메뉴 건너뛰기




Volumn 30, Issue 3, 2013, Pages 267-275

Banting Memorial Lecture 2012 Reversing the twin cycles of Type 2 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; ARGININE; FAT; GLUCOSE; GLYCOGEN; TRIACYLGLYCEROL;

EID: 84874185427     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/dme.12039     Document Type: Review
Times cited : (74)

References (38)
  • 1
    • 0032983666 scopus 로고    scopus 로고
    • Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group
    • Turner RC, Cull CA, Frighi V, Holman RR. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. J Am Med Assoc 1999; 281: 2005-2012.
    • (1999) J Am Med Assoc , vol.281 , pp. 2005-2012
    • Turner, R.C.1    Cull, C.A.2    Frighi, V.3    Holman, R.R.4
  • 2
    • 84874187310 scopus 로고    scopus 로고
    • Type 2 and you
    • Available at Last accessed 22 October 2012.
    • Davies NJ. Type 2 and you. Balance 2012. Available at http://www.diabetes.org.uk/How_we_help/Magazines/Balance/Past-issues/Balance/Type-2-and-you/ Last accessed 22 October 2012.
    • (2012) Balance
    • Davies, N.J.1
  • 3
    • 0028817815 scopus 로고
    • UK prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease
    • UK Prospective Diabetes Study Group.
    • UK Prospective Diabetes Study Group. UK prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes 1995; 44: 1249-1258.
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 4
    • 33847636157 scopus 로고    scopus 로고
    • Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes
    • Cnop M, Vidal J, Hull RL, Utzschneider KM, Carr DB, Schraw T, et al. Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes. Diabetes Care 2007; 30: 677-682.
    • (2007) Diabetes Care , vol.30 , pp. 677-682
    • Cnop, M.1    Vidal, J.2    Hull, R.L.3    Utzschneider, K.M.4    Carr, D.B.5    Schraw, T.6
  • 5
    • 33745302884 scopus 로고    scopus 로고
    • The natural course of beta-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study
    • Festa A, Williams K, D'Agostino R Jr, Wagenknecht LE, Haffner SM. The natural course of beta-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study. Diabetes 2006; 55: 1114-1120.
    • (2006) Diabetes , vol.55 , pp. 1114-1120
    • Festa, A.1    Williams, K.2    D'Agostino Jr., R.3    Wagenknecht, L.E.4    Haffner, S.M.5
  • 7
    • 0032742992 scopus 로고    scopus 로고
    • The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
    • Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 1999; 104: 787-794.
    • (1999) J Clin Invest , vol.104 , pp. 787-794
    • Weyer, C.1    Bogardus, C.2    Mott, D.M.3    Pratley, R.E.4
  • 8
    • 67649111182 scopus 로고    scopus 로고
    • Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study
    • Tabak AG, Jokela M, Akbaraly TN, Brunner EJ, Kivimaki M, Witte DR. Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study. Lancet 2009; 373: 2215-2221.
    • (2009) Lancet , vol.373 , pp. 2215-2221
    • Tabak, A.G.1    Jokela, M.2    Akbaraly, T.N.3    Brunner, E.J.4    Kivimaki, M.5    Witte, D.R.6
  • 9
    • 0027947379 scopus 로고
    • β-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-β-cell relationships
    • Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH. β-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-β-cell relationships. Proc Natl Acad Sci U S A 1994; 91: 10878-10882.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10878-10882
    • Lee, Y.1    Hirose, H.2    Ohneda, M.3    Johnson, J.H.4    McGarry, J.D.5    Unger, R.H.6
  • 10
    • 33748291464 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets
    • Lalloyer F, Vandewalle B, Percevault F, Torpier G, Kerr-Conte J, Oosterveer M, et al. Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets. Diabetes 2006; 55: 1605-1613.
    • (2006) Diabetes , vol.55 , pp. 1605-1613
    • Lalloyer, F.1    Vandewalle, B.2    Percevault, F.3    Torpier, G.4    Kerr-Conte, J.5    Oosterveer, M.6
  • 13
    • 84857435669 scopus 로고    scopus 로고
    • Free fatty acids block glucose-induced beta-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18
    • Pascoe J, Hollern D, Stamateris R, Abbasi M, Romano LC, Zou B, et al. Free fatty acids block glucose-induced beta-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18. Diabetes 2012; 61: 632-641.
    • (2012) Diabetes , vol.61 , pp. 632-641
    • Pascoe, J.1    Hollern, D.2    Stamateris, R.3    Abbasi, M.4    Romano, L.C.5    Zou, B.6
  • 14
    • 0028833276 scopus 로고
    • Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, loss of beta-cell GLUT 2 and glucose incompetence
    • Ohneda M, Inman LR, Unger RH. Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, loss of beta-cell GLUT 2 and glucose incompetence. Diabetologia 1995; 38: 173-179.
