Overexpression of peroxisome proliferator-activated receptor α in pancreatic β-cells improves glucose tolerance in diet-induced obese mice

Experimental Physiology

Volumn 98, Issue 2, 2013, Pages 564-575

  Hogh, K Lynn N ^a   Uy, Christopher E ^a   Asadi, Ali ^b   Baker, Robert K ^b   Riedel, Michael J ^b   Gray, Sarah L ^a  

^a UNIVERSITY OF NORTHERN BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A OXIDASE; CARBOHYDRATE; CARNITINE PALMITOYLTRANSFERASE I; INSULIN; LONG CHAIN ACYL COENZYME A DEHYDROGENASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; UNCOUPLING PROTEIN 2;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; GLUCOSE TOLERANCE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; LIPID DIET; LIPOTOXICITY; MALE; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 84872713717     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2012.068734     Document Type: Article

References (41)

1. Bergeron R, Yao J, Woods JW, Zycband EI, Liu C, Li Z, Adams A, Berger JP, Zhang BB, Moller DE & Doebber TW (2006). Peroxisome proliferator-activated receptor (PPAR)-α agonism prevents the onset of type 2 diabetes in Zucker diabetic fatty rats: a comparison with PPARγ agonism. Endocrinology 147, 4252-4262.
2. Bihan H, Rouault C, Reach G, Poitout V, Staels B & Guerre-Millo M (2005). Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARα). FEBS Lett 579, 2284-2288.
3. Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL, Vandesompele J & Wittwer CT (2009). The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem 55, 611-622.
4. Chavez JA & Summers SA (2010). Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms. Biochim Biophys Acta 1801, 252-265.
5. Chinetti G, Fruchart JC & Staels B (2000). Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Res 49, 497-505.
6. Choi D, Nguyen KT, Wang L, Schroer SA, Suzuki A, Mak TW & Woo M (2008). Partial deletion of Pten in the hypothalamus leads to growth defects that cannot be rescued by exogenous growth hormone. Endocrinology 149, 4382-4386.
7. Choudhury AI, Heffron H, Smith MA, Al-Qassab H, Xu AW, Selman C, Simmgen M, Clements M, Claret M, Maccoll G, Bedford DC, Hisadome K, Diakonov I, Moosajee V, Bell JD, Speakman JR, Batterham RL, Barsh GS, Ashford ML & Withers DJ (2005). The role of insulin receptor substrate 2 in hypothalamic and β cell function. J Clin Invest 115, 940-950.
8. Dalby B, Cates S, Harris A, Ohki EC, Tilkins ML, Price PJ & Ciccarone VC (2004). Advanced transfection with Lipofectamine 2000 reagent: primary neurons, siRNA, and high-throughput applications. Methods 33, 95-103.
9. Elsner M, Gehrmann W & Lenzen S (2011). Peroxisome-generated hydrogen peroxide as important mediator of lipotoxicity in insulin-producing cells. Diabetes 60, 200-208.
10. Frigerio F, Brun T, Bartley C, Usardi A, Bosco D, Ravnskjaer K, Mandrup S & Maechler P (2010). Peroxisome proliferator-activated receptor α (PPARα) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism. Diabetologia 53, 331-340.
11. Gaddy DF, Riedel MJ, Pejawar-Gaddy S, Kieffer TJ & Robbins PD (2010). In vivo expression of HGF/NK1 and GLP-1 from dsAAV vectors enhances pancreatic β-cell proliferation and improves pathology in the db/db mouse model of diabetes. Diabetes 59, 3108-3116.
12. Gehrmann W, Elsner M & Lenzen S (2010). Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β-cells. Diabetes Obes Metab 12(Suppl 2), 149-158.
13. Giacca A, Xiao C, Oprescu AI, Carpentier AC & Lewis GF (2011). Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies. Am J Physiol Endocrinol Metab 300, E255-E262.
14. Guerre-Millo M, Gervois P, Raspé E, Madsen L, Poulain P, Derudas B, Herbert JM, Winegar DA, Willson TM, Fruchart JC, Berge RK & Staels B (2000). Peroxisome proliferator-activated receptor α activators improve insulin sensitivity and reduce adiposity. J Biol Chem 275, 16638-16642.
15. Guerre-Millo M, Rouault C, Poulain P, André J, Poitout V, Peters JM, Gonzalez FJ, Fruchart JC, Reach G & Staels B (2001). PPAR-α-null mice are protected from high-fat diet-induced insulin resistance. Diabetes 50, 2809-2814.
16. 2+ homeostasis in β-cells. Am J Physiol Endocrinol Metab 296, E690-E701.
17. Hellemans K, Kerckhofs K, Hannaert JC, Martens G, Van Veldhoven P & Pipeleers D (2007). Peroxisome proliferator-activated receptor α-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity. FEBS J 274, 6094-6105.
18. Holland WL, Brozinick JT, Wang LP, Hawkins ED, Sargent KM, Liu Y, Narra K, Hoehn KL, Knotts TA, Siesky A, Nelson DH, Karathanasis SK, Fontenot GK, Birnbaum MJ & Summers SA (2007). Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab 5, 167-179.
