Long-term in vitro treatment of INS-1 rat pancreatic β-cells by unsaturated free fatty acids protects cells against gluco- and lipotoxicities via activation of GPR40 receptors

Clinical and Experimental Pharmacology and Physiology

Volumn 39, Issue 5, 2012, Pages 423-428

  Tuo, Ya ^a,b   Feng, Dan Dan ^c   Wang, Deng Feng ^b,d   Sun, Jian ^b   Li, Sheng Bin ^a   Chen, Chen ^b  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c CENTRAL SOUTH UNIVERSITY   (China)

^d SICHUAN UNIVERSITY   (China)

Author keywords

Free fatty acids; GPR40; INS 1 cell; Insulin secretion

Indexed keywords

G PROTEIN COUPLED RECEPTOR 40; GLUCOSE; INSULIN; LINOLEIC ACID; LINOLENIC ACID; MESSENGER RNA; OLEIC ACID; PALMITIC ACID;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; INSULIN RELEASE; LIPOTOXICITY; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; UPREGULATION;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CYTOPROTECTION; FATTY ACIDS, NONESTERIFIED; FATTY ACIDS, UNSATURATED; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; RATS; RECEPTORS, G-PROTEIN-COUPLED; TIME FACTORS; TREATMENT OUTCOME;

EID: 84860250275     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2012.05691.x     Document Type: Article

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