Oleate rescues INS-1E β-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response

Biochemical and Biophysical Research Communications

Volumn 441, Issue 4, 2013, Pages 770-776

  Sommerweiss, Dietlind ^a   Gorski, Theresa ^a   Richter, Sandy ^a   Garten, Antje ^a   Kiess, Wieland ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Apoptosis; Beta cell; ER stress; Oleate; Palmitate; UPR

Indexed keywords

CALNEXIN; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; MESSENGER RNA; OLEIC ACID; PALMITIC ACID; X BOX BINDING PROTEIN 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; NONHUMAN; PANCREAS ISLET BETA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING;

ACTIVATING-TRANSCRIPTION-FACTOR 6; APOPTOSIS; ATF6; BETA CELL; BIP/GRP78; C/EBP HOMOLOGOUS PROTEIN; CHOP; EIF2Α; ENDOPLASMIC RETICULUM; ER; ER STRESS; EUKARYOTIC INITIATION FACTOR 2Α; FFA; FREE FATTY ACID; GLUCOSE-REGULATED PROTEIN 94KDA; GRP94; IMMUNOGLOBULIN HEAVY-CHAIN BINDING PROTEIN; INOSITOL-REQUIRING-ENZYME1; IRE1; MONOUNSATURATED FATTY ACID; MUFA; OLEATE; PALMITATE; PDI; PERK; PROTEIN DISULFIDE ISOMERASE; PROTEIN-KINASE-REGULATED-BY-RNA-LIKE-ER-ASSOCIATED-KINASE; SATURATED FATTY ACID; SCD1; SFA; STEAROYL-COA DESATURASE 1; UNFOLDED PROTEIN RESPONSE; UPR; X-BOX-BINDING PROTEIN 1; XBP1;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOPROTECTION; INSULIN-SECRETING CELLS; MOLECULAR CHAPERONES; OLEIC ACID; PALMITATES; RATS; TRANSCRIPTION FACTOR CHOP; UNFOLDED PROTEIN RESPONSE; UP-REGULATION;

EID: 84888832151     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.10.130     Document Type: Article

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