19. Holness MJ, Smith ND, Greenwood GK & Sugden MC (2003). Acute (24 h) activation of peroxisome proliferator-activated receptor-α (PPARα) reverses high-fat feeding-induced insulin hypersecretion in vivo and in perifused pancreatic islets. J Endocrinol 177, 197-205.
20. Huynh FK, Levi J, Denroche HC, Gray SL, Voshol PJ, Neumann UH, Speck M, Chua SC, Covey SD & Kieffer TJ (2010). Disruption of hepatic leptin signaling protects mice from age- and diet-related glucose intolerance. Diabetes 59, 3032-3040.
21. Itani SI, Ruderman NB, Schmieder F & Boden G (2002). Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IκB-α. Diabetes 51, 2005-2011.
22. Koh EH, Kim MS, Park JY, Kim HS, Youn JY, Park HS, Youn JH & Lee KU (2003). Peroxisome proliferator-activated receptor (PPAR)-α activation prevents diabetes in OLETF rats: comparison with PPAR-γ activation. Diabetes 52, 2331-2337.
23. Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, Bain J, Stevens R, Dyck JR, Newgard CB, Lopaschuk GD & Muoio DM (2008). Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 7, 45-56.
24. Lalloyer F, Vandewalle B, Percevault F, Torpier G, Kerr-Conte J, Oosterveer M, Paumelle R, Fruchart JC, Kuipers F, Pattou F, Fiévet C & Staels B (2006). Peroxisome proliferator-activated receptor α improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets. Diabetes 55, 1605-1613.
25. Lee Y, Ravazzola M, Park BH, Bashmakov YK, Orci L & Unger RH (2007). Metabolic mechanisms of failure of intraportally transplanted pancreatic β-cells in rats: role of lipotoxicity and prevention by leptin. Diabetes 56, 2295-2301.
26. Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M & Vidal-Puig A (2007). PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet 3, e64.
27. Nolan CJ, Madiraju MS, Delghingaro-Augusto V, Peyot ML & Prentki M (2006). Fatty acid signaling in the β-cell and insulin secretion. Diabetes 55(Suppl 2), S16-S23.
28. Prentki M & Nolan CJ (2006). Islet β cell failure in type 2 diabetes. J Clin Invest 116, 1802-1812.
29. Ravnskjaer K, Boergesen M, Rubi B, Larsen JK, Nielsen T, Fridriksson J, Maechler P & Mandrup S (2005). Peroxisome proliferator-activated receptor α (PPARα) potentiates, whereas PPARγ attenuates, glucose-stimulated insulin secretion in pancreatic β-cells. Endocrinology 146, 3266-3276.
30. Riedel MJ, Gaddy DF, Asadi A, Robbins PD & Kieffer TJ (2010). DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes. Gene Ther 17, 171-180.
31. Smyth S & Heron A (2006). Diabetes and obesity: the twin epidemics. Nat Med 12, 75-80.
32. Staels B, Maes M & Zambon A (2008). Fibrates and future PPARα agonists in the treatment of cardiovascular disease. Nat Clin Pract Cardiovasc Med 5, 542-553.
33. Sugden MC, Greenwood GK, Smith ND & Holness MJ (2003). Peroxisome proliferator-activated receptor-α activation during pregnancy attenuates glucose-stimulated insulin hypersecretion in vivo by increasing insulin sensitivity, without impairing pregnancy-induced increases in β-cell glucose sensing and responsiveness. Endocrinology 144, 146-153.
34. Tordjman K, Standley KN, Bernal-Mizrachi C, Leone TC, Coleman T, Kelly DP & Semenkovich CF (2002). PPARα suppresses insulin secretion and induces UCP2 in insulinoma cells. J Lipid Res 43, 936-943.
35. Unger RH (2002). Lipotoxic diseases. Annu Rev Med 53, 319-336.
36. van Herpen NA & Schrauwen-Hinderling VB (2008). Lipid accumulation in non-adipose tissue and lipotoxicity. Physiol Behav 94, 231-241.
37. Virtue S & Vidal-Puig A (2010). Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome - an allostatic perspective. Biochim Biophys Acta 1801, 338-349.
38. Wang Z, Zhu T, Rehman KK, Bertera S, Zhang J, Chen C, Papworth G, Watkins S, Trucco M, Robbins PD, Li J & Xiao X (2006). Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes. Diabetes 55, 875-884.
39. Xiao C, Giacca A & Lewis GF (2008). Oral taurine but not N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men. Diabetologia 51, 139-146.
40. Xiao J, Gregersen S, Kruhoffer M, Pedersen SB, Orntoft TF & Hermansen K (2001). The effect of chronic exposure to fatty acids on gene expression in clonal insulin-producing cells: studies using high density oligonucleotide microarray. Endocrinology 142, 4777-4784.
41. Yessoufou A, Ategbo JM, Attakpa E, Hichami A, Moutairou K, Dramane KL & Khan NA (2009). Peroxisome proliferator-activated receptor-α modulates insulin gene transcription factors and inflammation in adipose tissues in mice. Mol Cell Biochem 323, 101-111.