Mol Pharmacol 54:1024-1035 (Pubitemid 29002046)
37. Lawrence CL, Proks P, Rodrigo GC et al (2001) Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells. Diabetologia 44:1019-1025 (Pubitemid 32778135)
38. Piaggi S, Novelli M, Martino L et al (2007) Cell death and impairment of glucose-stimulated insulin secretion induced by 2, 3, 7, 8-tetrachlorodibenzo-p- dioxin (TCDD) in the beta-cell line INS-1E. Toxicol Appl Pharmacol 220:333-340 (Pubitemid 46627843)
39. Assimacopoulos-Jeannet F, Thumelin S, Roche E, Esser V, McGarry JD, Prentki M (1997) Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1. J Biol Chem 272:1659-1664 (Pubitemid 27043249)
40. Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-917
41. Chisholm JW, Hong J, Mills SA, Lawn RM (2003) The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. J Lipid Res 44:2039-2048 (Pubitemid 37509619)
42. Davies JD, Carpenter KL, Challis IR et al (2005) Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells. J Biol Chem 280:3911-3919 (Pubitemid 40223860)
43. Seo JB, Moon HM, Kim WS et al (2004) Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol 24:3430-3444 (Pubitemid 38455438)
44. Zitzer H, Wente W, Brenner MB et al (2006) Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels. Endocrinology 147:3898-3905 (Pubitemid 44079395)
45. Efanov AM, Sewing S, Bokvist K, Gromada J (2004) Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells. Diabetes 53(Suppl 3):S75-S78 (Pubitemid 39564526)
46. Choi SE, Jung IR, Lee YJ et al (2011) Stimulation of lipogenesis as well as fatty acid oxidation protects against palmitate-induced INS-1 beta-cell death. Endocrinology 152:816-827
47. Hellemans KH, Hannaert JC, Denys B et al (2009) Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalphadependent stearoyl-coenzyme A desaturase. PLoS One 4:e7266
48. Green CD, Jump DB, Olson LK (2009) Elevated insulin secretion from liver X receptor-activated pancreatic beta-cells involves increased de novo lipid synthesis and triacylglyceride turnover. Endocrinology 150:2637-2645