Lipopolysaccharides impair insulin gene expression in isolated islets of langerhans via toll-like receptor-4 and nf-κb signalling

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Amyot, Julie ^a,b   Semache, Meriem ^a,b   Ferdaoussi, Mourad ^a   Fontés, Ghislaine ^a   Poitout, Vincent ^a,b  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1; HOMEODOMAIN PROTEIN; PANCREATIC AND DUODENAL HOMEOBOX 1 PROTEIN; RNA PRECURSOR; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INSULIN RELEASE; INTESTINE FLORA; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PROTEIN DEFICIENCY; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; IN VITRO STUDY; MALE; METABOLISM; PANCREAS ISLET; RAT; SECRETION;

AVES; MAMMALIA; MUS; RATTUS;

ANIMALS; CELL LINE; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; ISLETS OF LANGERHANS; LIPOPOLYSACCHARIDES; MALE; MICE; NF-KAPPA B; RATS; RNA PRECURSORS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TRANS-ACTIVATORS;

EID: 84860485809     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036200     Document Type: Article

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