PPAR-γ Activation Increases Insulin Secretion through the Up-regulation of the Free Fatty Acid Receptor GPR40 in Pancreatic β-Cells

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Kim, Hyo Sup ^a   Hwang, You Cheol ^b   Koo, Seung Hoi ^c   Park, Kyong Soo ^d   Lee, Myung Shik ^c   Kim, Kwang Won ^c   Lee, Moon Kyu ^c  

^a Samsung Medical Center   (South Korea)

^b Kyung Hee University College of Medicine   (South Korea)

^c Sungkyunkwan University School of Medicine   (South Korea)

^d Seoul National University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; G PROTEIN COUPLED RECEPTOR 40; GLUCOSE TRANSPORTER 2; HEPATOCYTE NUCLEAR FACTOR 3BETA; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; ROSIGLITAZONE; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; GENE EXPRESSION; GLUCOSE CLAMP TECHNIQUE; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; INSULIN SENSITIVITY; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; PANCREAS ISLET BETA CELL; PROTEIN PHOSPHORYLATION; RAT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION;

ADENOVIRIDAE; ANIMALS; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELL LINE, TUMOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FATTY ACIDS, NONESTERIFIED; GENE EXPRESSION REGULATION; GENETIC VECTORS; GLUCOSE TRANSPORTER TYPE 2; HOMEODOMAIN PROTEINS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-SECRETING CELLS; MALE; PHOSPHORYLATION; PPAR GAMMA; RATS; RATS, INBRED OLETF; RECEPTORS, G-PROTEIN-COUPLED; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THIAZOLIDINEDIONES; TRANS-ACTIVATORS;

RATTUS;

EID: 84872766663     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050128     Document Type: Article

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