Ubiquitin C-terminal hydrolase L1 is required for pancreatic beta cell survival and function in lipotoxic conditions

Diabetologia

Volumn 55, Issue 1, 2012, Pages 128-140

  Chu, K Y ^a   Li, H ^a   Wada, K ^b   Johnson, J D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

Apoptosis; Parkinson's disease; Type 2 diabetes; Ubiquitin proteasome system

Indexed keywords

CYCLINE; GLUCOSE; INSULIN; PALMITIC ACID; SNARE PROTEIN; SYNAPTOBREVIN 2; UBIQUITIN THIOLESTERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CALCIUM SIGNALING; CELL DEATH; CELL FATE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME DEFICIENCY; ENZYME LOCALIZATION; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; INSULIN TOLERANCE TEST; LIPID DIET; LIPOTOXICITY; MOUSE; NERVE FIBER DEGENERATION; NICK END LABELING; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET CELL HYPERPLASIA; PRIORITY JOURNAL; UBIQUITINATION; UPREGULATION;

ANIMALS; APOPTOSIS; CELL LINE; CELL PROLIFERATION; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITORS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; ISOENZYMES; MALE; MICE; MICE, NEUROLOGIC MUTANTS; NEUROAXONAL DYSTROPHIES; PALMITIC ACID; RNA, MESSENGER; SNARE PROTEINS; UBIQUITIN THIOLESTERASE; UBIQUITINATION; UP-REGULATION; VESICLE-ASSOCIATED MEMBRANE PROTEIN 2;

EID: 84856761759     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2323-1     Document Type: Article

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