The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

Diabetologia

Volumn 54, Issue 5, 2011, Pages 1098-1108

  Shimoda, M ^a   Kanda, Y ^a   Hamamoto, S ^a   Tawaramoto, K ^a   Hashiramoto, M ^a   Matsuki, M ^a   Kaku, K ^a  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

Author keywords

Apoptosis; Beta cell mass; Cellular differentiation; Cellular proliferation; ER stress; Glucagon like peptide 1; Oxidative stress

Indexed keywords

GLUCOSE; INSULIN; LIRAGLUTIDE; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL KINETICS; CELL PROLIFERATION; CELLULAR PARAMETERS; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFICACY; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; LASER CAPTURE MICRODISSECTION; LIPOGENESIS; MALE; MORPHOMETRICS; MOUSE; MOUSE STRAIN; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PANCREAS ISLET BETA CELL MASS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; DIABETES MELLITUS; EATING; ENDOPLASMIC RETICULUM; GLUCAGON-LIKE PEPTIDE 1; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; MICRODISSECTION; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; WEIGHT GAIN;

EID: 79954631160     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2069-9     Document Type: Article

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