    • (1995) Diabetologia , vol.38 , pp. 173-179
    • Ohneda, M.1    Inman, L.R.2    Unger, R.H.3
  • 15
    • 0036312905 scopus 로고    scopus 로고
    • Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
    • Seppala-Lindroos A, Vehkavaara S, Hakkinen AM, Goto T, Westerbacka J, Sovijarvi A, et al. Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 2002; 87: 3023-3028.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3023-3028
    • Seppala-Lindroos, A.1    Vehkavaara, S.2    Hakkinen, A.M.3    Goto, T.4    Westerbacka, J.5    Sovijarvi, A.6
  • 16
    • 14644435731 scopus 로고    scopus 로고
    • Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes
    • Petersen KF, Dufour S, Befroy D, Lehrke M, Hendler RE, Shulman GI. Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes 2005; 54: 603-608.
    • (2005) Diabetes , vol.54 , pp. 603-608
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Lehrke, M.4    Hendler, R.E.5    Shulman, G.I.6
  • 17
    • 51249092912 scopus 로고    scopus 로고
    • Dalla Man C, Firbank MJ, Lane A, English PT Pioglitazone decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic triglyceride content
    • Ravikumar B, Gerrard J. Dalla Man C, Firbank MJ, Lane A, English PT et al. Pioglitazone decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic triglyceride content. Diabetes 2008; 57: 2288-2295.
    • (2008) Diabetes , vol.57 , pp. 2288-2295
    • Ravikumar, B.1    Gerrard, J.2
  • 18
    • 0023924773 scopus 로고
    • Impaired glucose tolerance as a disorder of insulin action: longitudinal and cross sectional studies in Pima Indians
    • Lillioja S, Mott DM, Howard BV, Bennett PH, Yki-Jarvinen H, Freymond D, et al. Impaired glucose tolerance as a disorder of insulin action: longitudinal and cross sectional studies in Pima Indians. N Engl J Med 1988; 318: 1217-1225.
    • (1988) N Engl J Med , vol.318 , pp. 1217-1225
    • Lillioja, S.1    Mott, D.M.2    Howard, B.V.3    Bennett, P.H.4    Yki-Jarvinen, H.5    Freymond, D.6
  • 20
    • 84866621997 scopus 로고    scopus 로고
    • Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans
    • Sevastianova K, Santos A, Kotronen A, Hakkarainen A, Makkonen J, Silander K et al. Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans. Am J Clin Nutr 2012; 96: 727-734.
    • (2012) Am J Clin Nutr , vol.96 , pp. 727-734
    • Sevastianova, K.1    Santos, A.2    Kotronen, A.3    Hakkarainen, A.4    Makkonen, J.5    Silander, K.6
  • 21
    • 77953868236 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance: unravelling the mechanism
    • Samuel VT, Petersen KF, Shulman GI. Lipid-induced insulin resistance: unravelling the mechanism. Lancet 2010; 375: 2267-2277.
    • (2010) Lancet , vol.375 , pp. 2267-2277
    • Samuel, V.T.1    Petersen, K.F.2    Shulman, G.I.3
  • 22
    • 51249107750 scopus 로고    scopus 로고
    • Pathogenesis of Type 2 diabetes: tracing the reverse route from cure to cause
    • Taylor R. Pathogenesis of Type 2 diabetes: tracing the reverse route from cure to cause. Diabetologia 2008; 51: 1781-1789.
    • (2008) Diabetologia , vol.51 , pp. 1781-1789
    • Taylor, R.1
  • 23
    • 34047098736 scopus 로고    scopus 로고
    • Serial metabolic measurements and conversion to type 2 diabetes in the west of Scotland coronary prevention study: specific elevations in alanine aminotransferase and triglycerides suggest hepatic fat accumulation as a potential contributing factor
    • Sattar N, McConnachie A, Ford I, Gaw A, Cleland SJ, Forouhi NG, et al. Serial metabolic measurements and conversion to type 2 diabetes in the west of Scotland coronary prevention study: specific elevations in alanine aminotransferase and triglycerides suggest hepatic fat accumulation as a potential contributing factor. Diabetes 2007; 56: 984-991.
    • (2007) Diabetes , vol.56 , pp. 984-991
    • Sattar, N.1    McConnachie, A.2    Ford, I.3    Gaw, A.4    Cleland, S.J.5    Forouhi, N.G.6
  • 25
    • 80054091845 scopus 로고    scopus 로고
    • Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
    • Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia 2011; 54: 2506-2514.
    • (2011) Diabetologia , vol.54 , pp. 2506-2514
    • Lim, E.L.1    Hollingsworth, K.G.2    Aribisala, B.S.3    Chen, M.J.4    Mathers, J.C.5    Taylor, R.6
  • 26
    • 84874126045 scopus 로고    scopus 로고
    • Population response to information on reversibility of Type 2 diabetes
    • doi: 10.1111/dme.12116 (Epub ahead of print)
    • Steven S, Lim EL, Taylor R. Population response to information on reversibility of Type 2 diabetes. Diabet Med 2013; doi: 10.1111/dme.12116 (Epub ahead of print).
    • (2013) Diabet Med
    • Steven, S.1    Lim, E.L.2    Taylor, R.3
  • 29
    • 0024851469 scopus 로고
    • Study of human skeletal muscle in vitro: effect of NEFA supply on glucose storage
    • Argyraki M, Wright PD, Venables CW, Proud G, Taylor R. Study of human skeletal muscle in vitro: effect of NEFA supply on glucose storage. Metabolism 1989; 38: 1183-1187.
    • (1989) Metabolism , vol.38 , pp. 1183-1187
    • Argyraki, M.1    Wright, P.D.2    Venables, C.W.3    Proud, G.4    Taylor, R.5
  • 30
    • 0026517191 scopus 로고
    • The effect of increased fatty acid supply upon glucose metabolism and skeletal muscle glycogen synthase activity in normal man
    • Johnson AB, Argyraki M, Thoow JC, Cooper BG, Fulcher G, Taylor R. The effect of increased fatty acid supply upon glucose metabolism and skeletal muscle glycogen synthase activity in normal man. Clin Sci 1992; 82: 219-226.
    • (1992) Clin Sci , vol.82 , pp. 219-226
    • Johnson, A.B.1    Argyraki, M.2    Thoow, J.C.3    Cooper, B.G.4    Fulcher, G.5    Taylor, R.6
  • 31
    • 0026012861 scopus 로고
    • Peripheral and hepatic insulin sensitivity in healthy elderly human subjects
    • Broughton DL, James OW, Alberti KG, Taylor R. Peripheral and hepatic insulin sensitivity in healthy elderly human subjects. Eur J Clin Invest 1991; 21: 13-21.
    • (1991) Eur J Clin Invest , vol.21 , pp. 13-21
    • Broughton, D.L.1    James, O.W.2    Alberti, K.G.3    Taylor, R.4
  • 32
    • 0026606118 scopus 로고
    • Resistance to injection
    • Taylor R. Resistance to injection. Diabet Med 1992; 9: 104-108.
    • (1992) Diabet Med , vol.9 , pp. 104-108
    • Taylor, R.1
  • 33
    • 0026616869 scopus 로고
    • Validation of 13C NMR measurement of human skeletal muscle glycogen by direct biochemical assay of needle biopsy samples
    • Taylor R, Price TB, Rothman DL, Shulman RG, Shulman GI. Validation of 13C NMR measurement of human skeletal muscle glycogen by direct biochemical assay of needle biopsy samples. Magn Reson Med 1992; 27: 13-20.
    • (1992) Magn Reson Med , vol.27 , pp. 13-20
    • Taylor, R.1    Price, T.B.2    Rothman, D.L.3    Shulman, R.G.4    Shulman, G.I.5
  • 34
    • 0037376947 scopus 로고    scopus 로고
    • Direct assessment of muscle glycogen storage after mixed meals in normal and type 2 diabetic subjects
    • Carey PE, Halliday J, Snaar JEM, Morris PG, Taylor R. Direct assessment of muscle glycogen storage after mixed meals in normal and type 2 diabetic subjects. Am J Physiol 2003; 284: E286-E294.
    • (2003) Am J Physiol , vol.284
    • Carey, P.E.1    Halliday, J.2    Snaar, J.E.M.3    Morris, P.G.4    Taylor, R.5
  • 36
    • 49649115590 scopus 로고    scopus 로고
    • Increased daily walking improves lipid oxidation without changes in mitochondrial function in Type 2 diabetes
    • Trenell MI, Hollingsworth KG, Lim EL, Taylor R. Increased daily walking improves lipid oxidation without changes in mitochondrial function in Type 2 diabetes. Diabetes Care 2008; 31: 1644-1649.
    • (2008) Diabetes Care , vol.31 , pp. 1644-1649
    • Trenell, M.I.1    Hollingsworth, K.G.2    Lim, E.L.3    Taylor, R.4
  • 37
    • 79951717512 scopus 로고    scopus 로고
    • Utilizing the second-meal effect in type 2 diabetes: practical use of a soya-yogurt snack
    • Chen MJ, Jovanovic A, Taylor R. Utilizing the second-meal effect in type 2 diabetes: practical use of a soya-yogurt snack. Diabetes Care 2010; 33: 2552-2554.
    • (2010) Diabetes Care , vol.33 , pp. 2552-2554
    • Chen, M.J.1    Jovanovic, A.2    Taylor, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.